Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3781 | 0.4548 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.1361 | 0.1265 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7357 | 0.7328 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.7357 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.7357 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.7357 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.7357 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.7357 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0453 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7357 | 0.7328 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.4678 | 0.6015 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.3781 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4678 | 0.4619 |
Onchocerca volvulus | 0.003 | 0.4393 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.1367 | 0.0866 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.1361 | 0.108 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.4678 | 0.6015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.2226 | 0.2029 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7357 | 0.7328 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.7357 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.4393 | 0.548 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.3781 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.1367 | 0.0866 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.3781 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.3781 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4393 | 0.4331 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.1367 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.3781 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.1367 | 0.0866 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.0214 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0453 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.3781 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.8867 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.4393 | 0.5396 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4678 | 0.4619 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.1361 | 0.108 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.3781 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.1367 | 0.0695 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.1367 | 0.0695 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.3781 | 0.4445 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Cytotoxicity against human CEM cells assessed as decrease in cell viability | ChEMBL. | 19645484 |
MCC (ADMET) | > 100 uM | Cytotoxicity against HEL cells assessed as concentration required to cause alteration in cell alteration by microscopically | ChEMBL. | 19645484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.