Detailed information for compound 1054576

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 369.457 | Formula: C21H27N3O3
  • H donors: 2 H acceptors: 2 LogP: 4.96 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)Oc1nccc(c1)/C(=N/O)/NCC1CCCCC1
  • InChi: 1S/C21H27N3O3/c1-2-26-18-8-10-19(11-9-18)27-20-14-17(12-13-22-20)21(24-25)23-15-16-6-4-3-5-7-16/h8-14,16,25H,2-7,15H2,1H3,(H,23,24)
  • InChiKey: ZMMBOXHHRWNLBG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0067 0.0082 0.1062
Brugia malayi nuclear hormone receptor 0.0067 0.0082 0.0082
Brugia malayi nuclear hormone receptor 0.0032 0.003 0.003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0067 0.0082 0.1736
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0026 0.0026
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0117 0.0153 0.2012
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0149 0.0378
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0014 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0149 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.6886 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.0026 0.0058
Loa Loa (eye worm) hypothetical protein 0.0067 0.0082 0.0082
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.003 0.1855
Echinococcus granulosus neuropeptide receptor A26 0.0535 0.0763 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0001 0.0023
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0008 0.0168
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0067 0.0082 0.0082
Schistosoma mansoni eyes absent homolog 0.0102 0.0132 0.2802
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0023 1
Echinococcus granulosus survival motor neuron protein 1 0.052 0.074 0.97
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0008 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0067 0.0082 0.1075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0067 0.0082 0.1075
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0149 0.0149
Entamoeba histolytica protein kinase rad3, putative 0.0012 0.0001 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0001 0.0072
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0008 0.0008
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0032 0.003 0.0395
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0008 0.0533
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0014 0.0188
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.002 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0036 0.0036
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0023 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0014 0.4987
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0204
Schistosoma mansoni nuclear receptor 0.0032 0.003 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0001 0.0072
Echinococcus multilocularis muscleblind protein 1 0.0177 0.0241 0.3146
Echinococcus granulosus GPCR family 2 0.0052 0.0059 0.0772
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0026 0.0063
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.0221 0.0221
Brugia malayi hypothetical protein 0.052 0.074 0.074
Brugia malayi Protein kinase domain containing protein 0.0116 0.0152 0.0152
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0149 0.1944
Toxoplasma gondii cathepsin CPL 0.0017 0.0008 0.2165
Echinococcus multilocularis FTZ F1 alpha 0.0067 0.0082 0.1062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0067 0.0082 0.0082
Schistosoma mansoni kinase 0.0058 0.0068 0.1442
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.017 0.017
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0014 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0001 0.0072
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2706 0.3919 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0036 0.0756
Loa Loa (eye worm) hypothetical protein 0.0055 0.0064 0.0064
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.003 0.0395
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Echinococcus multilocularis muscleblind protein 0.0177 0.0241 0.3146
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0149 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0032 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0052 0.0059 0.1247
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0149 0.0361
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0075 0.0975
Onchocerca volvulus 0.0067 0.0082 0.5043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0008 0.009
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0014 0.0174
Brugia malayi Animal haem peroxidase family protein 0.0122 0.0161 0.0161
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0067 0.0082 0.0082
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.0138 0.0138
Leishmania major cathepsin L-like protease 0.0063 0.0076 0.0173
Echinococcus multilocularis geminin 0.0196 0.0269 0.3521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0001 0.0072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.0221 0.0221
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0008 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0535 0.0763 1
Echinococcus multilocularis GPCR, family 2 0.0052 0.0059 0.0759
Brugia malayi hypothetical protein 0.0032 0.003 0.003
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0075 0.1596
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0067 0.0082 0.1736
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Loa Loa (eye worm) nuclear receptor NHR-67 0.0032 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Echinococcus multilocularis neuropeptide s receptor 0.0535 0.0763 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0014 0.0034
Leishmania major cathepsin L-like protease 0.0063 0.0076 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0082 0.0082
Brugia malayi Peroxidasin 0.0122 0.0161 0.0161
Loa Loa (eye worm) animal heme peroxidase 0.0122 0.0161 0.0161
Loa Loa (eye worm) animal heme peroxidase 0.0122 0.0161 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0067 0.0082 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0082 0.1075
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0014 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0001 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0008 0.0533
Loa Loa (eye worm) hypothetical protein 0.0177 0.0241 0.0241
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0008 0.0008
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0012 0.0001 0.0072
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.003 0.0382
Onchocerca volvulus 0.0032 0.003 0.1855
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0014 0.0034
Brugia malayi nuclear receptor RXR 0.0036 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0149 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Brugia malayi ecdysone receptor 0.0032 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.0221 0.0221
Brugia malayi Animal haem peroxidase family protein 0.0122 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0052 0.0059 0.1247
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0032
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0014 0.0034
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0067 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Brugia malayi steroid hormone receptor 0.0067 0.0082 0.0082
Brugia malayi nuclear receptor NHR-88 0.0067 0.0082 0.0082
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0014 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0067 0.0082 0.0082
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0029 0.0026 0.1726
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0014 0.0016
Schistosoma mansoni hypothetical protein 0.0052 0.0059 0.1247
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0032 0.003 0.003
Trypanosoma brucei polo-like protein kinase 0.0114 0.0149 0.0373
Brugia malayi Muscleblind-like protein 0.0177 0.0241 0.0241
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0075 0.0975
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0014 0.0034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0059 0.0772
Onchocerca volvulus 0.0017 0.0008 0.0489
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0023 1
Schistosoma mansoni hypothetical protein 0.0052 0.0059 0.1247
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0059 0.0759
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0014 0.0304
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0014 0.0188
Schistosoma mansoni RAR-like nuclear receptor 0.0067 0.0082 0.1736
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0067 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Onchocerca volvulus Peroxidase homolog 0.0122 0.0161 0.9902
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.003 0.1855
Schistosoma mansoni hypothetical protein 0.0196 0.0269 0.5702
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0067 0.0082 0.1062
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0067 0.0082 0.1075
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0056 0.014
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0149 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0067 0.0082 0.1075
Brugia malayi orphan nuclear receptor NR2E1 0.0032 0.003 0.003
Onchocerca volvulus 0.0122 0.0161 0.9902
Echinococcus granulosus neuropeptide s receptor 0.0535 0.0763 1
Loa Loa (eye worm) animal heme peroxidase 0.0122 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0336 0.0472 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0064 0.0829
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2706 0.3919 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0067 0.0082 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0149 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Brugia malayi nuclear receptor NHR-67 0.0032 0.003 0.003
Brugia malayi hypothetical protein 0.0102 0.0132 0.0132
Loa Loa (eye worm) cysteine protease 0.0017 0.0008 0.0008
Echinococcus multilocularis ecdysone induced protein 78C 0.0067 0.0082 0.1062
Onchocerca volvulus 0.0017 0.0008 0.0489
Echinococcus granulosus FTZ F1 alpha 0.0067 0.0082 0.1075
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0064 0.3951
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0067 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0076 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Loa Loa (eye worm) hypothetical protein 0.052 0.074 0.074
Echinococcus multilocularis cysteine protease 0.0017 0.0008 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0067 0.0082 0.0082
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0075 0.0075
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.0026 0.0324
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0149 0.0149
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0075 0.0988
Brugia malayi nuclear hormone receptor family member odr-7 0.0032 0.003 0.003
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0064 0.0842
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0014 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0023
Brugia malayi ecdysteroid receptor 0.0067 0.0082 0.0082
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0001 0.0001
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0064 0.136
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Loa Loa (eye worm) fibroinase 0.0017 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0017 0.0008 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0014 0.0014
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0001 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0066 0.442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Loa Loa (eye worm) hypothetical protein 0.0067 0.0082 0.0082
Loa Loa (eye worm) DR-78 0.0032 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0196 0.0269 0.5702
Toxoplasma gondii FATC domain-containing protein 0.0029 0.0026 1
Onchocerca volvulus 0.0055 0.0064 0.3951
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0023 0.8868
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0036 0.0036 0.0455
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0067 0.0082 0.1736
Brugia malayi hypothetical protein 0.0017 0.0009 0.0009
Onchocerca volvulus Chorion peroxidase homolog 0.0122 0.0161 0.9902
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Brugia malayi tailless protein 0.0032 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0163 0.0221 0.0221
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0023 0.0056
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0068 0.017
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.03 0.3931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Leishmania major cathepsin L-like protease 0.0063 0.0076 0.0173
Schistosoma mansoni zinc finger protein 0.0032 0.003 0.0639
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0102 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0106 0.0138 0.2924
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0067 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0014 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0067 0.0082 0.1736
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0067 0.0082 0.0082
Schistosoma mansoni nuclear hormone receptor 0.0032 0.003 0.0639
Brugia malayi Animal haem peroxidase family protein 0.0122 0.0161 0.0161
Brugia malayi Animal haem peroxidase family protein 0.0122 0.0161 0.0161
Loa Loa (eye worm) ctsf protein 0.0017 0.0008 0.0008
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0075 0.0988
Loa Loa (eye worm) hypothetical protein 0.0067 0.0082 0.0082
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0064 0.136
Echinococcus multilocularis peroxidasin 0.0122 0.0161 0.2102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Loa Loa (eye worm) hypothetical protein 0.0102 0.0132 0.0132
Brugia malayi hypothetical protein 0.0122 0.0161 0.0161
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0059 0.0759
Loa Loa (eye worm) hypothetical protein 0.0067 0.0082 0.0082
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0014 0.0014
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2706 0.3919 1
Leishmania major malonyl-coa decarboxylase-like protein 0.2706 0.3919 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0008 0.0168
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0014 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0059
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0008 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Onchocerca volvulus Peroxidase homolog 0.0122 0.0161 0.9902
Onchocerca volvulus Protein ultraspiracle homolog 0.0067 0.0082 0.5043
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0032 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0001 0.0072
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Schistosoma mansoni survival motor neuron protein 0.0106 0.0138 0.2924
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Echinococcus granulosus peroxidasin 0.0122 0.0161 0.2113
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0014 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Onchocerca volvulus Bile acid receptor homolog 0.0067 0.0082 0.5043
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0014 0.0304
Loa Loa (eye worm) hypothetical protein 0.0063 0.0075 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0064 0.0829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0001 0.0072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0082 0.1062
Brugia malayi photoreceptor-specific nuclear receptor 0.0067 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0067 0.0082 0.0082
Schistosoma mansoni nuclear receptor 0.0032 0.003 0.0639
Echinococcus multilocularis cysteine protease 0.0017 0.0008 0.009
Brugia malayi conserved hypotetical protein 0.0032 0.003 0.003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0067 0.0082 0.1736
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0067 0.0082 0.5043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0067 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0067 0.0082 0.0082
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0014 0.0016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0067 0.0082 0.1062
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0032 0.003 0.0639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0067 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.003 0.0382
Echinococcus multilocularis survival motor neuron protein 1 0.052 0.074 0.9699
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0076 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0008 0.0533
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0008 0.0489
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi Nuclear hormone receptor E75 0.0032 0.003 0.003
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni nuclear hormone receptor 0.0032 0.003 0.0639
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0064 0.0842
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0067 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0146 0.0146
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0067 0.0082 0.1062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi mbt repeat family protein 0.0055 0.0064 0.0064
Loa Loa (eye worm) blistered cuticle protein 3 0.0122 0.0161 0.0161
Brugia malayi Nuclear hormone receptor E75 0.0032 0.003 0.003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0008 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Brugia malayi hypothetical protein 0.0032 0.003 0.003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0008 0.009
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0076 0.019
Onchocerca volvulus Peroxidasin homolog 0.0123 0.0163 1
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.6886 1 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.003 0.0395
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0149 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0032 0.003 0.0382
Onchocerca volvulus 0.0017 0.0008 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0003 0.0204
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0014 0.0963
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0032 0.003 0.0639
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0008
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0008 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0008 0.0489
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0149 0.9172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Onchocerca volvulus 0.0122 0.0161 0.9902
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0082 0.1075
Echinococcus granulosus geminin 0.0196 0.0269 0.3531
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0067 0.0082 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Onchocerca volvulus 0.0017 0.0008 0.0489
Loa Loa (eye worm) MBCTL1 0.0063 0.0075 0.0075
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0014 0.0016
Echinococcus granulosus muscleblind protein 0.0177 0.0241 0.3156
Brugia malayi nuclear receptor RXR 0.0032 0.003 0.003
Brugia malayi mbt repeat family protein 0.0055 0.0064 0.0064
Onchocerca volvulus Dual oxidase homolog 0.0122 0.0161 0.9902
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0067 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Onchocerca volvulus 0.0017 0.0008 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Onchocerca volvulus 0.0122 0.0161 0.9902
Loa Loa (eye worm) steroid hormone receptor 0.0067 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0066 0.442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0014 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0067 0.0082 0.1736
Brugia malayi nuclear receptor NHR-88 0.0032 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0067 0.0082 0.0082
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0008 0.0489
Loa Loa (eye worm) hypothetical protein 0.0122 0.0161 0.0161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0082 0.1062
Echinococcus granulosus ecdysone induced protein 78C 0.0067 0.0082 0.1075
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.0026 0.0545
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0032 0.003 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0067 0.0082 0.0082
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0067 0.0082 0.1062
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0116 0.0152 0.0152
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0008 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0036 0.0036
Loa Loa (eye worm) nuclear hormone receptor 0.0032 0.003 0.003
Schistosoma mansoni peroxidasin 0.0122 0.0161 0.3408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Onchocerca volvulus 0.0106 0.0138 0.8494
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0076 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Brugia malayi Steroid receptor seven-up type 2 0.0067 0.0082 0.0082
Schistosoma mansoni thyroid hormone receptor 0.0067 0.0082 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0026 0.1726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0014 0.0963
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Echinococcus multilocularis nuclear receptor nhr 48 0.0032 0.003 0.0382
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.003 0.0395
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Onchocerca volvulus 0.0017 0.0008 0.0489
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0036 0.0036 0.0756
Echinococcus granulosus cathepsin l1 0.0017 0.0008 0.0104
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0008 0.0533
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0002 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0067 0.0082 0.1736
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0067 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0149 0.0378
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0036 0.0036 0.0468
Echinococcus granulosus thyroid hormone receptor alpha 0.0032 0.003 0.0395
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni nuclear receptor nhr-48 0.0032 0.003 0.0639
Onchocerca volvulus Peroxidasin homolog 0.0122 0.0161 0.9902
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0059 0.0772
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0067 0.0082 0.0082
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0149 0.1955
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0023 0.0056
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.017 0.017
Onchocerca volvulus 0.0017 0.0008 0.0489
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0067 0.0082 0.1736
Brugia malayi Blistered cuticle protein 3 0.0122 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0111 0.0146 0.309
Schistosoma mansoni retinoic acid receptor RXR 0.0067 0.0082 0.1736
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0023 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Brugia malayi MH2 domain containing protein 0.0128 0.017 0.017
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.03 0.394
Echinococcus granulosus serine protein kinase ATM 0.0029 0.0026 0.0337
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0116 0.0152 0.1985
Loa Loa (eye worm) animal heme peroxidase 0.0122 0.0161 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0059 0.0059
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0064 0.136
Brugia malayi Animal haem peroxidase family protein 0.0122 0.0161 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Onchocerca volvulus 0.0032 0.003 0.1855
Schistosoma mansoni peroxidasin 0.0122 0.0161 0.3413
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0014 0.0034
Leishmania major hypothetical protein, conserved 0.0027 0.0023 0.0039
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.003 0.0382
Schistosoma mansoni coup transcription factor 0.0067 0.0082 0.1736
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0008 0.0533
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0149 1
Brugia malayi hypothetical protein 0.0027 0.0023 0.0023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0067 0.0082 0.1075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0008 0.0533
Giardia lamblia Kinase, PLK 0.0114 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0067 0.0082 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0076 0.0185
Loa Loa (eye worm) hypothetical protein 0.0067 0.0082 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0149 0.3157
Echinococcus granulosus nuclear receptor nhr 48 0.0032 0.003 0.0395

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 33 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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