Detailed information for compound 1054689

Basic information

Technical information
  • TDR Targets ID: 1054689
  • Name: 3-methyl-N-[(1R)-1-naphthalen-2-ylethyl]benza mide
  • MW: 289.371 | Formula: C20H19NO
  • H donors: 1 H acceptors: 1 LogP: 4.71 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)C(=O)N[C@@H](c1ccc2c(c1)cccc2)C
  • InChi: 1S/C20H19NO/c1-14-6-5-9-19(12-14)20(22)21-15(2)17-11-10-16-7-3-4-8-18(16)13-17/h3-13,15H,1-2H3,(H,21,22)/t15-/m1/s1
  • InChiKey: LVNRFCFYRYHIAZ-OAHLLOKOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-methyl-N-[(1R)-1-(2-naphthyl)ethyl]benzamide
  • ZINC06151896

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis acetylcholinesterase 0.0212 0.3325 1
Onchocerca volvulus 0.0032 0.0268 0.0137
Echinococcus granulosus flap endonuclease 1 0.0027 0.0188 0.0565
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0455 0.1368
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0166 0.1187
Plasmodium vivax SET domain protein, putative 0.0032 0.0268 0.5194
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0028 0.003
Schistosoma mansoni acetylcholinesterase 0.0036 0.0339 0.1019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0848 0.0848
Brugia malayi Carboxylesterase family protein 0.0212 0.3325 0.9585
Plasmodium vivax protease, putative 0.002 0.0076 0.0258
Brugia malayi Latrophilin receptor protein 2 0.005 0.0585 0.1687
Loa Loa (eye worm) carboxylesterase 0.0036 0.0339 0.0977
Giardia lamblia Fructose-bisphosphate aldolase 0.031 0.498 0.8641
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0455 1
Echinococcus granulosus CAAX prenyl protease 2 0.0098 0.1398 0.4205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.2429 0.7001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0189
Entamoeba histolytica CAAX amino terminal protease family 0.002 0.0076 0.0018
Entamoeba histolytica hypothetical protein 0.0101 0.1445 0.2425
Brugia malayi Carboxylesterase family protein 0.0036 0.0339 0.0977
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0564 0.9277 1
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0078 0.1059 0.7572
Echinococcus granulosus neuroligin 0.0036 0.0339 0.1019
Echinococcus multilocularis neuroligin 0.0036 0.0339 0.1019
Brugia malayi SWIRM domain containing protein 0.0043 0.0455 0.1311
Brugia malayi hypothetical protein 0.0036 0.0339 0.0977
Brugia malayi hypothetical protein 0.0133 0.1985 0.5722
Brugia malayi CAAX amino terminal protease family protein 0.0098 0.1398 0.4031
Trichomonas vaginalis set domain proteins, putative 0.0251 0.3985 0.7976
Echinococcus multilocularis musashi 0.0029 0.0216 0.065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1354 0.4073
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0198
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0339 0.1019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0848 0.0848
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0585 0.176
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0848 0.2552
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0036 0.0339 0.0556
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0455 0.1368
Echinococcus granulosus lamin dm0 0.0029 0.0216 0.065
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0819 0.236
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0078 0.1059 0.1059
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.002 0.0076 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1354 0.4073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0198
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0585 0.1687
Brugia malayi Trypsin family protein 0.0101 0.1446 0.4167
Entamoeba histolytica hypothetical protein 0.0038 0.0378 0.0549
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.1446 0.4348
Echinococcus multilocularis CAAX prenyl protease 2 0.0098 0.1398 0.4205
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0268 0.3157
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.2296 0.2296
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0078 0.1059 0.7572
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1354 0.4073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0268 0.0806
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0216 0.0623
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0166 0.0478
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0166 0.1187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.498 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.1985 0.5722
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0455 0.1311
Schistosoma mansoni amine oxidase 0.0043 0.0455 0.1368
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0078 0.1059 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.498 1
Loa Loa (eye worm) carboxylesterase 0.0036 0.0339 0.0977
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0198
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0361 0.1042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0455 0.1311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0339 0.0977
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0071
Echinococcus granulosus para nitrobenzyl esterase 0.0036 0.0339 0.1019
Onchocerca volvulus 0.0251 0.3985 1
Treponema pallidum fructose-bisphosphate aldolase 0.031 0.498 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.2296 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.498 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0455 0.0455
Mycobacterium tuberculosis Carboxylesterase LipT 0.0036 0.0339 0.0365
Trichomonas vaginalis spcc417.12 protein, putative 0.0036 0.0339 0.0556
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.0189
Plasmodium falciparum flap endonuclease 1 0.0027 0.0188 0.3141
Loa Loa (eye worm) hypothetical protein 0.0101 0.1446 0.4167
Schistosoma mansoni hypothetical protein 0.005 0.0585 0.176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0455 0.049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.2429 0.7001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.498 0.8641
Plasmodium falciparum protease, putative 0.002 0.0076 0.0258
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0455 0.0455
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0076 0.0082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0848 0.0848
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.1446 0.4348
Trypanosoma brucei CAAX amino terminal protease, putative 0.0098 0.1398 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0455 0.1368
Toxoplasma gondii hypothetical protein 0.002 0.0076 0.0892
Loa Loa (eye worm) hypothetical protein 0.0029 0.0216 0.0623
Loa Loa (eye worm) hypothetical protein 0.0036 0.0339 0.0977
Echinococcus multilocularis acetylcholinesterase 0.0212 0.3325 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0248 0.0746
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0848 0.2552
Mycobacterium ulcerans integral membrane protein 0.002 0.0076 0.0076
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0455 0.3254
Brugia malayi Carboxylesterase family protein 0.0036 0.0339 0.0977
Loa Loa (eye worm) hypothetical protein 0.0101 0.1446 0.4167
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0216 0.0623
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0078 0.1059 0.7572
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0188 0.0215
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0166 0.0478
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0188 0.0565
Brugia malayi hypothetical protein 0.0043 0.0455 0.1311
Onchocerca volvulus 0.0036 0.0339 0.0326
Loa Loa (eye worm) hypothetical protein 0.0036 0.0339 0.0977
Echinococcus granulosus carboxylesterase 5A 0.0212 0.3325 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0455 1
Schistosoma mansoni hypothetical protein 0.0038 0.0378 0.1136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.2429 0.7001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0268 0.0806
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0166 0.0166
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0585 0.176
Loa Loa (eye worm) hypothetical protein 0.0133 0.1985 0.5722
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0268 0.0806
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0819 0.0819
Mycobacterium ulcerans membrane protein ComEA 0.0017 0.0028 0.0028
Echinococcus multilocularis GPCR, family 2 0.005 0.0585 0.176
Echinococcus multilocularis geminin 0.0178 0.274 0.8239
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.0772
Giardia lamblia Hypothetical protein 0.0098 0.1398 0.2343
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0078 0.1059 0.7572
Mycobacterium ulcerans hypothetical protein 0.002 0.0076 0.0076
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0848 0.6068
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0268 0.0806
Treponema pallidum hypothetical protein 0.002 0.0076 0.0097
Brugia malayi Pre-SET motif family protein 0.0032 0.0268 0.0772
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0819 0.0882
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0455 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0339 0.0977
Loa Loa (eye worm) hypothetical protein 0.0043 0.0455 0.1311
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0455 0.1368
Schistosoma mansoni intermediate filament proteins 0.0029 0.0216 0.065
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0098 0.1398 0.2712
Echinococcus granulosus BC026374 protein S09 family 0.0036 0.0339 0.1019
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0455 1
Brugia malayi Cytochrome P450 family protein 0.0026 0.0166 0.0478
Echinococcus granulosus acetylcholinesterase 0.0212 0.3325 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0036 0.0339 0.0365
Loa Loa (eye worm) hypothetical protein 0.0109 0.1575 0.4541
Schistosoma mansoni BC026374 protein (S09 family) 0.0036 0.0339 0.1019
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0188 0.0215
Onchocerca volvulus Huntingtin homolog 0.0133 0.1985 0.4693
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0745 0.2149
Echinococcus granulosus intermediate filament protein 0.0029 0.0216 0.065
Onchocerca volvulus 0.0095 0.1334 0.2966
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0455 0.1368
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0339 0.1019
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0101 0.1445 0.2425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1354 0.4073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.498 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0036 0.0339 0.1019
Onchocerca volvulus 0.0101 0.1446 0.3262
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0166 0.0478
Loa Loa (eye worm) hypothetical protein 0.0212 0.3325 0.9585
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.498 0.8641
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0339 0.1019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0455 0.1311
Entamoeba histolytica CAAX amino terminal protease family 0.002 0.0076 0.0018
Onchocerca volvulus Huntingtin homolog 0.0133 0.1985 0.4693
Leishmania major UDP-galactopyranose mutase 0.0043 0.0455 0.3254
Schistosoma mansoni lamin 0.0029 0.0216 0.065
Loa Loa (eye worm) hypothetical protein 0.0043 0.0455 0.1311
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0455 1
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0848 1
Brugia malayi Cytochrome P450 family protein 0.0037 0.0361 0.1042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.498 1
Mycobacterium ulcerans oxidoreductase 0.0043 0.0455 0.0455
Brugia malayi Carboxylesterase family protein 0.0036 0.0339 0.0977
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0078 0.1059 0.2021
Leishmania major cytochrome p450-like protein 0.0026 0.0166 0.1187
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0378 0.1136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1354 0.4073
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0455 0.049
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0188 0.0542
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.002 0.0076 0.0082
Echinococcus multilocularis 0.0043 0.0455 0.1368
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0042 0.0443 0.0602
Entamoeba histolytica CAAX prenyl protease family 0.0098 0.1398 0.2343
Loa Loa (eye worm) hypothetical protein 0.0043 0.0455 0.1311
Schistosoma mansoni lamin 0.0029 0.0216 0.065
Loa Loa (eye worm) hypothetical protein 0.0159 0.2429 0.7001
Echinococcus granulosus geminin 0.0178 0.274 0.8239
Schistosoma mansoni gliotactin 0.0036 0.0339 0.1019
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0078 0.1059 0.2021
Toxoplasma gondii CAAX amino terminal protease family protein 0.002 0.0076 0.0892
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0078 0.1059 0.3184
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0848 0.2552
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0455 1
Onchocerca volvulus 0.0036 0.0339 0.0326
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0188 0.1344
Brugia malayi Flap endonuclease-1 0.0027 0.0188 0.0542
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0078 0.1059 0.1141
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.2296 0.2475
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0098 0.1398 1
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0078 0.1059 0.3184
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0188 0.0249
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0268 0.0806
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0078 0.1059 0.3052
Brugia malayi Carboxylesterase family protein 0.0036 0.0339 0.0977
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0356 0.5753 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0585 0.1687
Loa Loa (eye worm) acetylcholinesterase 1 0.0212 0.3325 0.9585
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.1575 0.4541
Mycobacterium tuberculosis Probable integral membrane protein 0.002 0.0076 0.0082
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0188 0.1344
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0036 0.0339 0.0365
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0819 0.2462
Echinococcus multilocularis lamin dm0 0.0029 0.0216 0.065
Schistosoma mansoni hypothetical protein 0.0178 0.274 0.8239
Echinococcus granulosus GPCR family 2 0.005 0.0585 0.176
Brugia malayi Carboxylesterase family protein 0.0212 0.3325 0.9585
Schistosoma mansoni flap endonuclease-1 0.0024 0.0144 0.0433
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1354 0.4073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1354 0.3904
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0166 0.1187
Loa Loa (eye worm) hypothetical protein 0.0098 0.1398 0.4031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1354 0.4073
Schistosoma mansoni hypothetical protein 0.005 0.0585 0.176
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0066 0.047
Schistosoma mansoni hypothetical protein 0.005 0.0585 0.176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0585 0.176
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.0077
Echinococcus multilocularis carboxylesterase 5A 0.0212 0.3325 1
Onchocerca volvulus 0.0036 0.0339 0.0326
Brugia malayi hypothetical protein 0.0038 0.0378 0.1089
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.047
Mycobacterium ulcerans dehydrogenase 0.0043 0.0455 0.0455
Entamoeba histolytica hypothetical protein 0.0038 0.0378 0.0549
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0078 0.1059 0.3184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0378 0.1136
Giardia lamblia DNA repair protein RAD52 0.0356 0.5753 1
Schistosoma mansoni hypothetical protein 0.005 0.0585 0.176
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0098 0.1398 0.4205
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0378 0.1136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0455 0.1311
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0455 1
Loa Loa (eye worm) carboxylesterase 0.0212 0.3325 0.9585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0268 0.0806
Loa Loa (eye worm) hypothetical protein 0.0212 0.3325 0.9585
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.498 1
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0455 0.5362
Loa Loa (eye worm) hypothetical protein 0.0036 0.0339 0.0977
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1354 0.3904
Echinococcus multilocularis para nitrobenzyl esterase 0.0036 0.0339 0.1019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.498 1
Schistosoma mansoni hypothetical protein 0.0109 0.1575 0.4738
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0036 0.0339 0.1019
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0098 0.1398 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.498 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0268 0.0806
Schistosoma mansoni amine oxidase 0.0043 0.0455 0.1368
Loa Loa (eye worm) hypothetical protein 0.0036 0.0339 0.0977
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0078 0.1059 0.7572
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0819 0.2462
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0078 0.1059 0.3052
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.047
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0455 0.1982
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0455 0.3254
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0188 0.3141
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0212 0.3325 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0585 0.1687
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0585 0.176
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0848 0.0915
Loa Loa (eye worm) hypothetical protein 0.0036 0.0339 0.0977
Brugia malayi Pre-SET motif family protein 0.0221 0.3469 1
Toxoplasma gondii hypothetical protein 0.002 0.0076 0.0892
Echinococcus multilocularis lamin 0.0029 0.0216 0.065
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0036 0.0339 0.1019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.047
Onchocerca volvulus 0.0043 0.0455 0.0634
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0066 0.0066
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0848 0.2552
Mycobacterium ulcerans carboxylesterase, LipT 0.0036 0.0339 0.0339
Mycobacterium ulcerans hypothetical protein 0.002 0.0076 0.0076
Echinococcus granulosus lamin 0.0029 0.0216 0.065
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0455 0.1368
Brugia malayi intermediate filament protein 0.0029 0.0216 0.0623
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0597
Onchocerca volvulus 0.0036 0.0339 0.0326
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0607 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0819 0.2462
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0216 0.0623
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.3469 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0036 0.0339 0.1019
Brugia malayi Cytochrome P450 family protein 0.0026 0.0166 0.0478
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0188 0.1344
Echinococcus granulosus acetylcholinesterase 0.0212 0.3325 1
Onchocerca volvulus 0.0036 0.0339 0.0326
Entamoeba histolytica hypothetical protein 0.0038 0.0378 0.0549
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0819 0.0819
Schistosoma mansoni hypothetical protein 0.0178 0.274 0.8239
Entamoeba histolytica hypothetical protein 0.0038 0.0378 0.0549
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0188 0.2215
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0819 0.5854
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0455 0.5362
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0198
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0455 1
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0098 0.1398 1
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0774
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0098 0.1398 0.4205

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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