Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4678 | 0.465 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.4393 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4393 | 0.4363 |
Onchocerca volvulus | 0.0033 | 0.4393 | 1 | |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.4393 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.2667 | 0.2628 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.2667 | 0.5651 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.1257 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.1916 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.8867 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.2667 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.1257 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.2667 | 0.5651 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.2667 | 0.5 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.2667 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.2667 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.2667 | 0.6023 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.4678 | 1 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4678 | 0.465 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0525 | 0.1969 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.1257 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.2667 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.4678 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.2667 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.1916 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.2667 | 0.6023 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.2667 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.2667 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.2667 | 1 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.2667 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.2667 | 0.2966 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0109 | 0.0056 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.2667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.2667 | 0.2628 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0584 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.2667 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.2667 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.1257 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0939 | 0.2042 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.092 | 0.1996 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.2667 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 19 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.