Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9577 | 1 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.4104 | 0.8205 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.4104 | 0.8205 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9577 | 0.9577 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.9526 | 0.9947 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.5002 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.5002 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.4104 | 1 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9577 | 0.9577 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.5002 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 31 uM | Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay | ChEMBL. | 19469546 |
IC50 (binding) | = 1.2 uM | Inhibition of SRC2 binding to TRalpha receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | ChEMBL. | 19469546 |
IC50 (binding) | = 2.7 uM | Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | ChEMBL. | 19469546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.