Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0694 | 0.099 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0216 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0694 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1847 | 0.2632 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.1633 | 0.1542 |
Plasmodium falciparum | chromodomain-helicase-DNA-binding protein 1 homolog, putative | 0.0023 | 0.0459 | 0.8168 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0694 | 0.1488 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.008 | 0.2456 | 0.2375 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0694 | 0.1488 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | chromobox protein, putative | 0.0142 | 0.4667 | 0.461 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.7016 | 1 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0023 | 0.0459 | 0.0984 |
Plasmodium falciparum | heterochromatin protein 1 | 0.0023 | 0.0459 | 0.8168 |
Trichomonas vaginalis | set domain proteins, putative | 0.0237 | 0.8036 | 0.8014 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0023 | 0.0459 | 0.0984 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0143 | 0.4699 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0562 | 1 |
Brugia malayi | Type III restriction enzyme, res subunit family protein | 0.0023 | 0.0459 | 0.0655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.1633 | 0.1542 |
Echinococcus multilocularis | chromobox protein 1 | 0.0142 | 0.4667 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0216 | 0.0307 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0562 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0411 | 0.7309 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0562 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0888 | 0.1266 |
Schistosoma mansoni | chromobox protein | 0.0142 | 0.4667 | 1 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0023 | 0.0459 | 0.0984 |
Brugia malayi | SET domain containing protein | 0.0024 | 0.0498 | 0.071 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0694 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.4078 | 0.5812 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0888 | 0.1903 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0216 | 0.0462 |
Onchocerca volvulus | 0.0237 | 0.8036 | 1 | |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0225 | 0.3245 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0053 | 0.1518 | 0.3252 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0234 | 0.0333 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0023 | 0.0459 | 0.0984 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0216 | 0.0462 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0025 | 0.0518 | 0.0415 |
Toxoplasma gondii | chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 | 0.0023 | 0.0459 | 0.6615 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0292 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0292 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Brugia malayi | M-phase phosphoprotein, mpp8 | 0.0023 | 0.0459 | 0.0655 |
Brugia malayi | Heterochromatin protein 1 | 0.0142 | 0.4667 | 0.6653 |
Onchocerca volvulus | 0.0023 | 0.0459 | 0.000000058524 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0023 | 0.0459 | 0.8168 |
Echinococcus granulosus | bloom syndrome protein | 0.0025 | 0.0518 | 0.111 |
Echinococcus multilocularis | chromobox protein 2 | 0.0023 | 0.0459 | 0.0984 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0562 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0025 | 0.0518 | 0.0739 |
Echinococcus multilocularis | bloom syndrome protein | 0.0025 | 0.0518 | 0.111 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0216 | 0.0462 |
Trichomonas vaginalis | chromobox protein, putative | 0.0023 | 0.0459 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0051 | 0.011 |
Brugia malayi | CHD4 protein | 0.0023 | 0.0459 | 0.0655 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0459 | 0.4912 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0459 | 0.4912 |
Onchocerca volvulus | 0.0062 | 0.1847 | 0.1832 | |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0142 | 0.4667 | 0.6653 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0562 | 0.7142 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0459 | 0.0984 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Echinococcus multilocularis | chromobox protein 1 | 0.0142 | 0.4667 | 1 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Loa Loa (eye worm) | helicase | 0.0023 | 0.0459 | 0.0655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Echinococcus granulosus | chromobox protein 2 | 0.0023 | 0.0459 | 0.0984 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0216 | 0.0307 |
Echinococcus granulosus | chromobox protein 1 | 0.0142 | 0.4667 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0086 | 0.267 | 0.2591 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0562 | 0.8099 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0216 | 0.0462 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1468 | 0.2093 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0655 | 0.1404 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Brugia malayi | Protein cec-1. | 0.0023 | 0.0459 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0459 | 0.0655 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0051 | 0.011 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0023 | 0.0459 | 0.0655 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0562 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1468 | 0.2093 |
Onchocerca volvulus | 0.0053 | 0.1518 | 0.1397 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | chromobox protein, putative | 0.0142 | 0.4667 | 0.461 |
Trichomonas vaginalis | hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0025 | 0.0518 | 0.0415 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0051 | 0.011 |
Trichomonas vaginalis | Heterochromatin protein, putative | 0.0023 | 0.0459 | 0.0356 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0694 | 0.1488 |
Echinococcus granulosus | Chromo domain | 0.0023 | 0.0459 | 0.0984 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0332 | 0.0712 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0023 | 0.0459 | 0.6615 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0459 | 0.0655 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.7016 | 1 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0023 | 0.0459 | 0.0984 |
Echinococcus granulosus | chromobox protein 1 | 0.0142 | 0.4667 | 1 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0023 | 0.0459 | 0.0984 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0694 | 0.1488 |
Trichomonas vaginalis | conserved hypothetical protein | 0.008 | 0.2456 | 0.2375 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0694 | 1 |
Schistosoma mansoni | chromobox protein | 0.0142 | 0.4667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0216 | 0.0307 |
Brugia malayi | Valyl-tRNA synthetase | 0.0023 | 0.0459 | 0.0655 |
Brugia malayi | chromobox protein homolog 3 | 0.008 | 0.2456 | 0.3501 |
Trichomonas vaginalis | chromobox protein, putative | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | chromobox protein, putative | 0.0086 | 0.267 | 0.2591 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0888 | 0.1266 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0216 | 0.0462 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0694 | 0.1488 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0216 | 0.0462 |
Brugia malayi | Associated with TFs and helicases family protein | 0.0023 | 0.0459 | 0.0655 |
Schistosoma mansoni | chromobox protein | 0.0023 | 0.0459 | 0.0984 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0216 | 0.0462 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0216 | 0.0462 |
Echinococcus granulosus | Chromobox protein 3 | 0.0023 | 0.0459 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2456 | 0.3501 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0694 | 0.1488 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1468 | 0.2093 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0459 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0459 | 0.0655 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0086 | 0.267 | 0.2918 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0459 | 0.0655 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0459 | 0.0655 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | chromobox protein, putative | 0.0023 | 0.0459 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0459 | 0.0655 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0216 | 0.0462 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.008 | 0.2456 | 0.2636 |
Plasmodium vivax | heterochromatin protein 1, putative | 0.0023 | 0.0459 | 0.4912 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 1 | 0.0023 | 0.0459 | 0.0984 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1468 | 0.2093 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Loa Loa (eye worm) | RecQ helicase | 0.0025 | 0.0518 | 0.0739 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0023 | 0.0459 | 0.6615 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0143 | 0.4699 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0216 | 0.0462 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0562 | 0.0801 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0143 | 0.4699 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0562 | 0.0801 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 1 | 0.0023 | 0.0459 | 0.0984 |
Schistosoma mansoni | chromobox protein | 0.0023 | 0.0459 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0459 | 0.0655 |
Echinococcus multilocularis | Chromo domain | 0.0023 | 0.0459 | 0.0984 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0023 | 0.0459 | 0.0984 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0459 | 0.0356 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 18 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.