Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ABL proto-oncogene 1, non-receptor tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | SRC proto-oncogene, non-receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Variant SH3 domain containing protein | 0.0016 | 0.003 | 0.003 |
Brugia malayi | hypothetical protein | 0.0206 | 0.1603 | 0.1603 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0018 | 0.0049 | 0.0049 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0647 | 0.526 | 0.526 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0364 | 0.0364 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0029 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0082 | 0.0082 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0206 | 0.1603 | 0.1603 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0016 | 0.003 | 0.003 |
Brugia malayi | SRC-1 | 0.0054 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1603 | 0.1603 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0705 | 0.0705 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0018 | 0.0049 | 0.0049 |
Brugia malayi | Variant SH3 domain containing protein | 0.0016 | 0.003 | 0.003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0075 | 0.0517 | 0.0517 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.1603 | 0.1603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0364 | 0.0364 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0075 | 0.0517 | 0.0517 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0206 | 0.1603 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0056 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | carboxylesterase | 0.0206 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1603 | 0.1603 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0046 | 0.0275 | 0.0275 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1603 | 0.1603 |
Brugia malayi | Pre-SET motif family protein | 0.016 | 0.1224 | 0.1224 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1218 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0082 | 0.0082 |
Echinococcus granulosus | acetylcholinesterase | 0.1218 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0056 | 0.0364 | 0.0364 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0206 | 0.1603 | 0.1603 |
Echinococcus multilocularis | acetylcholinesterase | 0.1218 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.026 | 0.2049 | 0.2049 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0043 | 0.0256 | 0.0256 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0038 | 0.0207 | 0.0207 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0075 | 0.0517 | 0.0517 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0038 | 0.0207 | 0.0207 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.026 | 0.2049 | 0.2049 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0022 | 0.0082 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0018 | 0.0049 | 0.0049 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.1603 | 0.1603 |
Onchocerca volvulus | 0.0206 | 0.1603 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0206 | 0.1603 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.004 | 0.0225 | 0.0225 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0206 | 0.1603 | 0.1603 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0206 | 0.1603 | 0.1603 |
Echinococcus multilocularis | acetylcholinesterase | 0.1218 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0046 | 0.0275 | 0.0275 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0022 | 0.0079 | 0.0079 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | carboxylesterase | 0.0206 | 0.1603 | 0.1603 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0206 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0016 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.003 | 0.003 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0075 | 0.0517 | 0.0517 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.004 | 0.0225 | 0.0225 |
Onchocerca volvulus | 0.0206 | 0.1603 | 1 | |
Loa Loa (eye worm) | TK protein kinase | 0.0038 | 0.0207 | 0.0207 |
Echinococcus granulosus | neuroligin | 0.0206 | 0.1603 | 0.1603 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0023 | 0.0086 | 0.0086 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0022 | 0.0082 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0114 | 0.0839 | 0.0839 |
Echinococcus granulosus | tyrosine kinase | 0.0046 | 0.0275 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1603 | 0.1603 |
Echinococcus granulosus | acetylcholinesterase | 0.1218 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0114 | 0.0839 | 0.0839 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0022 | 0.0082 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0054 | 0.0341 | 0.0341 |
Echinococcus multilocularis | tar DNA binding protein | 0.0056 | 0.0364 | 0.0364 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0075 | 0.0517 | 0.0517 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0018 | 0.0049 | 0.0049 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0056 | 0.0364 | 0.0364 |
Echinococcus multilocularis | NCK adaptor protein | 0.0016 | 0.003 | 0.003 |
Schistosoma mansoni | tyrosine kinase | 0.0054 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | carboxylesterase | 0.1218 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1218 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0121 | 0.0121 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0046 | 0.0275 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1603 | 0.1603 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0054 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | TK protein kinase | 0.0046 | 0.0275 | 0.0275 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0075 | 0.0517 | 0.0517 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0022 | 0.0082 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0206 | 0.1603 | 0.1603 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0016 | 0.003 | 0.003 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.0207 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0206 | 0.1603 | 0.1603 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0023 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1603 | 0.1603 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0023 | 0.0086 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0016 | 0.003 | 0.003 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0206 | 0.1603 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0023 | 0.0086 | 0.0086 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.004 | 0.0225 | 0.0225 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0049 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0121 | 0.0121 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0054 | 0.0341 | 0.0341 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0023 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.016 | 0.1224 | 0.1224 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.026 | 0.2049 | 0.2049 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | SRC-1 | 0.0054 | 0.0341 | 0.0341 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0206 | 0.1603 | 0.1603 |
Onchocerca volvulus | 0.0182 | 0.1407 | 0.8711 | |
Schistosoma mansoni | acetylcholinesterase | 0.0206 | 0.1603 | 0.1603 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0206 | 0.1603 | 0.5 |
Onchocerca volvulus | 0.0206 | 0.1603 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0054 | 0.0341 | 0.0341 |
Echinococcus multilocularis | neuroligin | 0.0206 | 0.1603 | 0.1603 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0054 | 0.0341 | 0.0341 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0206 | 0.1603 | 0.1603 |
Brugia malayi | Pre-SET motif family protein | 0.0023 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | TAR-binding protein | 0.0056 | 0.0364 | 0.0364 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0364 | 0.0364 |
Echinococcus granulosus | NCK adaptor protein | 0.0016 | 0.003 | 0.003 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0054 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0154 | 0.1172 | 0.1172 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0206 | 0.1603 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0054 | 0.0341 | 0.0341 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0029 | 0.0134 | 0.0134 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0016 | 0.003 | 0.003 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0054 | 0.0341 | 0.0341 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0075 | 0.0517 | 0.0517 |
Echinococcus granulosus | tar DNA binding protein | 0.0056 | 0.0364 | 0.0364 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0046 | 0.0275 | 0.0275 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0054 | 0.0341 | 0.0341 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0054 | 0.0341 | 0.0341 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0046 | 0.0275 | 0.0275 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0054 | 0.0341 | 0.0341 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0054 | 0.0341 | 0.0341 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0054 | 0.0341 | 0.0341 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0054 | 0.0341 | 0.0341 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0018 | 0.0049 | 0.0049 |
Plasmodium vivax | SET domain protein, putative | 0.0023 | 0.0086 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0027 | 0.0121 | 0.0121 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.1603 | 0.1603 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0206 | 0.1603 | 0.1603 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0022 | 0.0082 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0056 | 0.0364 | 0.0364 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0029 | 0.0134 | 0.0134 |
Brugia malayi | RNA binding protein | 0.0056 | 0.0364 | 0.0364 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1218 | 1 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0016 | 0.003 | 0.003 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0075 | 0.0517 | 0.0517 |
Schistosoma mansoni | tyrosine kinase | 0.0251 | 0.1981 | 0.1981 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0075 | 0.0517 | 0.0517 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0206 | 0.1603 | 1 |
Onchocerca volvulus | 0.0206 | 0.1603 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0206 | 0.1603 | 0.1603 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0023 | 0.0086 | 0.0086 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0054 | 0.0341 | 0.0341 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0054 | 0.0341 | 0.0341 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0023 | 0.0086 | 0.0086 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0054 | 0.0341 | 0.0341 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0016 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1603 | 0.1603 |
Brugia malayi | protein-tyrosine kinase | 0.0046 | 0.0275 | 0.0275 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0023 | 0.0086 | 0.0086 |
Schistosoma mansoni | tyrosine kinase | 0.0054 | 0.0341 | 0.0341 |
Schistosoma mansoni | adapter molecule crk | 0.0016 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0206 | 0.1603 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0134 | 0.0134 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0043 | 0.0256 | 0.0256 |
Echinococcus granulosus | carboxylesterase 5A | 0.1218 | 1 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0016 | 0.003 | 0.003 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0206 | 0.1603 | 0.1603 |
Leishmania major | hypothetical protein, conserved | 0.0022 | 0.0082 | 0.5 |
Schistosoma mansoni | nck2/grb4 | 0.0016 | 0.003 | 0.003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.