Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.4309 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.4309 | 0.4309 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.4309 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.1924 | 0.4264 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3537 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1668 | 0.3648 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.3537 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3537 | 0.3537 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.4309 | 0.4309 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.094 | 0.094 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.3537 | 0.3537 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0151 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0151 | 0.0151 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0151 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3537 | 0.3537 |
Schistosoma mansoni | lipoxygenase | 0.0082 | 0.5411 | 0.5411 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0117 | 0.8472 | 0.8472 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1668 | 0.3648 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0684 | 0.1283 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.1668 | 0.1668 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | TAR-binding protein | 0.0135 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0135 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0151 | 0.0151 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.1924 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0151 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.4309 | 0.4309 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0151 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0151 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0135 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.1924 | 0.4264 |
Echinococcus multilocularis | tar DNA binding protein | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1668 | 0.1668 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.3537 | 0.3537 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.4309 | 0.4309 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.1668 | 0.867 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0151 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.4309 | 0.4309 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0151 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0151 | 0.0151 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.3537 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0135 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.094 | 0.4887 | |
Loa Loa (eye worm) | RNA binding protein | 0.0135 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0151 | 0.0151 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0151 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0117 | 0.8472 | 0.8472 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0151 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0117 | 0.8472 | 0.8472 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3537 | 1 |
Brugia malayi | TAR-binding protein | 0.0135 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0684 | 0.1283 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.3537 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0151 | 0.0151 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.4309 | 0.4309 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 11 % | Growth inhibition of HEL cells harboring Val617Phe mutation in JAK2 at 25 uM after 72 hrs by trypan blue exclusion assay | ChEMBL. | 19447617 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.