Detailed information for compound 1055948

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 621.898 | Formula: C26H29ClIN5O3
  • H donors: 2 H acceptors: 4 LogP: 5.93 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCc1nc(c(n1CCCOc1cc2c(ncnc2cc1OC)Nc1cccc(c1)I)CO)Cl
  • InChi: 1S/C26H29ClIN5O3/c1-3-4-9-24-32-25(27)21(15-34)33(24)10-6-11-36-23-13-19-20(14-22(23)35-2)29-16-30-26(19)31-18-8-5-7-17(28)12-18/h5,7-8,12-14,16,34H,3-4,6,9-11,15H2,1-2H3,(H,29,30,31)
  • InChiKey: FKWCCCFETNOQDW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia DNA repair protein RAD52 0.1508 0.1801 0.5848
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0012 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.001 0.0028
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.003 0.0027
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0131 0.0138 0.0449
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0006 0.0013
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0034 0.002 0.0061
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0012 0.0035
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.003 0.079
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0131 0.0138 0.1308
Schistosoma mansoni hypothetical protein 0.0082 0.0079 0.0259
Loa Loa (eye worm) hypothetical protein 0.0051 0.0041 0.0129
Toxoplasma gondii NAC domain-containing protein 0.0145 0.0155 0.0504
Toxoplasma gondii ImpB/MucB/SamB family protein 0.007 0.0064 0.0209
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0027 0.0087
Echinococcus multilocularis snurportin 1 0.0644 0.0758 0.0756
Brugia malayi hypothetical protein 0.0108 0.011 0.0356
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0033 0.0104
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0006 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0041 0.003 0.0088
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0064 0.0057 0.0185
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0197 0.0634
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0092
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0064 0.0057 0.018
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0279 0.0317 0.1035
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Echinococcus multilocularis muscleblind protein 1 0.1523 0.182 0.1818
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0123 0.0128 0.042
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0003 0.0004
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0006 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0023 0.0068
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0029 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0069 0.0382
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0057 0.0055
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0567 0.0664 0.2182
Schistosoma mansoni ap endonuclease 0.0037 0.0024 0.0079
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0079
Schistosoma mansoni smad1 5 8 and 0.0077 0.0072 0.0237
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0003 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.003 0.0088
Brugia malayi nuclear hormone receptor 0.0041 0.003 0.0091
Schistosoma mansoni Smad4 0.0077 0.0072 0.0237
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0033 0.0108
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.003 0.0091
Brugia malayi hypothetical protein 0.0039 0.0027 0.0082
Trypanosoma brucei unspecified product 0.0041 0.0029 0.0089
Brugia malayi Bromodomain containing protein 0.0203 0.0225 0.0734
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0034 0.002 0.0061
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0006 0.0035
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.0038 0.0035
Echinococcus granulosus solute carrier family 5 0.0038 0.0026 0.0076
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0006 0.0035
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0082 0.0079 0.025
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0564 0.0661 0.2171
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0108 0.011 0.0361
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0055 0.0174
Schistosoma mansoni flap endonuclease-1 0.0024 0.0009 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.003 0.0091
Echinococcus granulosus chromobox protein 1 0.0074 0.0069 0.0218
Echinococcus granulosus cyclin dependent kinase 0.0048 0.0038 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.003 0.0783
Loa Loa (eye worm) hypothetical protein 0.0886 0.105 0.3453
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0123 0.0128 0.0125
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0173 0.0171
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.2565 0.3079 1
Brugia malayi ecdysone receptor 0.0019 0.0003 0.0004
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0006 0.0013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.003 0.0088
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.019 0.021 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0209 0.0672
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0006 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0027 0.0081
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0055 0.0177
Plasmodium vivax glycogen synthase kinase 3, putative 0.0102 0.0103 0.0335
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0064 0.0057 0.0188
Leishmania major 6-phosphogluconolactonase 0.0034 0.002 0.0061
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0069 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.003 0.0091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.001 0.0028
Onchocerca volvulus 0.0022 0.0006 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0004
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0006 0.0013
Schistosoma mansoni cpg binding protein 0.0072 0.0066 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.003 0.0091
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0026 0.0076
Echinococcus granulosus TGF beta signal transducer SmadC 0.0077 0.0072 0.0229
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0006 0.0013
Plasmodium falciparum glycogen synthase kinase 3 0.0102 0.0103 0.0335
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0319 0.0366 0.0363
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0069 0.0221
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0021 0.0063
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0034 0.002 0.0061
Loa Loa (eye worm) RecQ helicase 0.0025 0.001 0.0027
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0102 0.0103 0.0334
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0014 0.0035
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0203 0.0225 0.0222
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0311 0.1004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.003 0.0096
Brugia malayi intracellular kinase 0.0102 0.0103 0.0334
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.08 0.0797
Trypanosoma cruzi ISWI complex protein 0.0081 0.0078 0.0249
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.001 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0031 0.0101
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.003 0.0091
Schistosoma mansoni ap endonuclease 0.0037 0.0024 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.003 0.0091
Echinococcus multilocularis solute carrier family 5 0.0038 0.0026 0.0023
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0026 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.003 0.0027
Brugia malayi RNA, U transporter 1 0.0172 0.0187 0.061
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0069 0.0221
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0069 0.0382
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0023 0.0068
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0006 0.0035
Trypanosoma brucei protein kinase, putative 0.0102 0.0103 0.0334
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0023 0.0068
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0003 0.0004
Echinococcus multilocularis phd:f box containing protein 0.002 0.0004 0.0001
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0006 0.001
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0011 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0183 0.0201 0.0651
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0121 0.0125 0.0123
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.0038 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.003 0.0091
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0027 0.0024
Brugia malayi PHD-finger family protein 0.0135 0.0143 0.0465
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0004 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0051 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.003 0.0091
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0012 0.0067
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.001 0.0028
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0003 0.001
Entamoeba histolytica hypothetical protein 0.0108 0.011 0.0609
Loa Loa (eye worm) hypothetical protein 0.0564 0.0661 0.2171
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0004 0.0014
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0055 0.0174
Leishmania major importin beta-1 subunit, putative 0.0049 0.0039 0.0122
Onchocerca volvulus 0.0074 0.0069 0.1957
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0023 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.003 0.0091
Onchocerca volvulus 0.0022 0.0006 0.0081
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0069 0.0642
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0027 0.0087
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0039 0.0121
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0027 0.0024
Brugia malayi MH2 domain containing protein 0.1125 0.1339 0.4403
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0027 0.0087
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0003 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0209 0.0672
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0051 0.0048
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0003 0.0004
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.2531 0.3038 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.0317 0.1037
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.003 0.0027
Brugia malayi MH1 domain containing protein 0.0077 0.0072 0.0232
Trypanosoma brucei unspecified product 0.0041 0.0029 0.0089
Loa Loa (eye worm) hypothetical protein 0.0055 0.0046 0.0147
Brugia malayi Protein kinase domain containing protein 0.0048 0.0038 0.0118
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0009 0.0027
Schistosoma mansoni Smad4 0.0034 0.0021 0.0069
Trypanosoma brucei DNA polymerase eta, putative 0.0111 0.0114 0.0368
Brugia malayi Heterochromatin protein 1 0.0074 0.0069 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0197 0.0634
Schistosoma mansoni methyl-cpg binding protein mbd 0.009 0.0089 0.0292
Leishmania major hypothetical protein, conserved 0.0081 0.0078 0.0249
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.0038 0.0118
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.1653 0.1977 0.6422
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0102 0.0103 0.0334
Echinococcus granulosus PHD finger protein rhinoceros 0.0062 0.0055 0.0171
Echinococcus multilocularis cpg binding protein 0.0072 0.0066 0.0064
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0004 0.0004
Toxoplasma gondii LsmAD domain-containing protein 0.0183 0.0201 0.0652
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0034 0.002 0.0066
Trypanosoma brucei glucosidase, putative 0.0036 0.0023 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.0155 0.0499
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0069 0.0219
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0039 0.0122
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0069 0.0221
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0034 0.002 0.0061
Plasmodium vivax protein kinase Crk2 0.0048 0.0038 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0069 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0197 0.0634
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0197 0.0634
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.2531 0.3038 0.3036
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0057 0.0055
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0033 0.0104
Loa Loa (eye worm) hypothetical protein 0.0345 0.0397 0.1301
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0029 0.0087
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0003 0.0004
Echinococcus granulosus bloom syndrome protein 0.0025 0.001 0.0024
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0814 0.0964 0.3168
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0004 0.0006
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0027 0.0082
Brugia malayi MH2 domain containing protein 0.0077 0.0072 0.0232
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0006 0.0035
Schistosoma mansoni nuclear receptor 0.0019 0.0003 0.001
Trypanosoma cruzi ISWI complex protein 0.0081 0.0078 0.0249
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0006 0.0035
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0102 0.0103 0.0334
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0014
Giardia lamblia Kinase, CMGC GSK 0.0102 0.0103 0.0329
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0064 0.0057 0.0186
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0012 0.0035
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0839 0.0993 0.3265
Echinococcus granulosus zinc finger protein 0.0107 0.0109 0.035
Brugia malayi Bromodomain containing protein 0.04 0.0464 0.1521
Brugia malayi conserved hypotetical protein 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0337 0.0387 0.1269
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0006 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Echinococcus multilocularis transcription factor eb 0.0567 0.0664 0.0662
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0004 0.0006
Brugia malayi jmjC domain containing protein 0.002 0.0004 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0038 0.0123
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.0038 0.0118
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0012 0.001
Schistosoma mansoni ran 0.0044 0.0033 0.0109
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0027 0.0024
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0006 0.0018
Brugia malayi nuclear receptor NHR-67 0.0019 0.0003 0.0004
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0006 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Echinococcus multilocularis isocitrate dehydrogenase 0.0064 0.0057 0.0055
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0006 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0006 0.0019
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0051 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0103 0.0572
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0004 0.0007
Onchocerca volvulus 0.0298 0.0339 1
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0069 0.0221
Brugia malayi Pre-SET motif family protein 0.003 0.0016 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.003 0.0091
Loa Loa (eye worm) hypothetical protein 0.0183 0.0201 0.0654
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0034 0.002 0.2299
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0055 0.0177
Schistosoma mansoni thyroid hormone receptor 0.0041 0.003 0.0096
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0004 0.0006
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0006 0.0013
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0006 0.0013
Brugia malayi 6-phosphogluconolactonase family protein 0.0034 0.002 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0023 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0088 0.0087 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0197 0.0634
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Echinococcus granulosus Smad4 0.0077 0.0072 0.0229
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.003 0.0027
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0004 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0046 0.0147
Loa Loa (eye worm) hypothetical protein 0.0074 0.0069 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0023 0.0068
Schistosoma mansoni high-affinity choline transporter 0.0345 0.0397 0.1306
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0311 0.1004
Echinococcus granulosus histone lysine methyltransferase setb 0.0121 0.0125 0.0404
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0006
Leishmania major hypothetical protein, conserved 0.0183 0.0201 0.0654
Entamoeba histolytica hypothetical protein 0.0108 0.011 0.0609
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0012 0.0035
Mycobacterium ulcerans hypothetical protein 0.0074 0.0069 0.0221
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0006 0.0013
Plasmodium vivax importin-beta 2, putative 0.006 0.0053 0.017
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0069 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.003 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.003 0.0091
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.003 0.0096
Brugia malayi Muscleblind-like protein 0.1523 0.182 0.5989
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.013 0.0428
Loa Loa (eye worm) hypothetical protein 0.006 0.0053 0.0167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0024 0.0074
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0051 0.0048
Brugia malayi PHD-finger family protein 0.0034 0.002 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0006 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0006 0.0014
Echinococcus multilocularis zinc finger protein 0.0107 0.0109 0.0106
Loa Loa (eye worm) hypothetical protein 0.0195 0.0215 0.0703
Loa Loa (eye worm) RNA binding protein 0.0062 0.0055 0.0174
Entamoeba histolytica transcription factor BTF3, putative 0.0145 0.0155 0.0861
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0024 0.0071
Schistosoma mansoni hypothetical protein 0.041 0.0475 0.1563
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.005 0.0157
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0004 0.0012
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0027 0.0082
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0004 0.0006
Toxoplasma gondii hypothetical protein 0.0054 0.0045 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.0155 0.0499
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0173 0.0565
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0134 0.0141 0.0458
Schistosoma mansoni coup transcription factor 0.0041 0.003 0.0096
Loa Loa (eye worm) hypothetical protein 0.0229 0.0257 0.0839
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0027 0.0024
Brugia malayi Pre-SET motif family protein 0.0203 0.0225 0.0736
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0023 0.0075
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.1523 0.182 0.5989
Schistosoma mansoni chromobox protein 0.0074 0.0069 0.0226
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0057 0.0055
Brugia malayi hypothetical protein 0.0019 0.0003 0.0004
Echinococcus multilocularis mothers against decapentaplegic 5 0.0077 0.0072 0.007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0057 0.0182
Echinococcus granulosus smad 0.0077 0.0072 0.0229
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0365 0.042 0.1383
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0069 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0102 0.0103 0.0339
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0311 0.1004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1296 0.1546 0.5084
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0203 0.0225 0.0731
Brugia malayi Calcitonin receptor-like protein seb-1 0.1296 0.1546 0.5084
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0027 0.0079
Brugia malayi nuclear receptor NHR-88 0.0019 0.0003 0.0004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0023 0.0068
Schistosoma mansoni hypothetical protein 0.041 0.0475 0.1563
Loa Loa (eye worm) MH2 domain-containing protein 0.0077 0.0072 0.0232
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0033 0.0104
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0027 0.0079
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0006 0.0013
Echinococcus granulosus cyclin dependent kinase 5 0.0048 0.0038 0.0115
Loa Loa (eye worm) hypothetical protein 0.0074 0.0069 0.0221
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0037 0.0116
Trypanosoma brucei transcription factor BTF3, putative 0.0145 0.0155 0.0505
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0034 0.002 0.0061
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0046 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.003
Echinococcus multilocularis methyl CpG binding domain protein 2 0.009 0.0089 0.0086
Brugia malayi CXXC zinc finger family protein 0.0058 0.005 0.0159
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0063
Schistosoma mansoni alpha-glucosidase 0.0138 0.0146 0.0481
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0046 0.0147
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0004 0.0004
Echinococcus granulosus chromobox protein 1 0.0074 0.0069 0.0218
Plasmodium falciparum protein kinase 5 0.0048 0.0038 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.003 0.0783
Brugia malayi nuclear receptor RXR 0.0019 0.0003 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0027 0.0087
Echinococcus granulosus geminin 0.2275 0.2728 0.8978
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0055 0.0173
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0021 0.0063
Trypanosoma brucei 6-phosphogluconolactonase 0.0034 0.002 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0041 0.003 0.0096
Loa Loa (eye worm) bromodomain containing protein 0.0094 0.0093 0.0299
Echinococcus multilocularis bloom syndrome protein 0.0025 0.001 0.0007
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0046 0.015
Echinococcus multilocularis cyclin dependent kinase 5 0.0048 0.0038 0.0035
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.001 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0043 0.039
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.0215 0.6312
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0279 0.0317 0.0314
Brugia malayi mothers against decapentaplegic homolog 3 0.0034 0.0021 0.0063
Echinococcus granulosus mothers against decapentaplegic 5 0.0077 0.0072 0.0229
Loa Loa (eye worm) PHD-finger family protein 0.0109 0.0112 0.0362
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0024 0.5
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0006 0.0019
Echinococcus multilocularis geminin 0.2275 0.2728 0.2726
Loa Loa (eye worm) hypothetical protein 0.0126 0.0132 0.0429
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0027 0.0079
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0003 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.003 0.0096
Echinococcus granulosus tar DNA binding protein 0.0062 0.0055 0.0171
Entamoeba histolytica hypothetical protein 0.0049 0.0039 0.0214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.003 0.0091
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0046 0.0086
Giardia lamblia DINP protein human, muc B family 0.0059 0.0051 0.016
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Brugia malayi N-terminal motif family protein 0.0195 0.0215 0.0703
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0002 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0038 0.0117
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0026 0.0023
Brugia malayi hypothetical protein 0.0037 0.0025 0.0075
Loa Loa (eye worm) nuclear factor I 0.0042 0.0031 0.0096
Echinococcus granulosus cyclin dependent kinase 1 0.0048 0.0038 0.0115
Schistosoma mansoni ran 0.0044 0.0033 0.0109
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0173 0.0562
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0179
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0006 0.0013
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0041 0.003 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.003 0.0027
Onchocerca volvulus 0.0032 0.0019 0.0468
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0082
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0027 0.0079
Loa Loa (eye worm) ICD-1 protein 0.0145 0.0155 0.0505
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.003 0.0027
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0023 0.0068
Brugia malayi Flap endonuclease-1 0.0027 0.0012 0.0035
Schistosoma mansoni hypothetical protein 0.0062 0.0055 0.0179
Onchocerca volvulus 0.0102 0.0103 0.2977
Plasmodium vivax ataxin-2 like protein, putative 0.0183 0.0201 0.0651
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0006 0.0035
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0006 0.0013
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0003 0.0004
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0004 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0069 0.0221
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0033 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0179
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0004 0.0004
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0006 0.0011
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.0038 0.0118
Schistosoma mansoni hypothetical protein 0.2275 0.2728 0.8979
Brugia malayi regulator of G-protein signaling egl-10 0.0048 0.0038 0.012
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.0038 0.0118
Echinococcus granulosus transcription factor eb 0.0567 0.0664 0.218
Echinococcus multilocularis cyclin dependent kinase 0.0048 0.0038 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.003 0.0091
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.2531 0.3038 1
Brugia malayi hypothetical protein 0.0039 0.0027 0.0082
Brugia malayi hypothetical protein 0.0022 0.0006 0.0014
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0051 0.0283
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0429 0.0498 0.2764
Echinococcus multilocularis regulator of G protein signaling 7 0.0048 0.0038 0.0036
Brugia malayi Importin beta-1 subunit 0.006 0.0053 0.0167
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0103 0.033
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0024 0.0073
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0026 0.0079
Schistosoma mansoni inositol transporter 0.0038 0.0026 0.0084
Brugia malayi hypothetical protein 0.0022 0.0006 0.0014
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0006 0.0032
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.003 0.0091
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0064 0.0057 0.053
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0003 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0024 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.003 0.0096
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0057 0.0182
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0644 0.0758 0.249
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0027 0.0081
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0004 0.0013
Loa Loa (eye worm) isocitrate dehydrogenase 0.0064 0.0057 0.0182
Trypanosoma brucei ISWI complex protein 0.0081 0.0078 0.0249
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0173 0.0565
Leishmania major GTP-binding protein, putative 0.0044 0.0033 0.0104
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0034 0.0903
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0034 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0006 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.003 0.0091
Brugia malayi nuclear hormone receptor 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0082
Echinococcus granulosus phd:f box containing protein 0.002 0.0004 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.08 0.2632
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0027 0.0082
Onchocerca volvulus 0.0051 0.0041 0.1128
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0026 0.0076
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0077 0.0072 0.007
Echinococcus granulosus muscleblind protein 0.1523 0.182 0.5988
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0023 0.0125
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0055 0.0176
Loa Loa (eye worm) hypothetical protein 0.0062 0.0055 0.0173
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0033 0.0109
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.2565 0.3079 1
Schistosoma mansoni inositol transporter 0.0038 0.0026 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.003 0.0088
Brugia malayi tailless protein 0.0019 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.003 0.0091
Echinococcus granulosus regulator of G protein signaling 7 0.0048 0.0038 0.0117
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0002 0.0006
Giardia lamblia Kinase, CMGC CDK 0.0048 0.0038 0.0116
Onchocerca volvulus 0.0093 0.0092 0.2633
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0023 0.0125
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0051 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.001 0.0028
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0027 0.0087
Loa Loa (eye worm) hypothetical protein 0.0298 0.0339 0.1111
Loa Loa (eye worm) hypothetical protein 0.0048 0.0038 0.012
Brugia malayi Bromodomain containing protein 0.0074 0.007 0.0223
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0051 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0006 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1296 0.1546 0.5084
Brugia malayi RNA binding protein 0.0062 0.0055 0.0174
Entamoeba histolytica protein kinase, putative 0.0102 0.0103 0.0572
Brugia malayi latrophilin 2 splice variant baaae 0.0886 0.105 0.3453
Brugia malayi hypothetical protein 0.0183 0.0201 0.0654
Schistosoma mansoni transcription factor btf3 0.0145 0.0155 0.051
Toxoplasma gondii exonuclease III APE 0.0037 0.0024 0.0079
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0055 0.0046 0.0147
Schistosoma mansoni methyl-cpg binding protein mbd 0.009 0.0089 0.0292
Schistosoma mansoni bromodomain containing protein 0.0026 0.0011 0.0036
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.0038 0.0208
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.0173 0.0562
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0062 0.0055 0.0179
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0027 0.0082
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0027 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0006 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0024 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0029 0.0093
Echinococcus multilocularis regulator of G protein signaling 7 0.0048 0.0038 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0183 0.0201 0.0654
Entamoeba histolytica hypothetical protein 0.0145 0.0155 0.0861
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0033 0.0108
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0057 0.0182
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.003 0.0091
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0006 0.0019
Echinococcus multilocularis jumonji domain containing protein 0.0086 0.0084 0.0081
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0026 0.0023
Echinococcus granulosus methyl CpG binding domain protein 2 0.009 0.0089 0.0284
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.001 0.0028
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.003 0.0091
Echinococcus granulosus importin subunit beta 1 0.006 0.0053 0.0164
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0365 0.042 0.0418
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0029 0.0087
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0103 0.0572
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0023 0.0066
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0069 0.0382
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0024 0.0074
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0057 0.0186
Brugia malayi PXA domain containing protein 0.0039 0.0027 0.0082
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0027 0.0082
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0012 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0069 0.0642
Echinococcus multilocularis protein kinase shaggy 0.0102 0.0103 0.0101
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0006 0.0013
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0002 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.041 0.0475 0.1559
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0006 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0006 0.0013
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.003 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0103 0.033
Mycobacterium ulcerans hypothetical protein 0.0178 0.0194 0.0634
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0003 0.0001
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0051 0.0471
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.003 0.0027
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0279 0.0317 0.1042
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0082
Schistosoma mansoni regulator of G protein signaling 0.0048 0.0038 0.0125
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0012 0.0035
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0003 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0024 0.0212
Echinococcus multilocularis transcription factor btf3 0.0145 0.0155 0.0153
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.2531 0.3038 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.003 0.0095
Schistosoma mansoni protein phosphatase 2C 0.002 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0886 0.105 0.3456
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0029 0.0089
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0053 0.0167
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0006 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0183 0.0201 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0029 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Onchocerca volvulus 0.0058 0.005 0.1394
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0024 0.0134
Schistosoma mansoni jumonji domain containing protein 0.002 0.0004 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0003 0.001
Leishmania major DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0006 0.0013
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0064 0.0057 0.0182
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0003 0.0004
Brugia malayi hypothetical protein 0.0118 0.0122 0.0397
Brugia malayi glucose-6-phosphate dehydrogenase 0.2531 0.3038 1
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.2531 0.3038 1
Onchocerca volvulus 0.0042 0.0031 0.0824
Brugia malayi jmjC domain containing protein 0.002 0.0004 0.0006
Entamoeba histolytica hypothetical protein 0.0429 0.0498 0.2764
Brugia malayi MH1 domain containing protein 0.0042 0.0031 0.0096
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0029 0.0089
Loa Loa (eye worm) hypothetical protein 0.0111 0.0114 0.0368
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0006 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0043 0.039
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0034 0.002 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0179
Giardia lamblia Kinase, CMGC GSK 0.0102 0.0103 0.0329
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0197 0.0634
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0023 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0311 0.1004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.0129 0.042
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0037 0.0116
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0004 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0003 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0064 0.0057 0.0055
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0026 0.0084
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Schistosoma mansoni chromobox protein 0.0074 0.0069 0.0226
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0048 0.0038 0.0123
Echinococcus multilocularis tumor protein p63 0.0347 0.0399 0.0396
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.041 0.0475 0.0473
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0037 0.0116
Schistosoma mansoni cpg binding protein 0.0072 0.0066 0.0217
Loa Loa (eye worm) transcription factor SMAD2 0.1125 0.1339 0.4403
Brugia malayi Isocitrate dehydrogenase 0.0064 0.0057 0.0182
Brugia malayi isocitrate dehydrogenase 0.0064 0.0057 0.0182
Trypanosoma brucei cdc2-related kinase 3 0.0048 0.0038 0.0118
Echinococcus multilocularis chromobox protein 1 0.0074 0.0069 0.0066
Echinococcus multilocularis 6 phosphogluconolactonase 0.0034 0.002 0.0018
Plasmodium falciparum phd finger protein, putative 0.0062 0.0055 0.0176
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0069 0.0221
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0004 0.0006
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0006 0.0035
Onchocerca volvulus 0.0271 0.0307 0.903
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.003 0.0088
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0026 0.0023
Schistosoma mansoni 6-phosphogluconolactonase 0.0034 0.002 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.003 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0038 0.0117
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0048 0.0038 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0069 0.0221
Echinococcus multilocularis mothers against decapentaplegic 2 0.0034 0.0021 0.0018
Echinococcus granulosus transcription factor btf3 0.0145 0.0155 0.0502
Loa Loa (eye worm) MH2 domain-containing protein 0.1125 0.1339 0.4403
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0006 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.003 0.0091
Schistosoma mansoni zinc finger protein 0.0107 0.0109 0.0358
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0006 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0365 0.042 0.1375
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0064 0.0057 0.0182
Brugia malayi PXA domain containing protein 0.0039 0.0027 0.0082
Trypanosoma brucei beta lactamase 0.0063 0.0056 0.0177
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.2531 0.3038 1
Brugia malayi AF-10 protein 0.002 0.0004 0.0007
Brugia malayi CHD4 protein 0.0026 0.0011 0.0029
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0027 0.0079
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0011 0.0034
Echinococcus granulosus flap endonuclease 1 0.0027 0.0012 0.0032
Brugia malayi PHD-finger family protein 0.0062 0.0055 0.0173
Loa Loa (eye worm) hypothetical protein 0.041 0.0475 0.1559
Echinococcus multilocularis expressed protein 0.0757 0.0894 0.0891
Echinococcus granulosus regulator of G protein signaling 7 0.0048 0.0038 0.0117
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0006 0.0019
Echinococcus granulosus dna polymerase eta 0.0111 0.0114 0.0365
Echinococcus granulosus high affinity choline transporter 1 0.0345 0.0397 0.1299
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.2565 0.3079 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0024 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0051 0.0162
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0053 0.0171
Trichomonas vaginalis ran, putative 0.0044 0.0033 0.0103
Schistosoma mansoni nuclear hormone receptor 0.0041 0.003 0.0096
Entamoeba histolytica Ran family GTPase 0.0044 0.0033 0.0184
Mycobacterium ulcerans lipoprotein LpqF 0.0063 0.0056 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0043 0.039
Loa Loa (eye worm) hypothetical protein 0.0074 0.0069 0.0221
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0051 0.016
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0003 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.041 0.0475 0.1556
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0016 0.0053
Loa Loa (eye worm) hypothetical protein 0.0121 0.0125 0.0407
Schistosoma mansoni smad 0.0034 0.0021 0.0069
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0027 0.0081
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0259 0.0837
Schistosoma mansoni hypothetical protein 0.2275 0.2728 0.8979
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0027 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0015 0.0044
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0012 0.004
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0069 0.0219
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Echinococcus multilocularis importin subunit beta 1 0.006 0.0053 0.005
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0027 0.0087
Schistosoma mansoni sodium/solute symporter 0.0038 0.0026 0.0084
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0033 0.0104
Plasmodium falciparum flap endonuclease 1 0.0027 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0106 0.0108 0.0349
Echinococcus granulosus 6 phosphogluconolactonase 0.0034 0.002 0.0058
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0034 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.003 0.0088
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0023 0.0074
Onchocerca volvulus 0.0022 0.0006 0.0081
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0053 0.0167
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0009 0.0027
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0057 0.0186
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0024 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0023 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.003 0.0091
Echinococcus multilocularis smad 0.0077 0.0072 0.007
Brugia malayi hypothetical protein 0.0134 0.0141 0.0458
Brugia malayi hypothetical protein 0.0037 0.0025 0.0075
Onchocerca volvulus 0.0022 0.0006 0.0081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0014
Schistosoma mansoni smad 0.0077 0.0072 0.0237
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0051 0.0471
Entamoeba histolytica hypothetical protein 0.0039 0.0027 0.0147
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0024 0.0078
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0046 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0125 0.0412
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0029 0.0087
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.003 0.0096
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.2531 0.3038 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0003 0.001
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0034 0.002 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0051 0.0162
Schistosoma mansoni Smad4 0.0034 0.0021 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0179
Schistosoma mansoni 6-phosphogluconolactonase 0.0034 0.002 0.0066
Loa Loa (eye worm) oxidoreductase 0.0022 0.0006 0.0013
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0063 0.0056 0.0515
Echinococcus granulosus GPCR family 2 0.041 0.0475 0.1556
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0011 0.0026
Plasmodium falciparum basic transcription factor 3b, putative 0.0145 0.0155 0.0503
Schistosoma mansoni hypothetical protein 0.0644 0.0758 0.2495
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0027 0.0081
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0003 0.0001
Leishmania major hypothetical protein, conserved 0.002 0.0004 0.0006
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0034 0.002 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0038 0.0123
Brugia malayi Smad1 0.0077 0.0072 0.0232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0365 0.042 0.1375
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0225 0.0736
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0037 0.0116
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0024 0.0078
Echinococcus granulosus tumor protein p63 0.0347 0.0399 0.1306
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0027 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Schistosoma mansoni smad1 5 8 and 0.0077 0.0072 0.0237
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0006 0.0013
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.0311 0.1016
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0027 0.0081
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.011 0.0361
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0013
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0006 0.0013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.003 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0029 0.0089
Brugia malayi hypothetical protein 0.0298 0.0339 0.1111
Leishmania major DNA polymerase eta, putative 0.0111 0.0114 0.0368
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.003 0.0096
Loa Loa (eye worm) hypothetical protein 0.0216 0.024 0.0785
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0024 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0029 0.0093
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0173 0.0171
Loa Loa (eye worm) hypothetical protein 0.0055 0.0046 0.0147
Onchocerca volvulus 0.0038 0.0026 0.0671
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0006 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.003 0.0091
Loa Loa (eye worm) hypothetical protein 0.0034 0.002 0.0061
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0002 0.0006
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0337 0.0387 0.1269
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0034 0.002 0.0061
Echinococcus granulosus snurportin 1 0.0644 0.0758 0.2488
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0034 0.002 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.0134 0.0436
Echinococcus granulosus mothers against decapentaplegic 6 0.0034 0.0021 0.006
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0034 0.002 0.0061
Schistosoma mansoni hypothetical protein 0.041 0.0475 0.1563
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.2565 0.3079 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0141 0.0458
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0024 0.0074
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.2531 0.3038 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0027 0.0082
Loa Loa (eye worm) hypothetical protein 0.0032 0.0019 0.0056
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.2531 0.3038 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0055 0.0046 0.0147
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0012 0.004
Echinococcus multilocularis GPCR, family 2 0.041 0.0475 0.0473
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0024 0.0074
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0173 0.0562
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.0038 0.0118
Brugia malayi cell division control protein 2 homolog 0.0048 0.0038 0.0118
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.1653 0.1977 0.6506
Schistosoma mansoni jumonji domain containing protein 0.0161 0.0174 0.0573
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.2565 0.3079 1
Trypanosoma cruzi transcription factor btf3, putative 0.0145 0.0155 0.0505
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0038 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0069 0.0221
Brugia malayi jmjC domain containing protein 0.002 0.0004 0.0006
Trypanosoma brucei cdc2-related kinase 1 0.0048 0.0038 0.0118
Brugia malayi beta-NAC-like protein 0.0145 0.0155 0.0505
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0034 0.0021 0.0533
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.0038 0.0035
Schistosoma mansoni bromodomain containing protein 0.0338 0.0389 0.1278
Schistosoma mansoni importin beta-1 0.006 0.0053 0.0172
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.003 0.0027
Plasmodium falciparum importin beta, putative 0.006 0.0053 0.017
Brugia malayi hypothetical protein 0.0019 0.0003 0.0004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0033 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.0155 0.0499
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0077 0.0072 0.0237
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0004 0.0007
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0006 0.0019
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0011 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0006 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0365 0.042 0.0418
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.041 0.0475 0.1556
Schistosoma mansoni hypothetical protein 0.0081 0.0078 0.0255
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0365 0.042 0.1378
Loa Loa (eye worm) hypothetical protein 0.0203 0.0225 0.0736
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0027 0.0087
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0006 0.0035
Schistosoma mansoni phd/f-box containing protein 0.002 0.0004 0.0012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.003 0.0027
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0006 0.0019
Echinococcus granulosus dna polymerase kappa 0.0059 0.0051 0.016
Entamoeba histolytica hypothetical protein 0.0108 0.011 0.0609
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.003 0.0096
Schistosoma mansoni hypothetical protein 0.041 0.0475 0.1563
Echinococcus multilocularis PHD finger protein rhinoceros 0.0062 0.0055 0.0052
Brugia malayi TAR-binding protein 0.0062 0.0055 0.0174
Entamoeba histolytica hypothetical protein 0.0039 0.0027 0.0147
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.019 0.021 0.0681
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Schistosoma mansoni cpg binding protein 0.0058 0.005 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.003 0.0091
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.0311 0.1016
Plasmodium vivax basic transcription factor 3b, putative 0.0145 0.0155 0.0504
Loa Loa (eye worm) hypothetical protein 0.1296 0.1546 0.5084
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0039 0.0123
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0023 0.0068
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0027 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0311 0.1004
Brugia malayi MH1 domain containing protein 0.0042 0.0031 0.0096
Loa Loa (eye worm) hypothetical protein 0.1523 0.182 0.5989
Schistosoma mansoni jumonji/arid domain-containing protein 0.0088 0.0087 0.0284
Giardia lamblia PHD finger protein 15 0.0062 0.0055 0.0171
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0048 0.0038 0.0118
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0048 0.0038 0.0115
Trypanosoma cruzi transcription factor btf3, putative 0.0145 0.0155 0.0505
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0082 0.0079 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.011 0.0107
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Echinococcus multilocularis chromobox protein 1 0.0074 0.0069 0.0066
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0004 0.0012
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0102 0.0103 0.0331
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0023 0.0068
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.003 0.0096
Trypanosoma brucei unspecified product 0.0059 0.0051 0.0162
Brugia malayi Pax transcription factor protein 2 0.0271 0.0307 0.1004
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.2565 0.3079 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0125 0.0412
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0069 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.003 0.0091
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0102 0.0103 0.0334
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0026 0.0076
Echinococcus granulosus protein kinase shaggy 0.0102 0.0103 0.0331
Loa Loa (eye worm) Smad1 0.0077 0.0072 0.0232
Trypanosoma brucei PAB1-binding protein , putative 0.0183 0.0201 0.0654
Brugia malayi MH2 domain containing protein 0.0077 0.0072 0.0232
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0024 0.0073
Schistosoma mansoni alpha-glucosidase 0.0138 0.0146 0.0481
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0023 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0069 0.0221
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.0064 0.0205
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.001 0.0028
Brugia malayi nuclear receptor RXR 0.0022 0.0006 0.0014
Plasmodium vivax JmjC domain containing protein 0.002 0.0004 0.0012
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0102 0.0103 0.0336
Brugia malayi steroid hormone receptor 0.0041 0.003 0.0091
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0016 0.0014
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.003 0.0783
Schistosoma mansoni smad1 5 8 and 0.0077 0.0072 0.0237
Plasmodium vivax SET domain protein, putative 0.003 0.0016 0.0052
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0048 0.0038 0.0118
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0051 0.0162
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1508 0.1801 1
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.003 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0311 0.1004
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0034 0.002 0.0061
Onchocerca volvulus 0.0231 0.0259 0.7617
Brugia malayi MH1 domain containing protein 0.0077 0.0072 0.0232
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.005 0.0159
Echinococcus multilocularis high affinity choline transporter 1 0.0345 0.0397 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0003 0.0004
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0006 0.0013
Trypanosoma cruzi DNA polymerase eta, putative 0.0111 0.0114 0.0368
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0004 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.001 0.0028
Plasmodium falciparum ataxin-2 like protein, putative 0.0183 0.0201 0.0651
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.003 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.003 0.0091
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.2531 0.3038 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0043 0.039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0319 0.0366 0.1196
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0055 0.0174
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.0038 0.0118
Loa Loa (eye worm) MH1 domain-containing protein 0.0077 0.0072 0.0232
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0173 0.0562
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0197 0.0634
Echinococcus granulosus microtubule associated protein 2 0.0679 0.08 0.2626
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0029 0.0026
Schistosoma mansoni DNA polymerase eta 0.0111 0.0114 0.0373
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0002 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0051 0.0162
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.2565 0.3079 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.003 0.0096
Brugia malayi MH2 domain containing protein 0.0034 0.0021 0.0063
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.003 0.0091
Schistosoma mansoni zinc finger protein 0.0081 0.0078 0.0255
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.041 0.0475 0.0473
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0033 0.0104
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Leishmania major basic transcription factor 3a, putative 0.0145 0.0155 0.0505
Echinococcus multilocularis dna polymerase eta 0.0111 0.0114 0.0111
Brugia malayi ecdysteroid receptor 0.0041 0.003 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0015 0.0044
Onchocerca volvulus Alhambra homolog 0.0062 0.0055 0.1527
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0006 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.0194 0.1849
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.003 0.0091
Schistosoma mansoni zinc finger protein 0.0019 0.0003 0.001
Echinococcus granulosus cpg binding protein 0.0072 0.0066 0.0209
Brugia malayi nuclear receptor NHR-88 0.0041 0.003 0.0091
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0365 0.042 0.1378
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0006 0.002
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0041 0.0134
Brugia malayi ImpB/MucB/SamB family protein 0.0111 0.0114 0.0368
Loa Loa (eye worm) pax transcription factor protein 2 0.0271 0.0307 0.1004
Echinococcus granulosus expressed protein 0.0757 0.0894 0.2936
Echinococcus granulosus mothers against decapentaplegic 2 0.0034 0.0021 0.006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0088 0.0087 0.0284
Brugia malayi jmjC domain containing protein 0.002 0.0004 0.0006
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0006 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.011 0.0353
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0091
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0014
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0027 0.0087
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0027 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0016 0.0053
Echinococcus multilocularis muscleblind protein 0.1523 0.182 0.1818
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0006
Leishmania major DNA polymerase eta, putative 0.007 0.0064 0.0205
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.002 0.0057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.003 0.0096
Echinococcus granulosus lysine specific demethylase 5A 0.0088 0.0087 0.0276
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0051 0.0168
Loa Loa (eye worm) hypothetical protein 0.0047 0.0036 0.0112
Echinococcus granulosus peregrin 0.0074 0.007 0.022
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0003 0.001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0051 0.0168
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.003 0.0088
Brugia malayi jmjC domain containing protein 0.0203 0.0225 0.0734
Onchocerca volvulus 0.0041 0.003 0.0783
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0063 0.0056 0.7904
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0069 0.0221
Echinococcus multilocularis peregrin 0.0074 0.007 0.0067
Brugia malayi GH02984p 0.0345 0.0397 0.1301
Brugia malayi chromobox protein homolog 3 0.0041 0.003 0.0092
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0102 0.0103 0.0101
Schistosoma mansoni hypothetical protein 0.0109 0.0112 0.0367
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0004 0.0001
Echinococcus multilocularis mothers against decapentaplegic 6 0.0034 0.0021 0.0018
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0051 0.0162
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0051 0.0162
Brugia malayi Latrophilin receptor protein 2 0.041 0.0475 0.1559
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.002 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0179
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0878 0.1041 1
Echinococcus granulosus jumonji domain containing protein 0.0086 0.0084 0.0267
Leishmania major mitochondrial DNA polymerase beta 0.0337 0.0387 0.1269
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0006 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0027 0.0081
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0006 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0365 0.042 0.1383
Schistosoma mansoni alpha glucosidase 0.0036 0.0023 0.0074
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.001 0.0027
Brugia malayi jmjC domain containing protein 0.0088 0.0087 0.0279
Echinococcus granulosus fetal alzheimer antigen falz 0.0123 0.0128 0.0412
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0365 0.042 0.1383
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.0197 0.576
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0023 0.0068
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0051 0.0161
Entamoeba histolytica hypothetical protein 0.0108 0.011 0.0609
Schistosoma mansoni z-protein (S1r protein) 0.0048 0.0038 0.0125
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0048 0.0038 0.012
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.007 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0337 0.0387 0.1269
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.003 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0006 0.0035
Schistosoma mansoni nuclear receptor 0.0019 0.0003 0.001
Giardia lamblia Kinase, CMGC CDK 0.0048 0.0038 0.0116
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0006 0.0014
Loa Loa (eye worm) latrophilin receptor protein 2 0.041 0.0475 0.1559
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0069 0.0221
Echinococcus multilocularis Smad4 0.0077 0.0072 0.007
Schistosoma mansoni hypothetical protein 0.002 0.0004 0.0013
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0006 0.0014
Loa Loa (eye worm) DR-78 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0375 0.0432 0.1417
Entamoeba histolytica hypothetical protein 0.0039 0.0027 0.0147
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0096
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0055 0.0052

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9.95 uM Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay ChEMBL. 18771819

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18771819

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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