Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | atypical protein kinase C | 0.0168 | 0.2631 | 0.2631 |
Schistosoma mansoni | unc-13 (munc13) | 0.0088 | 0.0229 | 0.0229 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0316 | 0.7079 | 0.7079 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.8571 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0094 | 0.0399 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0094 | 0.0399 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0202 | 0.3659 | 0.3659 |
Brugia malayi | Protein kinase domain containing protein | 0.009 | 0.0276 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0051 | 0.006 |
Brugia malayi | Protein kinase domain containing protein | 0.009 | 0.0276 | 0.0374 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.009 | 0.0276 | 0.0374 |
Trichomonas vaginalis | AGC family protein kinase | 0.0094 | 0.0399 | 1 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0088 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.009 | 0.0276 | 0.0321 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0088 | 0.0229 | 0.0229 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.009 | 0.0276 | 0.0276 |
Schistosoma mansoni | serine/threonine protein kinase | 0.009 | 0.0276 | 0.0276 |
Schistosoma mansoni | serine/threonine protein kinase | 0.009 | 0.0276 | 0.0276 |
Entamoeba histolytica | protein kinase, putative | 0.0094 | 0.0399 | 0.0752 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0202 | 0.3659 | 0.4965 |
Schistosoma mansoni | vav2 | 0.0082 | 0.0051 | 0.0051 |
Brugia malayi | Protein kinase c protein 2 | 0.0326 | 0.7369 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0088 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.009 | 0.0276 | 0.0321 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.009 | 0.0276 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.4642 | 0.5415 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.3587 | 0.4185 |
Onchocerca volvulus | 0.0122 | 0.1232 | 0.1779 | |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.009 | 0.0276 | 0.0276 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.014 | 0.1793 | 0.1793 |
Brugia malayi | Protein kinase domain containing protein | 0.0094 | 0.0399 | 0.0541 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0248 | 0.5014 | 0.585 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0229 | 0.0267 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0413 | 1 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0168 | 0.2631 | 0.2631 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0082 | 0.0051 | 0.0051 |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 0.0276 | 0.3681 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1232 | 0.1438 |
Trichomonas vaginalis | AGC family protein kinase | 0.0094 | 0.0399 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0094 | 0.0399 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0094 | 0.0399 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0094 | 0.0399 | 0.0752 |
Echinococcus granulosus | protein kinase C gamma type | 0.0335 | 0.7645 | 0.7645 |
Schistosoma mansoni | serine/threonine kinase | 0.009 | 0.0276 | 0.0276 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0088 | 0.0229 | 0.0229 |
Schistosoma mansoni | protein kinase C | 0.0088 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.6997 | 0.8163 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.009 | 0.0276 | 0.0276 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0202 | 0.3659 | 0.4269 |
Brugia malayi | protein kinase C II. | 0.0316 | 0.7079 | 0.9606 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0235 | 0.4642 | 0.4642 |
Toxoplasma gondii | AGC kinase | 0.009 | 0.0276 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0335 | 0.7645 | 0.7645 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.009 | 0.0276 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.3711 | 0.4329 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0235 | 0.4642 | 0.4642 |
Onchocerca volvulus | 0.02 | 0.3587 | 0.5955 | |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 0.0276 | 0.3681 |
Echinococcus granulosus | unc 13 munc13 | 0.0088 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5869 | 0.6847 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5869 | 0.6847 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0094 | 0.0399 | 0.0465 |
Brugia malayi | Pleckstrin Homology Domain | 0.0082 | 0.0051 | 0.007 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.009 | 0.0276 | 0.0276 |
Brugia malayi | C1-like domain containing protein | 0.0202 | 0.3659 | 0.4965 |
Trichomonas vaginalis | AGC family protein kinase | 0.0094 | 0.0399 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.009 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.009 | 0.0276 | 0.0321 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.009 | 0.0276 | 0.0276 |
Trichomonas vaginalis | AGC family protein kinase | 0.0094 | 0.0399 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.009 | 0.0276 | 0.0276 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0228 | 0.4424 | 0.4424 |
Onchocerca volvulus | 0.0204 | 0.3711 | 0.6173 | |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 0.0276 | 0.3681 |
Onchocerca volvulus | 0.0276 | 0.5869 | 1 | |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0144 | 0.1916 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.8224 | 0.9595 |
Trichomonas vaginalis | AGC family protein kinase | 0.0094 | 0.0399 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0168 | 0.2631 | 0.2631 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0316 | 0.7079 | 0.7079 |
Schistosoma mansoni | serine/threonine protein kinase | 0.009 | 0.0276 | 0.0276 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.009 | 0.0276 | 0.0276 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0316 | 0.7079 | 0.8259 |
Brugia malayi | Hr1 repeat family protein | 0.009 | 0.0276 | 0.0374 |
Schistosoma mansoni | serine/threonine protein kinase | 0.009 | 0.0276 | 0.0276 |
Echinococcus granulosus | myotubularin protein 13 | 0.0082 | 0.0051 | 0.0051 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.009 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0124 | 0.1304 | 0.1521 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.009 | 0.0276 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5869 | 0.6847 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0316 | 0.7079 | 0.7079 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1232 | 0.1438 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0235 | 0.4642 | 0.4642 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.009 | 0.0276 | 0.0276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 25 uM | Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay | ChEMBL. | 19410457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.