Detailed information for compound 1056149

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 745.737 | Formula: C47H38Cl2N4O
  • H donors: 0 H acceptors: 1 LogP: 12.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(cc1)N1N=C(C(C21CCC1(C2=O)N(N=C(C1c1ccc(cc1)Cl)c1ccccc1)c1ccc(cc1)C)c1ccc(cc1)Cl)c1ccccc1
  • InChi: 1S/C47H38Cl2N4O/c1-31-13-25-39(26-14-31)52-46(41(33-17-21-37(48)22-18-33)43(50-52)35-9-5-3-6-10-35)29-30-47(45(46)54)42(34-19-23-38(49)24-20-34)44(36-11-7-4-8-12-36)51-53(47)40-27-15-32(2)16-28-40/h3-28,41-42H,29-30H2,1-2H3
  • InChiKey: ZJHZMRGLGBSOHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.0694 0.2016
Plasmodium vivax thioredoxin reductase, putative 0.0082 0.2829 0.5579
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0338 0.0294
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0231 0.0246
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0012 0.0054 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0735 0.0692
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0338 0.0557
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.0694 0.1302
Brugia malayi CHD4 protein 0.0013 0.007 0.0032
Trypanosoma brucei polo-like protein kinase 0.0092 0.3223 0.4137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0338 0.0388
Brugia malayi hypothetical protein 0.0029 0.0729 0.0908
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.7577 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0086 0.0141
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.2754 0.272
Brugia malayi isocitrate dehydrogenase 0.0015 0.0169 0.0163
Onchocerca volvulus 0.003 0.0737 0.085
Treponema pallidum NADH oxidase 0.0028 0.0694 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0169 0.016
Onchocerca volvulus 0.0031 0.0785 0.0904
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0012 0.0054 0.0011
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.1061 0.1223
Trypanosoma brucei trypanothione reductase 0.0082 0.2829 0.3623
Plasmodium falciparum thioredoxin reductase 0.0082 0.2829 0.5579
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0388
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.3223 0.4137
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.2754 0.3595
Loa Loa (eye worm) glutathione reductase 0.0082 0.2829 0.3696
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0694 0.0662
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0388
Loa Loa (eye worm) amidase 0.0012 0.0054 0.0011
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0694 0.0662
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0188 0.7014 0.8934
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0338 0.039
Plasmodium falciparum esterase, putative 0.0138 0.5029 1
Schistosoma mansoni coup transcription factor 0.002 0.0338 0.0294
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.046 0.0539
Schistosoma mansoni hypothetical protein 0.0164 0.6066 0.6048
Trypanosoma cruzi amidase, putative 0.0012 0.0054 0.0011
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0093 0.3263 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.3223 0.5314
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0012 0.0054 0.0011
Trichomonas vaginalis chromobox protein, putative 0.0041 0.1175 0.1224
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.0694 0.1287
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.0694 0.1302
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0338 0.0388
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0503 0.0586
Brugia malayi steroid hormone receptor 0.002 0.0338 0.0388
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0188 0.7014 0.8934
Schistosoma mansoni kinase 0.0047 0.144 0.1401
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0086 0.0141
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0338 0.0557
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.0694 0.1302
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0169 0.0158
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0093 0.3263 0.4272
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.0694 0.0845
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0694 0.0845
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0277 0.0174
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0046 0.0075
Schistosoma mansoni thyroid hormone receptor 0.002 0.0338 0.0294
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.0694 0.1287
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0149 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0729 0.0908
Giardia lamblia Kinase, PLK 0.0092 0.3223 0.9846
Mycobacterium ulcerans lysophospholipase 0.0138 0.5029 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0338 0.0557
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0338 0.0557
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0231 0.0246
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0694 0.0845
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.3263 0.3665
Onchocerca volvulus 0.0031 0.0811 0.0934
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0277 0.0174
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0694 0.0845
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0811 0.1016
Schistosoma mansoni cpg binding protein 0.0031 0.0785 0.0742
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.3263 0.6135
Echinococcus multilocularis musashi 0.0031 0.0811 0.1337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0735 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.5029 0.573
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0694 0.0845
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0388
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0694 0.0845
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0208 0.7846 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0149 0.0024
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0338 0.0388
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0103 0.3638 0.5997
Mycobacterium tuberculosis Probable reductase 0.0188 0.7014 0.8934
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.7728 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.1175 0.1224
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3223 0.3619
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0338 0.0388
Plasmodium falciparum glycogen synthase kinase 3 0.0093 0.3263 0.6451
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0694 0.0845
Onchocerca volvulus 0.0031 0.0811 0.0934
Trichomonas vaginalis chromobox protein, putative 0.0067 0.2236 0.2465
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0338 0.0388
Echinococcus multilocularis geminin 0.0164 0.6066 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0138 0.5029 0.573
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0093 0.3263 0.4188
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.007 0.0032
Brugia malayi Amidase family protein 0.0012 0.0054 0.0011
Trichomonas vaginalis chromobox protein, putative 0.0067 0.2236 0.2465
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.2754 0.4539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0338 0.0557
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0694 0.0845
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0338 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.7728 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0138 0.5029 0.573
Schistosoma mansoni hypothetical protein 0.0164 0.6066 0.6048
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.007 0.0115
Brugia malayi Thioredoxin reductase 0.0082 0.2829 0.3696
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.0694 0.1145
Brugia malayi intermediate filament protein 0.0031 0.0811 0.1016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0338 0.0388
Giardia lamblia Kinase, CMGC GSK 0.0093 0.3263 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0103 0.3638 0.3609
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0338 0.0388
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0169 0.016
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0012 0.0054 0.0089
Schistosoma mansoni cpg binding protein 0.0033 0.0854 0.0812
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0338 0.0388
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.0694 0.1287
Loa Loa (eye worm) hypothetical protein 0.003 0.0737 0.0919
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3223 0.3619
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0138 0.5029 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.3223 0.4137
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.046 0.1288
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0138 0.5029 0.573
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0138 0.5029 0.6388
Brugia malayi ecdysteroid receptor 0.002 0.0338 0.0388
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0729 0.089
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0169 0.0383
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3223 0.3619
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0169 0.016
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0503 0.0917
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.046 0.6338
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0503 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0338 0.0388
Trypanosoma cruzi monoglyceride lipase, putative 0.0138 0.5029 0.6486
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0012 0.0054 0.0008
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.2754 0.4539
Echinococcus granulosus FTZ F1 alpha 0.002 0.0338 0.0557
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0729 0.1358
Loa Loa (eye worm) hypothetical protein 0.008 0.2754 0.3595
Echinococcus granulosus fatty acid amide hydrolase 1 0.0103 0.3638 0.5997
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0169 0.0278
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0093 0.3263 0.5379
Plasmodium falciparum thioredoxin reductase 0.0028 0.0694 0.1287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0338 0.0388
Brugia malayi MH2 domain containing protein 0.0115 0.4145 0.5442
Schistosoma mansoni cpg binding protein 0.0033 0.0854 0.0812
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.3263 0.6135
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.7728 1
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0729 0.2125
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.046 0.0831
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.0694 0.1287
Leishmania major hypothetical protein, conserved 0.0029 0.0729 0.089
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1392 0.1478
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3223 0.3619
Schistosoma mansoni chromobox protein 0.0067 0.2236 0.2201
Loa Loa (eye worm) amidase 0.0012 0.0054 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0338 0.0294
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0735 0.1211
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0188 0.7014 0.8934
Plasmodium falciparum glutathione reductase 0.0082 0.2829 0.5579
Schistosoma mansoni lamin 0.0031 0.0811 0.0769
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0082 0.2829 0.3569
Mycobacterium ulcerans hypothetical protein 0.0024 0.0503 0.0917
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0503 0.0829
Leishmania major hypothetical protein, conserved 0.0206 0.7728 1
Mycobacterium ulcerans amidase 0.0012 0.0054 0.0017
Giardia lamblia Kinase, CMGC GSK 0.0093 0.3263 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0165 0.0272
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0338 0.0388
Loa Loa (eye worm) hypothetical protein 0.0038 0.1061 0.1349
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0277 0.0174
Onchocerca volvulus 0.023 0.8681 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.3223 0.6049
Schistosoma mansoni hypothetical protein 0.0013 0.0086 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.3223 0.3192
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.3263 0.3665
Echinococcus multilocularis protein kinase shaggy 0.0093 0.3263 0.5379
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0169 0.0278
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0338 0.0388
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.046 0.6338
Loa Loa (eye worm) thioredoxin reductase 0.0082 0.2829 0.3696
Echinococcus multilocularis lamin 0.0031 0.0811 0.1337
Schistosoma mansoni hypothetical protein 0.0035 0.0943 0.0902
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0338 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0338 0.0388
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0169 0.0278
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0503 0.0917
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.0694 0.0845
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0208 0.7846 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.0694 1
Entamoeba histolytica hypothetical protein 0.0035 0.0943 0.1058
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.5029 0.573
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0338 0.0557
Schistosoma mansoni lamin 0.0031 0.0811 0.0769
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3223 0.3619
Echinococcus granulosus geminin 0.0164 0.6066 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0666 0.1098
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0338 0.0388
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0103 0.3638 0.5997
Leishmania major monoglyceride lipase, putative 0.0138 0.5029 0.6486
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0188 0.7014 0.8934
Brugia malayi intracellular kinase 0.0093 0.3263 0.4272
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0338 0.0557
Mycobacterium ulcerans peptide amidase, GatA 0.0012 0.0054 0.0017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0277 0.0174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0277 0.0174
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.0694 0.0832
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0338 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0338 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0338 0.0388
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0138 0.5029 0.573
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0338 0.0557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0735 0.0692
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.1175 0.1354
Echinococcus granulosus thioredoxin glutathione reductase 0.0083 0.2849 0.4696
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0729 0.089
Schistosoma mansoni amidase 0.0103 0.3638 0.3609
Mycobacterium ulcerans amidase 0.0012 0.0054 0.0017
Echinococcus granulosus chromobox protein 1 0.0067 0.2236 0.3687
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0138 0.5029 0.573
Entamoeba histolytica hypothetical protein 0.0035 0.0943 0.1058
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3223 0.3619
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0338 0.0294
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0093 0.3263 0.5379
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0694 1
Onchocerca volvulus 0.002 0.0338 0.039
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0694 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0624 0.0579
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0338 0.039
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.3223 0.3713
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.007 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.1172 0.1132
Brugia malayi chromobox protein homolog 3 0.0038 0.1061 0.1349
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0503 0.0917
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0338 0.0557
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0394 0.0462
Leishmania major hypothetical protein, conserved 0.0012 0.0054 0.0011
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.3223 0.5314
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0388
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0811 0.1016
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0729 0.1358
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.3223 0.4219
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1061 0.1091
Echinococcus granulosus chromobox protein 1 0.0067 0.2236 0.3687
Schistosoma mansoni fatty-acid amide hydrolase 0.0012 0.0054 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3223 0.3619
Schistosoma mansoni nuclear hormone receptor 0.002 0.0338 0.0294
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.3223 0.4137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0338 0.0388
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.2197 0.2161
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.046 0.6338
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0338 0.0294
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0277 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.4145 0.5442
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0012 0.0054 0.0017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0338 0.0557
Loa Loa (eye worm) hypothetical protein 0.0103 0.3638 0.477
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0694 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.0694 0.0652
Trypanosoma brucei protein kinase, putative 0.0093 0.3263 0.4188
Mycobacterium tuberculosis Possible lysophospholipase 0.0138 0.5029 0.6388
Trypanosoma cruzi amidase, putative 0.0012 0.0054 0.0011
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0503 0.0595
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.046 0.0531
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0138 0.5029 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0338 0.0294
Mycobacterium tuberculosis Probable dehydrogenase 0.0188 0.7014 0.8934
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0338 0.0294
Echinococcus granulosus cpg binding protein 0.0033 0.0854 0.1408
Trypanosoma brucei monoglyceride lipase, putative 0.0138 0.5029 0.6486
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0338 0.0294
Echinococcus multilocularis chromobox protein 1 0.0067 0.2236 0.3687
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0811 0.1016
Mycobacterium ulcerans amidase 0.0012 0.0054 0.0017
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0338 0.0557
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.192 0.5827
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0338 0.0557
Brugia malayi SET domain containing protein 0.0013 0.0069 0.0031
Plasmodium falciparum glutathione reductase 0.0028 0.0694 0.1287
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0169 0.0278
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0012 0.0054 0.0089
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0169 0.0231
Brugia malayi amidase 0.0103 0.3638 0.477
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0169 0.016
Onchocerca volvulus 0.008 0.2754 0.3172
Entamoeba histolytica hypothetical protein 0.0035 0.0943 0.1058
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0012 0.0054 0.0011
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0503 0.0595
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0169 0.0163
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0012 0.0054 0.0011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.0694 0.2016
Echinococcus granulosus protein kinase shaggy 0.0093 0.3263 0.5379
Plasmodium falciparum lysophospholipase, putative 0.0138 0.5029 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0338 0.0388
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0012 0.0054 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0277 0.0174
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0729 0.1358
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0093 0.3263 0.4272
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0188 0.7014 0.8934
Schistosoma mansoni chromobox protein 0.0067 0.2236 0.2201
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.2236 0.2909
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0169 0.0278
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0503 0.0595
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0394 0.0462
Brugia malayi Cytochrome P450 family protein 0.0056 0.1768 0.2287
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0169 0.0163
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0338 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1061 0.1091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0169 0.0278
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0735 0.1211
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0694 0.0845
Leishmania major trypanothione reductase 0.0082 0.2829 0.3623
Brugia malayi Pre-SET motif family protein 0.003 0.0735 0.0915
Trypanosoma brucei monoglyceride lipase, putative 0.0138 0.5029 0.6486
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0735 0.2142
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.046 0.0816
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0694 0.0845
Onchocerca volvulus 0.0093 0.3263 0.3759
Brugia malayi Amidase family protein 0.0012 0.0054 0.0011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0943 0.1555
Schistosoma mansoni intermediate filament proteins 0.0031 0.0811 0.0769
Brugia malayi nuclear hormone receptor 0.002 0.0338 0.0388
Echinococcus granulosus intermediate filament protein 0.0031 0.0811 0.1337
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0694 0.0845
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0503 0.0438
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0338 0.0557
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0338 0.0294
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0694 0.0845
Mycobacterium ulcerans amidase 0.0012 0.0054 0.0017
Brugia malayi putative amidase 0.0012 0.0054 0.0011
Plasmodium vivax SET domain protein, putative 0.003 0.0735 0.1369
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0338 0.0388
Brugia malayi Pre-SET motif family protein 0.0202 0.7577 1
Plasmodium vivax glutathione reductase, putative 0.0082 0.2829 0.5579
Schistosoma mansoni thyroid hormone receptor 0.002 0.0338 0.0294
Brugia malayi Heterochromatin protein 1 0.0067 0.2236 0.2909
Brugia malayi hypothetical protein 0.0019 0.0316 0.0359
Echinococcus multilocularis cpg binding protein 0.0033 0.0854 0.1408
Entamoeba histolytica hypothetical protein 0.0035 0.0943 0.1058
Echinococcus multilocularis chromobox protein 1 0.0067 0.2236 0.3687
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.1768 0.2287
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0093 0.3263 0.3232
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0128
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0012 0.0054 0.0011
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.046 0.0816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0338 0.0388
Loa Loa (eye worm) hypothetical protein 0.0015 0.0165 0.0158
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.3223 0.4219
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.046 0.1288
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0012 0.0054 0.0089
Entamoeba histolytica protein kinase, putative 0.0093 0.3263 0.6135
Trichomonas vaginalis set domain proteins, putative 0.023 0.8681 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0338 0.0388
Plasmodium falciparum lysophospholipase, putative 0.0138 0.5029 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0503 0.0917
Echinococcus multilocularis 0.0012 0.0046 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0338 0.0557
Loa Loa (eye worm) hypothetical protein 0.003 0.0735 0.0915
Echinococcus granulosus fatty acid amide hydrolase 1 0.0012 0.0054 0.0089
Brugia malayi nuclear receptor NHR-88 0.002 0.0338 0.0388
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.0694 0.0861
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.4145 0.5442
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0624 0.0579
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0338 0.0557
Brugia malayi hypothetical protein 0.0035 0.0943 0.1192
Echinococcus multilocularis thioredoxin glutathione reductase 0.0083 0.2849 0.4696
Mycobacterium ulcerans amidase 0.0012 0.0054 0.0017
Plasmodium vivax glycogen synthase kinase 3, putative 0.0093 0.3263 0.6451
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0943 0.1555
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0694 0.0845
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0169 0.0231
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.046 0.0539
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0338 0.0557
Mycobacterium tuberculosis Probable oxidoreductase 0.0208 0.7846 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0169 0.016
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0169 0.0383
Echinococcus granulosus lamin dm0 0.0031 0.0811 0.1337
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0208 0.7846 1
Toxoplasma gondii thioredoxin reductase 0.0082 0.2829 0.8652
Echinococcus granulosus fatty acid amide hydrolase 1 0.0103 0.3638 0.5997
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0694 0.0845
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0694 0.0845
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0093 0.3263 0.4188
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.007 0.0115
Plasmodium falciparum lysophospholipase, putative 0.0138 0.5029 1
Mycobacterium ulcerans hypothetical protein 0.0138 0.5029 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1392 0.1478
Loa Loa (eye worm) hypothetical protein 0.0031 0.0811 0.1016
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0943 0.0902
Brugia malayi CXXC zinc finger family protein 0.0031 0.0785 0.0981
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0338 0.039
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0735 0.1211
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0012 0.0054 0.0011
Echinococcus multilocularis lamin dm0 0.0031 0.0811 0.1337
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0169 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0128
Brugia malayi glutathione reductase 0.0082 0.2829 0.3696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0338 0.0388
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0388
Loa Loa (eye worm) hypothetical protein 0.0031 0.0788 0.0986
Onchocerca volvulus 0.0041 0.1172 0.1351
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.0694 0.1145
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0785 0.0981
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0165 0.0272
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0729 0.089
Echinococcus granulosus lamin 0.0031 0.0811 0.1337
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0388
Mycobacterium tuberculosis Conserved protein 0.0024 0.0503 0.0586
Plasmodium vivax PST-A protein 0.0138 0.5029 1
Trypanosoma cruzi trypanothione reductase, putative 0.0082 0.2829 0.3623
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.046 0.0831
Mycobacterium leprae conserved hypothetical protein 0.0023 0.046 0.0531
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0138 0.5029 0.573

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) Antifungal activity against Candida albicans ATCC 20260 after 18 hrs by agar dilution technique ChEMBL. 19211175
MIC (functional) = 10 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar dilution technique ChEMBL. 19211175

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.