Detailed information for compound 1056158

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 485.624 | Formula: C28H35N7O
  • H donors: 1 H acceptors: 3 LogP: 5.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC1COCCN1c1nc(nc(n1)N1CCCc2c1cccc2)N1CCCc2c1cccc2
  • InChi: 1S/C28H35N7O/c1-2-15-29-25-20-36-19-18-35(25)28-31-26(33-16-7-11-21-9-3-5-13-23(21)33)30-27(32-28)34-17-8-12-22-10-4-6-14-24(22)34/h3-6,9-10,13-14,25,29H,2,7-8,11-12,15-20H2,1H3
  • InChiKey: ASSLPENHMGUHSU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase shark 0.0059 0.0023 0.0028
Schistosoma mansoni protein kinase 0.0117 0.0162 0.0332
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0129 0.0191 0.0389
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0203 0.388
Echinococcus multilocularis cyclin b3 0.0151 0.0242 0.0498
Echinococcus multilocularis cyclins 0.0151 0.0242 0.0498
Loa Loa (eye worm) hypothetical protein 0.4248 1 1
Echinococcus multilocularis cyclins 0.0151 0.0242 0.0498
Entamoeba histolytica cyclin family protein 0.0151 0.0242 0.478
Echinococcus multilocularis tyrosine protein kinase Abl 0.0178 0.0308 0.064
Loa Loa (eye worm) hypothetical protein 0.0062 0.0032 0.0021
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1669 0.3858 1
Schistosoma mansoni tyrosine kinase 0.0129 0.0191 0.0397
Plasmodium vivax protein kinase Crk2 0.0134 0.0203 1
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0116 0.016 0.0322
Brugia malayi Protein kinase domain containing protein 0.0268 0.0521 0.0511
Echinococcus multilocularis cyclin dependent kinase 1 0.0134 0.0203 0.0414
Echinococcus multilocularis cyclins 0.0151 0.0242 0.0498
Brugia malayi Variant SH3 domain containing protein 0.0062 0.0032 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0162 0.3046
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0203 0.388
Echinococcus multilocularis tyrosine kinase 0.0059 0.0023 0.0028
Trypanosoma cruzi cyclin, putative 0.0262 0.0506 0.1289
Brugia malayi Protein kinase domain containing protein 0.0077 0.0067 0.0056
Giardia lamblia Hypothetical protein 0.0151 0.0242 0.467
Toxoplasma gondii aurora kinase 0.0117 0.0162 0.3458
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0262 0.0506 0.1289
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0079 0.0072 0.0159
Plasmodium falciparum cyclin 0.0151 0.0242 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0268 0.0521 0.0511
Schistosoma mansoni tyrosine kinase 0.022 0.0407 0.0871
Trypanosoma brucei mitotic cyclin 6 0.0262 0.0506 0.1289
Schistosoma mansoni adapter molecule crk 0.0084 0.0084 0.0162
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0062 0.0031 0.0054
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0191 0.0389
Echinococcus granulosus tyrosine protein kinase Blk 0.0088 0.0092 0.0175
Trichomonas vaginalis cyclins, putative 0.0262 0.0506 1
Schistosoma mansoni tyrosine kinase 0.1964 0.4561 1
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0117 0.0162 0.319
Echinococcus granulosus cyclins 0.0151 0.0242 0.0498
Loa Loa (eye worm) hypothetical protein 0.0084 0.0084 0.0074
Loa Loa (eye worm) hypothetical protein 0.0121 0.0172 0.0161
Echinococcus multilocularis tyrosine protein kinase shark 0.0059 0.0023 0.0028
Trichomonas vaginalis cyclin B, putative 0.0262 0.0506 1
Echinococcus granulosus cyclins 0.0151 0.0242 0.0498
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0253 0.0485 0.1022
Schistosoma mansoni cyclin d 0.019 0.0337 0.0717
Echinococcus granulosus tyrosine protein kinase ABL1 0.0263 0.0509 0.1072
Plasmodium falciparum serine/threonine protein kinase, putative 0.0117 0.0162 0.2135
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0134 0.0203 0.0193
Loa Loa (eye worm) hypothetical protein 0.0094 0.0107 0.0097
Leishmania major malonyl-coa decarboxylase-like protein 0.1669 0.3858 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0262 0.0506 0.0496
Echinococcus granulosus dual specificity mitogen activated protein 0.0079 0.0072 0.0132
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1669 0.3858 1
Trichomonas vaginalis AGC family protein kinase 0.0108 0.014 0.2605
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0129 0.0191 0.0389
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0101 0.0123 0.0247
Schistosoma mansoni protein kinase 0.0079 0.0072 0.0135
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0061 0.0029 0.0041
Echinococcus multilocularis cyclin B3 1 0.0151 0.0242 0.0498
Giardia lamblia Kinase, NEK 0.0108 0.014 0.2605
Brugia malayi Cyclin, N-terminal domain containing protein 0.0261 0.0504 0.0494
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0134 0.0203 1
Brugia malayi protein-tyrosine kinase 0.0088 0.0092 0.0082
Loa Loa (eye worm) hypothetical protein 0.0121 0.0172 0.0161
Loa Loa (eye worm) cyclin domain-containing protein 0.0261 0.0504 0.0494
Brugia malayi Cyclin, N-terminal domain containing protein 0.019 0.0337 0.0327
Echinococcus multilocularis cyclin B 0.0262 0.0506 0.1067
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0062 0.0031 0.0054
Onchocerca volvulus 0.0059 0.0023 0.0261
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0134 0.0203 0.0414
Brugia malayi SH2 domain containing protein 0.0059 0.0023 0.0013
Trichomonas vaginalis STE family protein kinase 0.0108 0.014 0.2605
Onchocerca volvulus 0.0262 0.0506 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0262 0.0506 1
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0067 0.1138
Trichomonas vaginalis cyclin B, putative 0.0151 0.0242 0.467
Toxoplasma gondii hypothetical protein 0.0114 0.0155 0.2504
Echinococcus granulosus G1:S specific cyclin D1 0.019 0.0337 0.0702
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.0162 0.319
Brugia malayi serine/threonine-protein kinase 6 0.0117 0.0162 0.0151
Echinococcus multilocularis dual specificity mitogen activated protein 0.0079 0.0072 0.0132
Trypanosoma cruzi cyclin, putative 0.0262 0.0506 0.1289
Entamoeba histolytica protein kinase, putative 0.0117 0.0162 0.319
Echinococcus granulosus growth factor receptor bound protein 2 0.0084 0.0084 0.0159
Onchocerca volvulus Tyrosine kinase homolog 0.0157 0.0258 0.4982
Trichomonas vaginalis STE family protein kinase 0.0079 0.0072 0.1237
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0162 0.3046
Schistosoma mansoni tyrosine kinase 0.0101 0.0123 0.0247
Brugia malayi Protein kinase domain containing protein 0.0059 0.0023 0.0013
Echinococcus multilocularis cyclins 0.0151 0.0242 0.0498
Trichomonas vaginalis cyclins, putative 0.0262 0.0506 1
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0079 0.0072 0.0159
Echinococcus granulosus NCK adaptor protein 0.0084 0.0084 0.0159
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0079 0.0072 0.0061
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0134 0.0203 0.05
Echinococcus granulosus cyclin dependent kinase 0.0134 0.0203 0.0414
Trichomonas vaginalis cyclin A, putative 0.0262 0.0506 1
Brugia malayi Protein kinase domain containing protein 0.0059 0.0023 0.0013
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0117 0.0162 0.0325
Echinococcus granulosus cyclin dependent kinase 5 0.0134 0.0203 0.0414
Schistosoma mansoni kinase 0.0163 0.0272 0.0575
Schistosoma mansoni cyclin B 0.0262 0.0506 0.109
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0129 0.0191 0.0389
Brugia malayi Protein kinase domain containing protein 0.0059 0.0023 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0242 0.467
Echinococcus multilocularis cyclins 0.0151 0.0242 0.0498
Brugia malayi Protein kinase domain containing protein 0.0342 0.0697 0.0687
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0079 0.0072 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1669 0.3858 1
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0084 0.0162
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0253 0.0485 0.1022
Schistosoma mansoni tyrosine kinase 0.0265 0.0514 0.1106
Echinococcus multilocularis cyclin dependent kinase 5 0.0134 0.0203 0.0414
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0191 0.0389
Echinococcus multilocularis cyclin dependent kinase 0.0134 0.0203 0.0414
Trypanosoma cruzi cdc2-related kinase 3 0.0134 0.0203 0.05
Echinococcus multilocularis cyclins 0.0151 0.0242 0.0498
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0342 0.0697 0.0687
Entamoeba histolytica cell division protein kinase 2, putative 0.0134 0.0203 0.4006
Echinococcus granulosus c src tyrosine kinase 0.0101 0.0123 0.0241
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0084 0.0162
Entamoeba histolytica protein kinase, putative 0.0117 0.0162 0.319
Brugia malayi serine/threonine protein kinase 6 0.0117 0.0162 0.0151
Giardia lamblia Cyclin A 0.0151 0.0242 0.467
Loa Loa (eye worm) AUR protein kinase 0.0117 0.0162 0.0151
Echinococcus granulosus tyrosine kinase 0.0059 0.0023 0.0028
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0088 0.0092 0.0175
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0134 0.0203 0.0193
Echinococcus multilocularis NCK adaptor protein 0.0084 0.0084 0.0159
Echinococcus granulosus tyrosine kinase 0.0088 0.0092 0.0175
Echinococcus multilocularis G1:S specific cyclin D1 0.019 0.0337 0.0702
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0088 0.0092 0.0175
Brugia malayi SRC-1 0.0129 0.0191 0.0181
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0077 0.0067 0.0124
Schistosoma mansoni tyrosine kinase 0.0129 0.0191 0.0397
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0062 0.0032 0.0021
Loa Loa (eye worm) TK/ABL protein kinase 0.0263 0.0509 0.0499
Brugia malayi SH2 domain containing protein 0.0059 0.0023 0.0013
Brugia malayi hypothetical protein 0.0059 0.0023 0.0013
Trichomonas vaginalis cyclin B, putative 0.0262 0.0506 1
Entamoeba histolytica cyclin family protein 0.0151 0.0242 0.478
Trichomonas vaginalis cyclin D, putative 0.0151 0.0242 0.467
Echinococcus granulosus cyclin B 0.0262 0.0506 0.1067
Entamoeba histolytica cell division protein kinase 2, putative 0.0134 0.0203 0.4006
Echinococcus multilocularis tyrosine protein kinase Blk 0.0088 0.0092 0.0175
Echinococcus granulosus protein tyrosine kinase 0.0265 0.0514 0.1083
Loa Loa (eye worm) TK protein kinase 0.0088 0.0092 0.0082
Entamoeba histolytica serine/threonine protein kinase, putative 0.0053 0.001 0.0206
Loa Loa (eye worm) hypothetical protein 0.0111 0.0148 0.0137
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0191 0.0389
Trypanosoma brucei aurora B kinase 0.0117 0.0162 0.0393
Giardia lamblia Kinase, CMGC CDK 0.0134 0.0203 0.388
Leishmania major protein kinase, putative 0.0117 0.0162 0.0393
Echinococcus multilocularis growth factor receptor bound protein 2 0.0084 0.0084 0.0159
Schistosoma mansoni cyclins 0.0151 0.0242 0.0509
Trichomonas vaginalis cyclin B, putative 0.0262 0.0506 1
Trypanosoma cruzi cyclin 6, putative 0.0262 0.0506 0.1289
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0117 0.0162 0.319
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0129 0.0191 0.0389
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2006 0.466 1
Trypanosoma brucei wee1-like protein kinase 0.0062 0.0031 0.0054
Echinococcus multilocularis cyclin dependent kinase 1 0.0134 0.0203 0.0414
Loa Loa (eye worm) hypothetical protein 0.0253 0.0485 0.0475
Giardia lamblia Kinase, STE STE20 0.0079 0.0072 0.1237
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0162 0.3046
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2006 0.466 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0129 0.0191 0.0389
Loa Loa (eye worm) hypothetical protein 0.0154 0.025 0.024
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.0084 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0203 0.388
Trypanosoma cruzi CYC2-like cyclin, putative 0.0262 0.0506 0.1289
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0062 0.0031 0.0054
Schistosoma mansoni vav2 0.0062 0.0032 0.0047
Trichomonas vaginalis cyclin B, putative 0.0262 0.0506 1
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0061 0.0029 0.0041
Loa Loa (eye worm) AUR protein kinase 0.0117 0.0162 0.0151
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0117 0.0162 0.319
Brugia malayi Variant SH3 domain containing protein 0.0084 0.0084 0.0074
Echinococcus multilocularis c src tyrosine kinase 0.0101 0.0123 0.0241
Brugia malayi Protein kinase domain containing protein 0.0059 0.0023 0.0013
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0117 0.0162 0.3458
Loa Loa (eye worm) SRC-1 0.0129 0.0191 0.0181
Trypanosoma cruzi cdc2-related kinase 3 0.0134 0.0203 0.05
Brugia malayi hypothetical protein 0.0121 0.0172 0.0161
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0129 0.0191 0.0389
Trypanosoma cruzi cdc2-related kinase 1 0.0134 0.0203 0.05
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0134 0.0203 0.05
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0162 0.0332
Plasmodium falciparum protein kinase 5 0.0134 0.0203 0.6173
Onchocerca volvulus 0.0059 0.0023 0.0261
Onchocerca volvulus 0.0059 0.0023 0.0261
Schistosoma mansoni serine/threonine protein kinase 0.0342 0.0697 0.1508
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0077 0.0067 0.1138
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0162 0.3046
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0084 0.0084 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0067 0.1138
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0059 0.0023 0.0028
Brugia malayi Sex muscle abnormal protein 5 0.0084 0.0084 0.0074
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0261 0.0504 0.1061
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Onchocerca volvulus 0.0136 0.0208 0.3984
Loa Loa (eye worm) hypothetical protein 0.0128 0.0188 0.0178
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0077 0.0067 0.0121
Entamoeba histolytica cyclin, putative 0.0151 0.0242 0.478
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.4248 1 0.5
Echinococcus granulosus cyclin b3 0.0151 0.0242 0.0498
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Entamoeba histolytica protein kinase , putative 0.0117 0.0162 0.319
Echinococcus granulosus tyrosine protein kinase Srms 0.0059 0.0023 0.0028
Trichomonas vaginalis cyclins, putative 0.0262 0.0506 1
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0062 0.0031 0.0054
Entamoeba histolytica hypothetical protein 0.0061 0.0029 0.0579
Echinococcus granulosus cyclins 0.0151 0.0242 0.0498
Trichomonas vaginalis cyclins, putative 0.0262 0.0506 1
Schistosoma mansoni tyrosine kinase 0.0059 0.0023 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0203 0.0423
Brugia malayi Tyrosine-protein kinase abl-1 0.0178 0.0308 0.0298
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0263 0.0509 0.1072
Trypanosoma brucei cdc2-related kinase 3 0.0134 0.0203 0.05
Giardia lamblia Kinase, NEK 0.0108 0.014 0.2605
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0192 0.0341 0.0331
Giardia lamblia Kinase, CMGC CDK 0.0134 0.0203 0.388
Brugia malayi Variant SH3 domain containing protein 0.0084 0.0084 0.0074
Loa Loa (eye worm) hypothetical protein 0.019 0.0337 0.0327
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0191 0.0389
Loa Loa (eye worm) TTK protein kinase 0.0077 0.0067 0.0056
Echinococcus multilocularis tyrosine protein kinase Srms 0.0088 0.0092 0.0175
Echinococcus multilocularis aurora kinase A 0.0117 0.0162 0.0325
Brugia malayi serine/threonine kinase 12 0.0117 0.0162 0.0151
Brugia malayi Cyclin, N-terminal domain containing protein 0.0262 0.0506 0.0496
Trypanosoma cruzi cdc2-related kinase 1 0.0134 0.0203 0.05
Trypanosoma brucei cdc2-related kinase 1 0.0134 0.0203 0.05
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Trypanosoma cruzi aurora B kinase, putative 0.0117 0.0162 0.0393
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0129 0.0191 0.0389
Onchocerca volvulus 0.0059 0.0023 0.0261
Echinococcus granulosus aurora kinase A 0.0117 0.0162 0.0325
Trichomonas vaginalis STE family protein kinase 0.0079 0.0072 0.1237
Onchocerca volvulus 0.0059 0.0023 0.0261
Leishmania major cyclin 0.0262 0.0506 0.1289
Echinococcus granulosus cyclins 0.0151 0.0242 0.0498
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0117 0.0162 0.0325
Schistosoma mansoni nck2/grb4 0.0084 0.0084 0.0162
Loa Loa (eye worm) AUR protein kinase 0.0117 0.0162 0.0151
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0134 0.0203 0.0193
Brugia malayi cell division control protein 2 homolog 0.0134 0.0203 0.0193
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0062 0.0031 0.0054
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Echinococcus granulosus tyrosine protein kinase Src42A 0.0129 0.0191 0.0389
Onchocerca volvulus 0.0059 0.0023 0.0261
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0059 0.0023 0.0462
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0072 0.0054 0.0093
Trichomonas vaginalis cyclin B3, putative 0.0151 0.0242 0.467
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0077 0.0067 0.0121
Giardia lamblia Kinase, TTK 0.0077 0.0067 0.1138
Echinococcus granulosus tyrosine protein kinase Src64B 0.0129 0.0191 0.0389
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0191 0.0389
Echinococcus multilocularis cyclins 0.0151 0.0242 0.0498
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.0183 0.0173
Loa Loa (eye worm) hypothetical protein 0.0262 0.0506 0.0496
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0059 0.0023 0.0028
Brugia malayi Immunoglobulin I-set domain containing protein 0.0192 0.0341 0.0331
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0079 0.0072 0.0159
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0261 0.0504 0.1061
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0116 0.016 0.0322
Echinococcus granulosus tyrosine protein kinase Lyn 0.0136 0.0206 0.0421
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0129 0.0191 0.0389
Giardia lamblia Kinase, NEK 0.0108 0.014 0.2605
Echinococcus granulosus cyclin dependent kinase 1 0.0134 0.0203 0.0414
Entamoeba histolytica cyclin, putative 0.0262 0.0506 1
Echinococcus granulosus cyclin B3 1 0.0151 0.0242 0.0498
Trichomonas vaginalis STE family protein kinase 0.0079 0.0072 0.1237
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0084 0.0084 0.0162
Echinococcus granulosus tyrosine protein kinase Src42A 0.0072 0.0054 0.0093
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0061 0.0029 0.0041
Loa Loa (eye worm) hypothetical protein 0.0262 0.0506 0.0496
Echinococcus multilocularis protein tyrosine kinase 0.0265 0.0514 0.1083
Brugia malayi Protein kinase domain containing protein 0.0059 0.0023 0.0013
Brugia malayi Protein kinase domain containing protein 0.0134 0.0203 0.0193
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0023 0.0013
Schistosoma mansoni cyclin B3 0.0261 0.0504 0.1084
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0253 0.0485 0.1044
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0021 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0203 0.0423
Trichomonas vaginalis cyclin D, putative 0.0151 0.0242 0.467
Trichomonas vaginalis cyclins, putative 0.0147 0.0234 0.4512
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0191 0.0389
Trichomonas vaginalis cyclins, putative 0.0151 0.0242 0.467
Echinococcus granulosus cyclins 0.0151 0.0242 0.0498
Loa Loa (eye worm) hypothetical protein 0.0059 0.0023 0.0013
Schistosoma mansoni tyrosine kinase 0.0101 0.0123 0.0247
Giardia lamblia Aurora kinase 0.0117 0.0162 0.3046

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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