Detailed information for compound 1056169

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 304.323 | Formula: C10H16N4O5S
  • H donors: 4 H acceptors: 6 LogP: -2.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCSC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc(n1)C(=O)N
  • InChi: 1S/C10H16N4O5S/c11-8(18)9-12-4-14(13-9)10-7(17)6(16)5(19-10)3-20-2-1-15/h4-7,10,15-17H,1-3H2,(H2,11,18)/t5-,6-,7-,10-/m1/s1
  • InChiKey: YTVFKJQKVBHXOS-DAGMQNCNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0153 0.0835 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0051 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0648
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0411 0.1028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0097 0.0311
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0153 0.0835 0.5509
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0058 0.0064
Entamoeba histolytica hypothetical protein 0.0078 0.0395 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0089 0.0224
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.01 0.0526 0.3032
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0958 0.2405
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0058 0.0141
Loa Loa (eye worm) hypothetical protein 0.0255 0.143 0.3595
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0058 0.0141
Loa Loa (eye worm) hypothetical protein 0.0081 0.0411 0.1033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.1052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0269 0.1514 0.171
Loa Loa (eye worm) hypothetical protein 0.0269 0.1514 0.3806
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0051 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Mycobacterium tuberculosis Probable lipase LipD 0.0269 0.1514 0.1471
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0243
Loa Loa (eye worm) beta-lactamase 0.0269 0.1514 0.3806
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.143 0.3592
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0153 0.0835 0.5509
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0051 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0097 0.0389
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0089 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0058 0.0141
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0077 0.0085
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0005
Toxoplasma gondii ABC1 family protein 0.0269 0.1514 1
Brugia malayi RNA binding protein 0.069 0.3978 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0058 0.0146
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0238 0.1345
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0238 0.0266
Loa Loa (eye worm) RNA binding protein 0.069 0.3978 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0143
Schistosoma mansoni peptidase Clp (S14 family) 0.0153 0.0835 0.0942
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0058 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0112 0.0125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0143
Brugia malayi Importin beta-1 subunit 0.0032 0.0127 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0058 0.0141
Plasmodium vivax importin-beta 2, putative 0.0032 0.0127 0.0481
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0053 0.0248 0.1067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0058 0.0146
Echinococcus multilocularis thyroid hormone receptor alpha 0.0273 0.1541 0.1741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0039 0.0246
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0097 0.0238
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0051 0.008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0007 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0097 0.0389
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0058 0.0064
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0238 0.0266
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0077 0.0258
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0005
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0077 0.0194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0058 0.0141
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0106 0.0117
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0153 0.0835 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0411 0.0463
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0058 0.0141
Echinococcus granulosus snurportin 1 0.0342 0.1942 0.2195
Entamoeba histolytica hypothetical protein 0.0078 0.0395 1
Schistosoma mansoni tar DNA-binding protein 0.069 0.3978 0.4498
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0117 0.0763
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0058 0.0064
Mycobacterium ulcerans hypothetical protein 0.0269 0.1514 1
Brugia malayi beta-lactamase family protein 0.0269 0.1514 0.3803
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0146
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0057 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0039 0.0246
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0051 0.0055
Echinococcus granulosus dna polymerase eta 0.0019 0.0051 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0097 0.0311
Echinococcus multilocularis microtubule associated protein 2 0.152 0.8841 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0269 0.1514 0.1471
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0112 0.0125
Loa Loa (eye worm) hypothetical protein 0.0159 0.087 0.2186
Toxoplasma gondii hypothetical protein 0.0053 0.0248 0.1625
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0282
Schistosoma mansoni importin beta-1 0.0032 0.0127 0.0141
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0051 0.0123
Leishmania major hypothetical protein, conserved 0.0269 0.1514 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0269 0.1514 0.171
Echinococcus multilocularis dna polymerase eta 0.0019 0.0051 0.0055
Echinococcus multilocularis tar DNA binding protein 0.069 0.3978 0.4498
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0097 0.0389
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0253 0.1422 0.1606
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0051 0.0324
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0058 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0269 0.1514 0.171
Plasmodium falciparum importin beta, putative 0.0032 0.0127 0.09
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0238 0.1557
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0058 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0097 0.0311
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0077 0.0407
Schistosoma mansoni nuclear hormone receptor 0.002 0.0058 0.0064
Echinococcus granulosus GPCR family 2 0.0081 0.0411 0.0463
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0097 0.0046
Loa Loa (eye worm) hypothetical protein 0.0269 0.1514 0.3806
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.01 0.0526 0.0478
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.008
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0146
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0411 0.0463
Brugia malayi beta-lactamase 0.0269 0.1514 0.3803
Echinococcus granulosus dna polymerase kappa 0.0019 0.0051 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0097 0.0046
Loa Loa (eye worm) hypothetical protein 0.0174 0.0958 0.2409
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0058 0.0064
Onchocerca volvulus 0.0269 0.1514 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0058 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0058 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0097 0.0238
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0153 0.0835 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0058 0.0141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0097 0.1323
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0146
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0238 0.1477
Echinococcus granulosus peptidase Clp S14 family 0.01 0.0526 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0116 0.0752
Brugia malayi hypothetical protein 0.0078 0.0395 0.0988
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0089 0.042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0051 0.0128
Entamoeba histolytica hypothetical protein 0.0078 0.0395 1
Mycobacterium tuberculosis Conserved protein 0.0269 0.1514 0.1471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.01 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0116 0.0752
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0112 0.0125
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0238 0.1345
Loa Loa (eye worm) TAR-binding protein 0.069 0.3978 1
Trichomonas vaginalis D-aminoacylase, putative 0.0269 0.1514 1
Echinococcus multilocularis tumor protein p63 0.1086 0.6295 0.712
Schistosoma mansoni tar DNA-binding protein 0.069 0.3978 0.4498
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0243
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0051 0.0232
Leishmania major DNA polymerase kappa, putative 0.0019 0.0051 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0058 0.0146
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0077 0.0085
Mycobacterium tuberculosis Conserved protein 0.0269 0.1514 0.1471
Schistosoma mansoni hypothetical protein 0.0081 0.0411 0.0463
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0238 0.5421
Loa Loa (eye worm) hypothetical protein 0.0269 0.1514 0.3806
Schistosoma mansoni hypothetical protein 0.0012 0.0007 0.0005
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0057 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0177 0.1154
Schistosoma mansoni tar DNA-binding protein 0.069 0.3978 0.4498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0058 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Trichomonas vaginalis esterase, putative 0.0269 0.1514 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0153 0.0835 0.5358
Onchocerca volvulus 0.0269 0.1514 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0089 0.0341
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0058 0.0064
Giardia lamblia GTOR 0.0051 0.0238 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0112 0.0125
Schistosoma mansoni thyroid hormone receptor 0.0273 0.1541 0.1741
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0058 0.0064
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0097 0.1323
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0153 0.0835 0.0942
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0058 0.0141
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0238 0.0266
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0051 0.0001
Loa Loa (eye worm) hypothetical protein 0.0269 0.1514 0.3806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0648
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0007 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0089 0.042
Schistosoma mansoni hypothetical protein 0.0174 0.0958 0.1082
Entamoeba histolytica hypothetical protein 0.0026 0.0091 0.117
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0058 0.0146
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0077 0.0258
Entamoeba histolytica Ran family GTPase 0.0024 0.0077 0.0762
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0177 0.1071
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0112 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0117 0.0763
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Trichomonas vaginalis penicillin-binding protein, putative 0.0269 0.1514 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.1052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.143 0.3592
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0238 0.0592
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.008 0.0427
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0177 0.0932
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0058 0.0146
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0051 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.1052
Mycobacterium tuberculosis Probable esterase LipL 0.0269 0.1514 0.1471
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0058 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0232
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0089 0.0488
Loa Loa (eye worm) hypothetical protein 0.0269 0.1514 0.3806
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0053 0.0248 0.1311
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0097 0.0311
Trichomonas vaginalis D-aminoacylase, putative 0.0269 0.1514 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0058 0.0064
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0153 0.0835 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1146 0.2881
Loa Loa (eye worm) hypothetical protein 0.0153 0.0835 0.2099
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0146
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0238 0.1477
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0091 0.0591
Plasmodium vivax SET domain protein, putative 0.003 0.0112 0.0381
Brugia malayi Pre-SET motif family protein 0.0206 0.1146 0.2877
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0077 0.0498
Mycobacterium tuberculosis Probable hydrolase 0.0269 0.1514 0.1471
Plasmodium vivax hypothetical protein, conserved 0.0269 0.1514 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0051 0.0055
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0077 0.0263
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0153 0.0835 1
Brugia malayi steroid hormone receptor 0.002 0.0058 0.0141
Onchocerca volvulus 0.0159 0.087 0.5573
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0051 0.0123
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0097 0.1323
Echinococcus granulosus tumor protein p63 0.1086 0.6295 0.712
Onchocerca volvulus 0.0027 0.0097 0.0264
Mycobacterium ulcerans beta-lactamase 0.0269 0.1514 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0411 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0039 0.0246
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0058 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0051 0.0232
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0058 0.0064
Brugia malayi beta-lactamase family protein 0.0269 0.1514 0.3803
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0058 0.0141
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0005
Schistosoma mansoni ran 0.0024 0.0077 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0177 0.1154
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0146
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0051 0.0001
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0063 0.0312
Schistosoma mansoni thyroid hormone receptor 0.0273 0.1541 0.1741
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0051 0.0232
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0243
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0269 0.1514 0.3803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.01 0.065
Trichomonas vaginalis penicillin-binding protein, putative 0.0269 0.1514 1
Schistosoma mansoni hypothetical protein 0.0081 0.0411 0.0463
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0058 0.0141
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0077 0.0141
Brugia malayi hypothetical protein 0.0026 0.0089 0.022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0058 0.0064
Onchocerca volvulus 0.0235 0.1313 0.8617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0238 0.1557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0019 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.01 0.065
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0269 0.1514 0.1471
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0039 0.0153
Brugia malayi RNA recognition motif domain containing protein 0.069 0.3978 1
Onchocerca volvulus 0.0269 0.1514 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0127 0.0738
Mycobacterium leprae conserved hypothetical protein 0.0269 0.1514 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0077 0.1405
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0039 0.0042
Echinococcus granulosus tar DNA binding protein 0.069 0.3978 0.4498
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 0.1942 0.4883
Brugia malayi Pre-SET motif family protein 0.003 0.0112 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0058 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0177 0.1154
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0238 0.5421
Mycobacterium leprae Probable lipase LipE 0.0269 0.1514 1
Leishmania major importin beta-1 subunit, putative 0.0026 0.0091 0.0353
Trypanosoma brucei unspecified product 0.0019 0.0051 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0128
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0238 0.0597
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0395 0.0445
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0127 0.0825
Schistosoma mansoni tar DNA-binding protein 0.069 0.3978 0.4498
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0153 0.0835 0.5358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0177 0.1154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.01 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0039 0.0246
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0058 0.0064
Schistosoma mansoni cellular tumor antigen P53 0.0159 0.087 0.0981
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0269 0.1514 1
Schistosoma mansoni hypothetical protein 0.0078 0.0395 0.0445
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0653 0.1642
Echinococcus multilocularis GPCR, family 2 0.0081 0.0411 0.0463
Echinococcus multilocularis snurportin 1 0.0342 0.1942 0.2195
Onchocerca volvulus 0.003 0.0112 0.0371
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0058 0.0064
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0002 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0039 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0648
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0091 0.0591
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0058 0.0146
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0058 0.0141
Entamoeba histolytica hypothetical protein 0.0078 0.0395 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0058 0.0064
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0127 0.0141
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0153 0.0835 0.0942
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0058 0.0064
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0091 0.0591
Brugia malayi ecdysteroid receptor 0.002 0.0058 0.0141
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0395 0.0445
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0051 0.0232
Schistosoma mansoni microtubule-associated protein tau 0.152 0.8841 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0117 0.0763
Brugia malayi RNA, U transporter 1 0.0091 0.0473 0.1184
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0225
Echinococcus granulosus FTZ F1 alpha 0.002 0.0058 0.0064
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0091 0.0353
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0058 0.0064
Leishmania major hypothetical protein, conserved 0.0026 0.0089 0.0341
Brugia malayi TAR-binding protein 0.069 0.3978 1
Trichomonas vaginalis ran, putative 0.0024 0.0077 0.0498
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0097 0.0311
Schistosoma mansoni coup transcription factor 0.002 0.0058 0.0064
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0269 0.1514 0.3806
Loa Loa (eye worm) hypothetical protein 0.0032 0.0127 0.0319
Schistosoma mansoni ran 0.0024 0.0077 0.0085
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0039 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0133 0.0865
Echinococcus multilocularis peptidase Clp (S14 family) 0.01 0.0526 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.1052
Mycobacterium ulcerans lipase LipD 0.0269 0.1514 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0089 0.0578
Brugia malayi MH2 domain containing protein 0.0122 0.0653 0.1637
Brugia malayi nuclear hormone receptor 0.002 0.0058 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.1052
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0395 0.0445
Trypanosoma cruzi hypothetical protein, conserved 0.0269 0.1514 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0039 0.0153
Mycobacterium tuberculosis Conserved protein 0.0269 0.1514 0.1471
Schistosoma mansoni DNA polymerase eta 0.0019 0.0051 0.0055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0058 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0097 0.0238
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0097 0.0311
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0653 0.1642
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0411 0.1033
Trypanosoma cruzi hypothetical protein, conserved 0.0269 0.1514 1
Trichomonas vaginalis D-aminoacylase, putative 0.0269 0.1514 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0051 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0058 0.0141
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0253 0.1422 0.1606
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0058 0.0141
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1313 0.8668
Trypanosoma brucei hypothetical protein, conserved 0.0269 0.1514 1
Schistosoma mansoni hypothetical protein 0.0253 0.1422 0.1606
Leishmania major GTP-binding protein, putative 0.0024 0.0077 0.0258
Schistosoma mansoni hypothetical protein 0.0081 0.0411 0.0463
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0058 0.0064
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0411 0.1028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0411 0.0463
Brugia malayi nuclear receptor NHR-88 0.002 0.0058 0.0141
Mycobacterium ulcerans esterase/lipase LipP 0.0269 0.1514 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0146
Echinococcus granulosus importin subunit beta 1 0.0032 0.0127 0.0141
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0039 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.1052
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0177 0.1154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0139 0.0908
Brugia malayi Probable ClpP-like protease 0.0153 0.0835 0.2095
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0039 0.0042
Schistosoma mansoni hypothetical protein 0.0081 0.0411 0.0463
Echinococcus granulosus microtubule associated protein 2 0.152 0.8841 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0161 0.1052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0058 0.0064
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0051 0.008
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0177 0.0932
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0269 0.1514 0.1471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.1052
Brugia malayi hypothetical protein 0.0017 0.0036 0.0086
Schistosoma mansoni hypothetical protein 0.0342 0.1942 0.2195
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0097 0.0311
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0238 0.1345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.069 0.3978 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0269 0.1514 0.171
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.143 0.3595
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0112 0.0125
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0238 0.1345
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0039 0.0099
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0058 0.0064
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0127 0.0738
Schistosoma mansoni tar DNA-binding protein 0.069 0.3978 0.4498
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0058 0.0064
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0112 0.0729
Loa Loa (eye worm) hypothetical protein 0.0269 0.1514 0.3806
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0112 0.0125
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0248 0.2455
Mycobacterium ulcerans hypothetical protein 0.0027 0.0097 0.0311
Mycobacterium tuberculosis Probable lipase LipE 0.0269 0.1514 0.1471
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0822 0.4754 0.5376
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0058 0.0064
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0153 0.0835 0.5209
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.01 0.0526 0.0478
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0153 0.0835 0.534
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0146
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0077 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0194 0.1269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0238 0.1557

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Growth stimulation of pentamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243 at 100 uM after 48 hrs by Z1 zoulter counter ChEMBL. 17954686
IC50 (functional) Antitrypanosomal activity against diamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243-As10-3 after 48 hrs by Z1 zoulter counter ChEMBL. 17954686
IC50 (functional) Antitrypanosomal activity against pentamidine-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 269 after 48 hrs by Z1 zoulter counter ChEMBL. 17954686
Inhibition (functional) = 9 % Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei LAB 110 EATRO after 48 hrs by Z1 zoulter counter ChEMBL. 17954686

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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