Detailed information for compound 1056365

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.561 | Formula: C31H24N6O2
  • H donors: 0 H acceptors: 4 LogP: 3.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1C(=C(C(=O)N1c1ccccc1)n1ccc2c1cccn2)c1cn(c2c1cccc2)CCCn1ccnc1
  • InChi: 1S/C31H24N6O2/c38-30-28(24-20-35(26-11-5-4-10-23(24)26)17-7-16-34-19-15-32-21-34)29(31(39)37(30)22-8-2-1-3-9-22)36-18-13-25-27(36)12-6-14-33-25/h1-6,8-15,18-21H,7,16-17H2
  • InChiKey: KOBRAAHPNOSLII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0085 0.0145
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0077 0.2967
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0085 0.0145
Loa Loa (eye worm) hypothetical protein 0.0169 0.0914 0.1559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0182 0.031
Brugia malayi Carboxylesterase family protein 0.0169 0.0914 0.1559
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0157 0.093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.02 0.0341
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0017 0.0097
Schistosoma mansoni ap endonuclease 0.0018 0.0017 0.0029
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0113 0.0192
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0017 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0085 0.0145
Brugia malayi hypothetical protein 0.0016 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0085 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0085 0.0145
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0462 0.0788
Echinococcus granulosus peregrin 0.0028 0.0077 0.0131
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0085 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0085 0.0145
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0169 0.0914 0.1559
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0077 0.0131
Echinococcus multilocularis geminin 0.0166 0.0892 0.1521
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0077 0.0131
Schistosoma mansoni ap endonuclease 0.0018 0.0017 0.0029
Loa Loa (eye worm) twinkle helicase 0.0109 0.0555 0.0946
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0258 0.044
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0258 0.044
Echinococcus granulosus geminin 0.0166 0.0892 0.1521
Echinococcus granulosus acetylcholinesterase 0.1001 0.5865 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0381 0.2174 1
Echinococcus granulosus Smad4 0.0024 0.0051 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0085 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0113 0.0192
Schistosoma mansoni hypothetical protein 0.0048 0.019 0.0325
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1679 1
Brugia malayi MH2 domain containing protein 0.0024 0.0051 0.0087
Loa Loa (eye worm) hypothetical protein 0.0059 0.0258 0.044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0085 0.0145
Treponema pallidum replicative DNA helicase (dnaB) 0.0381 0.2174 1
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0085 0.0145
Brugia malayi hypothetical protein 0.0233 0.1294 0.2207
Brugia malayi Carboxylesterase family protein 0.0169 0.0914 0.1559
Mycobacterium tuberculosis Carboxylesterase LipT 0.0169 0.0914 0.0914
Brugia malayi hypothetical protein 0.0169 0.0914 0.1559
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0085 0.0145
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0257 0.0439
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0539 0.0919
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0001 0.0002
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0077 0.0131
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0169 0.0914 0.0914
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0085 0.0145
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0169 0.0914 0.0914
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0539 0.0919
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1294 0.2207
Schistosoma mansoni nuclear hormone receptor 0.003 0.0085 0.0145
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0245 0.0418
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0085 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0182 0.031
Entamoeba histolytica hypothetical protein 0.0106 0.0539 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0113 0.0192
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0085 0.0145
Plasmodium falciparum phd finger protein, putative 0.0028 0.0077 1
Loa Loa (eye worm) acetylcholinesterase 1 0.1001 0.5865 1
Schistosoma mansoni Smad4 0.0024 0.0051 0.0087
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0143 0.0244
Loa Loa (eye worm) hypothetical protein 0.0049 0.02 0.0341
Schistosoma mansoni BC026374 protein (S09 family) 0.0169 0.0914 0.1559
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0017 0.0097
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0051 0.0087
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0085 0.0145
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0957 0.3366
Mycobacterium leprae Conserved hypothetical protein 0.0499 0.2877 1
Loa Loa (eye worm) carboxylesterase 0.1001 0.5865 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.0085 0.0145
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0077 0.2967
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0211 0.1255
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0085 0.0145
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0107 0.0183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0085 0.0145
Leishmania major hypothetical protein, conserved 0.0025 0.0055 0.0327
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1679 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0094
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.4046 0.6899
Entamoeba histolytica hypothetical protein 0.0106 0.0539 1
Onchocerca volvulus 0.0169 0.0914 0.3203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0258 0.044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0085 0.0145
Loa Loa (eye worm) hypothetical protein 0.0169 0.0914 0.1559
Onchocerca volvulus 0.0048 0.019 0.0434
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0085 0.0145
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0051 0.0087
Brugia malayi steroid hormone receptor 0.003 0.0085 0.0145
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0113 0.0192
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0085 0.0145
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0085 0.0145
Brugia malayi MH2 domain containing protein 0.0355 0.2017 0.344
Echinococcus multilocularis acetylcholinesterase 0.1001 0.5865 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0327
Loa Loa (eye worm) carboxylesterase 0.0169 0.0914 0.1559
Loa Loa (eye worm) Smad1 0.0024 0.0051 0.0087
Giardia lamblia PHD finger protein 15 0.0028 0.0077 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0182 0.031
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0051 0.0087
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0001 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.2017 0.344
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0055 0.0327
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0001 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Schistosoma mansoni smad1 5 8 and 0.0024 0.0051 0.0087
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0157 0.093
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.019 0.0325
Onchocerca volvulus 0.0169 0.0914 0.3203
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0145
Brugia malayi Carboxylesterase family protein 0.0169 0.0914 0.1559
Brugia malayi Carboxylesterase family protein 0.1001 0.5865 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0914 0.1559
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0539 0.0919
Plasmodium vivax SET domain protein, putative 0.0059 0.0258 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0157 0.093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0085 0.0145
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1316 0.7734 0.7734
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.2628 0.4481
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1679 1
Brugia malayi jmjC domain containing protein 0.0034 0.0113 0.0192
Schistosoma mansoni acetylcholinesterase 0.0169 0.0914 0.1559
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0085 0.0145
Brugia malayi nuclear hormone receptor 0.003 0.0085 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0085 0.0145
Echinococcus multilocularis peregrin 0.0028 0.0077 0.0131
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0085 0.0145
Echinococcus granulosus FTZ F1 alpha 0.003 0.0085 0.0145
Loa Loa (eye worm) carboxylesterase 0.0169 0.0914 0.1559
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.2628 0.4481
Onchocerca volvulus 0.0169 0.0914 0.3203
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0085 0.0145
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0 0.0001
Schistosoma mansoni smad1 5 8 and 0.0024 0.0051 0.0087
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0017 0.0097
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.084 0.084
Brugia malayi Pre-SET motif family protein 0.0059 0.0258 0.044
Entamoeba histolytica hypothetical protein 0.0106 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.1001 0.5865 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0258 0.044
Echinococcus multilocularis acetylcholinesterase 0.1001 0.5865 1
Echinococcus granulosus neuropeptide s receptor 0.0457 0.2628 0.4481
Schistosoma mansoni thyroid hormone receptor 0.003 0.0085 0.0145
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.02 0.0341
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0131
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0077 0.2967
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0085 0.0145
Brugia malayi nuclear receptor RXR 0.0016 0.0001 0.0002
Brugia malayi Carboxylesterase family protein 0.1001 0.5865 1
Mycobacterium ulcerans hypothetical protein 0.0157 0.084 0.3818
Chlamydia trachomatis replicative DNA helicase 0.0381 0.2174 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0085 0.0145
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0055 0.2129
Schistosoma mansoni hypothetical protein 0.0166 0.0892 0.1521
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0381 0.2174 1
Brugia malayi hypothetical protein 0.0016 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0085 0.0145
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0085 0.0145
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0051 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0085 0.0145
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0085 0.0145
Brugia malayi PHD-finger family protein 0.0028 0.0077 0.0131
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0001 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0001 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.7175
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0258 0.044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0198 0.0338
Brugia malayi hypothetical protein 0.0016 0.0003 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0051 0.0087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0182 0.031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0085 0.0145
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1679 1
Onchocerca volvulus 0.0059 0.0258 0.0694
Schistosoma mansoni hypothetical protein 0.0034 0.0107 0.0183
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1001 0.5865 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0169 0.0914 0.1559
Loa Loa (eye worm) hypothetical protein 0.0233 0.1294 0.2207
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0131
Brugia malayi MH1 domain containing protein 0.0024 0.0051 0.0087
Brugia malayi MH2 domain containing protein 0.0024 0.0051 0.0087
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0085 0.0145
Schistosoma mansoni survival motor neuron protein 0.0048 0.019 0.0325
Echinococcus granulosus acetylcholinesterase 0.1001 0.5865 1
Onchocerca volvulus 0.003 0.0085 0.0031
Onchocerca volvulus 0.0169 0.0914 0.3203
Loa Loa (eye worm) hypothetical protein 0.0169 0.0914 0.1559
Toxoplasma gondii hypothetical protein 0.0048 0.0193 0.7477
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0258 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0001 0.0002
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0169 0.0914 0.1559
Loa Loa (eye worm) hypothetical protein 0.0169 0.0914 0.1559
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0746 0.4441
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0085 0.0145
Trichomonas vaginalis spcc417.12 protein, putative 0.0169 0.0914 0.3356
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0746 0.4441
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0017 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0085 0.0145
Echinococcus granulosus para nitrobenzyl esterase 0.0169 0.0914 0.1559
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0017 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.2017 0.344
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0157 0.093
Entamoeba histolytica hypothetical protein 0.0106 0.0539 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0182 0.031
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.2628 0.4481
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0055 0.2129
Brugia malayi Isocitrate dehydrogenase 0.0016 0 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0085 0.0145
Loa Loa (eye worm) hypothetical protein 0.0176 0.0957 0.1631
Loa Loa (eye worm) hypothetical protein 0.0034 0.0107 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0085 0.0145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0017 0.0634
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0017 0.0029
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0145
Echinococcus multilocularis Smad4 0.0024 0.0051 0.0087
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0182 0.031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0085 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0085 0.0145
Onchocerca volvulus 0.0169 0.0914 0.3203
Schistosoma mansoni coup transcription factor 0.003 0.0085 0.0145
Echinococcus multilocularis para nitrobenzyl esterase 0.0169 0.0914 0.1559
Schistosoma mansoni hypothetical protein 0.0106 0.0539 0.0919
Echinococcus multilocularis smad 0.0024 0.0051 0.0087
Brugia malayi Carboxylesterase family protein 0.0169 0.0914 0.1559
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0051 0.0087
Brugia malayi nuclear receptor NHR-88 0.003 0.0085 0.0145
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0017 0.0029
Echinococcus granulosus smad 0.0024 0.0051 0.0087
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0145
Brugia malayi ecdysteroid receptor 0.003 0.0085 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0145
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0085 0.0145
Schistosoma mansoni smad1 5 8 and 0.0024 0.0051 0.0087
Echinococcus granulosus neuroligin 0.0169 0.0914 0.1559
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0462 0.0788
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.7175
Brugia malayi jmjC domain containing protein 0.0093 0.0462 0.0788
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0169 0.0914 0.1559
Schistosoma mansoni Replicative DNA helicase 0.0381 0.2174 0.3707
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0085 0.0145
Schistosoma mansoni gliotactin 0.0169 0.0914 0.1559
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.2352 0.4011
Echinococcus multilocularis carboxylesterase 5A 0.1001 0.5865 1
Brugia malayi isocitrate dehydrogenase 0.0016 0 0.0001
Brugia malayi N-terminal motif family protein 0.0176 0.0957 0.1631
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0085 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0085 0.0145
Schistosoma mansoni hypothetical protein 0.0166 0.0892 0.1521
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Echinococcus granulosus jumonji domain containing protein 0.004 0.0143 0.0244
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0169 0.0914 0.1559
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0077 0.0131
Brugia malayi Bromodomain containing protein 0.0028 0.0077 0.0131
Brugia malayi hypothetical protein 0.0106 0.0539 0.0919
Loa Loa (eye worm) hypothetical protein 0.0169 0.0914 0.1559
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0085 0.0145
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0085 0.0031
Brugia malayi hypothetical protein 0.0025 0.0055 0.0094
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0258 0.044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0085 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0085 0.0145
Echinococcus granulosus carboxylesterase 5A 0.1001 0.5865 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0051 0.0087
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0085 0.0145
Brugia malayi Smad1 0.0024 0.0051 0.0087
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0017 0.2137
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0145
Echinococcus multilocularis BC026374 protein (S09 family) 0.0169 0.0914 0.1559
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0085 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0085 0.0145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0182 0.031
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0113 0.0192
Schistosoma mansoni smad 0.0024 0.0051 0.0087
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0169 0.0914 0.1559
Loa Loa (eye worm) hypothetical protein 0.1001 0.5865 1
Echinococcus granulosus microtubule associated protein 2 0.0696 0.4046 0.6899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0182 0.031
Onchocerca volvulus 0.0468 0.269 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0017 0.0634
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0746 0.4441
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0182 0.031
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0348 0.0594
Echinococcus multilocularis neuroligin 0.0169 0.0914 0.1559
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0169 0.0914 0.3356
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1294 0.2207
Loa Loa (eye worm) hypothetical protein 0.0169 0.0914 0.1559
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.4046 0.6899
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0258 0.044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0085 0.0145
Brugia malayi MH1 domain containing protein 0.0024 0.0051 0.0087
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0468 0.269 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0017 0.0097
Brugia malayi Pre-SET motif family protein 0.0411 0.2352 0.4011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0085 0.0145
Echinococcus granulosus BC026374 protein S09 family 0.0169 0.0914 0.1559
Mycobacterium ulcerans carboxylesterase, LipT 0.0169 0.0914 0.416
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.02 0.0341

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 73.34 uM Inhibition of recombinant GST-GSK3beta expressed in Escherichia coli BL21 (DE3) ChEMBL. 19481464

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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