Detailed information for compound 1056453

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.835 | Formula: C21H20ClF4NO3
  • H donors: 1 H acceptors: 2 LogP: 4.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=C(C)NC2=C(C1c1cc(cc(c1F)Cl)C(F)(F)F)C(=O)C(CC2)(C)C
  • InChi: 1S/C21H20ClF4NO3/c1-9-14(19(29)30-4)15(16-13(27-9)5-6-20(2,3)18(16)28)11-7-10(21(24,25)26)8-12(22)17(11)23/h7-8,15,27H,5-6H2,1-4H3
  • InChiKey: MIMYVHGDPTVAPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0139 0.0351
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.013 0.0572
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0169 0.2692
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0002 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.013 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0027 0.0027
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0075 0.0183 0.0183
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0027 0.012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0239 0.0239
Echinococcus multilocularis snurportin 1 0.0639 0.1778 0.7825
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0031 0.0138
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.0031
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0094 0.1898
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0074
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0046 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0027 0.0027
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0011 0.0002 0.0001
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0046 0.0907
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0079 0.1251
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.013 0.0389
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.013 0.0328
Schistosoma mansoni hypothetical protein 0.0097 0.0243 0.1069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0027 0.0027
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0046 0.0711
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.049 0.2154
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0079 0.1595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Brugia malayi kap beta 3 protein 0.0011 0.0001 0.0001
Leishmania major endonuclease/exonuclease protein-like protein 0.0011 0.0002 0.0001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0094 0.0094
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0011 0.0002 0.0001
Brugia malayi intermediate filament protein 0.0026 0.0044 0.0044
Trichomonas vaginalis esterase, putative 0.0184 0.049 0.7843
Loa Loa (eye worm) hypothetical protein 0.3543 1 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0027 0.012
Mycobacterium ulcerans lipase LipD 0.0184 0.049 1
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0031 0.0138
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0011 0.0002 0.0006
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0011 0.0002 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.049 0.1248
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0027 0.012
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0042
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0003 0.0014
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0009 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.049 0.1248
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0011 0.0002 0.0027
Onchocerca volvulus 0.0097 0.0243 0.3876
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0002 0.0002
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0012 0.0012
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0012 0.0051
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0094 0.0237
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0006 0.0074
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0085 0.6491
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.013 0.2633
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0027 0.012
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0117
Brugia malayi Importin beta-1 subunit 0.006 0.0139 0.0139
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0094 0.0094
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0002 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.049 0.2154
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0002 0.0006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0184 0.049 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Loa Loa (eye worm) beta-lactamase 0.0184 0.049 0.049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0079 0.1251
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0055
Mycobacterium ulcerans hypothetical protein 0.0184 0.049 1
Schistosoma mansoni hypothetical protein 0.0095 0.0239 0.1051
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1392 0.3911 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0012 0.0051
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.013 0.0329
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0012 0.0051
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1392 0.3911 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0027 0.0027
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0013 0.0055
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0002 0.0002
Onchocerca volvulus 0.0026 0.0044 0.067
Brugia malayi Inositol-1 0.0039 0.0079 0.0079
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0011 0.0002 0.0029
Echinococcus multilocularis beta LACTamase domain containing family member 0.0184 0.049 0.2154
Schistosoma mansoni cpg binding protein 0.0057 0.0131 0.0577
Brugia malayi CCR4 0.0011 0.0002 0.0002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Echinococcus granulosus beta LACTamase domain containing family member 0.0184 0.049 0.2154
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0026 0.0044 0.067
Echinococcus multilocularis lamin 0.0026 0.0044 0.0191
Echinococcus multilocularis synaptojanin 1 0.0011 0.0002 0.0008
Schistosoma mansoni survival motor neuron protein 0.0097 0.0243 0.1069
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0011 0.0002 0.0008
Schistosoma mansoni intermediate filament proteins 0.0026 0.0044 0.0191
Toxoplasma gondii ABC1 family protein 0.0184 0.049 1
Brugia malayi ecdysteroid receptor 0.002 0.0027 0.0027
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0002 0.0008
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0117 0.0514
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0002 0.0008
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0085 0.6481
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0015 0.0012 0.0051
Trichomonas vaginalis ran, putative 0.0044 0.0094 0.1489
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0079 0.6057
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0002 0.0008
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0011 0.0002 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0131 0.0131
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0107 0.1693
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0027 0.0027
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0011 0.0002 0.0006
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0031 0.0031
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0027 0.0027
Brugia malayi Flap endonuclease-1 0.0027 0.0046 0.0046
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0011 0.0002 0.0006
Schistosoma mansoni nocturnin 0.0011 0.0002 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.013 0.1235
Schistosoma mansoni importin-beta 2 0.0011 0.0001 0.0006
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0029
Schistosoma mansoni cpg binding protein 0.006 0.014 0.0618
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0074
Loa Loa (eye worm) hypothetical protein 0.012 0.031 0.031
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0046 0.0907
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0027 0.012
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0046 0.0046
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0055 0.0242
Mycobacterium ulcerans esterase/lipase LipP 0.0184 0.049 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0027 0.012
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0488 0.2146
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.013 0.0328
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0545 0.0545
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0075 0.0183 0.0806
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0184 0.049 0.049
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0085 0.134
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0243 0.0243
Echinococcus granulosus cpg binding protein 0.006 0.014 0.0618
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0094 0.1898
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0027 0.012
Schistosoma mansoni nuclear hormone receptor 0.002 0.0027 0.012
Echinococcus granulosus survival motor neuron protein 1 0.0474 0.131 0.5766
Onchocerca volvulus 0.0184 0.049 0.7841
Schistosoma mansoni lamin 0.0026 0.0044 0.0191
Plasmodium falciparum flap endonuclease 1 0.0027 0.0046 0.3221
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0029
Mycobacterium tuberculosis Conserved protein 0.0184 0.049 0.1482
Brugia malayi beta-lactamase family protein 0.0184 0.049 0.049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0079 0.1251
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0055 0.0242
Loa Loa (eye worm) hypothetical protein 0.0184 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Mycobacterium tuberculosis Conserved protein 0.0184 0.049 0.1482
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0027 0.012
Brugia malayi steroid hormone receptor 0.002 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Plasmodium vivax importin-beta 2, putative 0.006 0.0139 0.2815
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0002 0.0002
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0315 0.1388
Plasmodium vivax exodeoxyribonuclease III, putative 0.0011 0.0002 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0027 0.012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.0488 0.2146
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Echinococcus multilocularis cpg binding protein 0.006 0.014 0.0618
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.013 0.2065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0279 0.5682
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0085 0.0213
Entamoeba histolytica hypothetical protein 0.0049 0.0107 0.8197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0027 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.0488 0.2146
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0012 0.0012
Echinococcus multilocularis importin subunit beta 1 0.006 0.0139 0.0611
Echinococcus multilocularis survival motor neuron protein 1 0.0474 0.131 0.5766
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0075 0.0183 0.0183
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.049 0.7843
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0022 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0085 0.0374
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0008
Onchocerca volvulus 0.002 0.0027 0.0409
Brugia malayi follicle stimulating hormone receptor 0.0242 0.0654 0.0654
Mycobacterium tuberculosis Probable hydrolase 0.0184 0.049 0.1482
Schistosoma mansoni inositol monophosphatase 0.0039 0.0079 0.0349
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0012 0.0051
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0029
Trichomonas vaginalis helicase, putative 0.0013 0.0006 0.0074
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0046 0.0113
Toxoplasma gondii exonuclease III APE 0.0057 0.013 0.2633
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0239 0.0239
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0013 0.0055
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0184 0.049 0.049
Leishmania major hypothetical protein, conserved 0.0011 0.0002 0.0001
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0015 0.0012 0.0051
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0002 0.0006
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0011 0.0002 0.0001
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0012 0.0051
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0002 0.0006
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0085 0.0374
Schistosoma mansoni neutral sphingomyelinase 0.0011 0.0002 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0027 0.0027
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0005 0.0023
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0139 0.2815
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0027 0.0409
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0008
Leishmania major importin beta-1 subunit, putative 0.0049 0.0107 0.0269
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0027 0.012
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0139 0.0351
Brugia malayi CXXC zinc finger family protein 0.0057 0.0131 0.0131
Brugia malayi beta-lactamase family protein 0.0184 0.049 0.049
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0002 0.0002
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0031 0.0138
Leishmania major GTP-binding protein, putative 0.0044 0.0094 0.0237
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0074
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.013 0.013
Mycobacterium leprae Probable lipase LipE 0.0184 0.049 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0046 0.3444
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0044 0.0044
Entamoeba histolytica Ran family GTPase 0.0044 0.0094 0.7209
Onchocerca volvulus 0.0184 0.049 0.7841
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0094 0.0236
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0239 0.1051
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0079 0.0198
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0094 0.6744
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0011 0.0002 0.0006
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0012 0.0051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.013 0.0329
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0027 0.012
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0015 0.0012 0.0051
Plasmodium falciparum importin beta, putative 0.006 0.0139 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0031 0.0138
Echinococcus granulosus intermediate filament protein 0.0026 0.0044 0.0191
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0031 0.0138
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.012 0.031 0.031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.0654 0.0654
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0055 0.0242
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0184 0.049 0.1482
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0094 0.7201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0027 0.0027
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.013 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0012 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0027 0.0027
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0002 0.0002
Trypanosoma brucei RNA editing exonuclease 2 0.0011 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0184 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0184 0.049 0.049
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0027 0.0027
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0107 0.0269
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0085 0.0374
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0001 0.0001
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0011 0.0002 0.0027
Schistosoma mansoni hypothetical protein 0.0095 0.0239 0.1051
Echinococcus multilocularis tumor protein p63 0.0356 0.0976 0.4297
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0814 0.2273 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0624 1
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0002 0.0001
Onchocerca volvulus 0.003 0.0055 0.0854
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0027 0.012
Schistosoma mansoni importin beta-1 0.006 0.0139 0.0611
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0085 0.0212
Echinococcus multilocularis musashi 0.0026 0.0044 0.0191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0055 0.0242
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0085 0.0085
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0002 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1174 0.3293 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0184 0.049 0.1482
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.013 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0085 0.0213
Mycobacterium tuberculosis Probable esterase LipL 0.0184 0.049 0.1482
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0027 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0184 0.049 0.1249
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0012 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0203 0.0892
Loa Loa (eye worm) hypothetical protein 0.0184 0.049 0.049
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0085 0.0374
Brugia malayi nuclear hormone receptor 0.002 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0095 0.0239 0.1051
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0002 0.0008
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0002 0.0008
Plasmodium falciparum DNase I-like protein, putative 0.0011 0.0002 0.0027
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0002 0.0008
Onchocerca volvulus 0.0231 0.0624 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0027 0.0027
Echinococcus multilocularis lamin dm0 0.0026 0.0044 0.0191
Echinococcus granulosus lamin 0.0026 0.0044 0.0191
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0046 0.0201
Echinococcus granulosus transportin 1 0.0011 0.0001 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.0488 0.2146
Echinococcus multilocularis importin 5 0.0011 0.0001 0.0006
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0015 0.0012 0.0051
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0012 0.0164
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0085 0.0374
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0027 0.0409
Brugia malayi beta-lactamase 0.0184 0.049 0.049
Schistosoma mansoni hypothetical protein 0.0206 0.0551 0.2426
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0027 0.012
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.013 0.0572
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0107 0.1693
Echinococcus multilocularis GPCR, family 2 0.0095 0.0239 0.1051
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0044 0.0044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0027 0.012
Schistosoma mansoni synaptojanin 0.0011 0.0002 0.0008
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0012 0.0051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0184 0.049 0.1482
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0002 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0184 0.049 0.1482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0488 0.2146
Brugia malayi RNA, U transporter 1 0.017 0.0451 0.0451
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0005 0.0023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0027 0.0027
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0002 0.0008
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.3543 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0022 0.0099
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.013 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0027 0.012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0013 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.049 0.7843
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0002 0.0029
Echinococcus granulosus dnaJ subfamily B 0.0814 0.2273 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Echinococcus granulosus lamin dm0 0.0026 0.0044 0.0191
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0011 0.0002 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0044 0.0044
Echinococcus granulosus GPCR family 2 0.0095 0.0239 0.1051
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.013 0.2065
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0239 0.0239
Schistosoma mansoni cpg binding protein 0.006 0.014 0.0618
Schistosoma mansoni hypothetical protein 0.0639 0.1778 0.7825
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0085 0.134
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0027 0.012
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0002 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0488 0.2146
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0002 0.0002
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0002 0.0008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0027 0.012
Plasmodium vivax hypothetical protein, conserved 0.0184 0.049 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0027 0.0027
Leishmania major RNA-editing complex protein MP100, putative 0.0011 0.0002 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0027 0.0027
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0011 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Schistosoma mansoni carbon catabolite repressor protein 0.0011 0.0002 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0027 0.012
Echinococcus granulosus flap endonuclease 1 0.0027 0.0046 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0027 0.0027
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0008
Echinococcus granulosus translational activator gcn1 0.0011 0.0001 0.0006
Echinococcus granulosus snurportin 1 0.0639 0.1778 0.7825
Mycobacterium ulcerans beta-lactamase 0.0184 0.049 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0027 0.012
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.0551 0.0551
Mycobacterium tuberculosis Conserved protein 0.0184 0.049 0.1482
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0055 0.1096
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0301 0.0821 0.0821
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.0488 0.0488
Onchocerca volvulus 0.0057 0.0131 0.2079
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0002 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0027 0.0027
Brugia malayi Pre-SET motif family protein 0.0203 0.0545 0.0545
Schistosoma mansoni ap endonuclease 0.0057 0.013 0.0572
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0085 0.0212
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0011 0.0002 0.0027
Leishmania major malonyl-coa decarboxylase-like protein 0.1392 0.3911 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0046 0.0112
Schistosoma mansoni inositol monophosphatase 0.0039 0.0079 0.0349
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0012 0.0051
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0027 0.012
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0075 0.0183 0.0806
Brugia malayi hypothetical protein 0.012 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0095 0.0239 0.1051
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0027 0.0409
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0095 0.0239 0.0239
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0012 0.0051
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0107 0.1693
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0079 0.0349
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0013 0.0055
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0094 0.0236
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0239 0.1051
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0639 0.1778 0.1778
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0085 0.0374
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0011 0.0002 0.0001
Onchocerca volvulus Huntingtin homolog 0.012 0.031 0.4957
Schistosoma mansoni cript-related 0.0011 0.0002 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0027 0.012
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0079 0.0349
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0074
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0027 0.012
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0094 0.0414
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0012 0.0051
Schistosoma mansoni coup transcription factor 0.002 0.0027 0.012
Echinococcus multilocularis translational activator gcn1 0.0011 0.0001 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0239 0.1051
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0079 0.0199
Leishmania major hypothetical protein, conserved 0.0011 0.0002 0.0001
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0011 0.0002 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.049 0.7843
Brugia malayi Cyclic-nucleotide gated cation channel 0.0015 0.0012 0.0012
Leishmania major pantothenate kinase subunit, putative 0.0011 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0079 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Loa Loa (eye worm) hypothetical protein 0.006 0.0139 0.0139
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0027 0.012
Echinococcus granulosus tumor protein p63 0.0356 0.0976 0.4297
Schistosoma mansoni lamin 0.0026 0.0044 0.0191
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0027 0.0027
Loa Loa (eye worm) inositol-1 0.0039 0.0079 0.0079
Schistosoma mansoni ap endonuclease 0.0057 0.013 0.0572
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0046 0.3425
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Onchocerca volvulus Huntingtin homolog 0.012 0.031 0.4957
Mycobacterium tuberculosis Probable lipase LipE 0.0184 0.049 0.1482
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0006 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0301 0.0821 0.0821
Schistosoma mansoni flap endonuclease-1 0.0024 0.0038 0.0169
Schistosoma mansoni thyroid hormone receptor 0.002 0.0027 0.012
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0027 0.012
Loa Loa (eye worm) hypothetical protein 0.0206 0.0551 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0085 0.134
Loa Loa (eye worm) hypothetical protein 0.0474 0.131 0.131
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0002 0.0008
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0085 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Echinococcus granulosus synaptojanin 1 0.0011 0.0002 0.0008
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0002 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0239 0.1051
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0011 0.0002 0.0029
Echinococcus granulosus FTZ F1 alpha 0.002 0.0027 0.012
Brugia malayi Pre-SET motif family protein 0.003 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Onchocerca volvulus 0.0184 0.049 0.7841
Schistosoma mansoni ran 0.0044 0.0094 0.0414
Loa Loa (eye worm) hypothetical protein 0.0184 0.049 0.049
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0085 0.0374
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.013 0.9354
Onchocerca volvulus 0.0052 0.0117 0.1849
Plasmodium vivax SET domain protein, putative 0.003 0.0055 0.1096
Trichomonas vaginalis Phospholipase C precursor, putative 0.0011 0.0002 0.0006
Schistosoma mansoni ran 0.0044 0.0094 0.0414
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0022 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.049 0.7843
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0013 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0055 0.0242
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0027 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0301 0.0821 0.0821
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.0488 0.0488
Echinococcus granulosus importin 5 0.0011 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0085
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0012 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0055 0.0242
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0027 0.012
Schistosoma mansoni synaptojanin 0.0011 0.0002 0.0008
Schistosoma mansoni 60S ribosomal protein L21 0.0012 0.0003 0.0014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0022 0.0099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0055 0.0242
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0068 0.02
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0027 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0203 0.0892
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0169 0.2692
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0074
Mycobacterium leprae conserved hypothetical protein 0.0184 0.049 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.049 0.7843
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0031 0.0138
Loa Loa (eye worm) hypothetical protein 0.0301 0.0821 0.0821
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0094 0.0414
Loa Loa (eye worm) hypothetical protein 0.0066 0.0155 0.0155
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0048 0.0213
Leishmania major hypothetical protein, conserved 0.0184 0.049 0.1249
Echinococcus granulosus importin subunit beta 1 0.006 0.0139 0.0611
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.0488 0.2146
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0027 0.012
Schistosoma mansoni hypothetical protein 0.0814 0.2273 1
Echinococcus multilocularis transportin 1 0.0011 0.0001 0.0006
Brugia malayi hypothetical protein 0.0474 0.131 0.131
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0184 0.049 1
Leishmania major hypothetical protein, conserved 0.0011 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0012 0.0051
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0079 0.0199
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1392 0.3911 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.