Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0033 | 0.171 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0039 | 0.2257 | 0.3169 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0627 | 0.2129 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.7121 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0627 | 0.0627 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0627 | 0.2129 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.2257 | 0.7788 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.2257 | 0.3156 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0627 | 0.2734 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.7121 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0627 | 0.088 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0065 | 0.4452 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0047 | 0.2894 | 0.4053 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.4452 | 0.4445 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0094 | 0.0278 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0039 | 0.2257 | 0.3156 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.2257 | 0.7788 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0039 | 0.2257 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.7121 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0094 | 0.0278 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0047 | 0.2894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 1 | 1 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0039 | 0.2257 | 0.2246 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0627 | 0.1382 |
Echinococcus multilocularis | dna polymerase eta | 0.0047 | 0.2894 | 0.4053 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.1382 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0047 | 0.2894 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0627 | 0.2129 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.171 | 0.5888 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0065 | 0.4452 | 0.6245 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0039 | 0.2257 | 0.3169 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0627 | 0.0863 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0094 | 0.0278 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0627 | 0.0863 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.2257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2894 | 0.2894 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0065 | 0.4452 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0627 | 0.0614 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.2257 | 0.3156 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.7121 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0039 | 0.2257 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0627 | 0.2734 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0013 | 0.0014 | 0.0019 |
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.171 | 0.3821 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.2257 | 0.3156 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.2257 | 0.3156 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0047 | 0.2894 | 0.2885 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0065 | 0.4452 | 0.6245 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0039 | 0.2257 | 0.3156 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0014 | 0.0014 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0627 | 0.0863 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.7121 | 0.7118 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.7121 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.7121 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.7121 | 0.7121 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0627 | 0.0863 |
Plasmodium falciparum | NLI interacting factor-like phosphatase, putative | 0.0013 | 0.0014 | 0.5 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0013 | 0.0014 | 0.0019 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.2257 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0039 | 0.2257 | 0.5054 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.7121 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0627 | 0.2734 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0627 | 0.2734 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0094 | 0.0278 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0065 | 0.4452 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0065 | 0.4452 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.3753 | 0.3753 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2257 | 0.2257 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0065 | 0.4452 | 0.6252 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.2257 | 1 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.2257 | 0.7788 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0627 | 0.088 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0627 | 0.2129 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0047 | 0.2894 | 0.649 |
Schistosoma mansoni | DNA polymerase eta | 0.0047 | 0.2894 | 0.4064 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Plasmodium vivax | NLI interacting factor-like phosphatase, putative | 0.0013 | 0.0014 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0094 | 0.0278 |
Plasmodium vivax | NLI interacting factor-like phosphatase, putative | 0.0013 | 0.0014 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0627 | 0.2129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.