Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2663 | 0.2663 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0589 | 0.0589 |
Echinococcus granulosus | carbonic anhydrase | 0.0111 | 0.2663 | 0.2204 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0204 | 0.6751 | 0.6751 |
Echinococcus multilocularis | carbonic anhydrase | 0.0111 | 0.2663 | 0.2204 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0204 | 0.6751 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0111 | 0.2663 | 0.2204 |
Plasmodium falciparum | carbonic anhydrase | 0.0111 | 0.2663 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0589 | 0.0589 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0204 | 0.6751 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0204 | 0.6751 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0204 | 0.6751 | 0.6547 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0204 | 0.6751 | 0.6547 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0111 | 0.2663 | 0.2204 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0204 | 0.6751 | 0.6547 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0111 | 0.2663 | 0.3945 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0204 | 0.6751 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0111 | 0.2663 | 0.2204 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0111 | 0.2663 | 0.3945 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0204 | 0.6751 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0111 | 0.2663 | 0.3945 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0589 | 0.0873 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0204 | 0.6751 | 0.6751 |
Echinococcus multilocularis | carbonic anhydrase | 0.0111 | 0.2663 | 0.2204 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.2663 | 0.2204 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0589 | 0.0873 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0111 | 0.2663 | 0.3945 |
Echinococcus granulosus | carbonic anhydrase | 0.0111 | 0.2663 | 0.2204 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0111 | 0.2663 | 0.2663 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2663 | 0.2663 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0111 | 0.2663 | 0.3945 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0589 | 0.0589 |
Echinococcus multilocularis | carbonic anhydrase | 0.0111 | 0.2663 | 0.2204 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0589 | 0.0873 |
Leishmania major | carbonic anhydrase-like protein | 0.0204 | 0.6751 | 0.5 |
Brugia malayi | hypothetical protein | 0.0128 | 0.3428 | 0.5077 |
Toxoplasma gondii | hypothetical protein | 0.0111 | 0.2663 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0111 | 0.2663 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2663 | 0.2663 |
Echinococcus granulosus | carbonic anhydrase II | 0.0204 | 0.6751 | 0.6547 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0111 | 0.2663 | 0.2204 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0805 uM | Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE | ChEMBL. | 19618939 |
IC50 (binding) | = 0.189 uM | Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupole mass spectrometry | ChEMBL. | 19618939 |
IC50 (functional) | = 4.58 uM | Inhibition of ionomycin-stimulated LTB4 production in human whole blood treated 15 mins prior to ionomycin challenge measured after 30 mins of stimulation by enzyme-linked immunosorbent assay | ChEMBL. | 19618939 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19618939 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.