Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Displacement of [3H]-dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 9-12 nM | ChEMBL. | 15080982 |
IC50 (binding) | = 10 nM | Displacement of [3H]-dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 9-12 nM | ChEMBL. | 15080982 |
IC50 (functional) | = 129 nM | Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF) | ChEMBL. | 15080982 |
IC50 (functional) | = 129 nM | Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF) | ChEMBL. | 15080982 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.