Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.5248 | 0.9953 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5269 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5269 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4599 | 0.4792 |
Echinococcus granulosus | geminin | 0.0177 | 0.5269 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.5248 | 0.9953 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.9549 | 0.995 |
Brugia malayi | hypothetical protein | 0.0158 | 0.4599 | 0.4599 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9597 | 0.9597 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.4395 | 0.8065 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.4395 | 0.8065 |
Onchocerca volvulus | 0.0158 | 0.4599 | 0.5 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0177 | 0.5269 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.5248 | 0.9953 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9597 | 0.9597 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.075 | 0.0782 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.4395 | 0.8065 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9597 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 45 uM | Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay | ChEMBL. | 19469546 |
IC50 (binding) | = 2.4 uM | Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | ChEMBL. | 19469546 |
IC50 (binding) | = 4.7 uM | Inhibition of SRC2 binding to TRalpha receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | ChEMBL. | 19469546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.