Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0303 | 0.0451 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0049 | 0.1337 | 0.2488 |
Echinococcus granulosus | geminin | 0.0165 | 0.523 | 0.5439 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0015 | 0.0171 | 0.0178 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0049 | 0.1337 | 0.2488 |
Mycobacterium ulcerans | hypothetical protein | 0.0161 | 0.511 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0637 | 0.1152 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.1835 | 0.1906 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1835 | 0.346 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0495 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1169 | 0.1213 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0669 | 0.1214 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0048 | 0.1286 | 0.2403 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0039 | 0.0037 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0306 | 1 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0035 | 0.0856 | 0.5291 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0303 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0495 | 0.0511 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0032 | 0.075 | 0.4566 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0041 | 0.1058 | 0.4398 |
Mycobacterium ulcerans | thioesterase TesA | 0.0041 | 0.1058 | 0.1934 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0043 | 0.1121 | 0.1043 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0033 | 0.0771 | 0.2941 |
Brugia malayi | AMP-binding enzyme family protein | 0.0015 | 0.0181 | 0.0188 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.004 | 0.1011 | 0.1839 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0849 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.1835 | 0.1906 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0202 | 0.021 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0303 | 0.0218 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0012 | 0.0087 | 0.0086 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0039 | 0.0037 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0303 | 0.0218 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0053 | 0.144 | 0.2694 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0692 | 0.0717 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0303 | 0.0218 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0669 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.9612 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0495 | 0.0412 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0017 | 0.0242 | 0.033 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0849 | 0.156 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0074 | 0.2162 | 0.4144 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.1121 | 0.1043 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0495 | 0.0412 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0033 | 0.0771 | 0.1363 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.176 | 0.3315 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0053 | 0.144 | 0.9313 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0495 | 0.2811 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.004 | 0.1033 | 0.1901 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1169 | 0.1216 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.004 | 0.1011 | 0.4155 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3586 | 0.3729 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0692 | 0.1259 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0053 | 0.144 | 0.2711 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1835 | 0.346 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0053 | 0.144 | 0.6337 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0303 | 0.0311 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0669 | 0.0692 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0612 | 0.0633 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.1121 | 0.1043 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0637 | 0.0659 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.1439 | 0.1364 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0495 | 0.0412 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.523 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0074 | 0.2162 | 0.4144 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0495 | 0.0412 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.1835 | 0.1909 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0495 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0303 | 0.0508 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0053 | 0.144 | 0.6337 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0025 | 0.0511 | 0.2921 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3586 | 0.3731 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0303 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0669 | 0.0692 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0849 | 0.0883 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1169 | 0.1213 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0049 | 0.1337 | 0.2505 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0012 | 0.0087 | 0.009 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.004 | 0.1011 | 0.1839 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0012 | 0.0087 | 0.0092 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0306 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.1334 | 0.8584 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1835 | 0.346 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0669 | 0.4005 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0849 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0016 | 0.0192 | 0.0231 |
Schistosoma mansoni | methyltransferase-related | 0.0015 | 0.0171 | 0.0254 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0012 | 0.0087 | 0.5 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0094 | 0.2831 | 0.2945 |
Onchocerca volvulus | 0.0046 | 0.1227 | 0.0864 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0603 | 0.0623 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1169 | 0.2178 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0171 | 0.0085 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1835 | 0.346 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0849 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1835 | 0.346 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0036 | 0.0867 | 0.1571 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0495 | 0.0515 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0303 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0049 | 0.1314 | 0.1364 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0033 | 0.0771 | 0.1363 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0145 | 0.4558 | 0.451 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0669 | 0.1214 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0669 | 1 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.1835 | 0.1909 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0145 | 0.4558 | 0.451 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0074 | 0.2162 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0028 | 0.0617 | 0.1074 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0303 | 0.043 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3586 | 0.3729 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0303 | 0.3708 |
Mycobacterium ulcerans | polyketide synthase | 0.0049 | 0.1337 | 0.2488 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0849 | 0.156 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0303 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0012 | 0.0087 | 0.0086 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1169 | 0.1213 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0637 | 0.0663 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0692 | 0.1259 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0015 | 0.0181 | 0.0188 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0849 | 0.0879 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0145 | 0.4558 | 0.451 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0041 | 0.1058 | 0.1952 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0849 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0048 | 0.1286 | 0.2403 |
Echinococcus multilocularis | muscleblind protein | 0.0295 | 0.9612 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0295 | 0.9612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.9612 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0295 | 0.9612 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0303 | 0.0315 |
Mycobacterium tuberculosis | Conserved protein | 0.0015 | 0.0171 | 0.0189 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1169 | 0.1213 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.1121 | 0.1043 |
Onchocerca volvulus | 0.0231 | 0.7464 | 1 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0049 | 0.1337 | 0.581 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0012 | 0.0087 | 0.0086 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.002 | 0.0343 | 0.053 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0849 | 0.0879 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.1227 | 0.1277 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0049 | 0.1337 | 0.2488 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0049 | 0.1337 | 0.2505 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.154 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0015 | 0.0171 | 0.0189 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1169 | 0.1213 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0049 | 0.1337 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.2471 | 0.2568 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0669 | 0.1214 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0161 | 0.511 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0046 | 0.1227 | 0.1273 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0053 | 0.144 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0015 | 0.0181 | 0.0209 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.1835 | 0.1906 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0089 | 0.2676 | 0.2987 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0049 | 0.1337 | 0.2505 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0303 | 0.1485 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0016 | 0.0192 | 0.021 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0303 | 0.0218 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.652 | 0.6782 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0046 | 0.1227 | 0.2287 |
Onchocerca volvulus | 0.003 | 0.0669 | 0.0047 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0303 | 0.0181 |
Brugia malayi | RNA binding protein | 0.0064 | 0.1835 | 0.1909 |
Loa Loa (eye worm) | acyl carrier protein | 0.0023 | 0.0435 | 0.0449 |
Mycobacterium ulcerans | thioesterase | 0.0041 | 0.1058 | 0.1934 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0303 | 0.0508 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0303 | 0.0311 |
Mycobacterium ulcerans | polyketide synthase | 0.0053 | 0.144 | 0.2694 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0669 | 0.1214 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0053 | 0.144 | 0.2694 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.1835 | 0.1906 |
Brugia malayi | Muscleblind-like protein | 0.0295 | 0.9612 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0053 | 0.144 | 0.2711 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0303 | 0.5284 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.1835 | 0.1906 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0053 | 0.144 | 0.2711 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.652 | 0.6783 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.523 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0669 | 0.0692 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0692 | 0.0717 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0049 | 0.1337 | 0.2488 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0669 | 0.0692 |
Echinococcus multilocularis | geminin | 0.0165 | 0.523 | 0.5439 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0495 | 0.7017 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1169 | 0.2178 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0074 | 0.2162 | 0.4131 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0049 | 0.1337 | 0.581 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.7464 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0303 | 0.0181 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0306 | 1 | 1 |
Onchocerca volvulus | 0.0086 | 0.2572 | 0.2835 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1169 | 0.2178 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 38 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.