Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0277 | 0.0739 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1529 | 0.4076 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2447 | 0.6521 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1529 | 0.4076 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2447 | 0.6521 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0099 | 0.0099 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1751 | 0.2673 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.3752 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0277 | 0.0739 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2447 | 0.4159 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.3752 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2447 | 0.6521 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.4087 | 0.4087 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2447 | 0.2447 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.5183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2157 | 0.4395 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2447 | 0.2447 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2447 | 0.2447 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2447 | 0.5013 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2447 | 0.6521 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.4783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1757 | 0.3541 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1979 | 0.4014 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 15 uM | Cytotoxicity against human MT4 cells after 5 days by MTT assay | ChEMBL. | 19719237 |
IC50 (binding) | = 7.19 | Inhibition of HIV-1 integrase | ChEMBL. | 20488589 |
IC50 (binding) | = 0.065 uM | Inhibition of HIV1 integrase strand transfer activity | ChEMBL. | 19719237 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.