Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.7516 | 0.7363 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3921 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0579 | 0.0564 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0032 | 0.3392 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0579 | 0.0564 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.3392 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0032 | 0.3392 | 0.3381 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0019 | 0.1517 | 0.0996 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0579 | 0.0579 |
Brugia malayi | CHD4 protein | 0.0014 | 0.0815 | 0.0815 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.505 | 0.4746 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.5529 | 0.5254 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.5529 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3921 | 0.3548 |
Brugia malayi | Protein cec-1. | 0.0013 | 0.0579 | 0.0579 |
Brugia malayi | Kringle domain containing protein | 0.0032 | 0.3392 | 0.3392 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0019 | 0.1517 | 0.0996 |
Schistosoma mansoni | chromobox protein | 0.0077 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0019 | 0.1517 | 0.0996 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.3111 | 0.2688 |
Onchocerca volvulus | 0.0028 | 0.2875 | 0.4638 | |
Echinococcus multilocularis | Chromo domain | 0.0013 | 0.0579 | 0.0564 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0014 | 0.0815 | 0.08 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.2875 | 0.2864 |
Leishmania major | hypothetical protein, conserved | 0.0032 | 0.3392 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3921 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.3111 | 0.2688 |
Brugia malayi | Associated with TFs and helicases family protein | 0.0013 | 0.0579 | 0.0579 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0032 | 0.3392 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.3111 | 0.31 |
Echinococcus granulosus | chromobox protein 2 | 0.0013 | 0.0579 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3686 | 0.3675 |
Brugia malayi | Protein kinase domain containing protein | 0.0032 | 0.3392 | 0.3392 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.5529 | 0.5254 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0016 | 0.1014 | 0.0461 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.505 | 0.9031 |
Echinococcus granulosus | Chromobox protein 3 | 0.0013 | 0.0579 | 0.0564 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3921 | 0.3921 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0032 | 0.3392 | 0.3381 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0019 | 0.1517 | 0.0996 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0034 | 0.3709 | 0.3322 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0019 | 0.1517 | 0.0996 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0019 | 0.1517 | 0.0996 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.2875 | 0.2875 |
Onchocerca volvulus | 0.0013 | 0.067 | 0.0183 | |
Onchocerca volvulus | 0.0032 | 0.3392 | 0.5681 | |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.505 | 0.505 |
Brugia malayi | SET domain containing protein | 0.0013 | 0.067 | 0.067 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.3206 | 0.2789 |
Loa Loa (eye worm) | helicase | 0.0013 | 0.0579 | 0.0564 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3921 | 0.3548 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0014 | 0.0815 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0579 | 0.0564 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 1 | 0.0013 | 0.0579 | 0.0564 |
Brugia malayi | M-phase phosphoprotein, mpp8 | 0.0013 | 0.0579 | 0.0579 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.3111 | 0.31 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.6578 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0019 | 0.1517 | 0.0996 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.2875 | 0.2437 |
Toxoplasma gondii | kringle domain-containing protein | 0.0032 | 0.3392 | 0.4688 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0579 | 0.0564 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 1 | 0.0013 | 0.0579 | 0.0564 |
Brugia malayi | Type III restriction enzyme, res subunit family protein | 0.0013 | 0.0579 | 0.0579 |
Schistosoma mansoni | chromobox protein | 0.0077 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0077 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0019 | 0.1517 | 0.0996 |
Echinococcus granulosus | Chromo domain | 0.0013 | 0.0579 | 0.0564 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0013 | 0.067 | 0.0096 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0032 | 0.3392 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3921 | 0.3911 |
Brugia malayi | Valyl-tRNA synthetase | 0.0013 | 0.0579 | 0.0579 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0579 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0579 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0579 | 0.0564 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0014 | 0.0815 | 0.08 |
Onchocerca volvulus | 0.0034 | 0.3686 | 0.6276 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3921 | 1 |
Echinococcus multilocularis | chromobox protein 2 | 0.0013 | 0.0579 | 0.0564 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0013 | 0.0579 | 0.0564 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3921 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.3392 | 0.2985 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.3206 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3392 | 0.3381 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0016 | 0.1083 | 0.0534 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3921 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.505 | 0.4746 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0014 | 0.0815 | 0.0251 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0.1083 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.505 | 0.5042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 9 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/mL by broth microdilution method | ChEMBL. | 19620006 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.