Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Fructose-1,6-bisphosphatase | Starlite/ChEMBL | References |
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Sus scrofa | Fructose-1,6-bisphosphatase | Starlite/ChEMBL | References |
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | CES-1 homolog | Fructose-1,6-bisphosphatase | 338 aa | 324 aa | 58.6 % |
Toxoplasma gondii | fructose-bisphospatase I | Fructose-1,6-bisphosphatase | 338 aa | 322 aa | 31.1 % |
Trypanosoma congolense | sedoheptulose-1,7-bisphosphatase, putative | Fructose-1,6-bisphosphatase | 338 aa | 329 aa | 27.7 % |
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Neospora caninum | fructose-1,6-bisphosphatase, putative | Fructose-1,6-bisphosphatase | 338 aa | 302 aa | 32.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0099 | 0.06 | 0.0807 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0247 | 0.2772 | 0.3729 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0214 | 0.2287 | 0.1795 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0214 | 0.2287 | 0.2119 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0099 | 0.06 | 0.0807 |
Onchocerca volvulus | 0.0246 | 0.2757 | 1 | |
Plasmodium falciparum | plasmepsin II | 0.0214 | 0.2287 | 0.1795 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0099 | 0.06 | 0.0807 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0099 | 0.06 | 0.0807 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0099 | 0.06 | 0.0807 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0214 | 0.2287 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0572 | 0.077 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0246 | 0.2757 | 0.1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0572 | 0.077 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.06 | 0.0807 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0246 | 0.2757 | 0.2294 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0099 | 0.06 | 0.0807 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0211 | 0.2237 | 0.2056 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0099 | 0.06 | 0.0807 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.2287 | 0.3076 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0509 | 0.6591 | 0.8868 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0214 | 0.2287 | 0.2119 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0099 | 0.06 | 0.0807 |
Plasmodium falciparum | plasmepsin I | 0.0214 | 0.2287 | 0.1795 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.1788 | 0.2406 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0099 | 0.06 | 0.0807 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0099 | 0.06 | 0.0807 |
Toxoplasma gondii | aspartyl protease ASP5 | 0.0644 | 0.856 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0567 | 0.7433 | 1 |
Brugia malayi | Pepsin A precursor | 0.0099 | 0.06 | 0.0807 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0211 | 0.2237 | 0.2056 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.06 | 0.0807 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0567 | 0.7433 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0214 | 0.2287 | 0.3076 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0567 | 0.7433 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0214 | 0.2287 | 0.1795 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.1788 | 0.2406 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0099 | 0.06 | 0.0807 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.1788 | 0.2406 |
Brugia malayi | Protein kinase domain containing protein | 0.0247 | 0.2772 | 0.3729 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0572 | 0.077 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0509 | 0.6591 | 0.8868 |
Brugia malayi | Kringle domain containing protein | 0.0246 | 0.2757 | 0.3709 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0567 | 0.7433 | 1 |
Plasmodium vivax | plasmepsin V, putative | 0.0743 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0557 | 0.075 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0214 | 0.2287 | 0.3076 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.1788 | 0.2406 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2757 | 0.3709 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0214 | 0.2287 | 0.3076 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0246 | 0.2757 | 0.3709 |
Schistosoma mansoni | hypothetical protein | 0.0246 | 0.2757 | 0.3709 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0099 | 0.06 | 0.0807 |
Brugia malayi | hypothetical protein | 0.0099 | 0.06 | 0.0807 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0246 | 0.2757 | 0.3709 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0572 | 0.077 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0572 | 0.077 |
Toxoplasma gondii | kringle domain-containing protein | 0.0246 | 0.2757 | 0.2709 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0214 | 0.2287 | 0.3076 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0567 | 0.7433 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0567 | 0.7433 | 1 |
Leishmania major | 0.0567 | 0.7433 | 1 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0567 | 0.7433 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0567 | 0.7433 | 0.8584 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0099 | 0.06 | 0.0807 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0557 | 0.075 |
Plasmodium vivax | plasmepsin IV, putative | 0.0214 | 0.2287 | 0.1795 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0246 | 0.2757 | 0.2294 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0557 | 0.075 |
Brugia malayi | hypothetical protein | 0.0099 | 0.06 | 0.0807 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0099 | 0.06 | 0.0807 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0567 | 0.7433 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.1788 | 0.2406 |
Plasmodium falciparum | plasmepsin VI | 0.0214 | 0.2287 | 0.1795 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinase | ChEMBL. | 12190310 |
IC50 (binding) | = 4 nM | Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinase | ChEMBL. | 12190310 |
IC50 (binding) | = 0.25 uM | Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. | ChEMBL. | 11140724 |
IC50 (binding) | = 0.25 uM | Inhibition of human recombinant wild type fructose-1,6-bisphosphatase (F16BP) | ChEMBL. | 12190310 |
IC50 (binding) | = 0.25 uM | Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. | ChEMBL. | 11140724 |
IC50 (binding) | = 0.77 uM | Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase | ChEMBL. | 11140724 |
IC50 (binding) | = 0.77 uM | Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase | ChEMBL. | 11140724 |
IC50 (functional) | > 10 uM | Compound was evaluated for its concentration required to inhibit the rabbit liver F16BPase | ChEMBL. | 11140724 |
IC50 (binding) | > 10 uM | Compound was evaluated for its concentration required to inhibit the rat liver F16BPase | ChEMBL. | 11140724 |
IC50 (binding) | > 10 uM | Compound was evaluated for its concentration required to inhibit the rat liver F16BPase | ChEMBL. | 11140724 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.