Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0245 | 1 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0245 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0245 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0245 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0196 | 0.5765 | 0.5765 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0196 | 0.5765 | 0.5765 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0165 | 0.3182 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0245 | 1 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0245 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0245 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0245 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0245 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0245 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0245 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0245 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0245 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0245 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0165 | 0.3182 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0196 | 0.5765 | 0.5765 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0245 | 1 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0245 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0245 | 1 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0165 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0245 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0245 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0245 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0245 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0245 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0245 | 1 | 0.5 |
Onchocerca volvulus | 0.0245 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0245 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0165 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0245 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0245 | 1 | 1 |
Onchocerca volvulus | 0.0245 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0245 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0245 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0245 | 1 | 1 |
Onchocerca volvulus | 0.0245 | 1 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0196 | 0.5765 | 0.5765 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0165 | 0.3182 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0245 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0245 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0196 | 0.5765 | 0.5765 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0196 | 0.5765 | 0.5765 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0245 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0245 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0196 | 0.5765 | 0.5765 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0245 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Onchocerca volvulus | 0.0245 | 1 | 1 | |
Leishmania major | cysteine peptidase A (CPA) | 0.0245 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0245 | 1 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0196 | 0.5765 | 0.5765 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0245 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.3182 | 0.3182 |
Onchocerca volvulus | 0.0245 | 1 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0196 | 0.5765 | 0.5765 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0245 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0165 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | fibroinase | 0.0245 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0245 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.5765 | 0.3788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0245 | 1 | 1 |
Onchocerca volvulus | 0.0245 | 1 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0196 | 0.5765 | 0.5765 |
Echinococcus multilocularis | cysteine protease | 0.0245 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.3182 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.