TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 464.942 | Formula: C22H29ClN4O5
H donors: 4 H acceptors: 5 LogP: 3.93 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1nc(NCC(c2cc(O)cc(c2)O)O)nc2c1cc(OC)c(c2)OC)CC.Cl
InChi: 1S/C22H28N4O5.ClH/c1-5-26(6-2)21-16-10-19(30-3)20(31-4)11-17(16)24-22(25-21)23-12-18(29)13-7-14(27)9-15(28)8-13;/h7-11,18,27-29H,5-6,12H2,1-4H3,(H,23,24,25);1H
InChiKey: IYGAIVDNUWVUOR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase shark	0.011	0.1328	0.2333
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0143	0.1982	0.1982
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0143	0.1982	0.3481
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Onchocerca volvulus		0.0068	0.0519	0.0912
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0334	0.5694	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0068	0.0519	0.0519
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Echinococcus granulosus	protein tyrosine kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase csk	0.0068	0.0519	0.0519
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Giardia lamblia	Kinase, NEK	0.0068	0.0519	0.5
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0143	0.1982	0.3481
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus multilocularis	epidermal growth factor receptor	0.0068	0.0519	0.0519
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0334	0.5694	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.011	0.1328	0.1328
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0068	0.0519	0.0912
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TK protein kinase	0.0098	0.11	0.1932
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0113	0.1402	0.1402
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine protein kinase ABL1	0.011	0.1328	0.2333
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0068	0.0519	0.0519
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.014	0.1909	0.1909
Loa Loa (eye worm)	TK/DDR protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Brugia malayi	Guanylyl cyclase protein 23	0.0068	0.0519	0.0912
Echinococcus multilocularis	p2X purinoceptor 4	0.0201	0.3099	0.3099
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0143	0.1982	0.1982
Schistosoma mansoni	nck2/grb4	0.0045	0.0073	0.0128
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine kinase	0.011	0.1328	0.2333
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/EPH protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase Blk	0.014	0.1909	0.1909
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Variant SH3 domain containing protein	0.0045	0.0073	0.0128
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0068	0.0519	0.0912
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0143	0.1982	0.3481
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.011	0.1328	0.1328
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0334	0.5694	1
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0068	0.0519	0.0519
Entamoeba histolytica	receptor protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	growth factor receptor bound protein 2	0.0045	0.0073	0.0128
Echinococcus multilocularis	NCK adaptor protein	0.0045	0.0073	0.0073
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0068	0.0519	0.0519
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0143	0.1982	0.1982
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.011	0.1328	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	p2X purinoceptor 4	0.0201	0.3099	0.5443
Echinococcus multilocularis	tyrosine protein kinase Srms	0.014	0.1909	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine protein kinase csk	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Onchocerca volvulus		0.0068	0.0519	0.0912
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0334	0.5694	1
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0068	0.0519	0.0912
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0073	0.0128
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.011	0.1328	0.2333
Brugia malayi	Tyrosine-protein kinase abl-1	0.0113	0.1402	0.2461
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0068	0.0519	0.0912
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0159	0.2285	0.3411
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0519	0.0912
Onchocerca volvulus		0.011	0.1328	0.2333
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0068	0.0519	0.0912
Echinococcus multilocularis	integrin linked protein kinase	0.0068	0.0519	0.0519
Onchocerca volvulus		0.011	0.1328	0.2333
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0068	0.0519	0.0519
Entamoeba histolytica	cysteine surface protein, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	c src tyrosine kinase	0.0113	0.1402	0.2461
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0143	0.1982	0.1982
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0068	0.0519	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase csk	0.0068	0.0519	0.0519
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine kinase	0.0068	0.0519	0.0912
Onchocerca volvulus		0.0068	0.0519	0.0912
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0068	0.0519	0.0519
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Brugia malayi	C-terminal src kinase protein 1	0.0068	0.0519	0.0912
Echinococcus granulosus	natriuretic peptide receptor 1	0.0068	0.0519	0.0912
Brugia malayi	Furin-like cysteine rich region family protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	p2X purinoceptor 4	0.0201	0.3099	0.3099
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0068	0.0519	0.0912
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0068	0.0519	0.0912
Echinococcus granulosus	NCK adaptor protein	0.0045	0.0073	0.0128
Loa Loa (eye worm)	TK/RYK protein kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0334	0.5694	1
Schistosoma mansoni	ephrin receptor	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Echinococcus granulosus	receptor type guanylyl cyclase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Brugia malayi	ephrin receptor 1 precursor	0.0068	0.0519	0.0912
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine kinase	0.014	0.1909	0.3353
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0068	0.0519	0.0519
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0068	0.0519	0.0519
Echinococcus granulosus	tyrosine protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0113	0.1402	0.2461
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	kinase suppressor of Ras 1	0.0068	0.0519	0.0912
Onchocerca volvulus		0.011	0.1328	0.2333
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.011	0.1328	0.2333
Echinococcus granulosus	epidermal growth factor receptor	0.0068	0.0519	0.0912
Brugia malayi	Receptor family ligand binding region containing protein	0.0068	0.0519	0.0912
Echinococcus granulosus	p2X purinoceptor 4	0.0201	0.3099	0.5443
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0068	0.0519	0.0519
Schistosoma mansoni	growth factor receptor-bound protein	0.0045	0.0073	0.0128
Echinococcus multilocularis	insulin receptor	0.0068	0.0519	0.0519
Echinococcus granulosus	tyrosine protein kinase Blk	0.014	0.1909	0.3353
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Echinococcus granulosus	epidermal growth factor receptor	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0098	0.11	0.11
Onchocerca volvulus	Tyrosine kinase homolog	0.0068	0.0519	0.0912
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0068	0.0519	0.0912
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0068	0.0519	0.0519
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0143	0.1982	0.1982
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0143	0.1982	0.3481
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.0519	0.0912
Echinococcus granulosus	insulin receptor	0.0068	0.0519	0.0912
Brugia malayi	SRC-1	0.0143	0.1982	0.3481
Schistosoma mansoni	tyrosine kinase	0.011	0.1328	0.2333
Echinococcus multilocularis	tyrosine kinase	0.011	0.1328	0.1328
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0143	0.1982	0.1982
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.011	0.1328	0.2333
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0519	0.0912
Brugia malayi	Raf kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	epidermal growth factor receptor	0.0068	0.0519	0.0519
Schistosoma mansoni	P2X receptor subunit	0.0201	0.3099	0.5443
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Schistosoma mansoni	adapter molecule crk	0.0045	0.0073	0.0128
Entamoeba histolytica	hypothetical protein, conserved	0.0068	0.0519	0.3908
Entamoeba histolytica	ankyrin repeat protein	0.0068	0.0519	0.3908
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	activated cdc42 kinase 1	0.0068	0.0519	0.0519
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0519	0.0912
Brugia malayi	integrin-linked kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	ephrin type A receptor 4 A	0.0068	0.0519	0.0912
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0045	0.0073	0.0128
Onchocerca volvulus		0.011	0.1328	0.2333
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0113	0.1402	0.2461
Schistosoma mansoni	ephrin receptor	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0143	0.1982	0.3481
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TK/ABL protein kinase	0.011	0.1328	0.2333
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine protein kinase csk	0.0068	0.0519	0.0912
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0068	0.0519	0.0519
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	tyrosin kinase, putative	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.014	0.1909	0.3353
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0334	0.5694	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Schistosoma mansoni	growth factor receptor-bound protein	0.0045	0.0073	0.0128
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0071	0.0581	0.102
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0071	0.0581	0.0581
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Echinococcus granulosus	raf serine:threonine protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0068	0.0519	0.0519
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0143	0.1982	0.1982
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus multilocularis	protein tyrosine kinase	0.0068	0.0519	0.0519
Brugia malayi	SH2 domain containing protein	0.011	0.1328	0.2333
Echinococcus multilocularis	tyrosine kinase	0.0068	0.0519	0.0519
Echinococcus multilocularis	activin receptor type	0.0068	0.0519	0.0519
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.2285	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.011	0.1328	0.2333
Entamoeba histolytica	tyrosin kinase, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0143	0.1982	0.3481
Brugia malayi	protein-tyrosine kinase	0.014	0.1909	0.3353
Brugia malayi	hypothetical protein	0.0159	0.2285	0.4012
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Onchocerca volvulus		0.011	0.1328	0.2333
Schistosoma mansoni	P2X receptor subunit	0.0201	0.3099	0.5443
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	hypothetical protein	0.011	0.1328	0.2333
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus multilocularis	transfer RNA-Thr	0.0068	0.0519	0.0519
Loa Loa (eye worm)	TK/CSK protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Loa Loa (eye worm)	serine/threonine protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0519	0.3908
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0334	0.5694	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0068	0.0519	0.0519
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0143	0.1982	0.1982
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	c src tyrosine kinase	0.0113	0.1402	0.1402
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0143	0.1982	0.3481
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	receptor protein kinase, putative	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0068	0.0519	0.0519
Echinococcus granulosus	thymidylate synthase	0.0334	0.5694	1
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Giardia lamblia	Protein 21.1	0.0068	0.0519	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.011	0.1328	0.2333
Echinococcus multilocularis	protein kinase	0.0068	0.0519	0.0519
Onchocerca volvulus		0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0068	0.0519	0.0519
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0143	0.1982	0.1982
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0068	0.0519	0.0912
Brugia malayi	Sex muscle abnormal protein 5	0.0045	0.0073	0.0128
Loa Loa (eye worm)	TK/INSR protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Schistosoma mansoni	hypothetical protein	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	activated cdc42 kinase 1	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0068	0.0519	0.0519
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0068	0.0519	0.3908
Schistosoma mansoni	protein tyrosine kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	heat shock protein 70	0.0068	0.0519	0.0519
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	protein kinase	0.0068	0.0519	0.0519
Schistosoma mansoni	protein kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0143	0.1982	0.3481
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Onchocerca volvulus		0.011	0.1328	0.2333
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0143	0.1982	0.3481
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.011	0.1328	0.2333
Echinococcus granulosus	p2X purinoceptor 4	0.0201	0.3099	0.5443
Brugia malayi	Tyrosine-protein kinase PR2	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK protein kinase	0.014	0.1909	0.3353
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Onchocerca volvulus		0.0334	0.5694	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0334	0.5694	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.011	0.1328	0.1328
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0113	0.1402	0.1402
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0113	0.1402	0.2461
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase, putative	0.0098	0.11	0.828
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0068	0.0519	0.3908
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0045	0.0073	0.0128
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0519	0.3908
Onchocerca volvulus		0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.011	0.1328	0.2333
Echinococcus multilocularis	thymidylate synthase	0.0334	0.5694	0.5694
Loa Loa (eye worm)	TK/ACK protein kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	integrin linked protein kinase	0.0068	0.0519	0.0912
Brugia malayi	hypothetical protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0045	0.0073	0.0073
Echinococcus granulosus	tyrosine protein kinase HCK	0.0098	0.11	0.1932
Loa Loa (eye worm)	hypothetical protein	0.011	0.1328	0.2333
Loa Loa (eye worm)	thymidylate synthase	0.0334	0.5694	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0068	0.0519	0.0912
Brugia malayi	Variant SH3 domain containing protein	0.0045	0.0073	0.0128
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	p2X purinoceptor 4	0.0201	0.3099	0.3099
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase csk	0.0068	0.0519	0.0519
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	tyrosine protein kinase	0.0068	0.0519	0.0519
Brugia malayi	SH2 domain containing protein	0.011	0.1328	0.2333
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Onchocerca volvulus		0.0068	0.0519	0.0912
Onchocerca volvulus		0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0068	0.0519	0.0519
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0068	0.0519	0.0912
Entamoeba histolytica	ankyrin repeat protein	0.0068	0.0519	0.3908
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0334	0.5694	1
Schistosoma mansoni	P2X receptor subunit	0.0201	0.3099	0.5443
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0045	0.0073	0.0128
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0519	0.0912
Giardia lamblia	Kinase	0.0068	0.0519	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0068	0.0519	0.0519
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0068	0.0519	0.0912
Mycobacterium ulcerans	thymidylate synthase	0.0334	0.5694	0.5
Echinococcus granulosus	activin receptor type	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine protein kinase csk	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/ALK protein kinase	0.0068	0.0519	0.0912
Echinococcus multilocularis	FL cytokine receptor	0.0068	0.0519	0.0519
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0068	0.0519	0.0519
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Schistosoma mansoni	P2X receptor subunit	0.0201	0.3099	0.5443
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0113	0.1402	0.2461
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Schistosoma mansoni	serine/threonine RGC	0.0068	0.0519	0.0912
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase, putative	0.0068	0.0519	0.3908
Echinococcus granulosus	protein kinase	0.0068	0.0519	0.0912
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0592	0.104
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0068	0.0519	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	hypothetical protein	0.0068	0.0519	0.3908
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0068	0.0519	0.0519
Echinococcus granulosus	tyrosine protein kinase pr2	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TK/ROR protein kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0143	0.1982	0.3481
Giardia lamblia	Kinase, NEK	0.0068	0.0519	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	Protein kinase domain containing protein	0.011	0.1328	0.2333
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0068	0.0519	0.3908
Onchocerca volvulus		0.0068	0.0519	0.0912
Echinococcus multilocularis	tyrosine protein kinase csk	0.0068	0.0519	0.0519
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0068	0.0519	0.0912
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0519	0.3908
Brugia malayi	thymidylate synthase	0.0334	0.5694	1
Entamoeba histolytica	tyrosin kinase, putative	0.0068	0.0519	0.3908
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0519	0.0912
Onchocerca volvulus		0.0068	0.0519	0.0912
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0068	0.0519	0.0912
Brugia malayi	hypothetical protein	0.0068	0.0519	0.0912
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0519	0.0912
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/Met protein kinase	0.0068	0.0519	0.0912
Loa Loa (eye worm)	TK/FER protein kinase	0.011	0.1328	0.2333
Loa Loa (eye worm)	SRC-1	0.0143	0.1982	0.3481
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0068	0.0519	0.0912
Schistosoma mansoni	tyrosine kinase	0.0068	0.0519	0.0912
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0068	0.0519	0.0912

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 432 uM	Inhibition of bovine heart cAMP-phosphodiesterase	ChEMBL.	3965705
Ratio (binding)	= 0.43	Ratio of Ki/Km for inhibition of bovine heart cAMP-phosphodiesterase	ChEMBL.	3965705

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL558224

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1057343