Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.2962 | 0.2229 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0543 | 0.1698 | 0.1698 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Leishmania major | cathepsin L-like protease | 0.102 | 0.6283 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0464 | 0.0942 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0464 | 0.0942 | 0.0942 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Plasmodium vivax | vivapain-2 | 0.0674 | 0.2962 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0674 | 0.2962 | 1 |
Echinococcus granulosus | cathepsin b | 0.1407 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0674 | 0.2962 | 0.2962 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0674 | 0.2962 | 0.2229 |
Giardia lamblia | Cathepsin B precursor | 0.0543 | 0.1698 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0543 | 0.1698 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0674 | 0.2962 | 0.2962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0543 | 0.1698 | 0.5733 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0674 | 0.2962 | 0.2962 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.2962 | 0.2756 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0674 | 0.2962 | 0.2962 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.2962 | 0.2962 |
Plasmodium vivax | vivapain-2 | 0.0674 | 0.2962 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Leishmania major | cathepsin L-like protease | 0.102 | 0.6283 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0543 | 0.1698 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0674 | 0.2962 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0543 | 0.1698 | 0.2702 |
Onchocerca volvulus | Cathepsin F homolog | 0.0674 | 0.2962 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0674 | 0.2962 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1407 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0464 | 0.0942 | 0.3182 |
Echinococcus multilocularis | cathepsin b | 0.1407 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1407 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1407 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1407 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0674 | 0.2962 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0543 | 0.1698 | 0.0834 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0674 | 0.2962 | 0.2962 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.2962 | 0.2756 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0543 | 0.1698 | 0.1698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Onchocerca volvulus | 0.0674 | 0.2962 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0674 | 0.2962 | 0.2962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.2962 | 0.2756 |
Onchocerca volvulus | 0.0674 | 0.2962 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0674 | 0.2962 | 0.2962 |
Loa Loa (eye worm) | ctsf protein | 0.0674 | 0.2962 | 0.2229 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.2962 | 0.2962 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0464 | 0.0942 | 0.0942 |
Loa Loa (eye worm) | fibroinase | 0.0674 | 0.2962 | 0.2229 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.102 | 0.6283 | 0.6283 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0674 | 0.2962 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0674 | 0.2962 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.081 | 0.4264 | 0.4264 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0502 | 0.1302 | 0.1302 |
Onchocerca volvulus | 0.0674 | 0.2962 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.2962 | 0.2962 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0674 | 0.2962 | 0.2962 |
Echinococcus granulosus | cathepsin l1 | 0.0464 | 0.0942 | 0.0942 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.2962 | 0.2756 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Leishmania major | cathepsin L-like protease | 0.102 | 0.6283 | 1 |
Onchocerca volvulus | 0.0674 | 0.2962 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.102 | 0.6283 | 0.6283 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.2962 | 0.2962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0674 | 0.2962 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0674 | 0.2962 | 0.2962 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0464 | 0.0942 | 0.0942 |
Onchocerca volvulus | 0.0674 | 0.2962 | 1 | |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0586 | 0.2111 | 0.2111 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.2962 | 0.2962 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0674 | 0.2962 | 0.2229 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1407 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0674 | 0.2962 | 0.2962 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1407 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0674 | 0.2962 | 0.2962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Onchocerca volvulus | 0.0674 | 0.2962 | 1 | |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0586 | 0.2111 | 0.2111 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Onchocerca volvulus | 0.0674 | 0.2962 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.102 | 0.6283 | 0.6283 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.102 | 0.6283 | 0.6283 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.2962 | 0.2962 |
Brugia malayi | Cathepsin L-like precursor | 0.0464 | 0.0942 | 0.0942 |
Brugia malayi | Cathepsin L-like precursor | 0.0464 | 0.0942 | 0.0942 |
Leishmania major | cysteine peptidase A (CPA) | 0.0674 | 0.2962 | 0.2756 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0464 | 0.0942 | 0.3182 |
Loa Loa (eye worm) | cysteine protease | 0.0674 | 0.2962 | 0.2229 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0674 | 0.2962 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0674 | 0.2962 | 0.2962 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.2962 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0674 | 0.2962 | 0.2962 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1407 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0674 | 0.2962 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1407 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.102 | 0.6283 | 1 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.2962 | 0.2756 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 42 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.