Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1071 | 0.0362 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0252 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.013 | 0.4017 | 0.4017 |
Schistosoma mansoni | jun-related protein | 0.0071 | 0.1071 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.6669 | 0.9403 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.4599 | 0.3967 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4017 | 0.512 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.1047 | 0.0323 |
Brugia malayi | hypothetical protein | 0.0068 | 0.0954 | 0.0954 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.4017 | 0.6024 |
Echinococcus multilocularis | jun protein | 0.0087 | 0.1874 | 0.281 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.4017 | 0.6024 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2648 | 0.1788 |
Echinococcus multilocularis | geminin | 0.0184 | 0.6669 | 1 |
Brugia malayi | TAR-binding protein | 0.013 | 0.4017 | 0.4017 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1757 | 0.0793 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.4017 | 0.3318 |
Echinococcus granulosus | jun protein | 0.0087 | 0.1874 | 0.281 |
Onchocerca volvulus | 0.0068 | 0.0954 | 0.2025 | |
Brugia malayi | bZIP transcription factor family protein | 0.0087 | 0.1874 | 0.1874 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.1047 | 0.1047 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0125 | 0.3752 | 0.3752 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.378 | 0.3053 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4017 | 0.512 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.4017 | 0.3318 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0087 | 0.1874 | 0.281 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0143 | 0.4627 | 0.6938 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.2648 | 0.1788 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.4017 | 0.4017 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4017 | 0.512 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0192 | 0.7038 | 1 |
Echinococcus granulosus | geminin | 0.0184 | 0.6669 | 1 |
Onchocerca volvulus | 0.0142 | 0.4599 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.6669 | 0.9403 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0087 | 0.1874 | 0.281 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4017 | 0.512 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.3752 | 0.3021 |
Mycobacterium ulcerans | putative regulatory protein | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4017 | 0.512 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0143 | 0.4627 | 0.6938 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.2648 | 0.2648 |
Brugia malayi | PAS domain containing protein | 0.0066 | 0.0847 | 0.0847 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.2648 | 0.2648 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.4017 | 0.3318 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -1 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.