TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 601.668 | Formula: C28H37BrN6S2
H donors: 0 H acceptors: 0 LogP: 9.9 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: N=c1sc(nn1CCCCCCCCCCCCn1nc(sc1=N)c1ccccc1)c1ccccc1.Br
InChi: 1S/C28H36N6S2.BrH/c29-27-33(31-25(35-27)23-17-11-9-12-18-23)21-15-7-5-3-1-2-4-6-8-16-22-34-28(30)36-26(32-34)24-19-13-10-14-20-24;/h9-14,17-20,29-30H,1-8,15-16,21-22H2;1H
InChiKey: GQTSRNHSQKPEKN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	beta tubulin	0.0823478	1	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0411573	0.472279	0.463086
Loa Loa (eye worm)	tubulin alpha 2	0.0411573	0.472279	0.463086
Trypanosoma brucei	beta tubulin	0.0437246	0.505171	0.496551
Giardia lamblia	Heat shock protein HSP 90-alpha	0.00563061	0.017122	0.017122
Trypanosoma cruzi	heat shock protein 85, putative	0.00563061	0.017122	0.017122
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Echinococcus granulosus	heat shock protein 90	0.00563061	0.017122	0.017122
Echinococcus granulosus	tubulin alpha 1C chain	0.060142	0.715505	0.715505
Loa Loa (eye worm)	tubulin beta chain	0.0189847	0.188211	0.174069
Schistosoma mansoni	tubulin subunit beta	0.0823478	1	1
Plasmodium falciparum	alpha tubulin 2	0.060142	0.715505	0.710549
Echinococcus multilocularis	Tubulin alpha 1 chain	0.060142	0.715505	0.715505
Schistosoma mansoni	tubulin subunit delta	0.0189847	0.188211	0.174069
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0354021	0.398545	0.398545
Entamoeba histolytica	tubulin family protein	0.0823478	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.060142	0.715505	0.710549
Loa Loa (eye worm)	tubulin alpha 2	0.0164174	0.155319	0.140604
Echinococcus granulosus	beta tubulin	0.0823478	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.060142	0.715505	0.715505
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0823478	1	1
Leishmania major	beta tubulin	0.0823478	1	1
Brugia malayi	Tubulin gamma chain	0.0437246	0.505171	0.496551
Leishmania major	beta tubulin	0.0823478	1	1
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Trypanosoma brucei	alpha tubulin	0.060142	0.715505	0.710549
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Leishmania major	beta tubulin	0.0823478	1	1
Trypanosoma cruzi	tubulin delta chain	0.0189847	0.188211	0.188211
Leishmania major	beta tubulin	0.0823478	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0823478	1	1
Leishmania major	beta tubulin	0.0823478	1	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0437246	0.505171	0.505171
Schistosoma mansoni	tubulin subunit beta	0.0823478	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0247399	0.261945	0.261945
Trichomonas vaginalis	tubulin beta chain, putative	0.0247399	0.261945	0.261945
Plasmodium falciparum	tubulin delta chain, putative	0.0189847	0.188211	0.174069
Echinococcus multilocularis	Tubulin beta 2C chain	0.0823478	1	1
Trypanosoma cruzi	alpha tubulin, putative	0.060142	0.715505	0.715505
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0189847	0.188211	0.174069
Brugia malayi	alpha-tubulin	0.060142	0.715505	0.710549
Loa Loa (eye worm)	hypothetical protein	0.0354021	0.398545	0.388068
Trichomonas vaginalis	tubulin beta chain, putative	0.060142	0.715505	0.715505
Brugia malayi	Tubulin alpha chain	0.060142	0.715505	0.710549
Trypanosoma cruzi	tubulin delta chain	0.0189847	0.188211	0.188211
Echinococcus multilocularis	tubulin alpha chain	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0189847	0.188211	0.188211
Leishmania major	beta tubulin	0.0823478	1	1
Echinococcus granulosus	tubulin alpha chain	0.060142	0.715505	0.715505
Brugia malayi	Tubulin beta chain	0.0189847	0.188211	0.174069
Echinococcus granulosus	Tubulin beta 2C chain	0.0823478	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.060142	0.715505	0.715505
Giardia lamblia	Alpha-tubulin	0.060142	0.715505	0.715505
Echinococcus multilocularis	beta tubulin	0.0823478	1	1
Giardia lamblia	Delta tubulin	0.0189847	0.188211	0.188211
Trichomonas vaginalis	tubulin beta chain, putative	0.060142	0.715505	0.715505
Trypanosoma cruzi	heat shock protein 85, putative	0.00563061	0.017122	0.017122
Giardia lamblia	Epsilon tubulin	0.0189847	0.188211	0.188211
Trypanosoma brucei	alpha tubulin	0.060142	0.715505	0.710549
Echinococcus granulosus	tubulin epsilon chain	0.0437246	0.505171	0.505171
Trichomonas vaginalis	tubulin alpha chain, putative	0.0823478	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin, putative	0.0189847	0.188211	0.188211
Giardia lamblia	Beta tubulin	0.0823478	1	1
Trypanosoma brucei	beta tubulin	0.0823478	1	1
Leishmania major	beta tubulin	0.0823478	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0437246	0.505171	0.496551
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin alpha chain, putative	0.0247399	0.261945	0.261945
Onchocerca volvulus		0.0247399	0.261945	0.5
Echinococcus granulosus	tubulin alpha chain	0.060142	0.715505	0.715505
Toxoplasma gondii	beta-tubulin, putative	0.0823478	1	1
Plasmodium falciparum	tubulin beta chain	0.0823478	1	1
Brugia malayi	Tubulin alpha chain	0.0189847	0.188211	0.174069
Trichomonas vaginalis	tubulin gamma chain, putative	0.0823478	1	1
Echinococcus multilocularis	tubulin subunit beta	0.0823478	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0247399	0.261945	0.261945
Loa Loa (eye worm)	beta-tubulin	0.0823478	1	1
Brugia malayi	Tubulin alpha-2 chain	0.060142	0.715505	0.710549
Trypanosoma cruzi	beta tubulin, putative	0.0823478	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.060142	0.715505	0.715505
Echinococcus multilocularis	tubulin alpha chain	0.060142	0.715505	0.715505
Echinococcus multilocularis	tubulin delta chain	0.0189847	0.188211	0.188211
Schistosoma mansoni	tubulin subunit alpha	0.060142	0.715505	0.710549
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Trypanosoma cruzi	zeta tubulin, putative	0.0189847	0.188211	0.188211
Trichomonas vaginalis	conserved hypothetical protein	0.0189847	0.188211	0.188211
Giardia lamblia	Beta tubulin	0.0823478	1	1
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0411573	0.472279	0.472279
Trypanosoma cruzi	epsilon tubulin, putative	0.0437246	0.505171	0.505171
Trichomonas vaginalis	tubulin, putative	0.0247399	0.261945	0.261945
Echinococcus multilocularis	tubulin alpha 1C chain	0.060142	0.715505	0.715505
Toxoplasma gondii	beta tubulin	0.0823478	1	1
Schistosoma mansoni	alpha tubulin	0.060142	0.715505	0.710549
Plasmodium vivax	tubulin alpha chain, putative	0.060142	0.715505	0.710549
Loa Loa (eye worm)	tubulin beta chain	0.0823478	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0823478	1	1
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Echinococcus multilocularis	heat shock protein	0.00563061	0.017122	0.017122
Trypanosoma cruzi	zeta tubulin, putative	0.0189847	0.188211	0.188211
Echinococcus multilocularis	hypothetical protein	0.060142	0.715505	0.715505
Echinococcus granulosus	tubulin alpha chain	0.060142	0.715505	0.715505
Treponema pallidum	cell division protein FtsZ	0.0189847	0.188211	1
Leishmania major	beta tubulin	0.0823478	1	1
Trypanosoma brucei	beta tubulin	0.0823478	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0823478	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0823478	1	1
Trypanosoma brucei	tubulin gamma chain	0.0437246	0.505171	0.496551
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Schistosoma mansoni	tubulin subunit alpha	0.060142	0.715505	0.710549
Echinococcus granulosus	tubulin alpha chain	0.060142	0.715505	0.715505
Loa Loa (eye worm)	hypothetical protein	0.060142	0.715505	0.710549
Echinococcus multilocularis	heat shock protein 90	0.00563061	0.017122	0.017122
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Echinococcus granulosus	tubulin delta chain	0.0189847	0.188211	0.188211
Echinococcus multilocularis	peroxisome assembly protein 26	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin beta chain, putative	0.060142	0.715505	0.715505
Trypanosoma brucei	zeta tubulin	0.0189847	0.188211	0.174069
Echinococcus multilocularis	tubulin alpha chain	0.060142	0.715505	0.715505
Schistosoma mansoni	alpha tubulin	0.060142	0.715505	0.710549
Trypanosoma cruzi	epsilon tubulin, putative	0.0437246	0.505171	0.505171
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Echinococcus multilocularis	tubulin alpha chain	0.060142	0.715505	0.715505
Loa Loa (eye worm)	tubulin alpha chain	0.060142	0.715505	0.710549
Entamoeba histolytica	tubulin alpha-1 chain	0.060142	0.715505	0.710549
Leishmania major	beta tubulin	0.0823478	1	1
Leishmania major	beta tubulin	0.0823478	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0189847	0.188211	0.188211
Loa Loa (eye worm)	hypothetical protein	0.0411573	0.472279	0.463086
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Schistosoma mansoni	tubulin subunit beta	0.0823478	1	1
Brugia malayi	Tubulin beta chain	0.0247399	0.261945	0.249087
Leishmania major	beta tubulin	0.0823478	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.0437246	0.505171	0.496551
Echinococcus granulosus	tubulin alpha	0.0437246	0.505171	0.505171
Echinococcus granulosus	alpha tubulin	0.060142	0.715505	0.715505
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0354021	0.398545	0.388068
Brugia malayi	Tubulin beta-1 chain	0.0823478	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0823478	1	1
Plasmodium falciparum	alpha tubulin 1	0.060142	0.715505	0.710549
Giardia lamblia	Beta tubulin	0.0823478	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0189847	0.188211	0.174069
Echinococcus granulosus	tubulin gamma 1 chain	0.0437246	0.505171	0.505171
Plasmodium vivax	tubulin beta chain, putative	0.0823478	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0437246	0.505171	0.496551
Loa Loa (eye worm)	tubulin gamma chain	0.0437246	0.505171	0.496551
Loa Loa (eye worm)	tubulin beta-2A chain	0.0823478	1	1
Brugia malayi	tubulin alpha-2 chain	0.060142	0.715505	0.710549
Echinococcus multilocularis	Tubulin alpha 1 chain	0.060142	0.715505	0.715505
Trypanosoma brucei	epsilon tubulin	0.0437246	0.505171	0.496551
Trypanosoma brucei	epsilon tubulin	0.0437246	0.505171	0.496551
Trypanosoma brucei	epsilon tubulin	0.0437246	0.505171	0.496551
Trypanosoma cruzi	tubulin gamma chain	0.0437246	0.505171	0.505171
Echinococcus granulosus	Tubulin beta 2C chain	0.0823478	1	1
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin epsilon chain, putative	0.060142	0.715505	0.715505
Trypanosoma brucei	alpha tubulin	0.060142	0.715505	0.710549
Echinococcus granulosus	tubulin subunit beta	0.0823478	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.060142	0.715505	0.715505
Trypanosoma cruzi	Heat shock protein 83, putative	0.00563061	0.017122	0.017122
Schistosoma mansoni	alpha tubulin	0.060142	0.715505	0.710549
Echinococcus granulosus	tubulin subunit TubB	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin, putative	0.0823478	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0823478	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin gamma chain, putative	0.0189847	0.188211	0.188211
Echinococcus granulosus	peroxisome assembly protein 26	0.060142	0.715505	0.715505
Leishmania major	zeta tubulin, putative	0.0189847	0.188211	0.188211
Leishmania major	beta tubulin	0.0823478	1	1
Leishmania major	beta tubulin	0.0823478	1	1
Brugia malayi	Tubulin alpha-2 chain	0.060142	0.715505	0.710549
Trichomonas vaginalis	tubulin gamma chain, putative	0.0437246	0.505171	0.505171
Echinococcus granulosus	tubulin alpha chain	0.060142	0.715505	0.715505
Trichomonas vaginalis	heat shock protein, putative	0.00563061	0.017122	0.017122
Leishmania major	beta tubulin	0.0823478	1	1
Giardia lamblia	Gamma tubulin	0.0437246	0.505171	0.505171
Giardia lamblia	Alpha-tubulin	0.060142	0.715505	0.715505
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0437246	0.505171	0.496551
Brugia malayi	beta-tubulin, identical	0.0823478	1	1
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Entamoeba histolytica	tubulin gamma chain	0.0437246	0.505171	0.496551
Brugia malayi	Cell division protein ftsZ	0.0189847	0.188211	0.174069
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Echinococcus granulosus	Tubulin beta 2C chain	0.0823478	1	1
Trypanosoma cruzi	heat shock protein 85, putative	0.00563061	0.017122	0.017122
Mycobacterium leprae	cell division protein FtsZ	0.0189847	0.188211	1
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.060142	0.715505	0.715505
Trypanosoma brucei	alpha tubulin, putative	0.0247399	0.261945	0.249087
Echinococcus granulosus	Tubulin beta 2C chain	0.0823478	1	1
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Echinococcus granulosus	heat shock protein	0.00563061	0.017122	0.017122
Loa Loa (eye worm)	tubulin alpha-2 chain	0.060142	0.715505	0.710549
Leishmania major	epsilon tubulin, putative	0.0437246	0.505171	0.505171
Brugia malayi	tubulin alpha chain - mouse	0.060142	0.715505	0.710549
Plasmodium vivax	delta tubulin, putative	0.0189847	0.188211	0.174069
Mycobacterium ulcerans	cell division protein FtsZ	0.0189847	0.188211	1
Loa Loa (eye worm)	tubulin alpha 2	0.0411573	0.472279	0.463086
Echinococcus granulosus	tubulin beta 4A class IVa	0.0823478	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.060142	0.715505	0.715505
Loa Loa (eye worm)	alpha-tubulin	0.060142	0.715505	0.710549
Echinococcus granulosus	tubulin beta 1 chain	0.0823478	1	1
Trypanosoma brucei	alpha tubulin	0.060142	0.715505	0.710549
Loa Loa (eye worm)	alpha-tubulin	0.060142	0.715505	0.710549
Schistosoma mansoni	tubulin subunit gamma	0.0437246	0.505171	0.496551
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0189847	0.188211	0.188211
Echinococcus multilocularis	tubulin alpha 3 chain	0.060142	0.715505	0.715505
Loa Loa (eye worm)	tubulin beta-1 chain	0.0823478	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0437246	0.505171	0.505171
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Schistosoma mansoni	tubulin subunit beta	0.0189847	0.188211	0.174069
Schistosoma mansoni	tubulin subunit beta	0.0823478	1	1
Toxoplasma gondii	alpha-tubulin I, putative	0.060142	0.715505	0.710549
Schistosoma mansoni	tubulin subunit epsilon	0.0437246	0.505171	0.496551
Trichomonas vaginalis	tubulin, putative	0.0247399	0.261945	0.261945
Trichomonas vaginalis	tubulin beta chain, putative	0.0823478	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0823478	1	1
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Schistosoma mansoni	tubulin subunit beta	0.0823478	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0437246	0.505171	0.505171
Echinococcus multilocularis	beta tubulin	0.0823478	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0823478	1	1
Leishmania major	beta tubulin	0.0823478	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0189847	0.188211	1
Plasmodium vivax	tubulin alpha chain, putative	0.060142	0.715505	0.710549
Entamoeba histolytica	tubulin alpha chain, putative	0.060142	0.715505	0.710549
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Trypanosoma cruzi	heat shock protein 90, putative	0.00563061	0.017122	0.017122
Trichomonas vaginalis	tubulin epsilon chain, putative	0.060142	0.715505	0.715505
Trypanosoma brucei	beta tubulin	0.0823478	1	1
Leishmania major	delta tubulin, putative	0.0189847	0.188211	0.188211
Trypanosoma brucei	zeta tubulin, putative	0.0189847	0.188211	0.174069
Echinococcus multilocularis	Tubulin beta 2C chain	0.0823478	1	1
Entamoeba histolytica	tubulin family protein	0.0823478	1	1
Echinococcus multilocularis	tubulin epsilon chain	0.0437246	0.505171	0.505171
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Schistosoma mansoni	tubulin subunit beta	0.0823478	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.060142	0.715505	0.710549
Echinococcus granulosus	beta tubulin	0.0823478	1	1
Trypanosoma brucei	tubulin delta chain	0.0189847	0.188211	0.174069
Leishmania major	beta tubulin	0.0823478	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0189847	0.188211	0.174069
Echinococcus granulosus	Tubulin alpha 1 chain	0.060142	0.715505	0.715505
Echinococcus multilocularis	tubulin alpha 3 chain	0.060142	0.715505	0.715505
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Trypanosoma brucei	beta tubulin	0.0823478	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0823478	1	1
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Echinococcus granulosus	tubulin alpha 3 chain	0.060142	0.715505	0.715505
Trichomonas vaginalis	tubulin alpha chain, putative	0.0247399	0.261945	0.261945
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Schistosoma mansoni	tubulin subunit alpha	0.060142	0.715505	0.710549
Echinococcus granulosus	Tubulin alpha 1 chain	0.060142	0.715505	0.715505
Echinococcus multilocularis	tubulin alpha chain	0.060142	0.715505	0.715505
Echinococcus multilocularis	tubulin subunit TubB	0.060142	0.715505	0.715505
Toxoplasma gondii	beta-1 tubulin, putative	0.0823478	1	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0189847	0.188211	1
Loa Loa (eye worm)	BEN-1 protein	0.0823478	1	1
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Leishmania major	beta tubulin	0.0823478	1	1
Plasmodium falciparum	tubulin gamma chain	0.0437246	0.505171	0.496551
Leishmania major	gamma-tubulin	0.0437246	0.505171	0.505171
Leishmania major	heat shock protein 83-1	0.00563061	0.017122	0.017122
Leishmania major	alpha tubulin	0.060142	0.715505	0.715505
Echinococcus granulosus	tubulin alpha 1C chain	0.060142	0.715505	0.715505
Echinococcus multilocularis	tubulin alpha	0.0437246	0.505171	0.505171

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 760 nM	Antimalarial activity against Plasmodium falciparum Nigerian in human erythrocytes after 48 hrs	ChEMBL.	18004799

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	18004799

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL558378

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1057478