Detailed information for compound 1057524

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.86 | Formula: C21H23ClF3NO3
  • H donors: 2 H acceptors: 2 LogP: 3.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](CN1CCC(CC1)(O)c1cccc(c1)C(F)(F)F)COc1ccc(cc1)Cl
  • InChi: 1S/C21H23ClF3NO3/c22-17-4-6-19(7-5-17)29-14-18(27)13-26-10-8-20(28,9-11-26)15-2-1-3-16(12-15)21(23,24)25/h1-7,12,18,27-28H,8-11,13-14H2/t18-/m1/s1
  • InChiKey: GZACZULYTMPTEI-GOSISDBHSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0037 0.0182 0.0134
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0726 1 1
Schistosoma mansoni hypothetical protein 0.0166 0.201 0.197
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0199 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0037 0.0182 0.0169
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.038 0.5059 0.5052
Loa Loa (eye worm) aminopeptidase N 0.0039 0.0199 0.0199
Brugia malayi TATA binding protein associated factor 0.0039 0.0199 0.0269
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1026 0.1755
Brugia malayi jmjC domain containing protein 0.0037 0.0182 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Schistosoma mansoni lamin 0.0053 0.0405 0.0358
Onchocerca volvulus 0.0039 0.0199 0.0234
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1026 0.1755
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Schistosoma mansoni phd/f-box containing protein 0.0037 0.0182 0.0134
Loa Loa (eye worm) hypothetical protein 0.0066 0.059 0.059
Onchocerca volvulus 0.0053 0.0405 0.0557
Loa Loa (eye worm) jmjC domain-containing protein 0.0239 0.306 0.306
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0199 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0142 0.1671 0.163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0049 0.0049
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0405 0.0639
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0151 0.0151
Onchocerca volvulus 0.0476 0.6438 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1301 0.1301
Brugia malayi jmjC domain containing protein 0.0037 0.0182 0.0239
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0332 0.0289
Brugia malayi Pre-SET motif family protein 0.0419 0.5615 1
Brugia malayi hypothetical protein 0.0039 0.0199 0.0269
Toxoplasma gondii PHD-finger domain-containing protein 0.0116 0.1301 1
Onchocerca volvulus 0.0035 0.0151 0.0159
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1026 0.1026
Giardia lamblia Fructose-bisphosphate aldolase 0.0329 0.4335 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0199 0.0151
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0054 0.0054
Onchocerca volvulus 0.0039 0.0199 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0281 0.0233
Onchocerca volvulus 0.0048 0.0329 0.0438
Echinococcus granulosus intermediate filament protein 0.0053 0.0405 0.0392
Toxoplasma gondii PHD-finger domain-containing protein 0.0038 0.0189 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0085
Echinococcus granulosus geminin 0.0166 0.201 0.1999
Echinococcus multilocularis musashi 0.0053 0.0405 0.0392
Leishmania major hypothetical protein, conserved 0.0037 0.0182 0.6531
Onchocerca volvulus 0.0035 0.0151 0.0159
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1938 0.6612
Brugia malayi Peptidase family M1 containing protein 0.0039 0.0199 0.0269
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0037 0.0182 0.6531
Schistosoma mansoni jumonji domain containing protein 0.0302 0.3947 0.3917
Echinococcus granulosus phd:f box containing protein 0.0037 0.0182 0.0169
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0205 0.0191
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Brugia malayi hypothetical protein 0.0234 0.2983 0.5271
Plasmodium vivax SET domain protein, putative 0.0061 0.0512 0.3144
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0039 0.0199 0.015
Toxoplasma gondii aminopeptidase N protein 0.0039 0.0199 0.042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.4335 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0038 0.0189 0.7923
Loa Loa (eye worm) PHD-finger family protein 0.0116 0.1301 0.1301
Loa Loa (eye worm) peptidase family M1 containing protein 0.0039 0.0199 0.0199
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Brugia malayi PHD-finger family protein 0.0039 0.0212 0.0292
Schistosoma mansoni hypothetical protein 0.0166 0.201 0.197
Brugia malayi jmjC domain containing protein 0.0037 0.0182 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0036
Echinococcus multilocularis geminin 0.0166 0.201 0.1999
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0199 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0039 0.0199 0.0151
Toxoplasma gondii aminopeptidase n, putative 0.0039 0.0199 0.042
Schistosoma mansoni jumonji/arid domain-containing protein 0.0142 0.1671 0.163
Echinococcus multilocularis lysine specific demethylase 6a 0.0037 0.0182 0.0169
Echinococcus granulosus peregrin 0.012 0.1358 0.1346
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.0199 0.042
Schistosoma mansoni protein phosphatase 2C 0.0037 0.0182 0.0134
Echinococcus granulosus lamin dm0 0.0053 0.0405 0.0392
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.4335 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Trypanosoma brucei Aminopeptidase M1, putative 0.0039 0.0199 1
Schistosoma mansoni hypothetical protein 0.0048 0.0329 0.0281
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0037 0.0182 0.6531
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0281 0.0267
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2854 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0151 0.0137
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0151 0.0137
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0512 0.0499
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.1908 0.1896
Echinococcus granulosus PHD finger protein rhinoceros 0.0116 0.1301 0.1289
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Schistosoma mansoni aminopeptidase A (M01 family) 0.0039 0.0199 0.0151
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0039 0.0199 0.0151
Brugia malayi beta-lactamase family protein 0.0035 0.0151 0.0182
Echinococcus multilocularis jumonji domain containing protein 0.0161 0.1948 0.1937
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0085 0.0064
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0275 0.0833
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0085 0.0064
Plasmodium falciparum phd finger protein, putative 0.0116 0.1301 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0037 0.0182 0.0274
Plasmodium vivax JmjC domain containing protein 0.0037 0.0182 0.0274
Trypanosoma cruzi aminopeptidase, putative 0.0039 0.0199 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.0199 0.042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0085 0.0071
Schistosoma mansoni cpg binding protein 0.003 0.0072 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.0199 0.0077
Schistosoma mansoni hypothetical protein 0.0066 0.059 0.0544
Echinococcus granulosus lamin 0.0053 0.0405 0.0392
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0512 0.0499
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0038 0.0189 0.7923
Schistosoma mansoni jumonji domain containing protein 0.0037 0.0182 0.0134
Echinococcus granulosus cpg binding protein 0.003 0.0072 0.0058
Schistosoma mansoni survival motor neuron protein 0.0048 0.0329 0.0281
Schistosoma mansoni intermediate filament proteins 0.0053 0.0405 0.0358
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0529 0.0482
Trypanosoma brucei aminopeptidase, putative 0.0039 0.0199 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0281 0.0233
Trypanosoma brucei Aminopeptidase M1, putative 0.0039 0.0199 1
Echinococcus granulosus JmjC domain containing protein 4 0.0037 0.0182 0.0169
Echinococcus multilocularis phd:f box containing protein 0.0037 0.0182 0.0169
Schistosoma mansoni hypothetical protein 0.0038 0.0189 0.014
Loa Loa (eye worm) hypothetical protein 0.0061 0.0512 0.0512
Loa Loa (eye worm) TATA binding protein associated factor 0.0039 0.0199 0.0199
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0332 0.0289
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0512 0.0465
Trichomonas vaginalis set domain proteins, putative 0.0476 0.6438 1
Brugia malayi Pre-SET motif family protein 0.0061 0.0512 0.0832
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0039 0.0199 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0053 0.0405 0.0405
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0343 0.0527
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0151 0.0102
Onchocerca volvulus 0.0035 0.0151 0.0159
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0495 0.2998
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Loa Loa (eye worm) beta-lactamase 0.0035 0.0151 0.0151
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.5615 0.5615
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0037 0.0182 0.0274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0281 0.0267
Plasmodium vivax hypothetical protein, conserved 0.004 0.0213 0.0545
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0085 0.0085
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.0199 1
Brugia malayi AF-10 protein 0.0038 0.0189 0.0251
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.032 0.0272
Giardia lamblia PHD finger protein 15 0.0116 0.1301 0.2526
Schistosoma mansoni cpg binding protein 0.003 0.0072 0.0023
Schistosoma mansoni hypothetical protein 0.0116 0.1301 0.1258
Echinococcus granulosus GPCR family 2 0.0031 0.0085 0.0071
Schistosoma mansoni lamin 0.0053 0.0405 0.0358
Loa Loa (eye worm) jmjC domain-containing protein 0.0142 0.1671 0.1671
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.0199 1
Echinococcus multilocularis lysine specific demethylase 5A 0.014 0.1648 0.1637
Loa Loa (eye worm) hypothetical protein 0.0052 0.0391 0.0391
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0726 1 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0116 0.1301 0.1258
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0054 0.0009
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.0199 0.0077
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0039 0.0199 1
Brugia malayi Peptidase family M1 containing protein 0.0039 0.0199 0.0269
Echinococcus multilocularis lamin 0.0053 0.0405 0.0392
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0405 0.0405
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.0199 0.0077
Brugia malayi Peptidase family M1 containing protein 0.0039 0.0199 0.0269
Brugia malayi beta-lactamase 0.0035 0.0151 0.0182
Loa Loa (eye worm) hypothetical protein 0.0097 0.1026 0.1026
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.1973 0.1933
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0085 0.0071
Onchocerca volvulus 0.0053 0.0405 0.0557
Echinococcus multilocularis peregrin 0.012 0.1358 0.1346
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Brugia malayi hypothetical protein 0.0039 0.0199 0.0269
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0726 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0036
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2983 0.2974
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.059 0.0972
Echinococcus granulosus jumonji domain containing 1A 0.0037 0.0182 0.0169
Loa Loa (eye worm) hypothetical protein 0.0037 0.0182 0.0182
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0039 0.0199 0.015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0085 0.0071
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0182 0.0182
Onchocerca volvulus 0.0061 0.0512 0.0725
Brugia malayi jmjC domain containing protein 0.0142 0.1671 0.2914
Brugia malayi PHD-finger family protein 0.0116 0.1301 0.2249
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0512 0.0465
Echinococcus granulosus aminopeptidase N 0.0039 0.0199 0.0185
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Echinococcus multilocularis GPCR, family 2 0.0031 0.0085 0.0071
Toxoplasma gondii PHD-finger domain-containing protein 0.0116 0.1301 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0182 0.0182
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0332 0.158
Onchocerca volvulus 0.0039 0.0199 0.0234
Loa Loa (eye worm) hypothetical protein 0.0234 0.2983 0.2983
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0151 0.0182
Toxoplasma gondii aminopeptidase N, putative 0.0039 0.0199 0.042
Brugia malayi hypothetical protein 0.0334 0.4408 0.7831
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.004 0.0213 0.0278
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0512 0.3144
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.1973 0.1962
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0281 0.0267
Echinococcus multilocularis PHD finger protein rhinoceros 0.0116 0.1301 0.1289
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1938 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Onchocerca volvulus Alhambra homolog 0.0116 0.1301 0.1959
Echinococcus multilocularis cpg binding protein 0.003 0.0072 0.0058
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1301 1
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.1973 0.3456
Trypanosoma cruzi Aminopeptidase M1, putative 0.0039 0.0199 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0039 0.0199 0.027
Brugia malayi jmjC domain containing protein 0.0037 0.0182 0.0239
Schistosoma mansoni phosphatidylserine receptor 0.0037 0.0182 0.0134
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0512 0.0499
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0205 0.0191
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0037 0.0182 0.6531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Echinococcus multilocularis jumonji domain containing 1A 0.0037 0.0182 0.0169
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0275 0.0185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0151 0.0102
Trypanosoma cruzi aminopeptidase, putative 0.0039 0.0199 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0038 0.0189 0.0333
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.038 0.5059 0.5052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0281 0.0233
Echinococcus multilocularis aminopeptidase N 0.0039 0.0199 0.0185
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0405 0.0405
Echinococcus granulosus lysine specific demethylase 6a 0.0037 0.0182 0.0169
Echinococcus granulosus lysine specific demethylase 5A 0.0142 0.1671 0.166
Echinococcus multilocularis lamin dm0 0.0053 0.0405 0.0392
Loa Loa (eye worm) acetyltransferase 0.0163 0.1973 0.1973
Brugia malayi jmjC domain containing protein 0.038 0.5059 0.9001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Loa Loa (eye worm) hypothetical protein 0.0199 0.2481 0.2481
Mycobacterium ulcerans aminopeptidase N PepN 0.0039 0.0199 0.027
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0332 0.158
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0332 0.0319
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0199 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1938 1
Treponema pallidum fructose-bisphosphate aldolase 0.0329 0.4335 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0036
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2983 0.2974
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0039 0.0199 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0332 0.158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0512 0.0465
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0472 0.0459
Brugia malayi intermediate filament protein 0.0053 0.0405 0.0639
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0039 0.0199 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0039 0.0199 0.0185
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0512 0.0465
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0182 0.0182
Brugia malayi beta-lactamase family protein 0.0035 0.0151 0.0182
Echinococcus granulosus jumonji domain containing protein 0.0161 0.1948 0.1937
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0281 0.0267
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0085 0.0071
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0329 0.0503
Loa Loa (eye worm) hypothetical protein 0.0037 0.0182 0.0182
Brugia malayi Bromodomain containing protein 0.012 0.1358 0.2351
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0281 0.0416

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 25 ug ml-1 Antimicrobial activity against Mycobacterium tuberculosis H37Rv after 9 to 12 days by CLSI microbroth dilution technique ChEMBL. 19386501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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