Detailed information for compound 1057524

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.86 | Formula: C21H23ClF3NO3
  • H donors: 2 H acceptors: 2 LogP: 3.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](CN1CCC(CC1)(O)c1cccc(c1)C(F)(F)F)COc1ccc(cc1)Cl
  • InChi: 1S/C21H23ClF3NO3/c22-17-4-6-19(7-5-17)29-14-18(27)13-26-10-8-20(28,9-11-26)15-2-1-3-16(12-15)21(23,24)25/h1-7,12,18,27-28H,8-11,13-14H2/t18-/m1/s1
  • InChiKey: GZACZULYTMPTEI-GOSISDBHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Onchocerca volvulus 0.0035 0.0151 0.0159
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Onchocerca volvulus 0.0053 0.0405 0.0557
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0199
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0037 0.0182 0.6531
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0039 0.0199 1
Echinococcus multilocularis lamin dm0 0.0053 0.0405 0.0392
Echinococcus multilocularis cpg binding protein 0.003 0.0072 0.0058
Echinococcus granulosus PHD finger protein rhinoceros 0.0116 0.1301 0.1289
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.5615 0.5615
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.4335 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0037 0.0182 0.0169
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.0199 0.0077
Echinococcus granulosus lysine specific demethylase 5A 0.0142 0.1671 0.166
Toxoplasma gondii aminopeptidase N protein 0.0039 0.0199 0.042
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0512 0.0499
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0205 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1301 1
Echinococcus multilocularis jumonji domain containing 1A 0.0037 0.0182 0.0169
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0039 0.0199 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.038 0.5059 0.5052
Schistosoma mansoni hypothetical protein 0.0066 0.059 0.0544
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0039 0.0199 0.0151
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0054 0.0009
Loa Loa (eye worm) hypothetical protein 0.0234 0.2983 0.2983
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0037 0.0182 0.0134
Echinococcus granulosus peregrin 0.012 0.1358 0.1346
Loa Loa (eye worm) jmjC domain-containing protein 0.0142 0.1671 0.1671
Onchocerca volvulus 0.0048 0.0329 0.0438
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0085 0.0071
Leishmania major hypothetical protein, conserved 0.0037 0.0182 0.6531
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2854 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0281 0.0267
Brugia malayi jmjC domain containing protein 0.0142 0.1671 0.2914
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0512 0.0465
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0085 0.0085
Echinococcus granulosus GPCR family 2 0.0031 0.0085 0.0071
Echinococcus multilocularis musashi 0.0053 0.0405 0.0392
Plasmodium falciparum phd finger protein, putative 0.0116 0.1301 1
Echinococcus granulosus jumonji domain containing protein 0.0161 0.1948 0.1937
Onchocerca volvulus 0.0476 0.6438 1
Brugia malayi jmjC domain containing protein 0.0037 0.0182 0.0239
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0472 0.0459
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0151 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1938 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0405 0.0405
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0182 0.0182
Schistosoma mansoni hypothetical protein 0.0166 0.201 0.197
Echinococcus multilocularis aminopeptidase N 0.0039 0.0199 0.0185
Onchocerca volvulus 0.0053 0.0405 0.0557
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0512 0.0499
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0085 0.0064
Brugia malayi AF-10 protein 0.0038 0.0189 0.0251
Brugia malayi Peptidase family M1 containing protein 0.0039 0.0199 0.0269
Mycobacterium ulcerans aminopeptidase N PepN 0.0039 0.0199 0.027
Brugia malayi Pre-SET motif family protein 0.0061 0.0512 0.0832
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0039 0.0199 0.0151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0085 0.0071
Echinococcus multilocularis PHD finger protein rhinoceros 0.0116 0.1301 0.1289
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.0199 0.042
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0329 0.0503
Echinococcus granulosus lamin dm0 0.0053 0.0405 0.0392
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0405 0.0405
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0085 0.0071
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.0199 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0039 0.0199 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Schistosoma mansoni phosphatidylserine receptor 0.0037 0.0182 0.0134
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.0199 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0529 0.0482
Toxoplasma gondii aminopeptidase N, putative 0.0039 0.0199 0.042
Brugia malayi hypothetical protein 0.0334 0.4408 0.7831
Brugia malayi hypothetical protein 0.0234 0.2983 0.5271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0199 1
Onchocerca volvulus 0.0039 0.0199 0.0234
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0182 0.0182
Brugia malayi Pre-SET motif family protein 0.0419 0.5615 1
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.059 0.0972
Toxoplasma gondii PHD-finger domain-containing protein 0.0038 0.0189 0.0333
Echinococcus multilocularis lysine specific demethylase 5A 0.014 0.1648 0.1637
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0039 0.0199 0.015
Schistosoma mansoni aminopeptidase A (M01 family) 0.0039 0.0199 0.0151
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0039 0.0199 1
Trypanosoma cruzi aminopeptidase, putative 0.0039 0.0199 1
Echinococcus multilocularis lamin 0.0053 0.0405 0.0392
Brugia malayi hypothetical protein 0.0039 0.0199 0.0269
Toxoplasma gondii aminopeptidase n, putative 0.0039 0.0199 0.042
Loa Loa (eye worm) hypothetical protein 0.0097 0.1026 0.1026
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0726 1 1
Brugia malayi Peptidase family M1 containing protein 0.0039 0.0199 0.0269
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.004 0.0213 0.0278
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0281 0.0267
Schistosoma mansoni hypothetical protein 0.0166 0.201 0.197
Loa Loa (eye worm) acetyltransferase 0.0163 0.1973 0.1973
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0151 0.0137
Schistosoma mansoni jumonji domain containing protein 0.0037 0.0182 0.0134
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0332 0.158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0512 0.0465
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0281 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0512 0.0465
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0049 0.0049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0512 0.0499
Loa Loa (eye worm) PHD-finger family protein 0.0116 0.1301 0.1301
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2983 0.2974
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0281 0.0267
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0281 0.0416
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0332 0.0319
Echinococcus multilocularis GPCR, family 2 0.0031 0.0085 0.0071
Brugia malayi hypothetical protein 0.0039 0.0199 0.0269
Loa Loa (eye worm) TATA binding protein associated factor 0.0039 0.0199 0.0199
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0116 0.1301 0.1258
Loa Loa (eye worm) hypothetical protein 0.0066 0.059 0.059
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0036
Plasmodium vivax JmjC domain containing protein 0.0037 0.0182 0.0274
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2983 0.2974
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0085 0.0071
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0332 0.0289
Brugia malayi Peptidase family M1 containing protein 0.0039 0.0199 0.0269
Echinococcus multilocularis geminin 0.0166 0.201 0.1999
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0205 0.0191
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0343 0.0527
Echinococcus granulosus aminopeptidase N 0.0039 0.0199 0.0185
Onchocerca volvulus 0.0039 0.0199 0.0234
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0151 0.0182
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0038 0.0189 0.0333
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0332 0.158
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0726 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Giardia lamblia Fructose-bisphosphate aldolase 0.0329 0.4335 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0151 0.0151
Schistosoma mansoni survival motor neuron protein 0.0048 0.0329 0.0281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0281 0.0267
Loa Loa (eye worm) hypothetical protein 0.0199 0.2481 0.2481
Plasmodium vivax hypothetical protein, conserved 0.004 0.0213 0.0545
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.4335 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0199 0.0151
Echinococcus multilocularis phd:f box containing protein 0.0037 0.0182 0.0169
Onchocerca volvulus 0.0035 0.0151 0.0159
Loa Loa (eye worm) hypothetical protein 0.0116 0.1301 0.1301
Schistosoma mansoni jumonji/arid domain-containing protein 0.0142 0.1671 0.163
Brugia malayi jmjC domain containing protein 0.0037 0.0182 0.0239
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0199
Trypanosoma brucei Aminopeptidase M1, putative 0.0039 0.0199 1
Onchocerca volvulus 0.0035 0.0151 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0512 0.3144
Echinococcus granulosus lysine specific demethylase 6a 0.0037 0.0182 0.0169
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0726 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0116 0.1301 1
Echinococcus granulosus lamin 0.0053 0.0405 0.0392
Brugia malayi jmjC domain containing protein 0.0037 0.0182 0.0239
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0275 0.0833
Treponema pallidum fructose-bisphosphate aldolase 0.0329 0.4335 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0391 0.0391
Onchocerca volvulus 0.0039 0.0199 0.0234
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0038 0.0189 0.7923
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.1973 0.3456
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1026 0.1755
Loa Loa (eye worm) hypothetical protein 0.0037 0.0182 0.0182
Schistosoma mansoni jumonji domain containing protein 0.0302 0.3947 0.3917
Echinococcus granulosus jumonji domain containing 1A 0.0037 0.0182 0.0169
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0085
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus multilocularis lysine specific demethylase 6a 0.0037 0.0182 0.0169
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.038 0.5059 0.5052
Echinococcus granulosus intermediate filament protein 0.0053 0.0405 0.0392
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.0199 0.0077
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Schistosoma mansoni hypothetical protein 0.0038 0.0189 0.014
Trypanosoma brucei aminopeptidase, putative 0.0039 0.0199 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0039 0.0199 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0061 0.0512 0.0512
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0405 0.0639
Toxoplasma gondii PHD-finger domain-containing protein 0.0116 0.1301 1
Echinococcus granulosus JmjC domain containing protein 4 0.0037 0.0182 0.0169
Echinococcus multilocularis jumonji domain containing protein 0.0161 0.1948 0.1937
Brugia malayi beta-lactamase family protein 0.0035 0.0151 0.0182
Echinococcus granulosus phd:f box containing protein 0.0037 0.0182 0.0169
Echinococcus granulosus cpg binding protein 0.003 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.1908 0.1896
Brugia malayi jmjC domain containing protein 0.038 0.5059 0.9001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0281 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0512 0.0465
Echinococcus multilocularis peregrin 0.012 0.1358 0.1346
Brugia malayi PHD-finger family protein 0.0039 0.0212 0.0292
Brugia malayi PHD-finger family protein 0.0116 0.1301 0.2249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0281 0.0233
Schistosoma mansoni lamin 0.0053 0.0405 0.0358
Brugia malayi jmjC domain containing protein 0.0037 0.0182 0.0239
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0405 0.0405
Schistosoma mansoni phd/f-box containing protein 0.0037 0.0182 0.0134
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0332 0.158
Brugia malayi beta-lactamase 0.0035 0.0151 0.0182
Plasmodium vivax SET domain protein, putative 0.0061 0.0512 0.3144
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0036
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0199 1
Schistosoma mansoni cpg binding protein 0.003 0.0072 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0085 0.0064
Trypanosoma cruzi aminopeptidase, putative 0.0039 0.0199 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0199 1
Echinococcus granulosus geminin 0.0166 0.201 0.1999
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0039 0.0199 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0239 0.306 0.306
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0151 0.0137
Brugia malayi intermediate filament protein 0.0053 0.0405 0.0639
Mycobacterium ulcerans aminopeptidase N PepN 0.0039 0.0199 0.027
Brugia malayi beta-lactamase family protein 0.0035 0.0151 0.0182
Onchocerca volvulus 0.0061 0.0512 0.0725
Brugia malayi Bromodomain containing protein 0.012 0.1358 0.2351
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0037 0.0182 0.6531
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1938 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0039 0.0199 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Schistosoma mansoni hypothetical protein 0.0116 0.1301 0.1258
Schistosoma mansoni lamin 0.0053 0.0405 0.0358
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Loa Loa (eye worm) peptidase family M1 containing protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1026 0.1026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1938 0.6612
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0038 0.0189 0.7923
Trypanosoma cruzi Aminopeptidase M1, putative 0.0039 0.0199 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4335 0.6654
Trichomonas vaginalis set domain proteins, putative 0.0476 0.6438 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0037 0.0182 0.0274
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0182 0.0182
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0036
Giardia lamblia PHD finger protein 15 0.0116 0.1301 0.2526
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.0199 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0281 0.0233
Loa Loa (eye worm) beta-lactamase 0.0035 0.0151 0.0151
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0199 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Schistosoma mansoni hypothetical protein 0.0048 0.0329 0.0281
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0151 0.0102
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.0199 0.0185
Loa Loa (eye worm) aminopeptidase N 0.0039 0.0199 0.0199
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0037 0.0182 0.6531
Onchocerca volvulus Alhambra homolog 0.0116 0.1301 0.1959
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0495 0.2998
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1026 0.1755
Loa Loa (eye worm) hypothetical protein 0.0035 0.0151 0.0151
Schistosoma mansoni intermediate filament proteins 0.0053 0.0405 0.0358
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0037 0.0182 0.0274
Schistosoma mansoni jumonji/arid domain-containing protein 0.0142 0.1671 0.163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.032 0.0272
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0332 0.0289
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0275 0.0185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0182 0.0182
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.1973 0.1933
Schistosoma mansoni protein phosphatase 2C 0.0037 0.0182 0.0134
Brugia malayi TATA binding protein associated factor 0.0039 0.0199 0.0269
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.1973 0.1962
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.0199 0.042
Schistosoma mansoni cpg binding protein 0.003 0.0072 0.0023

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 25 ug ml-1 Antimicrobial activity against Mycobacterium tuberculosis H37Rv after 9 to 12 days by CLSI microbroth dilution technique ChEMBL. 19386501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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