Detailed information for compound 1057904

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.818 | Formula: C19H18ClN3O2
  • H donors: 2 H acceptors: 3 LogP: 3.31 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)[C@@H](NC(=O)c1cccc(c1)C)Cc1cccc(c1)Cl
  • InChi: 1S/C19H18ClN3O2/c1-13-4-2-6-15(10-13)18(24)23-17(19(25)22-9-8-21)12-14-5-3-7-16(20)11-14/h2-7,10-11,17H,9,12H2,1H3,(H,22,25)(H,23,24)/t17-/m0/s1
  • InChiKey: RNABZOAFYBXFAJ-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin V Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin V 334 aa 357 aa 29.7 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Thioredoxin reductase 0.0048 0.0944 0.0819
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Plasmodium falciparum thioredoxin reductase 0.0048 0.0944 0.3162
Toxoplasma gondii thioredoxin reductase 0.0048 0.0944 0.2902
Brugia malayi Cathepsin L-like precursor 0.0077 0.1837 0.1725
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0211 0.0472
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.1385 0.1441
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.1385 0.136
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0025 0.0249 0.0759
Echinococcus granulosus cathepsin b 0.0186 0.5136 0.5763
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.5136 0.5763
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.1385 0.1267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0249 0.0131
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1332 0.1437
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Echinococcus multilocularis musashi 0.0027 0.032 0.0213
Loa Loa (eye worm) hypothetical protein 0.0029 0.0366 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0025 0.0249 0.0136
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1332 0.1437
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0119 0.3123 0.3444
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0249 0.0115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1356 0.4382
Plasmodium vivax vivapain-2 0.0113 0.292 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.3873 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0249 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1837 0.1813
Brugia malayi Cathepsin L-like precursor 0.0036 0.0576 0.0447
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0036 0.0576 0.0447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0119 0.3123 0.3444
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0249 0.0759
Echinococcus multilocularis cathepsin L cysteine protease 0.0113 0.292 0.321
Mycobacterium tuberculosis Probable reductase 0.0109 0.2802 0.7235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.053 0.0455
Echinococcus granulosus cysteine protease 0.0061 0.1332 0.1379
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1332 0.1437
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0211 0.5911 0.6657
Echinococcus granulosus snurportin 1 0.0307 0.8812 1
Brugia malayi RNA, U transporter 1 0.0082 0.1975 0.1865
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Schistosoma mansoni hypothetical protein 0.0062 0.1385 0.1441
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.3873 1
Plasmodium falciparum serine repeat antigen 2 0.0025 0.0249 0.0759
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Schistosoma mansoni hypothetical protein 0.0031 0.0423 0.0332
Onchocerca volvulus 0.0025 0.0249 0.0097
Loa Loa (eye worm) glutathione reductase 0.0048 0.0944 0.0917
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0249 0.0136
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0249 0.0759
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0249 0.0115
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.1332 0.1213
Echinococcus granulosus intermediate filament protein 0.0027 0.032 0.0213
Onchocerca volvulus 0.0113 0.292 0.6916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Echinococcus multilocularis GPCR, family 2 0.0062 0.1385 0.1441
Loa Loa (eye worm) hypothetical protein 0.0024 0.0211 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0025 0.0249 0.0759
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.292 0.5569
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1332 0.1379
Echinococcus multilocularis cysteine protease 0.0113 0.292 0.321
Plasmodium vivax vivapain-3 0.0061 0.1332 0.4505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Schistosoma mansoni importin beta-1 0.0029 0.0366 0.0266
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0249 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.053 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Echinococcus multilocularis cathepsin L 0.0061 0.1332 0.1379
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0249 0.0136
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0249 0.0131
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0211 0.0472
Schistosoma mansoni zinc finger protein 0.0031 0.0423 0.0332
Onchocerca volvulus Cathepsin F homolog 0.0113 0.292 0.6916
Schistosoma mansoni bromodomain containing protein 0.0127 0.3341 0.3695
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Plasmodium falciparum cysteine proteinase falcipain 3 0.0113 0.292 1
Plasmodium falciparum serine repeat antigen 1 0.0025 0.0249 0.0759
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0366 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0113 0.292 0.3346
Loa Loa (eye worm) hypothetical protein 0.0153 0.4128 0.4111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1332 0.4296
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0025 0.0249 0.0759
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0249 0.022
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2802 0.7235
Onchocerca volvulus 0.0153 0.4128 1
Toxoplasma gondii cathepsin B 0.0075 0.176 0.5834
Trypanosoma cruzi cysteine protease, putative 0.0061 0.1332 0.2393
Schistosoma mansoni lamin 0.0027 0.032 0.0213
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0944 0.3162
Loa Loa (eye worm) intermediate filament protein 0.0027 0.032 0.0292
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0201 0.0131
Giardia lamblia Cathepsin B precursor 0.0075 0.176 0.1952
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.292 0.5569
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.3582 0.3493
Giardia lamblia Cathepsin L-like protease 0.0025 0.0249 0.0136
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.8459 1
Giardia lamblia Cysteine protease 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.1332 0.1437
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0025 0.0249 0.0136
Entamoeba histolytica cysteine protease, putative 0.0113 0.292 0.3346
Trypanosoma cruzi ISWI complex protein 0.0031 0.0423 0.0576
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0249 0.0115
Echinococcus granulosus cathepsin L 0.0025 0.0249 0.0131
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0249 0.0136
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0211 0.027
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0211 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0249 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Plasmodium falciparum cysteine proteinase falcipain 1 0.0061 0.1332 0.4505
Schistosoma mansoni hypothetical protein 0.0307 0.8812 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Echinococcus multilocularis cysteine protease 0.0113 0.292 0.321
Entamoeba histolytica hypothetical protein 0.0023 0.0201 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Echinococcus multilocularis cathepsin b 0.0186 0.5136 0.5763
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0201 0.0079
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Onchocerca volvulus Cathepsin L homolog 0.0113 0.292 0.6916
Loa Loa (eye worm) hypothetical protein 0.0034 0.053 0.0502
Brugia malayi Latrophilin receptor protein 2 0.0062 0.1385 0.1267
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.292 0.5569
Loa Loa (eye worm) hypothetical protein 0.0113 0.292 0.29
Schistosoma mansoni lamin 0.0027 0.032 0.0213
Brugia malayi hypothetical protein 0.0153 0.4128 0.4048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0211 0.0472
Leishmania major hypothetical protein, conserved 0.0031 0.0423 0.1034
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.053 0.0455
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0025 0.0249 0.0136
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0249 0.0097
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0249 0.0227
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0186 0.5136 0.5763
Toxoplasma gondii cathepsin CPC2 0.0025 0.0249 0.0407
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1332 0.4296
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0249 0.0115
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2802 0.7235
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0944 0.1616
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0864 0.084
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.032 0.0292
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.1332 0.1213
Echinococcus granulosus importin subunit beta 1 0.0029 0.0366 0.0266
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2802 0.7235
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.2802 0.7075
Loa Loa (eye worm) hypothetical protein 0.0027 0.0305 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0249 0.022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.8459 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0366 0.0828
Giardia lamblia Cysteine protease 0.0025 0.0249 0.0136
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0211 0.0472
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1356 0.3451
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.053 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0075 0.176 0.1952
Brugia malayi Importin beta-1 subunit 0.0029 0.0366 0.0234
Giardia lamblia Cathepsin L-like protease 0.0025 0.0249 0.0136
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Loa Loa (eye worm) hypothetical protein 0.0036 0.0576 0.0548
Echinococcus granulosus GPCR family 2 0.0062 0.1385 0.1441
Loa Loa (eye worm) hypothetical protein 0.0142 0.3794 0.3775
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0061 0.1332 0.2393
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.292 0.321
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0025 0.0249 0.0759
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Echinococcus granulosus cathepsin l1 0.0113 0.292 0.321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.1332 0.1437
Plasmodium falciparum serine repeat antigen 9 0.0025 0.0249 0.0759
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1356 0.1406
Schistosoma mansoni hypothetical protein 0.0041 0.0748 0.0706
Giardia lamblia Encystation-specific protease 0.0025 0.0249 0.0136
Plasmodium falciparum glutathione reductase 0.0048 0.0944 0.3162
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.8459 0.5
Loa Loa (eye worm) hypothetical protein 0.0135 0.3582 0.3563
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0576 0.0548
Toxoplasma gondii cathepsin CPL 0.0113 0.292 1
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Onchocerca volvulus 0.0113 0.292 0.6916
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0249 0.0136
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0201 0.0079
Brugia malayi MH2 domain containing protein 0.0119 0.3107 0.3012
Echinococcus granulosus cathepsin l1 0.0077 0.1837 0.1962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.3107 0.3087
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0025 0.0249 0.0759
Onchocerca volvulus 0.0113 0.292 0.6916
Echinococcus granulosus lamin 0.0027 0.032 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0113 0.292 0.3346
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1332 0.1379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0113 0.292 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0113 0.292 0.321
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0249 0.0759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Loa Loa (eye worm) hypothetical protein 0.0036 0.0576 0.0548
Echinococcus granulosus lamin dm0 0.0027 0.032 0.0213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0113 0.292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Loa Loa (eye worm) hypothetical protein 0.0036 0.0576 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0025 0.0249 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0211 0.0544
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0249 0.0136
Brugia malayi cathepsin L-like precursor 0.0077 0.1837 0.1725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0944 0.0917
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0249 0.0115
Leishmania major importin beta-1 subunit, putative 0.0023 0.0201 0.0235
Loa Loa (eye worm) hypothetical protein 0.0085 0.2086 0.2063
Echinococcus multilocularis cathepsin b 0.0186 0.5136 0.5763
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.1332 0.2393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Echinococcus granulosus cathepsin b 0.0186 0.5136 0.5763
Entamoeba histolytica hypothetical protein 0.0025 0.0249 0.0136
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.8459 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.197 0.1947
Loa Loa (eye worm) ctsf protein 0.0113 0.292 0.29
Schistosoma mansoni hypothetical protein 0.0062 0.1385 0.1441
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1678 0.1778
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0025 0.0249 0.0759
Plasmodium vivax importin-beta 2, putative 0.0029 0.0366 0.1164
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Onchocerca volvulus 0.0027 0.032 0.028
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.3171 0.8188
Loa Loa (eye worm) hypothetical protein 0.0062 0.1385 0.136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.1332 0.2393
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0113 0.292 0.29
Trypanosoma cruzi cruzipain precursor, putative 0.0113 0.292 0.5569
Schistosoma mansoni hypothetical protein 0.0062 0.1385 0.1441
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1678 0.1778
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0075 0.176 0.5834
Toxoplasma gondii cathepsin CPC1 0.0025 0.0249 0.0407
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0576 0.0447
Giardia lamblia Cathepsin B precursor 0.0075 0.176 0.1952
Loa Loa (eye worm) hypothetical protein 0.0077 0.1826 0.1802
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0211 0.0182
Brugia malayi cathepsin L precursor 0.0025 0.0249 0.0115
Loa Loa (eye worm) hypothetical protein 0.0027 0.032 0.0292
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1837 0.1813
Echinococcus multilocularis snurportin 1 0.0307 0.8812 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.1837 0.2045
Plasmodium vivax vivapain-2 0.0113 0.292 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0029 0.0076
Toxoplasma gondii preprocathepsin c precursor, putative 0.0025 0.0249 0.0407
Brugia malayi Cathepsin L-like cysteine proteinase 0.0077 0.1837 0.1725
Leishmania major cysteine peptidase A (CPA) 0.0113 0.292 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Schistosoma mansoni hypothetical protein 0.0171 0.4691 0.5251
Echinococcus granulosus geminin 0.0171 0.4691 0.5251
Onchocerca volvulus 0.0113 0.292 0.6916
Schistosoma mansoni zinc finger protein 0.0039 0.0683 0.0632
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0249 0.0136
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.292 0.3346
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0864 0.084
Echinococcus granulosus cathepsin L cysteine proteinase 0.0113 0.292 0.321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Echinococcus multilocularis zinc finger protein 0.0039 0.0683 0.0632
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Onchocerca volvulus Cathepsin L homolog 0.0113 0.292 0.6916
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0249 0.022
Trypanosoma cruzi ISWI complex protein 0.0031 0.0423 0.0576
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0186 0.5136 1
Brugia malayi PHD-finger family protein 0.005 0.1008 0.0884
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0249 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Brugia malayi Cathepsin L-like precursor 0.0077 0.1837 0.1725
Trypanosoma brucei ISWI complex protein 0.0031 0.0423 0.1034
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.292 0.5569
Plasmodium falciparum serine repeat antigen 6 0.0025 0.0249 0.0759
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0113 0.292 0.29
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.053 0.0455
Plasmodium vivax unspecified product 0.0025 0.0249 0.0759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.1332 0.2393
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0944 0.0931
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0366 0.0828
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0201 0.0079
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0135 0.0367
Loa Loa (eye worm) hypothetical protein 0.0186 0.5136 0.5122
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0075 0.176 0.3249
Plasmodium falciparum serine repeat antigen 3 0.0025 0.0249 0.0759
Brugia malayi glutathione reductase 0.0048 0.0944 0.0819
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0211 0.0544
Trypanosoma brucei cysteine peptidase C (CPC) 0.0075 0.176 0.5834
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0211 0.0472
Schistosoma mansoni hypothetical protein 0.0171 0.4691 0.5251
Entamoeba histolytica cysteine proteinase, putative 0.0077 0.1837 0.2045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0211 0.009
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0567 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Onchocerca volvulus 0.0113 0.292 0.6916
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0366 0.0828
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0075 0.176 0.1873
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.053 0.0455
Loa Loa (eye worm) hypothetical protein 0.0024 0.0211 0.0182
Echinococcus granulosus cathepsin L 0.0061 0.1332 0.1379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Plasmodium falciparum serine repeat antigen 7 0.0025 0.0249 0.0759
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0249 0.0131
Brugia malayi intermediate filament protein 0.0027 0.032 0.0187
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1332 0.1379
Loa Loa (eye worm) hypothetical protein 0.0346 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1356 0.1406
Plasmodium vivax vivapain-1 0.0061 0.1332 0.4505
Onchocerca volvulus 0.0027 0.032 0.028
Plasmodium vivax unspecified product 0.0061 0.1332 0.4505
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0211 0.5911 0.6657
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.5136 0.5763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0211 0.0076
Onchocerca volvulus 0.0113 0.292 0.6916
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Schistosoma mansoni hypothetical protein 0.0062 0.1385 0.1441
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.5474 0.5412
Giardia lamblia Cysteine protease 0.0025 0.0249 0.0136
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0249 0.0131
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0211 0.009
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0025 0.0249 0.0759
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.053 0.0455
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1332 0.1437
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0576 0.0881
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1356 0.3451
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0025 0.0249 0.0759
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0135 0.0106
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0249 0.0131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0211 0.009
Loa Loa (eye worm) cathepsin B 0.0075 0.176 0.1736
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0249 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.1837 0.2045
Entamoeba histolytica cysteine proteinase 2 0.0061 0.1332 0.1437
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Giardia lamblia Hypothetical protein 0.0025 0.0249 0.0136
Echinococcus granulosus zinc finger protein 0.0039 0.0683 0.0632
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.3107 0.3087
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0211 0.027
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0864 0.084
Plasmodium falciparum serine repeat antigen 4 0.0025 0.0249 0.0759
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.5474 0.5461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Plasmodium falciparum serine repeat antigen 8 0.0025 0.0249 0.0759
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0135 0.0367
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Schistosoma mansoni cathepsin F (C01 family) 0.0077 0.1837 0.1962
Schistosoma mansoni cathepsin s 0.0036 0.0576 0.0508
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.3171 0.8188
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1356 0.4382
Echinococcus granulosus cathepsin l cysteine peptidase 0.0113 0.292 0.321
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2802 0.7235
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0249 0.0115
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0113 0.292 0.321
Plasmodium falciparum serine repeat antigen 5 0.0025 0.0249 0.0759
Echinococcus multilocularis cathepsin L cysteine protease 0.0113 0.292 0.321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Giardia lamblia Cathepsin B precursor 0.0075 0.176 0.1952
Brugia malayi Bromodomain containing protein 0.0077 0.1822 0.171
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0025 0.0249 0.0136
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.5136 0.5763
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0748 0.0721
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0249 0.0131
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0025 0.0249 0.0759
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.3171 0.8188
Entamoeba histolytica cysteine proteinase 1, putative 0.0061 0.1332 0.1437
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Mycobacterium ulcerans hypothetical protein 0.0024 0.0211 0.0472
Echinococcus multilocularis cathepsin L 0.0025 0.0249 0.0131
Leishmania major trypanothione reductase 0.0048 0.0944 0.2902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Schistosoma mansoni hypothetical protein 0.0135 0.3582 0.3972
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Brugia malayi fibroinase precursor 0.0025 0.0249 0.0115
Brugia malayi cathepsin B-like cysteine proteinase 0.0186 0.5136 0.5069
Echinococcus multilocularis lamin 0.0027 0.032 0.0213
Schistosoma mansoni cathepsin C 0.0025 0.0249 0.0131
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0211 0.0076
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.3171 0.8084
Schistosoma mansoni intermediate filament proteins 0.0027 0.032 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0249 0.0136
Trypanosoma cruzi cruzipain precursor, putative 0.0036 0.0576 0.0881
Giardia lamblia Hypothetical protein 0.0025 0.0249 0.0136
Plasmodium vivax glutathione reductase, putative 0.0048 0.0944 0.3162
Trypanosoma brucei trypanothione reductase 0.0048 0.0944 0.2902
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.292 0.3346
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.3873 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.292 0.321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0944 0.2436
Giardia lamblia Cysteine protease 0.0025 0.0249 0.0136
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0025 0.0249 0.0759
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1356 0.1406
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0249 0.0759
Plasmodium falciparum importin beta, putative 0.0029 0.0366 0.1164
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1356 0.3451
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.8812 0.8808
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1356 0.1406
Onchocerca volvulus 0.0113 0.292 0.6916
Brugia malayi Bromodomain containing protein 0.015 0.4054 0.3972
Echinococcus multilocularis geminin 0.0171 0.4691 0.5251
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1356 0.3501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.053 0.0455
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.032 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Brugia malayi Papain family cysteine protease containing protein 0.0113 0.292 0.2823
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0249 0.0136
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2802 0.7235
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0029 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.1385 0.1441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0249 0.0136
Echinococcus granulosus cathepsin L cysteine protease 0.0061 0.1332 0.1379
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0077 0.1837 0.3403
Loa Loa (eye worm) cysteine protease 0.0113 0.292 0.29
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0249 0.0227
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0944 0.0931
Onchocerca volvulus 0.0077 0.1837 0.4152
Plasmodium vivax unspecified product 0.0036 0.0576 0.1891
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0025 0.0249 0.0759
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0211 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0211 0.0472
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0211 0.027
Loa Loa (eye worm) hypothetical protein 0.0077 0.1837 0.1813
Echinococcus multilocularis lamin dm0 0.0027 0.032 0.0213
Loa Loa (eye worm) fibroinase 0.0113 0.292 0.29

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.2 Inhibition of cathepsin K ChEMBL. 19515558
IC50 (binding) = 5.3 Inhibition of cathepsin B ChEMBL. 19515558
IC50 (binding) = 6.1 Inhibition of cathepsin L2 ChEMBL. 19515558
IC50 (binding) = 6.4 Inhibition of cathepsin S ChEMBL. 19515558
IC50 (binding) = 6.6 Inhibition of cathepsin L ChEMBL. 19515558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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