Detailed information for compound 105797

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 414.382 | Formula: C22H28BrN3
  • H donors: 0 H acceptors: 2 LogP: 6.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(C1CC1)C1CC1)c1nc(C)c(c(n1)c1ccc(cc1)Br)C
  • InChi: 1S/C22H28BrN3/c1-4-13-26(21(17-5-6-17)18-7-8-18)22-24-15(3)14(2)20(25-22)16-9-11-19(23)12-10-16/h9-12,17-18,21H,4-8,13H2,1-3H3
  • InChiKey: DXBZAZZHAFBGOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0101 0.0434
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0101 0.0185
Plasmodium falciparum heat shock protein 90 0.0032 0.0108 1
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.064 0.118
Onchocerca volvulus 0.0056 0.0301 0.0948
Onchocerca volvulus 0.0056 0.0301 0.0948
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0054 0.0074
Echinococcus multilocularis tumor protein p63 0.0337 0.2588 0.4048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0091 0.0141
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.01 0.0184
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0301 0.1303
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1247 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0392
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0382 0.0597
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0101 0.2621
Echinococcus granulosus geminin 0.0338 0.2597 0.4795
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Loa Loa (eye worm) hypothetical protein 0.0049 0.0247 0.1066
Echinococcus multilocularis X box binding protein 1 0.0286 0.2171 0.3396
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0074 0.3947
Schistosoma mansoni hypothetical protein 0.004 0.0174 0.0319
Trichomonas vaginalis pc-MYB2, putative 0.0028 0.0074 0.3947
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0075 0.4006
Echinococcus granulosus peroxidasin 0.0056 0.0301 0.0555
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0049 0.4193
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0652 0.2825
Echinococcus granulosus X box binding protein 1 0.0286 0.2171 0.4007
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0392
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0001 0.0024
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0054 0.0098
Brugia malayi ecdysteroid receptor 0.003 0.0091 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0091 0.0392
Schistosoma mansoni endoplasmin 0.0032 0.0108 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0091 0.0392
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0091 0.0141
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0003 0.0008
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0054 0.2869
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0101 0.0434
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0108 0.0462
Schistosoma mansoni heat shock protein 0.0032 0.0108 0.0197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0001 0.0024
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0301 0.1303
Echinococcus granulosus microtubule associated protein 2 0.0684 0.5416 1
Echinococcus multilocularis heat shock protein 90 0.0032 0.0108 0.0167
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0101 0.0156
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0074 0.1144
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0028 0.0075 0.01
Echinococcus multilocularis heat shock protein 90 0.0026 0.0054 0.0083
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0101 0.2639
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0091 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0091 0.0392
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0091 0.0141
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.064 0.2772
Onchocerca volvulus Peroxidase homolog 0.0056 0.0301 0.0948
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0301 0.1303
Brugia malayi Peroxidasin 0.0056 0.0301 0.1303
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0352 0.2708 0.2707
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.064 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.0091 0.0167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0091 0.0167
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0074 0.3947
Loa Loa (eye worm) blistered cuticle protein 3 0.0056 0.0301 0.1303
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0382 0.1655
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0382 0.597
Brugia malayi hypothetical protein 0.0025 0.0049 0.0207
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0301 0.1303
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0392
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0091 0.0392
Loa Loa (eye worm) hypothetical protein 0.0051 0.0263 0.1137
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0156 0.0243
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0301 0.1303
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0392
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0091 0.0167
Echinococcus multilocularis protein patched 0.0042 0.0186 0.029
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0091 0.0167
Echinococcus granulosus FTZ F1 alpha 0.003 0.0091 0.0167
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0108 0.2812
Leishmania major cytochrome p450-like protein 0.0019 0.0003 0.005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0091 0.0167
Loa Loa (eye worm) hypothetical protein 0.0121 0.0834 0.3614
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0101 0.014
Schistosoma mansoni hypothetical protein 0.0031 0.01 0.0184
Onchocerca volvulus 0.0049 0.0247 0.0701
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0091 0.0141
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0049 0.1271
Loa Loa (eye worm) pax transcription factor protein 2 0.024 0.1799 0.7798
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0101 0.0197
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0091 0.0392
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0382 0.0704
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0091 0.0392
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0301 0.1303
Echinococcus granulosus endoplasmin 0.0026 0.0054 0.0098
Trypanosoma brucei heat shock protein, putative 0.0032 0.0108 0.2794
Echinococcus multilocularis geminin 0.0338 0.2597 0.4063
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0108 0.0221
Schistosoma mansoni nuclear hormone receptor 0.003 0.0091 0.0167
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0091 0.0167
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0652 0.2825
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0108 0.2794
Trichomonas vaginalis MYB, putative 0.0028 0.0075 0.4006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0091 0.0167
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0247 0.0454
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0382 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0091 0.0392
Trichomonas vaginalis MYB3r3, putative 0.0028 0.0074 0.3947
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.01 0.0432
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0896 0.7137 1
Echinococcus granulosus tumor protein p63 0.0337 0.2588 0.4777
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0352 0.2708 0.3747
Schistosoma mansoni heat shock protein 0.0032 0.0108 0.0197
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0101 0.9349
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0652 0.1203
Trypanosoma brucei heat shock protein, putative 0.0032 0.0108 0.2794
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0382 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0091 0.0167
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0186 0.0804
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Schistosoma mansoni hypothetical protein 0.0031 0.01 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0091 0.0392
Echinococcus multilocularis endoplasmin 0.0026 0.0054 0.0083
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0382 1
Schistosoma mansoni hypothetical protein 0.0031 0.01 0.0184
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0091 0.0167
Trypanosoma brucei heat shock protein, putative 0.0032 0.0108 0.2794
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0074 0.3947
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0091 0.0141
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0054 0.1394
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Brugia malayi Blistered cuticle protein 3 0.0056 0.0301 0.1303
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0003 0.0002
Brugia malayi Cytochrome P450 family protein 0.0019 0.0003 0.0008
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0074 0.3947
Brugia malayi CHE-14 protein 0.0042 0.0186 0.0804
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0003 0.0074
Schistosoma mansoni hypothetical protein 0.004 0.0174 0.0319
Echinococcus multilocularis expressed conserved protein 0.0092 0.0592 0.0925
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0392
Brugia malayi MH2 domain containing protein 0.0118 0.0809 0.3505
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0091 0.0141
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0054 0.2869
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0108 1
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0108 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0652 0.2825
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0101 0.0156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0091 0.0141
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0054 0.2869
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0091 0.0167
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0054 0.4987
Echinococcus granulosus heat shock protein 0.0032 0.0108 0.0197
Schistosoma mansoni hypothetical protein 0.0338 0.2597 0.4795
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.01 0.0432
Brugia malayi steroid hormone receptor 0.003 0.0091 0.0392
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Brugia malayi hypothetical protein 0.0056 0.0301 0.1303
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0091 0.0167
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.01 0.0184
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0108 0.2812
Brugia malayi hypothetical protein 0.0302 0.2306 1
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.5416 0.8474
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0382 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0091 0.0392
Brugia malayi heat shock protein 90 0.0032 0.0108 0.0462
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0074 0.1144
Echinococcus granulosus expressed conserved protein 0.0092 0.0592 0.1091
Echinococcus granulosus heat shock protein 90 0.0032 0.0108 0.0197
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0101 0.0197
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0003 0.005
Plasmodium vivax endoplasmin, putative 0.0032 0.0108 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0001 0.0024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0091 0.0167
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Schistosoma mansoni peroxidasin 0.0056 0.0301 0.0555
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.5416 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.01 0.0156
Echinococcus multilocularis GPCR, family 2 0.0031 0.01 0.0156
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0382 0.1655
Onchocerca volvulus 0.024 0.1799 0.7709
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0392
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0108 0.2812
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0003 0.0008
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0101 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0091 0.0392
Brugia malayi Cytochrome P450 family protein 0.0019 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0098 0.064 0.2772
Schistosoma mansoni hypothetical protein 0.004 0.0174 0.0319
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0091 0.0392
Schistosoma mansoni hypothetical protein 0.0068 0.0397 0.0731
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0049 0.125
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0397 0.1717
Giardia lamblia Myb 1-like protein 0.0028 0.0075 0.6959
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Onchocerca volvulus Huntingtin homolog 0.0121 0.0834 0.3354
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0091 0.0392
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.064 0.1
Onchocerca volvulus Chorion peroxidase homolog 0.0056 0.0301 0.0948
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Schistosoma mansoni thyroid hormone receptor 0.003 0.0091 0.0167
Brugia malayi Cytochrome P450 family protein 0.003 0.0087 0.0373
Echinococcus multilocularis peroxidasin 0.0056 0.0301 0.047
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0392
Echinococcus granulosus heat shock protein 90 0.0026 0.0054 0.0098
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0091 0.0392
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0896 0.7137 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0809 0.3505
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0091 0.0392
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0074 0.3947
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0652 0.2825
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0108 0.1668
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0091 0.0167
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0101 0.8879
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0091 0.0392
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0003 0.0074
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0301 0.1303
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Onchocerca volvulus 0.0056 0.0301 0.0948
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0108 0.2812
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0049 0.4193
Schistosoma mansoni peroxidasin 0.0056 0.0301 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0091 0.0392
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0392
Loa Loa (eye worm) endoplasmin 0.0032 0.0108 0.0462
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0074 0.1144
Leishmania major hypothetical protein, conserved 0.0025 0.0049 0.125
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0301 0.1303
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0186 0.0342
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Brugia malayi Endoplasmin precursor 0.0032 0.0108 0.0462
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0091 0.0167
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0981 0.1534
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0352 0.2708 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0108 0.2812
Onchocerca volvulus Peroxidase homolog 0.0056 0.0301 0.0948
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0101 0.0185
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0091 0.0141
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0108 0.2794
Schistosoma mansoni hypothetical protein 0.0286 0.2171 0.4007
Loa Loa (eye worm) hypothetical protein 0.0068 0.0397 0.1717
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0101 0.2621
Onchocerca volvulus Peroxidasin homolog 0.0056 0.0301 0.0948
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.6391 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0091 0.0392
Schistosoma mansoni hypothetical protein 0.0031 0.01 0.0184
Echinococcus multilocularis heat shock protein 0.0032 0.0108 0.0167
Echinococcus granulosus GPCR family 2 0.0031 0.01 0.0184
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0054 0.1414
Giardia lamblia Grp94/Hsp90 0.0026 0.0054 0.4987
Schistosoma mansoni hypothetical protein 0.0338 0.2597 0.4795
Brugia malayi Latrophilin receptor protein 2 0.0031 0.01 0.0432
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0108 0.5753
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0074 0.3947
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0101 0.2639
Brugia malayi isocitrate dehydrogenase 0.0031 0.0101 0.0434
Trichomonas vaginalis endoplasmin, putative 0.002 0.0006 0.0278
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1247 1 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0108 0.2794
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Onchocerca volvulus Dual oxidase homolog 0.0056 0.0301 0.0948
Schistosoma mansoni endoplasmin 0.0032 0.0108 0.0197
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0091 0.0392
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Schistosoma mansoni patched 1 0.0042 0.0186 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0091 0.0392
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0087 0.0373
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0809 0.3505
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Onchocerca volvulus Huntingtin homolog 0.0121 0.0834 0.3354
Trypanosoma brucei heat shock protein, putative 0.0032 0.0108 0.2794
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0156 0.0287
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0001 0.0024
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0981 0.181
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0074 0.1144
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0382 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0091 0.0392
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0301 0.1303
Trypanosoma brucei heat shock protein, putative 0.0032 0.0108 0.2794
Brugia malayi nuclear receptor NHR-88 0.003 0.0091 0.0392
Leishmania major heat shock protein 83-1 0.0032 0.0108 0.2794
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0075 0.4006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0091 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0186 1
Onchocerca volvulus Peroxidasin homolog 0.0056 0.0301 0.0948
Trichomonas vaginalis MYB72, putative 0.0028 0.0074 0.3947
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1303
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0108 0.2794
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.0432
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0091 0.0392
Brugia malayi Pax transcription factor protein 2 0.024 0.1799 0.7798
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0101 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0091 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0091 0.0392
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0054 0.1414
Loa Loa (eye worm) hypothetical protein 0.0121 0.0834 0.3614
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0108 0.0221
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0186 0.029
Trichomonas vaginalis C-MYB, putative 0.0028 0.0074 0.3947
Schistosoma mansoni coup transcription factor 0.003 0.0091 0.0167
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0108 0.1668
Trypanosoma brucei heat shock protein, putative 0.0032 0.0108 0.2794
Trichomonas vaginalis pc-MYB2, putative 0.0028 0.0074 0.3947
Echinococcus multilocularis protein dispatched 1 0.0048 0.0234 0.0365
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0054 0.0053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.01 0.0156
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0091 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0049 0.1271
Loa Loa (eye worm) hypothetical protein 0.0302 0.2306 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0091 0.0167
Trichomonas vaginalis heat shock protein, putative 0.002 0.0006 0.0278
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0186 0.0342
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0101 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0091 0.0167
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1247 1 1
Onchocerca volvulus 0.0302 0.2306 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0101 0.2621
Trichomonas vaginalis C-MYB, putative 0.0028 0.0074 0.3947
Trypanosoma brucei heat shock protein, putative 0.0032 0.0108 0.2794
Brugia malayi hypothetical protein 0.0121 0.0834 0.3614
Schistosoma mansoni hypothetical protein 0.004 0.0174 0.0319
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.0804
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0074 0.1144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0001 0.0024
Brugia malayi nuclear hormone receptor 0.003 0.0091 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0091 0.0392

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) 0 nM Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells; IA means Inactive ChEMBL. 15080983

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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