Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.4349 | 0.4001 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4349 | 0.4349 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.4349 | 0.4001 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.42 | 0.42 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.4349 | 0.4263 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.4349 | 0.4263 |
Echinococcus granulosus | lamin | 0.0031 | 0.4349 | 0.4263 |
Onchocerca volvulus | 0.0031 | 0.4349 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.4349 | 0.4349 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.4349 | 0.4263 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.058 | 0.058 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.4349 | 0.4349 |
Echinococcus multilocularis | lamin | 0.0031 | 0.4349 | 0.4263 |
Echinococcus multilocularis | musashi | 0.0031 | 0.4349 | 0.4263 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0149 | 0.0149 |
Onchocerca volvulus | 0.0031 | 0.4349 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 26 % | Displacement of [3H]ZM241385 from human adenosine A2a receptor expressed in human HeLa cells at 1 uM | ChEMBL. | 19346133 |
Activity (binding) | = 70 % | Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells at 1 uM | ChEMBL. | 19346133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.