TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.304 | Formula: C20H19Cl2N5
H donors: 0 H acceptors: 3 LogP: 4.48 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCC(c1nncn1C)N(c1ccc(c(c1)Cl)C#N)Cc1ccccc1Cl
InChi: 1S/C20H19Cl2N5/c1-3-19(20-25-24-13-26(20)2)27(12-15-6-4-5-7-17(15)21)16-9-8-14(11-23)18(22)10-16/h4-10,13,19H,3,12H2,1-2H3
InChiKey: PJVZVXZGMSGYOI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 19	Starlite/ChEMBL	References
Homo sapiens	progesterone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	cytochrome p450-like protein	cytochrome P450, family 2, subfamily C, polypeptide 19	490 aa	411 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0068	0.1574	0.1574
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.003	0.0479	0.0479
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0358	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0091	0.2258	0.2258
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0017	0.0091	0.0091
Giardia lamblia	Cysteine protease	0.0017	0.0091	0.0091
Leishmania major	cysteine peptidase A (CPA)	0.0091	0.2258	0.2258
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0017	0.0091	0.0091
Loa Loa (eye worm)	oxidoreductase	0.0358	1	1
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0358	1	1
Leishmania major	cathepsin L-like protease	0.0091	0.2258	0.2258
Onchocerca volvulus		0.0091	0.2258	0.2187
Echinococcus multilocularis	importin subunit beta 1	0.003	0.048	0.048
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0313	0.0313
Echinococcus granulosus	cathepsin L	0.0047	0.0969	0.0969
Trypanosoma brucei	aldo-keto reductase, putative	0.0358	1	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0247	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Entamoeba histolytica	aldose reductase, putative	0.0358	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Brugia malayi	Cathepsin L-like precursor	0.0091	0.2258	0.2258
Schistosoma mansoni	tyrosine kinase	0.0221	0.6013	0.6013
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Brugia malayi	Cathepsin L-like precursor	0.0061	0.1379	0.1379
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0394	0.0394
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.002	0.0171	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0072	0.168	0.168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Chlamydia trachomatis	glutamine binding protein	0.002	0.0171	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0017	0.0091	0.0091
Echinococcus granulosus	cathepsin l1	0.0091	0.2258	0.2258
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0358	1	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0358	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Brugia malayi	Cathepsin L-like precursor	0.0091	0.2258	0.2258
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0017	0.0091	0.0091
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0017	0.0091	0.0091
Echinococcus granulosus	cysteine protease	0.0047	0.0969	0.0969
Plasmodium falciparum	serine repeat antigen 2	0.0017	0.0091	0.0091
Trypanosoma cruzi	aldo/keto reductase, putative	0.0358	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0091	0.0091
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0358	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0969	0.0969
Giardia lamblia	Cathepsin L-like protease	0.0017	0.0091	0.0091
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0017	0.0091	0.0091
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0017	0.0091	0.0091
Mycobacterium leprae	Possible oxidoreductase	0.0358	1	1
Loa Loa (eye worm)	oxidoreductase	0.0358	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0091	0.2258	0.2258
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.048	0.048
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Onchocerca volvulus	Cathepsin L homolog	0.0091	0.2258	0.2187
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0091	0.2258	0.2258
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Schistosoma mansoni	ran	0.0022	0.0247	0.0247
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0358	1	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0068	0.1574	0.1574
Mycobacterium tuberculosis	Probable reductase	0.0091	0.2232	0.2232
Plasmodium falciparum	serine repeat antigen 4	0.0017	0.0091	0.0091
Brugia malayi	Cathepsin L-like precursor	0.0091	0.2258	0.2258
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0358	1	1
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0358	1	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0091	0.0091
Trypanosoma brucei	prostaglandin f synthase	0.0358	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Plasmodium vivax	importin-beta 2, putative	0.003	0.048	0.048
Entamoeba histolytica	cysteine proteinase, putative	0.0091	0.2258	0.2187
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0017	0.0091	0.0091
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1379	0.1379
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0091	0.2258	0.2258
Giardia lamblia	Cathepsin L precursor	0.0017	0.0091	0.0091
Onchocerca volvulus	Cathepsin F homolog	0.0091	0.2258	0.2187
Trichomonas vaginalis	aldo/keto reductase, putative	0.0358	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0017	0.0091	0.0091
Onchocerca volvulus		0.0061	0.1379	0.13
Giardia lamblia	Cysteine protease	0.0017	0.0091	0.0091
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0969	0.0969
Onchocerca volvulus		0.0091	0.2258	0.2187
Brugia malayi	cathepsin L-like cysteine proteinase	0.0017	0.0091	0.0091
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0091	0.2258	0.2258
Plasmodium vivax	unspecified product	0.0017	0.0091	0.0091
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0017	0.0091	0.0091
Schistosoma mansoni	pol-related	0.0358	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.003	0.0479	0.0479
Mycobacterium ulcerans	oxidoreductase	0.0358	1	1
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0174	0.4654	0.4654
Echinococcus multilocularis	cathepsin b	0.0017	0.0091	0.0091
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0247	0.0158
Schistosoma mansoni	cathepsin s	0.003	0.0479	0.0479
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Plasmodium falciparum	thioredoxin reductase	0.004	0.0754	0.0754
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0017	0.0091	0.0091
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0017	0.0091	0.0091
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0969	0.0887
Brugia malayi	Cathepsin L-like precursor	0.0061	0.1379	0.1379
Plasmodium vivax	serine-repeat antigen (SERA)	0.0017	0.0091	0.0091
Onchocerca volvulus		0.0358	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0061	0.1379	0.1379
Schistosoma mansoni	potassium channel beta	0.0358	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.002	0.0171	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.1379	0.1379
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Plasmodium falciparum	serine repeat antigen 7	0.0017	0.0091	0.0091
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0017	0.0091	0.0091
Trypanosoma cruzi	aldo-keto reductase	0.0358	1	1
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.0754	0.067
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.002	0.0171	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0358	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Leishmania major	cathepsin L-like protease	0.0091	0.2258	0.2258
Plasmodium falciparum	serine repeat antigen 8	0.0017	0.0091	0.0091
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0091	0.2232	0.2232
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Onchocerca volvulus		0.0091	0.2258	0.2187
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0017	0.0091	0.0091
Onchocerca volvulus		0.0358	1	1
Giardia lamblia	Cathepsin L-like protease	0.0017	0.0091	0.0091
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0091	0.2258	0.2258
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0174	0.4654	0.4654
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0017	0.0091	0.0091
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.048	0.048
Schistosoma mansoni	cathepsin S (C01 family)	0.0017	0.0091	0.0091
Schistosoma mansoni	ran	0.0022	0.0247	0.0247
Onchocerca volvulus		0.0091	0.2258	0.2187
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Brugia malayi	RNA, U transporter 1	0.0086	0.2101	0.2101
Giardia lamblia	Hypothetical protein	0.0017	0.0091	0.0091
Mycobacterium tuberculosis	Probable dehydrogenase	0.0091	0.2232	0.2232
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0358	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0174	0.4654	0.4654
Loa Loa (eye worm)	oxidoreductase	0.0358	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0394	0.0306
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0969	0.0969
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0358	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.048	0.0393
Onchocerca volvulus		0.0358	1	1
Entamoeba histolytica	aldose reductase, putative	0.0358	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0969	0.0969
Echinococcus multilocularis	aldo keto reductase	0.0358	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0969	0.0969
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0174	0.4654	0.4654
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0174	0.4654	0.4654
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0174	0.4654	0.4654
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0969	0.0887
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Plasmodium vivax	unspecified product	0.003	0.0479	0.0479
Plasmodium falciparum	glutathione reductase	0.004	0.0754	0.0754
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0323	0.899	0.8981
Onchocerca volvulus		0.0358	1	1
Giardia lamblia	Cathepsin L precursor	0.0017	0.0091	0.0091
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0017	0.0091	0.0091
Giardia lamblia	Cathepsin B precursor	0.0017	0.0091	0.0091
Echinococcus granulosus	cathepsin l1	0.0061	0.1379	0.1379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0091	0.0091
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Trypanosoma cruzi	major cysteine proteinase, putative	0.0017	0.0091	0.0091
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0017	0.0091	0.0091
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0091	0.2258	0.2258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0017	0.0091	0.0091
Toxoplasma gondii	aldo-keto reductase	0.0358	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Leishmania major	cathepsin L-like protease	0.0091	0.2258	0.2258
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0091	0.2232	0.2232
Echinococcus multilocularis	cathepsin L	0.0017	0.0091	0.0091
Brugia malayi	Thioredoxin reductase	0.004	0.0754	0.0754
Leishmania major	cathepsin L-like protease	0.0091	0.2258	0.2258
Trypanosoma brucei	trypanothione reductase	0.004	0.0754	0.0754
Trichomonas vaginalis	aldo/keto reductase, putative	0.0358	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0091	0.2258	0.2258
Giardia lamblia	Aldose reductase	0.0358	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0091	0.2258	0.2187
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0358	1	1
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0358	1	1
Plasmodium vivax	vivapain-2	0.0091	0.2258	0.2258
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0969	0.0969
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0174	0.4654	0.4654
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2258	0.2187
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Toxoplasma gondii	thioredoxin reductase	0.004	0.0754	0.0754
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0091	0.0091
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0068	0.1574	0.1574
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0969	0.0887
Toxoplasma gondii	cathepsin CPC1	0.0017	0.0091	0.0091
Schistosoma mansoni	cathepsin F (C01 family)	0.0091	0.2258	0.2258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0091	0.0091
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.002	0.0171	0.0171
Echinococcus multilocularis	aldo keto reductase	0.0358	1	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.6163	0.6163
Trypanosoma cruzi	cruzipain precursor, putative	0.0091	0.2258	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1379	0.13
Loa Loa (eye worm)	hypothetical protein	0.003	0.0479	0.0392
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0072	0.168	0.168
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0072	0.168	0.168
Echinococcus granulosus	thioredoxin glutathione reductase	0.004	0.0769	0.0769
Toxoplasma gondii	aldose reductase, putative	0.0358	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0017	0.0091	0.0091
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0174	0.4654	0.4654
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0358	1	1
Echinococcus multilocularis	aldo keto reductase	0.0358	1	1
Brugia malayi	cathepsin L precursor	0.0017	0.0091	0.0091
Leishmania major	dihydroorotate dehydrogenase	0.0174	0.4654	0.4654
Brugia malayi	Cathepsin L-like precursor	0.0091	0.2258	0.2258
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0358	1	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0017	0.0091	0.0091
Echinococcus granulosus	cathepsin L	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0017	0.0091	0.0091
Plasmodium falciparum	serine repeat antigen 3	0.0017	0.0091	0.0091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0072	0.168	0.168
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.003	0.0479	0.0392
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0969	0.0969
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0017	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1379	0.13
Echinococcus multilocularis	snurportin 1	0.0323	0.899	0.899
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Onchocerca volvulus	Cathepsin L homolog	0.0091	0.2258	0.2187
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0017	0.0091	0.0091
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0017	0.0091	0.0091
Mycobacterium tuberculosis	Probable oxidoreductase	0.0101	0.2526	0.2526
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Echinococcus granulosus	cathepsin b	0.0017	0.0091	0.0091
Schistosoma mansoni	aldo-keto reductase	0.0358	1	1
Trichomonas vaginalis	ran, putative	0.0022	0.0247	0.0247
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Echinococcus multilocularis	cathepsin L	0.0047	0.0969	0.0969
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.0754	0.0754
Giardia lamblia	Cathepsin B precursor	0.0017	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1379	0.13
Brugia malayi	Cathepsin L-like precursor	0.0091	0.2258	0.2258
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Echinococcus granulosus	cathepsin b	0.0017	0.0091	0.0091
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0091	0.0091
Onchocerca volvulus		0.0091	0.2258	0.2187
Plasmodium vivax	serine-repeat antigen (SERA)	0.0017	0.0091	0.0091
Echinococcus granulosus	tyrosine protein kinase shark	0.0226	0.6163	0.6163
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0091	0.2232	0.2232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0358	1	1
Plasmodium falciparum	aldehyde reductase, putative	0.0358	1	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0174	0.4654	0.4654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0017	0.0091	0.0091
Echinococcus multilocularis	aldo keto reductase	0.0358	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0017	0.0091	0.0091
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0101	0.2526	0.2526
Giardia lamblia	Cathepsin B precursor	0.0017	0.0091	0.0091
Trypanosoma cruzi	cysteine peptidase, putative	0.0091	0.2258	0.2258
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.003	0.0479	0.0479
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0358	1	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0358	1	1
Toxoplasma gondii	cathepsin CPC2	0.0017	0.0091	0.0091
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Plasmodium vivax	vivapain-3	0.0047	0.0969	0.0969
Plasmodium falciparum	serine repeat antigen 5	0.0017	0.0091	0.0091
Giardia lamblia	Cathepsin L precursor	0.0017	0.0091	0.0091
Brugia malayi	cathepsin F-like cysteine proteinase	0.003	0.0479	0.0479
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Brugia malayi	fibroinase precursor	0.0017	0.0091	0.0091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0313	0.0313
Giardia lamblia	Cysteine protease	0.0017	0.0091	0.0091
Leishmania major	cathepsin L-like protease	0.0091	0.2258	0.2258
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.048	0.048
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0969	0.0969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1379	0.1379
Entamoeba histolytica	cysteine protease, putative	0.0091	0.2258	0.2187
Giardia lamblia	Cathepsin L precursor	0.0017	0.0091	0.0091
Plasmodium vivax	vivapain-1	0.0047	0.0969	0.0969
Leishmania major	cathepsin L-like protease	0.0091	0.2258	0.2258
Trypanosoma cruzi	cysteine peptidase, putative	0.0091	0.2258	0.2258
Schistosoma mansoni	cathepsin B (C01 family)	0.0017	0.0091	0.0091
Onchocerca volvulus		0.0091	0.2258	0.2187
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0091	0.2258	0.2187
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.002	0.0171	0.0171
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Plasmodium falciparum	serine repeat antigen 9	0.0017	0.0091	0.0091
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0247	0.0247
Trichomonas vaginalis	aldo/keto reductase, putative	0.0358	1	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0072	0.168	0.168
Schistosoma mansoni	aldo-keto reductase	0.0358	1	1
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0313	0.0313
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0247	0.0247
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0091	0.0091
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0247	0.0247
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0017	0.0091	0.0091
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0017	0.0091	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0091	0.0091
Giardia lamblia	Aldose reductase	0.0358	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0358	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0017	0.0091	0.0091
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Echinococcus multilocularis	cysteine protease	0.0091	0.2258	0.2258
Schistosoma mansoni	cathepsin C	0.0017	0.0091	0.0091
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0969	0.0887
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Echinococcus multilocularis	cathepsin b	0.0017	0.0091	0.0091
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0174	0.4654	0.4654
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0017	0.0091	0.0091
Trypanosoma cruzi	major cysteine proteinase, putative	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Entamoeba histolytica	aldose reductase, putative	0.0358	1	1
Echinococcus granulosus	aldo keto reductase	0.0358	1	1
Giardia lamblia	Cathepsin B precursor	0.0017	0.0091	0.0091
Trypanosoma cruzi	aldo/keto reductase, putative	0.0358	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0174	0.4654	0.3118
Mycobacterium tuberculosis	Conserved protein	0.0358	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Loa Loa (eye worm)	hypothetical protein	0.003	0.0479	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0017	0.0091	0.0091
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0068	0.1574	0.1574
Schistosoma mansoni	hypothetical protein	0.0323	0.899	0.899
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0247	0.0247
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Giardia lamblia	Cathepsin B precursor	0.0017	0.0091	0.0091
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0969	0.0969
Plasmodium falciparum	importin beta, putative	0.003	0.048	0.048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Echinococcus multilocularis	nmda type glutamate receptor	0.0027	0.0394	0.0394
Loa Loa (eye worm)	oxidoreductase	0.0358	1	1
Leishmania major	aldo-keto reductase-like protein	0.0358	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0017	0.0091	0.0091
Echinococcus multilocularis	thioredoxin glutathione reductase	0.004	0.0769	0.0769
Trypanosoma cruzi	cysteine peptidase, putative	0.0091	0.2258	0.2258
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0969	0.0887
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0017	0.0091	0.0091
Giardia lamblia	Hypothetical protein	0.0017	0.0091	0.0091
Loa Loa (eye worm)	glutathione reductase	0.004	0.0754	0.067
Echinococcus multilocularis	cysteine protease	0.0091	0.2258	0.2258
Brugia malayi	Papain family cysteine protease containing protein	0.0091	0.2258	0.2258
Plasmodium vivax	unspecified product	0.0047	0.0969	0.0969
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0091	0.2258	0.2258
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0247	0.0247
Leishmania major	GTP-binding protein, putative	0.0022	0.0247	0.0247
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Plasmodium vivax	aldehyde reductase, putative	0.0358	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Leishmania major	prostaglandin f synthase, putative	0.0358	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0017	0.0091	0.0091
Toxoplasma gondii	cathepsin CPL	0.0091	0.2258	0.2258
Brugia malayi	Zinc finger, C2H2 type family protein	0.0068	0.1574	0.1574
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0969	0.0969
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.0969	0.0969
Plasmodium falciparum	serine repeat antigen 1	0.0017	0.0091	0.0091
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Onchocerca volvulus		0.0358	1	1
Giardia lamblia	Cathepsin L precursor	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0969	0.0969
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0969	0.0969
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0247	0.0247
Echinococcus granulosus	aldo keto reductase	0.0358	1	1
Giardia lamblia	Cathepsin B precursor	0.0017	0.0091	0.0091
Trypanosoma brucei	aldo/keto reductase, putative	0.0358	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0072	0.168	0.168
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Entamoeba histolytica	cysteine proteinase, putative	0.0091	0.2258	0.2187
Echinococcus multilocularis	cathepsin L cysteine protease	0.0091	0.2258	0.2258
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0091	0.2232	0.2232
Trichomonas vaginalis	aldo-keto reductase, putative	0.0358	1	1
Loa Loa (eye worm)	ctsf protein	0.0091	0.2258	0.2187
Trichomonas vaginalis	conserved hypothetical protein	0.0358	1	1
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0358	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0017	0.0091	0.0091
Giardia lamblia	Cathepsin B precursor	0.0017	0.0091	0.0091
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0027	0.0394	0.0394
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0969	0.0887
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0358	1	1
Brugia malayi	cathepsin L-like precursor	0.0061	0.1379	0.1379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0174	0.4654	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0091	0.0091
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0091	0.0091
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1379	0.13
Brugia malayi	Importin beta-1 subunit	0.003	0.048	0.048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0969	0.0969
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0061	0.1379	0.1379
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0091	0.0091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Leishmania major	cathepsin L-like protease	0.0091	0.2258	0.2258
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0247	0.0247
Loa Loa (eye worm)	cysteine protease	0.0091	0.2258	0.2187
Brugia malayi	NADH-dependent xylose reductase	0.0358	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0017	0.0091	0.0091
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0358	1	1
Loa Loa (eye worm)	fibroinase	0.0091	0.2258	0.2187
Entamoeba histolytica	hypothetical protein	0.0025	0.0313	0.0225
Loa Loa (eye worm)	hypothetical protein	0.003	0.0479	0.0392
Mycobacterium tuberculosis	Probable oxidoreductase	0.0358	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0969	0.0969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0313	0.0313
Echinococcus granulosus	aldo keto reductase	0.0358	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Entamoeba histolytica	Ran family GTPase	0.0022	0.0247	0.0158
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0358	1	1
Giardia lamblia	Cathepsin L precursor	0.0017	0.0091	0.0091
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0068	0.1574	0.1574
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0174	0.4654	0.4654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.2258	0.2258
Echinococcus granulosus	voltage gated potassium channel subunit	0.0358	1	1
Giardia lamblia	Cathepsin B precursor	0.0017	0.0091	0.0091
Echinococcus granulosus	snurportin 1	0.0323	0.899	0.899
Plasmodium falciparum	serine repeat antigen 6	0.0017	0.0091	0.0091
Schistosoma mansoni	importin beta-1	0.003	0.048	0.048
Plasmodium vivax	glutathione reductase, putative	0.004	0.0754	0.0754
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0174	0.4654	0.4654
Loa Loa (eye worm)	oxidoreductase	0.0358	1	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0247	0.0247
Echinococcus granulosus	nmda type glutamate receptor	0.0027	0.0394	0.0394
Plasmodium vivax	vivapain-2	0.0091	0.2258	0.2258
Onchocerca volvulus		0.0091	0.2258	0.2187
Mycobacterium ulcerans	hypothetical protein	0.0358	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0091	0.2258	0.2258
Leishmania major	trypanothione reductase	0.004	0.0754	0.0754
Leishmania major	cathepsin L-like protease	0.0091	0.2258	0.2258
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.0754	0.0754
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0969	0.0969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0091	0.0091
Giardia lamblia	Encystation-specific protease	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0091	0.2258	0.2258
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0247	0.0247
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.004	0.0754	0.0754
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0091	0.2258	0.2258
Echinococcus multilocularis	tyrosine protein kinase shark	0.0226	0.6163	0.6163
Brugia malayi	Cathepsin L-like precursor	0.0091	0.2258	0.2258
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0017	0.0091	0.0091
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0101	0.2526	0.2526
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0072	0.168	0.1604
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0017	0.0091	0.0091
Giardia lamblia	Cysteine protease	0.0017	0.0091	0.0091
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0101	0.2526	0.0378
Echinococcus granulosus	hypothetical protein	0.0358	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0091	0.2258	0.2258
Onchocerca volvulus		0.0358	1	1
Brugia malayi	glutathione reductase	0.004	0.0754	0.0754
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0358	1	1
Brugia malayi	Cathepsin L-like precursor	0.003	0.0479	0.0479
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0091	0.2258	0.2258
Onchocerca volvulus		0.0358	1	1
Toxoplasma gondii	cathepsin B	0.0017	0.0091	0.0091
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0313	0.0313
Echinococcus granulosus	importin subunit beta 1	0.003	0.048	0.048
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0969	0.0887

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.02 nM	Agonist activity at progesterone receptor in human T47D cells by alkaline phosphatase release based reporter gene assay	ChEMBL.	19376703
IC50 (binding)	= 16 nM	Binding affinity to progesterone receptor ligand binding domain by fluorimetric assay	ChEMBL.	19376703
IC50 (ADMET)	< 0.33 uM	Inhibition of CYP2C19	ChEMBL.	19376703
Intrinsic activity (functional)	= 97 %	Intrinsic agonist activity at progesterone receptor in human T47D cells by alkaline phosphatase release based reporter gene assay relative to progesterone	ChEMBL.	19376703

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL557293

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1058358