TDR Targets

Basic information

Technical information

TDR Targets ID: 1058458
Name: 5-[5-(3,4-dimethoxyphenyl)-3-thiophen-2-yl-4, 5-dihydropyrazol-1-yl]-5-oxopentanoic acid
MW: 402.464 | Formula: C20H22N2O5S
H donors: 1 H acceptors: 3 LogP: 2.45 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)C1CC(=NN1C(=O)CCCC(=O)O)c1cccs1
InChi: 1S/C20H22N2O5S/c1-26-16-9-8-13(11-17(16)27-2)15-12-14(18-5-4-10-28-18)21-22(15)19(23)6-3-7-20(24)25/h4-5,8-11,15H,3,6-7,12H2,1-2H3,(H,24,25)
InChiKey: OTCCCUZGVIZLFG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

5-[5-(3,4-dimethoxyphenyl)-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]-5-oxo-pentanoic acid
5-[5-(3,4-dimethoxyphenyl)-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]-5-oxopentanoic acid
5-[5-(3,4-dimethoxyphenyl)-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]-5-keto-valeric acid
5-[5-(3,4-dimethoxyphenyl)-3-thiophen-2-yl-4,5-dihydropyrazol-1-yl]-5-oxo-pentanoic acid
STOCK3S-47511
AP-845/42065538
BAS 06208279

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0782	0.0691
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.0165	0.1349
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0645	0.1254
Brugia malayi	hypothetical protein	0.0042	0.0217	0.0421
Loa Loa (eye worm)	hypothetical protein	0.013	0.1224	0.2382
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0645	0.1254
Brugia malayi	hypothetical protein	0.0042	0.0217	0.0421
Brugia malayi	nuclear hormone receptor family member odr-7	0.0037	0.0165	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0645	0.1254
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0115	0.1054	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.031	0.0147
Brugia malayi	nuclear receptor RXR	0.0037	0.0165	0.0321
Brugia malayi	nuclear receptor NHR-88	0.0079	0.0645	0.1254
Loa Loa (eye worm)	hypothetical protein	0.005	0.0311	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0645	0.1254
Schistosoma mansoni	nuclear hormone receptor	0.0079	0.0645	0.0487
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0206	0.0041
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0079	0.0645	0.0487
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0079	0.0645	0.0487
Brugia malayi	hypothetical protein	0.0037	0.0165	0.0321
Schistosoma mansoni	RAR-like nuclear receptor	0.0079	0.0645	0.0487
Schistosoma mansoni	survival motor neuron protein	0.0096	0.0839	0.0685
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0782	0.0627
Brugia malayi	Thioredoxin reductase	0.0039	0.0182	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0829	0.1613
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0079	0.0645	0.0487
Trichomonas vaginalis	inositol monophosphatase, putative	0.0115	0.1054	1
Entamoeba histolytica	hypothetical protein	0.0072	0.0559	0.5301
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0115	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0217	0.0421
Onchocerca volvulus		0.0037	0.0165	0.1349
Loa Loa (eye worm)	steroid hormone receptor	0.0079	0.0645	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0645	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1548	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0206	0.04
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0165	0.0321
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0165	0.0321
Onchocerca volvulus		0.0079	0.0645	0.5265
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0645	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0975	0.1898
Brugia malayi	photoreceptor-specific nuclear receptor	0.0079	0.0645	0.1254
Brugia malayi	hypothetical protein	0.0037	0.0165	0.0321
Brugia malayi	nuclear receptor RXR	0.0042	0.0217	0.0421
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0079	0.0645	0.1254
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0165	0.0321
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0079	0.0645	0.0537
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0037	0.0165	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0645	0.1254
Schistosoma mansoni	hypothetical protein	0.0039	0.0189	0.0024
Schistosoma mansoni	thyroid hormone receptor	0.0897	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0079	0.0645	0.1254
Schistosoma mansoni	inositol monophosphatase	0.0115	0.1054	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Echinococcus granulosus	geminin	0.0174	0.1729	0.1752
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.1297	0.1268
Schistosoma mansoni	patched 1	0.0041	0.0206	0.0041
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0158	0.1548	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0559	0.04
Onchocerca volvulus	Huntingtin homolog	0.013	0.1224	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0402	0.4336	0.8437
Entamoeba histolytica	hypothetical protein	0.0072	0.0559	0.5301
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0645	0.1254
Brugia malayi	nuclear hormone receptor	0.0037	0.0165	0.0321
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0206	0.0045
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0782	0.1522
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0217	0.0421
Brugia malayi	ecdysteroid receptor	0.0079	0.0645	0.1254
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0364	0.3908	0.7604
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0103	0.0916	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0099	0.0865	0.9434
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0182	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0079	0.0645	0.0487
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0782	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0786	0.873	0.8709
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0079	0.0645	0.1254
Brugia malayi	CHE-14 protein	0.0041	0.0206	0.04
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0079	0.0645	0.0537
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0079	0.0645	0.1254
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0645	0.1254
Schistosoma mansoni	hypothetical protein	0.005	0.031	0.0147
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0206	0.0045
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0079	0.0645	0.5265
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.031	0.0603
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0206	0.04
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0115	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0645	0.1254
Brugia malayi	nuclear receptor NHR-67	0.0037	0.0165	0.0321
Brugia malayi	ecdysone receptor	0.0037	0.0165	0.0321
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0182	0.1983
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0817	0.9092	0.9077
Brugia malayi	Inositol-1	0.0115	0.1054	0.2052
Echinococcus multilocularis	geminin	0.0174	0.1729	0.159
Brugia malayi	Nuclear hormone receptor-like 1	0.0364	0.3908	0.7604
Echinococcus granulosus	inositol monophosphatase 1	0.0115	0.1054	0.0996
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0559	0.0441
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0115	0.1054	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0079	0.0645	0.0487
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0188	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0089	0.0751	0.8199
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0089	0.0751	0.8199
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.0829	0.1613
Mycobacterium tuberculosis	Probable reductase	0.0089	0.0751	0.8199
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0079	0.0645	0.1254
Schistosoma mansoni	hypothetical protein	0.0096	0.0839	0.0685
Schistosoma mansoni	retinoic acid receptor RXR	0.0079	0.0645	0.0487
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0079	0.0645	0.0487
Onchocerca volvulus	Bile acid receptor homolog	0.0079	0.0645	0.5265
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0079	0.0645	0.1254
Onchocerca volvulus	Huntingtin homolog	0.013	0.1224	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0115	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0217	0.0421
Schistosoma mansoni	hypothetical protein	0.0174	0.1729	0.159
Echinococcus granulosus	GPCR family 2	0.005	0.031	0.0162
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0042	0.0217	0.0052
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.031	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0217	0.0421
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0079	0.0645	0.0537
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0079	0.0645	0.1254
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0099	0.0865	0.9434
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0782	0.0627
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0817	0.9092	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.031	0.0603
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0645	0.0537
Entamoeba histolytica	hypothetical protein	0.0072	0.0559	0.5301
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0272	0.0108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0782	0.0627
Schistosoma mansoni	hypothetical protein	0.005	0.031	0.0147
Loa Loa (eye worm)	DR-78	0.0037	0.0165	0.0321
Loa Loa (eye worm)	inositol-1	0.0115	0.1054	0.2052
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0782	0.1522
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0645	0.0487
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0089	0.0751	0.8199
Echinococcus multilocularis	expressed conserved protein	0.009	0.0763	0.0608
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0037	0.0165	0.0321
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0115	0.1054	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.0829	0.0675
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0079	0.0645	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0037	0.0165	0.0321
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0079	0.0645	0.0487
Echinococcus multilocularis	survival motor neuron protein 1	0.0472	0.5139	0.5058
Loa Loa (eye worm)	nuclear hormone receptor	0.0037	0.0165	0.0321
Schistosoma mansoni	hypothetical protein	0.0817	0.9092	0.9077
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0115	0.1054	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0079	0.0645	0.0487
Entamoeba histolytica	hypothetical protein	0.0072	0.0559	0.5301
Brugia malayi	hypothetical protein	0.0072	0.0559	0.1088
Brugia malayi	hypothetical protein	0.013	0.1224	0.2382
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0079	0.0645	0.1254
Brugia malayi	hypothetical protein	0.0472	0.5139	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0108	0.0975	0.1898
Schistosoma mansoni	hypothetical protein	0.0039	0.0189	0.0024
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0042	0.0217	0.0052
Brugia malayi	steroid hormone receptor	0.0079	0.0645	0.1254
Echinococcus multilocularis	protein patched	0.0041	0.0206	0.0041
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0182	0.0354
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0079	0.0645	0.1254
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.031	0.0147
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0645	0.0487
Echinococcus granulosus	expressed conserved protein	0.009	0.0763	0.0669
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0645	0.1254
Brugia malayi	tailless protein	0.0037	0.0165	0.0321
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0079	0.0645	0.0487
Echinococcus granulosus	FTZ F1 alpha	0.0079	0.0645	0.0537
Echinococcus multilocularis	GPCR, family 2	0.005	0.031	0.0147
Echinococcus granulosus	ecdysone induced protein 78C	0.0079	0.0645	0.0537
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0079	0.0645	0.1254
Schistosoma mansoni	hypothetical protein	0.005	0.031	0.0147
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.0829	0.0744
Mycobacterium tuberculosis	Probable dehydrogenase	0.0089	0.0751	0.8199
Onchocerca volvulus	Protein ultraspiracle homolog	0.0079	0.0645	0.5265
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0079	0.0645	0.0487
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0115	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0115	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Brugia malayi	nuclear hormone receptor	0.0079	0.0645	0.1254
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0079	0.0645	0.1254
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0079	0.0645	0.1254
Schistosoma mansoni	coup transcription factor	0.0079	0.0645	0.0487
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0846	0.0692
Schistosoma mansoni	hypothetical protein	0.005	0.031	0.0147
Brugia malayi	glutathione reductase	0.0039	0.0182	0.0354
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0099	0.0865	0.9434
Mycobacterium tuberculosis	Probable oxidoreductase	0.0099	0.0865	0.9434
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0158	0.1548	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5139	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0189	0.0024
Schistosoma mansoni	thyroid hormone receptor	0.0897	1	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.0165	0.1349
Onchocerca volvulus		0.0096	0.0839	0.6853
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.031	0.0603
Schistosoma mansoni	hypothetical protein	0.0039	0.0189	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0645	0.1254
Schistosoma mansoni	hypothetical protein	0.0108	0.0975	0.0824
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0079	0.0645	0.0537
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0217	0.0052
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0645	0.1254
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0182	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0037	0.0165	0.0321
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0115	0.1054	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0079	0.0645	0.0537
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.0829	0.7861
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0079	0.0645	0.0487
Loa Loa (eye worm)	hypothetical protein	0.036	0.3857	0.7505
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0042	0.0217	0.0058
Echinococcus multilocularis	ecdysone induced protein 78C	0.0079	0.0645	0.0487
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0182	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.031	0.0162
Schistosoma mansoni	hypothetical protein	0.0174	0.1729	0.159
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0089	0.0751	0.8199
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0645	0.0537
Brugia malayi	Latrophilin receptor protein 2	0.005	0.031	0.0603
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.1297	0.1151
Loa Loa (eye worm)	hypothetical protein	0.013	0.1224	0.2382
Brugia malayi	conserved hypotetical protein	0.0037	0.0165	0.0321
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0559	0.04
Onchocerca volvulus		0.0037	0.0165	0.1349
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0321
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0103	0.0916	1
Plasmodium falciparum	glutathione reductase	0.0039	0.0182	0.5
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0182	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0645	0.1254
Echinococcus multilocularis	inositol monophosphatase 1	0.0115	0.1054	0.0904
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0079	0.0645	0.1254
Brugia malayi	orphan nuclear receptor NR2E1	0.0037	0.0165	0.0321
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0158	0.1548	0.3013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0079	0.0645	0.1254
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0089	0.0751	0.8199
Schistosoma mansoni	hypothetical protein	0.0072	0.0559	0.04
Leishmania major	trypanothione reductase	0.0039	0.0182	0.1723
Brugia malayi	Nuclear hormone receptor-like 1	0.0364	0.3908	0.7604
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0079	0.0645	0.1254
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0782	0.0627
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0188	0.0023
Schistosoma mansoni	inositol monophosphatase	0.0115	0.1054	0.0904
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0096	0.0839	0.1632
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0782	0.0627
Echinococcus granulosus	survival motor neuron protein 1	0.0472	0.5139	0.5572
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0217	0.0421

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.8184 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1865522

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1058458