Detailed information for compound 105849

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.457 | Formula: C23H25FN4NaO4
  • H donors: 2 H acceptors: 7 LogP: 2.69 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H](C[C@H](/C=C/c1c(nn(c1c1ccc(cc1)F)c1cnccn1)C(C)C)O)CC(=O)[O-].[NaH+]
  • InChi: 1S/C23H25FN4O4.Na/c1-14(2)22-19(8-7-17(29)11-18(30)12-21(31)32)23(15-3-5-16(24)6-4-15)28(27-22)20-13-25-9-10-26-20;/h3-10,13-14,17-18,29-30H,11-12H2,1-2H3,(H,31,32);/q;+1/p-1/b8-7+;/t17?,18-;/m1./s1
  • InChiKey: TVZACJNNVHKXCP-VFYXEWCOSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0545 0.2317
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0438 0.0428
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0072 0.0116
Echinococcus multilocularis fat cadherin tumor suppressor 0.0127 0.1551 0.1541
Echinococcus multilocularis protein jagged 2 0.0127 0.1551 0.1541
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.002 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3978 0.91
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0121 0.0478
Echinococcus multilocularis neurogenic locus notch protein 0.0127 0.1551 0.1541
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1991 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0072 0.0116
Schistosoma mansoni laminin gamma-3 chain 0.0127 0.1551 0.2933
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1859 0.3534
Loa Loa (eye worm) hypothetical protein 0.0136 0.167 0.3161
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0173
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0072 0.0116
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0545 0.1226
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0037 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0072 0.0136
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0545 0.1207
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0072 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1767 0.3873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0401 0.0744
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0072 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0072 0.0136
Echinococcus granulosus muscleblind protein 0.0148 0.184 0.3212
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0072 0.0136
Entamoeba histolytica hypothetical protein 0.0036 0.028 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0659 0.1488
Echinococcus multilocularis neuropeptide s receptor 0.0426 0.5704 0.5699
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1426 0.2696
Loa Loa (eye worm) hypothetical protein 0.015 0.1859 0.3521
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0053 0.0515 0.2792
Schistosoma mansoni hypothetical protein 0.0198 0.2537 0.4812
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0072 0.0061
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Echinococcus multilocularis dihydrofolate reductase 0.0053 0.0515 0.0505
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1767 0.4028
Loa Loa (eye worm) dihydrofolate reductase 0.0053 0.0515 0.096
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0037 0.0027
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0072 0.0116
Schistosoma mansoni hypothetical protein 0.0127 0.1551 0.2933
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0101 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0072 0.0136
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.033 0.4371 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0121 0.0478
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.002 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0438 0.075
Schistosoma mansoni coup transcription factor 0.0021 0.0072 0.0116
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0072 0.0061
Loa Loa (eye worm) hypothetical protein 0.0102 0.1201 0.2268
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.033 0.4371 0.7658
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.002
Brugia malayi EGF-like domain containing protein 0.0127 0.1551 0.2947
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.1582 0.794
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0101 0.3366
Brugia malayi dihydrofolate reductase family protein 0.0053 0.0515 0.0979
Brugia malayi GCC2 and GCC3 family protein 0.0127 0.1551 0.2947
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0101 0.0208
Brugia malayi steroid hormone receptor 0.0021 0.0072 0.0136
Toxoplasma gondii hypothetical protein 0.0049 0.0457 0.1935
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0072 0.0136
Brugia malayi EGF-like domain containing protein 0.0127 0.1551 0.2947
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.3978 0.91
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0072 0.0116
Onchocerca volvulus 0.0395 0.526 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.2097 0.3973
Onchocerca volvulus 0.0127 0.1551 0.2933
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0545 0.1207
Mycobacterium ulcerans hypothetical protein 0.0023 0.0101 0.0187
Loa Loa (eye worm) hypoxia-induced factor 1 0.0154 0.1917 0.3631
Schistosoma mansoni notch 0.0127 0.1551 0.2933
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0072 0.0116
Brugia malayi Cadherin domain containing protein 0.0127 0.1551 0.2947
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0101 0.0187
Loa Loa (eye worm) hypothetical protein 0.0047 0.0438 0.0813
Onchocerca volvulus 0.0127 0.1551 0.2933
Schistosoma mansoni hypothetical protein 0.0127 0.1551 0.2933
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0377 0.5013 0.9529
Loa Loa (eye worm) hypothetical protein 0.033 0.4371 0.8305
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.047 0.0876
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0072 0.0116
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0037 0.0027
Loa Loa (eye worm) animal heme peroxidase 0.0395 0.526 1
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Brugia malayi EGF-like domain containing protein 0.0127 0.1551 0.2947
Brugia malayi Calcium binding EGF domain containing protein 0.0127 0.1551 0.2947
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0116
Brugia malayi hypothetical protein 0.0019 0.0037 0.0071
Echinococcus granulosus GPCR family 2 0.0047 0.0438 0.075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0116
Echinococcus multilocularis muscleblind protein 1 0.0148 0.184 0.1831
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0637 0.1437
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0072 0.0061
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0072 0.0061
Echinococcus granulosus neurogenic locus notch protein 0.0127 0.1551 0.2705
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Brugia malayi Animal haem peroxidase family protein 0.0395 0.526 1
Onchocerca volvulus 0.0127 0.1551 0.2933
Echinococcus multilocularis protein patched 0.0136 0.167 0.1661
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Brugia malayi hypothetical protein 0.0062 0.0637 0.1212
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0101 0.3366
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0438 0.0813
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0037 0.0071
Echinococcus granulosus protein jagged 2 0.0127 0.1551 0.2705
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0136 0.167 0.3161
Schistosoma mansoni notch 0.0127 0.1551 0.2933
Schistosoma mansoni peroxidasin 0.0395 0.526 1
Brugia malayi Calcium binding EGF domain containing protein 0.0127 0.1551 0.2947
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0401 0.0391
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0037 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0072 0.0116
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0072 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0072 0.0136
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0072 0.0107
Mycobacterium ulcerans thymidylate synthase 0.013 0.1582 0.3591
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0545 0.1018
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Echinococcus multilocularis neuropeptide receptor A26 0.0426 0.5704 0.5699
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0637 0.3177
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0173
Onchocerca volvulus 0.0058 0.0585 0.1093
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0121 0.0478
Loa Loa (eye worm) blistered cuticle protein 3 0.0395 0.526 1
Echinococcus granulosus protein jagged 2 0.0127 0.1551 0.2705
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0401 0.0762
Echinococcus granulosus notch 0.0127 0.1551 0.2705
Echinococcus multilocularis protein dispatched 1 0.0136 0.167 0.1661
Entamoeba histolytica hypothetical protein 0.0036 0.028 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0018
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0585 0.1093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0401 0.0686
Echinococcus granulosus neurogenic locus notch protein 0.0127 0.1551 0.2705
Loa Loa (eye worm) thymidylate synthase 0.013 0.1582 0.2994
Brugia malayi EGF-like domain containing protein 0.0127 0.1551 0.2947
Onchocerca volvulus 0.0395 0.526 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0053 0.0515 0.1137
Leishmania major cathepsin L-like protease 0.0063 0.0659 0.1488
Schistosoma mansoni hypothetical protein 0.0036 0.028 0.0513
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0127 0.1551 0.2933
Schistosoma mansoni dihydrofolate reductase 0.0053 0.0515 0.096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0072 0.0116
Onchocerca volvulus Putative cubilin 0.0127 0.1551 0.2933
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.002
Brugia malayi Calcium binding EGF domain containing protein 0.0127 0.1551 0.2947
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.2317 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0072 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0072 0.0136
Echinococcus granulosus geminin 0.0198 0.2537 0.4437
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0401 0.0391
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0545 0.2712
Schistosoma mansoni dishevelled 0.0019 0.0037 0.0051
Onchocerca volvulus 0.013 0.1582 0.2994
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0291 0.0553
Echinococcus multilocularis neurogenic locus protein delta 0.0127 0.1551 0.1541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0051
Brugia malayi hypoxia-induced factor 1 0.0154 0.1917 0.3644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3978 0.91
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0155 0.1934 1
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0471 0.1056
Schistosoma mansoni hypothetical protein 0.0047 0.0438 0.0813
Schistosoma mansoni hypothetical protein 0.0127 0.1551 0.2933
Echinococcus granulosus fibropellin Ia 0.0127 0.1551 0.2705
Loa Loa (eye worm) Notch2 0.0127 0.1551 0.2933
Loa Loa (eye worm) animal heme peroxidase 0.0395 0.526 1
Echinococcus granulosus single minded 2 0.0037 0.0291 0.0492
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0101 0.3366
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0659 0.1488
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0116
Echinococcus granulosus sterol regulatory element binding protein 0.0136 0.167 0.2914
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1201 0.2283
Schistosoma mansoni peroxidasin 0.0395 0.526 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0127 0.1551 0.2705
Loa Loa (eye worm) animal heme peroxidase 0.0395 0.526 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0101 0.0476
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0438 0.0832
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0155 0.1934 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0101 0.0187
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1767 0.4028
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0037 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0072 0.0107
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.002
Echinococcus multilocularis protein jagged 1 0.0127 0.1551 0.1541
Echinococcus granulosus neuropeptide s receptor 0.0426 0.5704 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0101 0.0193
Echinococcus multilocularis notch 0.0127 0.1551 0.1541
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0072 0.0061
Brugia malayi EGF-like domain containing protein 0.0127 0.1551 0.2947
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.2317 1
Brugia malayi Muscle positioning protein 4 0.0127 0.1551 0.2947
Echinococcus multilocularis neurogenic locus protein delta 0.0127 0.1551 0.1541
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0072 0.0107
Echinococcus multilocularis fibropellin Ia 0.0127 0.1551 0.1541
Onchocerca volvulus 0.0127 0.1551 0.2933
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0401 0.0744
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0072 0.0107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.028 0.027
Echinococcus multilocularis neurogenic locus notch protein 0.0127 0.1551 0.1541
Onchocerca volvulus Peroxidasin homolog 0.0395 0.526 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0121 0.0253
Schistosoma mansoni hypothetical protein 0.0127 0.1551 0.2933
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.033 0.4371 0.8305
Echinococcus granulosus delta-like protein 1 0.0127 0.1551 0.2705
Schistosoma mansoni notch 0.0127 0.1551 0.2933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0183 0.2317 0.5291
Echinococcus multilocularis tumor protein p63 0.0396 0.5278 0.5273
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0072 0.0136
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0037 0.0047
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Echinococcus multilocularis peroxidasin 0.0395 0.526 0.5255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0037 0.0051
Onchocerca volvulus Peroxidase homolog 0.0395 0.526 1
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Brugia malayi hypothetical protein 0.0167 0.2097 0.3985
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0127 0.1551 0.2947
Schistosoma mansoni slit 0.0127 0.1551 0.2933
Chlamydia trachomatis dihydrofolate reductase 0.0053 0.0515 1
Schistosoma mansoni cell polarity protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Schistosoma mansoni dishevelled 0.0019 0.0037 0.0051
Leishmania major hypothetical protein, conserved 0.0025 0.0121 0.0253
Echinococcus multilocularis muscleblind protein 0.0148 0.184 0.1831
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.1582 0.2994
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.167 0.2914
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0438 0.0832
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0037 0.0051
Schistosoma mansoni dep domain containing protein 0.0019 0.0037 0.0051
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.002 0.0041
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0037 0.0047
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0545 0.0939
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.1582 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0072 0.0061
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1859 0.3521
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0037 0.0047
Schistosoma mansoni hypothetical protein 0.0047 0.0438 0.0813
Schistosoma mansoni patched 1 0.0136 0.167 0.3161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0116
Brugia malayi EGF-like domain containing protein 0.0127 0.1551 0.2947
Echinococcus granulosus protein jagged 1 0.0127 0.1551 0.2705
Schistosoma mansoni hypothetical protein 0.0102 0.1201 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.167 0.8629
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0121 0.0253
Schistosoma mansoni notch 0.0127 0.1551 0.2933
Brugia malayi Delta serrate ligand family protein 0.0127 0.1551 0.2947
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0037 0.0047
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.033 0.4371 1
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.033 0.4371 0.4365
Brugia malayi DIX domain containing protein 0.0019 0.0037 0.0071
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0155 0.1934 1
Schistosoma mansoni hypothetical protein 0.0047 0.0438 0.0813
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0438 0.075
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0499 0.1121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0116
Onchocerca volvulus Chorion peroxidase homolog 0.0395 0.526 1
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0072 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0072 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Onchocerca volvulus Peroxidase homolog 0.0395 0.526 1
Echinococcus multilocularis geminin 0.0198 0.2537 0.2529
Mycobacterium ulcerans hypothetical protein 0.0159 0.1991 0.4531
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.167 0.1661
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0072 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0583 0.1313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0401 0.0744
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0072 0.0116
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0037 0.0051
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.028 0.0473
Onchocerca volvulus 0.0127 0.1551 0.2933
Schistosoma mansoni hypothetical protein 0.0047 0.0438 0.0813
Echinococcus multilocularis neurogenic locus notch protein 4 0.0127 0.1551 0.1541
Schistosoma mansoni hypothetical protein 0.0127 0.1551 0.2933
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0101 0.0193
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0101 0.0476
Onchocerca volvulus Dual oxidase homolog 0.0395 0.526 1
Brugia malayi Muscleblind-like protein 0.0148 0.184 0.3497
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0037 0.0051
Brugia malayi hypothetical protein 0.0036 0.028 0.0532
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0072 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0101 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Echinococcus granulosus slit 2 protein 0.0127 0.1551 0.2705
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0072 0.0107
Brugia malayi PAS domain containing protein 0.005 0.047 0.0894
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0545 0.1018
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.028 0.0513
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0072 0.0116
Onchocerca volvulus 0.0023 0.0101 0.0173
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0072 0.0107
Brugia malayi Blistered cuticle protein 3 0.0395 0.526 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0072 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0101 0.0193
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0183 0.2317 0.5168
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0018
Loa Loa (eye worm) animal heme peroxidase 0.0395 0.526 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.037 0.0825
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.037 0.0825
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0116
Echinococcus multilocularis sterol regulatory element binding protein 0.0136 0.167 0.1661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0401 0.0744
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0127 0.1551 0.2933
Brugia malayi Animal haem peroxidase family protein 0.0395 0.526 1
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0072 0.0116
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Echinococcus granulosus neuropeptide receptor A26 0.0426 0.5704 1
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.033 0.4371 0.8309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0148 0.184 0.3484
Brugia malayi nuclear hormone receptor 0.0021 0.0072 0.0136
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0072 0.0107
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0011 0.002
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0072 0.0061
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0037 0.0071
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0037 0.0071
Brugia malayi nuclear receptor NHR-88 0.0021 0.0072 0.0136
Brugia malayi hypothetical protein 0.0395 0.526 1
Leishmania major cathepsin L-like protease 0.0063 0.0659 0.1488
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0155 0.1934 1
Brugia malayi ecdysteroid receptor 0.0021 0.0072 0.0136
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0291 0.0623
Schistosoma mansoni hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0127 0.1551 0.2933
Schistosoma mansoni hypothetical protein 0.0198 0.2537 0.4812
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0072 0.0136
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0072 0.0116
Loa Loa (eye worm) hypothetical protein 0.0377 0.5013 0.9529
Schistosoma mansoni single-minded 0.005 0.047 0.0876
Brugia malayi hypothetical protein 0.0025 0.0121 0.023
Onchocerca volvulus Slit protein homolog 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Echinococcus granulosus neurogenic locus protein delta 0.0127 0.1551 0.2705
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0121 0.0478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Entamoeba histolytica hypothetical protein 0.0036 0.028 1
Schistosoma mansoni notch 0.0127 0.1551 0.2933
Echinococcus granulosus peroxidasin 0.0395 0.526 0.9221
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0072 0.0136
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0072 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Echinococcus multilocularis thymidylate synthase 0.013 0.1582 0.1573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0659 0.1267
Brugia malayi N-terminal motif family protein 0.0377 0.5013 0.953
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0072 0.0116
Brugia malayi thymidylate synthase 0.013 0.1582 0.3008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0072 0.0116
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0101 0.0187
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0072 0.0116
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0101 0.0187
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.037 0.0825
Loa Loa (eye worm) hypothetical protein 0.0148 0.184 0.3484
Entamoeba histolytica hypothetical protein 0.0036 0.028 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0183 0.2317 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0101 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0401 0.0686
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0659 0.1488
Brugia malayi CHE-14 protein 0.0136 0.167 0.3174
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0072 0.0107
Schistosoma mansoni septate junction protein 0.0127 0.1551 0.2933
Brugia malayi hypothetical protein 0.0019 0.0037 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0637 0.3259
Echinococcus granulosus neural cadherin 0.0127 0.1551 0.2705
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.3978 0.9076
Brugia malayi Cadherin domain containing protein 0.0127 0.1551 0.2947
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0116
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0659 0.1488
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0072 0.0061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0121 0.021
Schistosoma mansoni notch 0.0127 0.1551 0.2933
Echinococcus granulosus thymidylate synthase 0.013 0.1582 0.2761
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.033 0.4371 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0053 0.0515 0.256
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) notch protein 0.0127 0.1551 0.2933
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0037 0.0051
Brugia malayi EGF-like domain containing protein 0.0127 0.1551 0.2947
Loa Loa (eye worm) hypothetical protein 0.0395 0.526 1
Brugia malayi Animal haem peroxidase family protein 0.0395 0.526 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Loa Loa (eye worm) hypothetical protein 0.0127 0.1551 0.2933
Brugia malayi Animal haem peroxidase family protein 0.0395 0.526 1
Echinococcus granulosus tumor protein p63 0.0396 0.5278 0.9252
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0037 0.0027
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1426 0.2696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0072 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0101 0.0208
Onchocerca volvulus 0.0037 0.0291 0.0534
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.033 0.4371 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0072 0.0136
Toxoplasma gondii hypothetical protein 0.0019 0.0037 0.0116
Echinococcus granulosus Protein patched homolog 1 0.0136 0.167 0.2914
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0183 0.2317 0.5291
Loa Loa (eye worm) hypothetical protein 0.0058 0.0585 0.1093
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.037 0.0587
Echinococcus granulosus protein jagged 1 0.0127 0.1551 0.2705
Onchocerca volvulus Peroxidasin homolog 0.0395 0.526 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0116
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0438 0.0428
Echinococcus multilocularis protein jagged 1 0.0127 0.1551 0.1541
Brugia malayi Peroxidasin 0.0395 0.526 1
Echinococcus multilocularis GPCR, family 2 0.0047 0.0438 0.0428
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0291 0.0281
Onchocerca volvulus 0.0021 0.0072 0.0116
Schistosoma mansoni hypothetical protein 0.0127 0.1551 0.2933
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.033 0.4371 1
Brugia malayi MH2 domain containing protein 0.0118 0.1426 0.2711
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0545 0.1207
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1859 0.3534
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0072 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0072 0.0116
Onchocerca volvulus 0.0019 0.0037 0.0051
Brugia malayi Animal haem peroxidase family protein 0.0395 0.526 1
Toxoplasma gondii EGF family domain-containing protein 0.0127 0.1551 0.6675
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0072 0.0136
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0101 0.0187
Leishmania major cathepsin L-like protease 0.0063 0.0659 0.1488
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0136 0.167 0.3161
Echinococcus multilocularis slit 2 protein 0.0127 0.1551 0.1541
Brugia malayi notch-like transmembrane receptor 0.0127 0.1551 0.2947
Leishmania major protein kinase, putative 0.0021 0.0072 0.0141
Onchocerca volvulus 0.0395 0.526 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0173
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0545 0.0535
Echinococcus granulosus dihydrofolate reductase 0.0053 0.0515 0.0886
Brugia malayi Dihydrofolate reductase 0.0053 0.0515 0.0979
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0018
Echinococcus multilocularis neural cadherin 0.0127 0.1551 0.1541

Activities

Activity type Activity value Assay description Source Reference
clogP = 0.73 Calculated partition coefficient (clogP) ChEMBL. 1992149
clogP = 0.73 Calculated partition coefficient (clogP) ChEMBL. 1597859
IC50 (binding) = 6.6 nM Ability to inhibit microsomal preparation of HMG-CoA reductase in rat liver. ChEMBL. 1992149
IC50 (functional) = 10 nM Incorporation of [14C]- acetate into sterols measured in rat liver. ChEMBL. 1992149
IC50 (functional) = 20 nM Incorporation of [14C]- acetate into sterols measured in rat spleen. ChEMBL. 1992149
IC50 (functional) = 64 nM Incorporation of [14C]- acetate into sterols measured in rat testis. ChEMBL. 1992149
IC50 (binding) = 0.007 uM Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations. ChEMBL. 1597859
IC50 (binding) = 0.066 uM Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations. ChEMBL. 1597859
IC50 ratio (functional) = 2 IC50 ratio evaluated as the IC50 values of spleen to that of liver. ChEMBL. 1992149
IC50 ratio (functional) = 6.4 IC50 ratio evaluated as the IC50 values of testis to that of liver. ChEMBL. 1992149
Inhibition (functional) = 75 % Tested in vivo for the inhibition of cholesterol biosynthesis in chow-fed rats at 1.0 mg/kg. ChEMBL. 1597859
Inhibition (functional) = 91 % The compound was tested in vivo for the inhibition of cholesterol biosynthesis in chow-fed rats. ChEMBL. 1597859

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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