TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.508 | Formula: C23H30N4O5
H donors: 1 H acceptors: 3 LogP: 3.31 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)OC)N1CCN(CC1)CCCCNC(=O)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C23H30N4O5/c1-31-20-9-10-21(22(17-20)32-2)26-15-13-25(14-16-26)12-4-3-11-24-23(28)18-5-7-19(8-6-18)27(29)30/h5-10,17H,3-4,11-16H2,1-2H3,(H,24,28)
InChiKey: MHWHIBSVOPCJKK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	beta tubulin	0.0449	1	1
Leishmania major	beta tubulin	0.0449	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0342	0.7425	0.7392
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0249	0.5191	0.4142
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Schistosoma mansoni	tubulin subunit beta	0.0108	0.1791	0.1791
Trypanosoma brucei	alpha tubulin	0.0342	0.7425	0.6863
Trichomonas vaginalis	tubulin, putative	0.0108	0.1791	0.1684
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7425	0.7392
Schistosoma mansoni	tubulin subunit beta	0.0449	1	1
Schistosoma mansoni	tubulin subunit beta	0.0449	1	1
Echinococcus multilocularis	beta tubulin	0.0449	1	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0157	0.2969	0.1435
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0435	0.0435
Echinococcus multilocularis	Tubulin beta 2C chain	0.0449	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0249	0.5191	0.5128
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0185	0.3645	0.2258
Echinococcus granulosus	tubulin alpha 3 chain	0.0342	0.7425	0.7425
Entamoeba histolytica	tubulin family protein	0.0449	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0342	0.7425	0.7425
Leishmania major	beta tubulin	0.0449	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0234	0.4816	0.4816
Leishmania major	beta tubulin	0.0449	1	1
Trypanosoma brucei	beta tubulin	0.0449	1	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0185	0.3645	0.3645
Plasmodium vivax	tubulin alpha chain, putative	0.0342	0.7425	0.6863
Echinococcus multilocularis	beta tubulin	0.0449	1	1
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Loa Loa (eye worm)	tubulin alpha 2	0.0234	0.4816	0.4816
Echinococcus multilocularis	epidermal growth factor receptor	0.0157	0.2975	0.2975
Loa Loa (eye worm)	RNA binding protein	0.0136	0.2467	0.2467
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0201	0.4025	0.4025
Echinococcus granulosus	tubulin epsilon chain	0.0249	0.5191	0.5191
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.1767	0.1767
Loa Loa (eye worm)	beta-tubulin	0.0449	1	1
Leishmania major	beta tubulin	0.0449	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0141	0.2582	0.2486
Loa Loa (eye worm)	tubulin alpha chain	0.0342	0.7425	0.7425
Schistosoma mansoni	tubulin subunit beta	0.0449	1	1
Schistosoma mansoni	tubulin subunit delta	0.0108	0.1791	0.1791
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.2467	0.2467
Brugia malayi	tubulin alpha chain - mouse	0.0342	0.7425	0.7425
Loa Loa (eye worm)	alpha-tubulin	0.0342	0.7425	0.7425
Echinococcus granulosus	tubulin subunit TubB	0.0342	0.7425	0.7425
Echinococcus granulosus	tubulin beta 1 chain	0.0449	1	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0388	0.8543	1
Leishmania major	beta tubulin	0.0449	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0108	0.1791	0.1684
Echinococcus multilocularis	insulin receptor	0.005	0.0394	0.0394
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0108	0.1791	0.1684
Schistosoma mansoni	tubulin subunit alpha	0.0342	0.7425	0.7425
Entamoeba histolytica	tubulin gamma chain	0.0249	0.5191	0.5178
Echinococcus granulosus	tubulin alpha 3 chain	0.0342	0.7425	0.7425
Giardia lamblia	Alpha-tubulin	0.0342	0.7425	0.6863
Trypanosoma cruzi	tubulin gamma chain	0.0249	0.5191	0.4142
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7425	0.7425
Leishmania major	beta tubulin	0.0449	1	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.005	0.0394	0.0394
Giardia lamblia	Alpha-tubulin	0.0342	0.7425	0.6863
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.2467	0.2467
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7425	0.7425
Echinococcus multilocularis	snurportin 1	0.03	0.6408	0.6408
Entamoeba histolytica	tubulin family protein	0.0449	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0449	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0136	0.2467	0.2467
Echinococcus multilocularis	hypothetical protein	0.0342	0.7425	0.7425
Schistosoma mansoni	tyrosine kinase	0.005	0.0394	0.0394
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0435	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2729	0.2729
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0039	0.0128	0.0102
Schistosoma mansoni	tyrosine kinase	0.0084	0.122	0.122
Loa Loa (eye worm)	tubulin beta chain	0.0449	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0141	0.2582	0.2486
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Loa Loa (eye worm)	tubulin beta chain	0.0108	0.1791	0.1791
Schistosoma mansoni	tubulin subunit beta	0.0449	1	1
Echinococcus multilocularis	tubulin subunit TubB	0.0342	0.7425	0.7425
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0185	0.3645	0.3645
Trichomonas vaginalis	tubulin gamma chain, putative	0.0449	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0342	0.7425	0.7425
Echinococcus granulosus	snurportin 1	0.03	0.6408	0.6408
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.005	0.0394	0.0394
Schistosoma mansoni	alpha tubulin	0.0342	0.7425	0.7425
Echinococcus multilocularis	tubulin subunit beta	0.0449	1	1
Leishmania major	beta tubulin	0.0449	1	1
Trypanosoma brucei	beta tubulin	0.0449	1	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0157	0.2969	0.1435
Echinococcus granulosus	Tubulin beta 2C chain	0.0449	1	1
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Echinococcus granulosus	beta tubulin	0.0449	1	1
Loa Loa (eye worm)	hypothetical protein	0.0201	0.4025	0.4025
Giardia lamblia	Gamma tubulin	0.0249	0.5191	0.4142
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0163	0.3101	0.3101
Echinococcus multilocularis	tubulin alpha	0.0249	0.5191	0.5191
Echinococcus granulosus	Tubulin alpha 1 chain	0.0342	0.7425	0.7425
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.1767	0.1767
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0342	0.7425	0.7425
Schistosoma mansoni	alpha tubulin	0.0342	0.7425	0.7425
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7425	0.7425
Entamoeba histolytica	tubulin alpha chain, putative	0.0342	0.7425	0.7418
Echinococcus granulosus	tubulin alpha 1C chain	0.0342	0.7425	0.7425
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0027	0.0027
Echinococcus granulosus	tubulin alpha 1C chain	0.0342	0.7425	0.7425
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0435	0.0435
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0185	0.3645	0.3645
Loa Loa (eye worm)	tubulin gamma chain	0.0249	0.5191	0.5191
Schistosoma mansoni	tyrosine kinase	0.0084	0.1199	0.1199
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0027	0.0027
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0163	0.3101	0.3101
Brugia malayi	hypothetical protein	0.0147	0.2729	0.2729
Trypanosoma brucei	alpha tubulin	0.0342	0.7425	0.6863
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0449	1	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.0394	0.0394
Brugia malayi	TAR-binding protein	0.0136	0.2467	0.2467
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0185	0.3645	0.2258
Trichomonas vaginalis	tubulin, putative	0.0449	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0342	0.7425	0.7425
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0185	0.3645	0.3645
Echinococcus granulosus	Tubulin beta 2C chain	0.0449	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0949	0.0949
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0185	0.3645	0.3645
Brugia malayi	Cell division protein ftsZ	0.0108	0.1791	0.1791
Schistosoma mansoni	hypothetical protein	0.0035	0.0027	0.0027
Schistosoma mansoni	tubulin subunit beta	0.0449	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0084	0.122	0.122
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7425	0.7392
Plasmodium falciparum	tubulin beta chain	0.0449	1	1
Echinococcus granulosus	tubulin subunit beta	0.0449	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0157	0.2975	0.2975
Leishmania major	epsilon tubulin, putative	0.0249	0.5191	0.4142
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Leishmania major	beta tubulin	0.0449	1	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.0394	0.0394
Schistosoma mansoni	tubulin subunit gamma	0.0249	0.5191	0.5191
Trichomonas vaginalis	tubulin beta chain, putative	0.0449	1	1
Echinococcus multilocularis	tubulin epsilon chain	0.0249	0.5191	0.5191
Schistosoma mansoni	tubulin subunit epsilon	0.0249	0.5191	0.5191
Trypanosoma brucei	alpha tubulin	0.0342	0.7425	0.6863
Giardia lamblia	NADPH oxidoreductase, putative	0.0157	0.2969	0.1435
Echinococcus granulosus	beta tubulin	0.0449	1	1
Schistosoma mansoni	tyrosine kinase	0.0157	0.2975	0.2975
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0157	0.2969	0.2877
Echinococcus multilocularis		0.0049	0.0356	0.0356
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0201	0.4025	0.3948
Trichomonas vaginalis	tubulin gamma chain, putative	0.0108	0.1791	0.1684
Loa Loa (eye worm)	tubulin beta-4 chain	0.0449	1	1
Loa Loa (eye worm)	hypothetical protein	0.0342	0.7425	0.7425
Echinococcus granulosus	tubulin delta chain	0.0108	0.1791	0.1791
Echinococcus multilocularis	Tubulin beta 2C chain	0.0449	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7425	0.7425
Echinococcus granulosus	tubulin gamma 1 chain	0.0249	0.5191	0.5191
Loa Loa (eye worm)	BEN-1 protein	0.0449	1	1
Giardia lamblia	Beta tubulin	0.0449	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7425	0.7425
Brugia malayi	Tubulin alpha chain	0.0342	0.7425	0.7425
Brugia malayi	Tubulin alpha chain	0.0108	0.1791	0.1791
Echinococcus granulosus	epidermal growth factor receptor	0.0157	0.2975	0.2975
Brugia malayi	beta-tubulin, identical	0.0449	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0449	1	1
Trypanosoma brucei	beta tubulin	0.0449	1	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.8543	0.8543
Treponema pallidum	cell division protein FtsZ	0.0108	0.1791	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7425	0.7392
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Echinococcus multilocularis	Tubulin beta 2C chain	0.0449	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Echinococcus granulosus	tubulin alpha	0.0249	0.5191	0.5191
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7425	0.7425
Echinococcus multilocularis	Tubulin beta 2C chain	0.0449	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.1791	0.1684
Echinococcus multilocularis	tubulin delta chain	0.0108	0.1791	0.1791
Toxoplasma gondii	alpha-tubulin I, putative	0.0342	0.7425	0.6863
Brugia malayi	alpha-tubulin	0.0342	0.7425	0.7425
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0435	0.0435
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Echinococcus multilocularis	tubulin alpha 1C chain	0.0342	0.7425	0.7425
Echinococcus multilocularis	peroxisome assembly protein 26	0.0342	0.7425	0.7425
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.6408	0.6408
Echinococcus multilocularis	epidermal growth factor receptor	0.0084	0.122	0.122
Trichomonas vaginalis	tubulin, putative	0.0141	0.2582	0.2486
Onchocerca volvulus		0.0147	0.2729	0.0247
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0435	0.0435
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0435	0.0435
Echinococcus granulosus	Tubulin beta 2C chain	0.0449	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0449	1	1
Mycobacterium leprae	cell division protein FtsZ	0.0108	0.1791	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7425	0.7392
Plasmodium vivax	tubulin gamma chain, putative	0.0249	0.5191	0.4142
Schistosoma mansoni	tyrosine kinase	0.0084	0.1199	0.1199
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0136	0.2467	0.2467
Toxoplasma gondii	beta-1 tubulin, putative	0.0449	1	1
Giardia lamblia	Beta tubulin	0.0449	1	1
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0163	0.3101	0.3101
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0108	0.1791	0.5
Entamoeba histolytica	tubulin alpha-1 chain	0.0342	0.7425	0.7418
Trypanosoma brucei	alpha tubulin	0.0342	0.7425	0.6863
Trichomonas vaginalis	tubulin alpha chain, putative	0.0141	0.2582	0.2486
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7425	0.7392
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0435	0.0435
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.2467	0.2467
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Leishmania major	beta tubulin	0.0449	1	1
Trypanosoma brucei	epsilon tubulin	0.0249	0.5191	0.4142
Trypanosoma cruzi	alpha tubulin, putative	0.0342	0.7425	0.6863
Loa Loa (eye worm)	BEN-1 protein	0.0449	1	1
Toxoplasma gondii	beta tubulin	0.0449	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0249	0.5191	0.4142
Plasmodium falciparum	tubulin gamma chain	0.0249	0.5191	0.4142
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0949	0.0949
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0342	0.7425	0.7425
Echinococcus granulosus	Tubulin alpha 1 chain	0.0342	0.7425	0.7425
Plasmodium vivax	tubulin epsilon chain, putative	0.0249	0.5191	0.4142
Schistosoma mansoni	tubulin subunit alpha	0.0342	0.7425	0.7425
Leishmania major	beta tubulin	0.0449	1	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0157	0.2969	0.2877
Loa Loa (eye worm)	tubulin beta-2A chain	0.0449	1	1
Brugia malayi	RNA binding protein	0.0136	0.2467	0.2467
Leishmania major	beta tubulin	0.0449	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Echinococcus granulosus	alpha tubulin	0.0342	0.7425	0.7425
Echinococcus granulosus	Tubulin beta 2C chain	0.0449	1	1
Schistosoma mansoni	hypothetical protein	0.03	0.6408	0.6408
Trypanosoma brucei	tubulin gamma chain	0.0249	0.5191	0.4142
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0342	0.7425	0.7392
Trypanosoma brucei	beta tubulin	0.0449	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.2467	0.2467
Echinococcus granulosus	tubulin beta 4A class IVa	0.0449	1	1
Echinococcus granulosus	tar DNA binding protein	0.0136	0.2467	0.2467
Loa Loa (eye worm)	TAR-binding protein	0.0136	0.2467	0.2467
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0435	0.0435
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.1767	0.1767
Echinococcus multilocularis	tubulin alpha 3 chain	0.0342	0.7425	0.7425
Trypanosoma brucei	epsilon tubulin	0.0249	0.5191	0.4142
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0163	0.3101	0.3101
Plasmodium falciparum	tubulin epsilon chain, putative	0.0249	0.5191	0.4142
Loa Loa (eye worm)	hypothetical protein	0.0234	0.4816	0.4816
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7425	0.7392
Schistosoma mansoni	hypothetical protein	0.0073	0.0949	0.0949
Trichomonas vaginalis	tubulin, putative	0.0141	0.2582	0.2486
Trypanosoma brucei	alpha tubulin, putative	0.0141	0.2582	0.0963
Echinococcus multilocularis	tubulin alpha 3 chain	0.0342	0.7425	0.7425
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Schistosoma mansoni	tyrosine kinase	0.0084	0.1199	0.1199
Mycobacterium ulcerans	cell division protein FtsZ	0.0108	0.1791	0.5
Trichomonas vaginalis	tubulin alpha chain, putative	0.0141	0.2582	0.2486
Leishmania major	beta tubulin	0.0449	1	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0234	0.4816	0.4816
Echinococcus multilocularis	tubulin alpha 1C chain	0.0342	0.7425	0.7425
Trichomonas vaginalis	tubulin gamma chain, putative	0.0249	0.5191	0.5128
Echinococcus granulosus	peroxisome assembly protein 26	0.0342	0.7425	0.7425
Brugia malayi	tubulin alpha-2 chain	0.0342	0.7425	0.7425
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0027	0.0027
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7425	0.7425
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0342	0.7425	0.7392
Echinococcus multilocularis	Tubulin beta 2C chain	0.0449	1	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0084	0.122	0.122
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Leishmania major	beta tubulin	0.0449	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0108	0.1791	0.1791
Brugia malayi	Tubulin beta chain	0.0108	0.1791	0.1791
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Leishmania major	beta tubulin	0.0449	1	1
Brugia malayi	RNA, U transporter 1	0.008	0.1107	0.1107
Leishmania major	beta tubulin	0.0449	1	1
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0039	0.0128	0.0102
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7425	0.7425
Plasmodium vivax	tubulin beta chain, putative	0.0449	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0157	0.2975	0.2975
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Brugia malayi	hypothetical protein	0.0035	0.0027	0.0027
Trypanosoma cruzi	beta tubulin, putative	0.0449	1	1
Schistosoma mansoni	tyrosine kinase	0.005	0.0394	0.0394
Echinococcus multilocularis	tar DNA binding protein	0.0136	0.2467	0.2467
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0141	0.2582	0.2486
Schistosoma mansoni	tubulin subunit beta	0.0449	1	1
Schistosoma mansoni	tyrosine kinase	0.0084	0.122	0.122
Loa Loa (eye worm)	tubulin alpha chain	0.0342	0.7425	0.7425
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0234	0.4816	0.4749
Trichomonas vaginalis	tubulin gamma chain, putative	0.0249	0.5191	0.5128
Schistosoma mansoni	alpha tubulin	0.0342	0.7425	0.7425
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Plasmodium falciparum	alpha tubulin 2	0.0342	0.7425	0.6863
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7425	0.7425
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7425	0.7425
Entamoeba histolytica	hypothetical protein	0.0039	0.0128	0.0102
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0342	0.7425	0.7425
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0449	1	1
Giardia lamblia	Beta tubulin	0.0449	1	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0157	0.2969	0.2877
Toxoplasma gondii	alpha tubulin TUBA1	0.0342	0.7425	0.6863
Brugia malayi	Tubulin beta chain	0.0141	0.2582	0.2582
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1767	0.1767
Loa Loa (eye worm)	tubulin beta-1 chain	0.0449	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0449	1	1
Leishmania major	beta tubulin	0.0449	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0342	0.7425	0.7425
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Trypanosoma brucei	beta tubulin	0.0249	0.5191	0.4142
Trypanosoma brucei	epsilon tubulin	0.0249	0.5191	0.4142
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0435	0.0435
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Leishmania major	beta tubulin	0.0449	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0342	0.7425	0.6863
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Loa Loa (eye worm)	tubulin alpha 2	0.0093	0.1416	0.1416
Loa Loa (eye worm)	hypothetical protein	0.0185	0.3645	0.3645
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.2023	0.1919
Trypanosoma cruzi	epsilon tubulin, putative	0.0249	0.5191	0.4142
Toxoplasma gondii	beta-tubulin, putative	0.0449	1	1
Brugia malayi	N-terminal motif family protein	0.0388	0.8543	0.8543
Leishmania major	gamma-tubulin	0.0249	0.5191	0.4142
Plasmodium falciparum	alpha tubulin 1	0.0342	0.7425	0.6863
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.1791	0.1684
Echinococcus granulosus	insulin receptor	0.005	0.0394	0.0394
Leishmania major	alpha tubulin	0.0342	0.7425	0.6863
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0108	0.1791	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.2467	0.2467
Brugia malayi	Tubulin alpha-2 chain	0.0342	0.7425	0.7425
Echinococcus multilocularis	tubulin gamma 1 chain	0.0249	0.5191	0.5191
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2969	0.2877
Brugia malayi	Tubulin gamma chain	0.0249	0.5191	0.5191
Loa Loa (eye worm)	alpha-tubulin	0.0342	0.7425	0.7425

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 30 uM	Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay	ChEMBL.	19515567

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL565962

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1058576