Detailed information for compound 1058632

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 562.48 | Formula: C25H26N2O13
  • H donors: 2 H acceptors: 7 LogP: 0.55 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)OC[C@H]1O[C@@H](Oc2cccc(c2)C=C2C(=O)NC(=O)NC2=O)[C@@H]([C@H]([C@@H]1OC(=O)C)OC(=O)C)OC(=O)C
  • InChi: 1S/C25H26N2O13/c1-11(28)35-10-18-19(36-12(2)29)20(37-13(3)30)21(38-14(4)31)24(40-18)39-16-7-5-6-15(8-16)9-17-22(32)26-25(34)27-23(17)33/h5-9,18-21,24H,10H2,1-4H3,(H2,26,27,32,33,34)/t18-,19-,20+,21-,24-/m1/s1
  • InChiKey: POPQBEKIQZSVDA-XQWURTRYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0039 0.099 1
Echinococcus granulosus GPCR family 2 0.0049 0.1393 0.1347
Loa Loa (eye worm) hypothetical protein 0.0039 0.099 0.088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0378 0.0261
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.1254 0.1148
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0137 0.483 0.4802
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1931 0.3931
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0046 0.1254 0.117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.2633 0.5451
Entamoeba histolytica protein kinase rad3, putative 0.0026 0.0468 0.0201
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.4691 0.4663
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0468 0.0855
Brugia malayi intermediate filament protein 0.0083 0.2707 0.2565
Schistosoma mansoni hypothetical protein 0.0049 0.1393 0.2806
Onchocerca volvulus 0.0039 0.099 0.1085
Schistosoma mansoni thyroid hormone receptor 0.0133 0.4691 0.971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.3451 0.7146
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0046 0.1254 0.1803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.3729 0.7721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.2355 0.4876
Echinococcus multilocularis pyruvate kinase 0.0034 0.0781 0.0732
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0781 0.0718
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.099 0.1197
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0468 0.0417
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.099 0.088
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0109 0.3734 0.7292
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1931 0.1832
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0781 0.756
Schistosoma mansoni pyruvate kinase 0.0034 0.0781 0.1523
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.1602 0.1438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1254 0.2597
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0057 0.1685 0.279
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0137 0.483 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.3451 0.7146
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.1393 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.2351 0.4867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.3729 0.7721
Loa Loa (eye worm) hypothetical protein 0.0107 0.3648 0.3571
Brugia malayi Latrophilin receptor protein 2 0.0049 0.1393 0.1225
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1931 0.1888
Schistosoma mansoni hypothetical protein 0.002 0.0237 0.0385
Echinococcus granulosus pyruvate kinase 0.0017 0.0133 0.008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0468 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1254 0.2597
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.099 0.2049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.4048 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.1393 0.1288
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.9286 1
Echinococcus multilocularis lamin dm0 0.0083 0.2707 0.2669
Loa Loa (eye worm) hypothetical protein 0.004 0.1022 0.0913
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.099 0.2049
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.1195 0.1088
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.099 0.0814
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0781 0.0668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.3451 0.7146
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.099 0.0942
Loa Loa (eye worm) hypothetical protein 0.0083 0.2707 0.2618
Echinococcus multilocularis pyruvate kinase 0.0017 0.0133 0.008
Loa Loa (eye worm) hypothetical protein 0.0039 0.099 0.088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1275 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.4043 0.8371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1275 0.2557
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0137 0.483 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.099 0.1961
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1275 0.1168
Onchocerca volvulus 0.0083 0.2707 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.099 0.0246
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0137 0.483 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0137 0.483 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1275 0.1228
Loa Loa (eye worm) hypothetical protein 0.0038 0.0963 0.0852
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0781 0.0668
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.099 0.2049
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0781 0.0601
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0781 0.0718
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1275 0.2557
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.1254 0.2407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0894 0.185
Brugia malayi TAR-binding protein 0.0063 0.1931 0.1773
Echinococcus multilocularis survival motor neuron protein 1 0.0268 1 1
Schistosoma mansoni cpg binding protein 0.0065 0.2015 0.4108
Brugia malayi CXXC zinc finger family protein 0.0062 0.1877 0.1718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0121 0.025
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0137 0.483 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.099 0.088
Schistosoma mansoni hypothetical protein 0.0049 0.1393 0.2806
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.099 0.2049
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1931 0.3931
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.1393 0.1225
Echinococcus granulosus survival motor neuron protein 1 0.0268 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1931 0.3931
Loa Loa (eye worm) hypothetical protein 0.0039 0.099 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.2942 0.6092
Schistosoma mansoni cpg binding protein 0.0062 0.1877 0.3818
Loa Loa (eye worm) phosphatidylinositol 3 0.0137 0.483 0.4767
Giardia lamblia GTOR 0.0137 0.483 1
Brugia malayi FAT domain containing protein 0.002 0.0237 0.0046
Echinococcus multilocularis cpg binding protein 0.0065 0.2015 0.1973
Echinococcus granulosus lamin 0.0083 0.2707 0.2669
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.1254 0.1084
Chlamydia trachomatis pyruvate kinase 0.0034 0.0781 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.2355 0.4876
Echinococcus multilocularis pyruvate kinase 0.0034 0.0781 0.0732
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.3648 0.3524
Echinococcus granulosus pyruvate kinase 0.0017 0.0133 0.008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.5591 0.5505
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.099 0.0942
Schistosoma mansoni survival motor neuron protein 0.0055 0.1602 0.3243
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.099 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.099 0.0246
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.4302 0.4271
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.1022 0.0974
Echinococcus granulosus tar DNA binding protein 0.0063 0.1931 0.1888
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.099 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0468 0.0968
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.1195 0.1023
Mycobacterium leprae Probable lipase LipE 0.0039 0.099 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0201 0.0149
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0026 0.0468 0.0737
Onchocerca volvulus 0.0062 0.1877 0.569
Schistosoma mansoni hypothetical protein 0.0049 0.1393 0.2806
Echinococcus granulosus intermediate filament protein 0.0083 0.2707 0.2669
Loa Loa (eye worm) hypothetical protein 0.0039 0.099 0.088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1275 0.1228
Echinococcus multilocularis pyruvate kinase 0.0027 0.05 0.045
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0137 0.483 0.4802
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0026 0.0468 0.0201
Schistosoma mansoni pyruvate kinase 0.0034 0.0781 0.1523
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0781 0.1654
Loa Loa (eye worm) hypothetical protein 0.0038 0.0963 0.0852
Plasmodium vivax hypothetical protein, conserved 0.0039 0.099 1
Schistosoma mansoni intermediate filament proteins 0.0083 0.2707 0.5557
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0137 0.483 1
Onchocerca volvulus 0.0055 0.1602 0.4263
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.099 0.1846
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.1393 0.1347
Onchocerca volvulus 0.0039 0.099 0.1085
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0137 0.483 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.4199 0.4128
Loa Loa (eye worm) hypothetical protein 0.0029 0.0584 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.2355 0.4876
Mycobacterium ulcerans lipase LipD 0.0039 0.099 1
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.099 0.0246
Schistosoma mansoni pyruvate kinase 0.0017 0.0133 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.3451 0.7146
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0468 0.0868
Onchocerca volvulus 0.0083 0.2707 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1931 0.3931
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.4302 0.4271
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0781 0.0668
Schistosoma mansoni cpg binding protein 0.0065 0.2015 0.4108
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.5591 0.5537
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0468 0.0737
Schistosoma mansoni fkbp-rapamycin associated protein 0.0026 0.0468 0.0868
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0201 0.0149
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0026 0.0468 0.0417
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.1022 0.0974
Loa Loa (eye worm) hypothetical protein 0.0156 0.5591 0.5537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0468 0.0968
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0781 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1254 0.2597
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.002 0.0237 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.3729 0.7721
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.1393 0.1347
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.099 0.2049
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.1254 0.2407
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0065 0.1994 0.35
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0109 0.3734 0.7487
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1931 0.1832
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.002 0.0237 0.0185
Leishmania major hypothetical protein, conserved 0.0039 0.099 0.0516
Loa Loa (eye worm) hypothetical protein 0.0039 0.099 0.088
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1931 0.1773
Schistosoma mansoni lamin 0.0083 0.2707 0.5557
Echinococcus granulosus pyruvate kinase 0.0034 0.0781 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1254 0.2597
Echinococcus granulosus cpg binding protein 0.0065 0.2015 0.1973
Schistosoma mansoni thyroid hormone receptor 0.0133 0.4691 0.971
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0237 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.2355 0.4876
Loa Loa (eye worm) intermediate filament protein 0.0083 0.2707 0.2618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1275 0.2557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.483 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0237 0.0118
Schistosoma mansoni hypothetical protein 0.0055 0.1602 0.3243
Toxoplasma gondii target of rapamycin (TOR), putative 0.0102 0.3451 0.8476
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0046 0.1254 0.1208
Loa Loa (eye worm) hypothetical protein 0.0034 0.0781 0.0668
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0201 0.0081
Echinococcus multilocularis musashi 0.0083 0.2707 0.2669
Brugia malayi beta-lactamase 0.0039 0.099 0.0814
Echinococcus multilocularis lamin 0.0083 0.2707 0.2669
Schistosoma mansoni hypothetical protein 0.0123 0.4302 0.8894
Loa Loa (eye worm) beta-lactamase 0.0039 0.099 0.088
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0137 0.483 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.2665 0.5517
Brugia malayi beta-lactamase family protein 0.0039 0.099 0.0814
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.5591 0.5505
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0046 0.1254 0.2515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.3729 0.7721
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0468 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1931 0.3931
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.099 0.0246
Giardia lamblia Pyruvate kinase 0.0034 0.0781 0.1379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.3059 0.6333
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.099 0.0246
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.1877 0.1778
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0046 0.1254 0.1208
Trypanosoma cruzi target of rapamycin kinase 3 0.0109 0.3734 0.7672
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.099 0.1846
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.4598 0.9514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.3451 0.7146
Plasmodium falciparum pyruvate kinase 0.0034 0.0781 1
Mycobacterium ulcerans hypothetical protein 0.0039 0.099 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0781 0.1402
Brugia malayi RNA binding protein 0.0063 0.1931 0.1773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.483 1
Trichomonas vaginalis esterase, putative 0.0039 0.099 0.2049
Loa Loa (eye worm) hypothetical protein 0.0028 0.0546 0.0431
Mycobacterium ulcerans beta-lactamase 0.0039 0.099 1
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0468 0.0417
Schistosoma mansoni lamin 0.0083 0.2707 0.5557
Toxoplasma gondii ABC1 family protein 0.0039 0.099 0.2188
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1275 0.1228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.2351 0.4867
Echinococcus multilocularis pyruvate kinase 0.0017 0.0133 0.008
Leishmania major phosphatidylinositol 3-kinase, putative 0.0046 0.1254 0.117
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0781 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.3451 0.7146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.1393 0.1347
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0029 0.0584 0.1152
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0378 0.0261
Echinococcus granulosus pyruvate kinase 0.0017 0.0133 0.008
Loa Loa (eye worm) hypothetical protein 0.0268 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1275 0.1228
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0468 0.0282
Mycobacterium tuberculosis Conserved protein 0.0039 0.099 0.0246
Schistosoma mansoni hypothetical protein 0.0049 0.1393 0.2806
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.099 0.0246
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0137 0.483 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.3729 0.7721
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.099 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.2351 0.4867
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0781 0.1616
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.099 0.1961
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0137 0.483 0.4729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.3451 0.7146
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0781 0.1616
Echinococcus multilocularis GPCR, family 2 0.0049 0.1393 0.1347
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.1393 0.1347
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0026 0.0468 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0584 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0468 0.0968
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.099 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0781 0.0732
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.4199 0.4128
Echinococcus granulosus lamin dm0 0.0083 0.2707 0.2669
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0046 0.1254 0.1803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.2633 0.5451
Onchocerca volvulus 0.0039 0.099 0.1085
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0121 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.2665 0.5517
Loa Loa (eye worm) hypothetical protein 0.0081 0.2648 0.2558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.2665 0.5517
Mycobacterium tuberculosis Conserved protein 0.0039 0.099 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.483 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1254 0.2597
Brugia malayi beta-lactamase family protein 0.0039 0.099 0.0814
Entamoeba histolytica hypothetical protein 0.0026 0.0468 0.0201
Echinococcus multilocularis pyruvate kinase 0.0017 0.0133 0.008
Brugia malayi MH2 domain containing protein 0.0121 0.4199 0.4086
Loa Loa (eye worm) RNA binding protein 0.0063 0.1931 0.1832
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.2707 0.2565
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.2707 0.2618
Schistosoma mansoni hypothetical protein 0.0107 0.3648 0.7526

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 3 mmol/L Inhibition of diphenolase activity of mushroom tyrosinase ChEMBL. 19564107

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.