Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0045 | 0.0394 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0394 | 0.1054 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0045 | 0.0394 | 0.0394 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0037 | 0.5279 |
Echinococcus multilocularis | snurportin 1 | 0.0307 | 0.4389 | 0.4389 |
Echinococcus granulosus | neuroligin | 0.0045 | 0.0394 | 0.0394 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0045 | 0.0394 | 0.0394 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0394 | 0.1054 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0037 | 0.0098 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0675 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0394 | 0.1054 |
Loa Loa (eye worm) | carboxylesterase | 0.0045 | 0.0394 | 0.0898 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.096 | 0.2568 |
Echinococcus granulosus | acetylcholinesterase | 0.0264 | 0.3736 | 0.3736 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0152 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0264 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | carboxylesterase | 0.0264 | 0.3736 | 0.8513 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0069 | 0.1763 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0152 | 0.0152 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0045 | 0.0394 | 1 |
Echinococcus multilocularis | neuroligin | 0.0045 | 0.0394 | 0.0394 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0045 | 0.0394 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0045 | 0.0394 | 0.0898 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0037 | 0.5279 |
Echinococcus granulosus | snurportin 1 | 0.0307 | 0.4389 | 0.4389 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0394 | 0.0898 |
Echinococcus multilocularis | acetylcholinesterase | 0.0264 | 0.3736 | 0.3736 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0037 | 0.5279 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0152 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0149 | 0.1983 | 0.1983 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0037 | 0.2408 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0152 | 0.0152 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0045 | 0.0394 | 0.0394 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0069 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0394 | 0.1054 |
Schistosoma mansoni | gliotactin | 0.0045 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0394 | 0.0898 |
Echinococcus multilocularis | acetylcholinesterase | 0.0264 | 0.3736 | 0.3736 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0045 | 0.0394 | 0.0394 |
Onchocerca volvulus | 0.0045 | 0.0394 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0.0394 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0394 | 0.0898 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0045 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0037 | 0.0084 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0045 | 0.0394 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.3736 | 0.8513 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0394 | 0.0898 |
Echinococcus granulosus | carboxylesterase 5A | 0.0264 | 0.3736 | 0.3736 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0045 | 0.0394 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0045 | 0.0394 | 1 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0037 | 0.5279 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0045 | 0.0394 | 0.0394 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0152 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1983 | 0.4518 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0045 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0394 | 0.0898 |
Brugia malayi | Muscleblind-like protein | 0.0149 | 0.1983 | 0.5307 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0152 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0037 | 0.0037 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0045 | 0.0394 | 0.0394 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0264 | 0.3736 | 0.3736 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.4389 | 0.4389 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0307 | 0.4389 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0264 | 0.3736 | 0.3736 |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 0.3736 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0069 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0045 | 0.0394 | 0.0394 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0037 | 1 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0037 | 0.0931 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0394 | 0.1054 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0045 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.3736 | 0.8513 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0394 | 0.0898 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0037 | 0.2408 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0037 | 0.2408 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0069 | 0.1763 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0152 | 0.0152 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0045 | 0.0394 | 0.0394 |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 0.3736 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0152 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0149 | 0.1983 | 0.1983 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0264 | 0.3736 | 0.8513 |
Schistosoma mansoni | acetylcholinesterase | 0.0045 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0394 | 0.0898 |
Echinococcus multilocularis | muscleblind protein | 0.0149 | 0.1983 | 0.1983 |
Onchocerca volvulus | 0.0045 | 0.0394 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0045 | 0.0394 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0675 | 1 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0069 | 0.1763 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1983 | 0.4518 |
Onchocerca volvulus | 0.0045 | 0.0394 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0152 | 0.0347 |
Schistosoma mansoni | ran | 0.0021 | 0.0037 | 0.0037 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0037 | 0.2408 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0037 | 0.0037 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0069 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.