Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | LCCL domain-containing protein | 0.0118 | 0.2418 | 0.5 |
Echinococcus granulosus | glutamate receptor 4 | 0.0085 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2418 | 0.515 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0145 | 0.3363 | 0.3363 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0332 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 1 | 0.0085 | 0.1228 | 0.1228 |
Echinococcus multilocularis | acetylcholinesterase | 0.0145 | 0.3369 | 0.3369 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.006 | 0.034 | 0.034 |
Echinococcus multilocularis | RUN | 0.0118 | 0.2418 | 0.2418 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.006 | 0.034 | 0.034 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.006 | 0.034 | 0.034 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0145 | 0.3363 | 0.3363 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1228 | 0.2616 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0145 | 0.3369 | 0.3369 |
Echinococcus granulosus | acetylcholinesterase | 0.0145 | 0.3369 | 0.3369 |
Schistosoma mansoni | rab6-interacting | 0.0118 | 0.2418 | 0.2418 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0126 | 0.2699 | 0.2699 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0145 | 0.3363 | 0.3363 |
Loa Loa (eye worm) | carboxylesterase | 0.0145 | 0.3369 | 0.7178 |
Loa Loa (eye worm) | doublecortin family protein | 0.0118 | 0.2418 | 0.515 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.006 | 0.034 | 0.034 |
Schistosoma mansoni | loxhd1 | 0.0118 | 0.2418 | 0.2418 |
Schistosoma mansoni | rab6-interacting | 0.0118 | 0.2418 | 0.2418 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2418 | 0.515 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1228 | 0.2616 |
Schistosoma mansoni | glutamate receptor NMDA | 0.006 | 0.034 | 0.034 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0118 | 0.2418 | 0.2418 |
Brugia malayi | hypothetical protein | 0.0182 | 0.4694 | 1 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0104 | 0.1892 | 0.1892 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0118 | 0.2418 | 0.2418 |
Echinococcus granulosus | glutamate receptor 2 | 0.0126 | 0.2699 | 0.2699 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0135 | 0.3023 | 0.3023 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0135 | 0.3023 | 0.2658 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.4694 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0145 | 0.3369 | 0.7178 |
Schistosoma mansoni | lipoxygenase | 0.0332 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0145 | 0.3369 | 0.3369 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0145 | 0.3369 | 0.3369 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0118 | 0.2418 | 0.5 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0118 | 0.2418 | 0.2418 |
Echinococcus granulosus | RUN | 0.0118 | 0.2418 | 0.2418 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.3369 | 0.7178 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0118 | 0.2418 | 0.2418 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.2418 | 0.2418 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.3369 | 0.7178 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0085 | 0.1228 | 0.1228 |
Echinococcus multilocularis | acetylcholinesterase | 0.0145 | 0.3369 | 0.3369 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0104 | 0.1892 | 0.1892 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1228 | 0.2616 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0118 | 0.2418 | 0.2418 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.006 | 0.034 | 0.034 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0135 | 0.3023 | 0.6439 |
Brugia malayi | Carboxylesterase family protein | 0.0145 | 0.3369 | 0.418 |
Schistosoma mansoni | polycystin 1-related | 0.0118 | 0.2418 | 0.2418 |
Brugia malayi | Carboxylesterase family protein | 0.0145 | 0.3369 | 0.418 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0118 | 0.2418 | 0.2418 |
Onchocerca volvulus | 0.0182 | 0.4694 | 1 | |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.006 | 0.034 | 0.034 |
Echinococcus granulosus | glutamate receptor 2 | 0.0145 | 0.3363 | 0.3363 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.2418 | 0.2418 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0135 | 0.3023 | 0.2658 |
Echinococcus granulosus | acetylcholinesterase | 0.0145 | 0.3369 | 0.3369 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.