Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0236 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0334 | 0.0365 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0402 | 0.0457 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.14 | 0.5988 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1333 | 0.57 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.14 | 0.5988 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.6096 | 0.6096 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0156 | 0.6365 | 0.6365 |
Brugia malayi | Muscleblind-like protein | 0.015 | 0.6096 | 0.6096 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0689 | 0.0709 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0689 | 0.0689 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.01 | 0.5 |
Brugia malayi | hypothetical protein | 0.0169 | 0.6961 | 0.6961 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0402 | 0.0402 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.01 | 0.0047 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0334 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0334 | 0.0334 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0334 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0334 | 0.0365 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0334 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.01 | 0.0047 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0402 | 0.0402 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.01 | 0.0103 |
Echinococcus multilocularis | muscleblind protein | 0.015 | 0.6096 | 0.6274 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.2338 | 0.2338 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.018 | 0.7445 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.9717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.9717 | 0.9717 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.01 | 0.01 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.018 | 0.7445 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.018 | 0.7445 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0689 | 0.0709 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.01 | 0.0105 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0402 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0334 | 1 |
Onchocerca volvulus | 0.0047 | 0.14 | 1 | |
Echinococcus multilocularis | muscleblind protein 1 | 0.015 | 0.6096 | 0.6274 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0334 | 0.0334 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0334 | 0.0365 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0402 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0402 | 0.0457 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.01 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0689 | 0.2949 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0689 | 0.0689 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.018 | 0.7445 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1333 | 0.1333 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0334 | 0.7762 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2338 | 0.2338 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0065 | 0.0065 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0334 | 0.7762 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.01 | 0.0103 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0334 | 0.0421 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0689 | 0.0709 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.018 | 0.7445 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.3758 | 0.3758 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1333 | 0.1371 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0689 | 0.0709 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0334 | 0.7762 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0334 | 0.0334 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0689 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0065 | 0.0065 |
Echinococcus granulosus | single minded 2 | 0.0037 | 0.0966 | 0.0994 |
Schistosoma mansoni | single-minded | 0.005 | 0.1562 | 0.668 |
Brugia malayi | hypoxia-induced factor 1 | 0.0156 | 0.6365 | 0.6365 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0689 | 0.2949 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.3758 | 0.3758 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0334 | 0.0365 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0334 | 0.0334 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0402 | 1 |
Echinococcus granulosus | muscleblind protein | 0.015 | 0.6096 | 0.6274 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0402 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1333 | 0.57 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.6096 | 0.6096 |
Mycobacterium ulcerans | putative regulatory protein | 0.0037 | 0.0966 | 0.1221 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1333 | 0.1371 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0334 | 0.0334 |
Brugia malayi | bHLH-PAS transcription factor | 0.0037 | 0.0966 | 0.0966 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0402 | 0.0457 |
Brugia malayi | PAS domain containing protein | 0.005 | 0.1562 | 0.1562 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.018 | 0.7445 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0689 | 0.0689 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.14 | 0.14 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1333 | 0.1371 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0689 | 0.2949 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.01 | 0.0427 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0037 | 0.0966 | 0.0994 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0236 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.9717 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0689 | 0.0709 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0334 | 0.0365 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1333 | 0.57 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.01 | 0.0427 |
Onchocerca volvulus | 0.0037 | 0.0966 | 0.5927 | |
Brugia malayi | hypothetical protein | 0.023 | 0.9717 | 0.9717 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3758 | 0.3758 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0334 | 0.0365 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.01 | 0.01 |
Trichomonas vaginalis | hypothetical protein | 0.018 | 0.7445 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0065 | 0.0065 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.005 | 0.1562 | 0.668 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1333 | 0.1371 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0689 | 0.2949 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1333 | 0.1333 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0334 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.6961 | 0.6961 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0334 | 0.0421 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0689 | 0.0689 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.018 | 0.7445 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.3758 | 0.3758 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0402 | 0.0412 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0065 | 0.0059 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.018 | 0.7445 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 96 % | Antituberculosis activity against Mycobacterium tuberculosis at a concentration of 12.5 ug/mL | ChEMBL. | 11514148 |
Inhibition (functional) | = 96 % | Antituberculosis activity against Mycobacterium tuberculosis at a concentration of 12.5 ug/mL | ChEMBL. | 11514148 |
Inhibition (functional) | = 96 % | Antimicrobial activity against Mycobacterium tuberculosis assessed as growth inhibition at 12.5 mg/ml | ChEMBL. | 25019478 |
MIC (functional) | > 12.5 ug ml-1 | Minimum inhibitory concentration against Mycobacterium tuberculosis | ChEMBL. | 11514148 |
MIC (functional) | > 12.5 ug ml-1 | Minimum inhibitory concentration against Mycobacterium tuberculosis | ChEMBL. | 11514148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.