Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.1662 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.1662 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.1662 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.1662 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 0.1662 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0.1662 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.1662 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.1662 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.1662 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0416 | 0.2503 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.1662 | 0.1662 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 20 ug ml-1 | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 19427785 |
GI50 (functional) | > 20 ug ml-1 | Cytotoxicity against human HepG2 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 19427785 |
GI50 (functional) | > 20 ug ml-1 | Cytotoxicity against human AGS cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 19427785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.