Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.1556 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.1556 | 0.1556 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.1556 | 0.1556 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.1556 | 0.1556 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.1556 | 0.1556 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.1556 | 0.1556 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.1556 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.1556 | 0.1556 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1556 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1556 | 0.1556 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.1556 | 0.1556 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.1556 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1556 | 0.1556 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.1556 | 0.1556 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1556 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.1556 | 0.1556 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1556 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.1556 | 1 |
Onchocerca volvulus | 0.001 | 0.1556 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.1556 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.1556 | 0.1556 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.1556 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1556 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.1556 | 0.1556 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.1556 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.1556 | 0.1556 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.1556 | 0.1556 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.1556 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.1556 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1556 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1556 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.1556 | 0.1556 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1556 | 0.1556 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.1556 | 0.1556 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.1556 | 0.1556 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.1556 | 0.1556 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.1556 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1556 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.1556 | 0.1556 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1556 | 0.1556 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.1556 | 0.1556 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.1556 | 0.1556 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1556 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.1556 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.1556 | 0.1556 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.1556 | 0.1556 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 40 mm | Antibacterial activity against Escherichia coli MTCC 722 at 1000 ug/ml after 24 hrs by agar diffusion method | ChEMBL. | 18996622 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 722 after 24 hrs by liquid dilution method | ChEMBL. | 18996622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.