Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0271 | 0.1366 | 0.1366 |
Loa Loa (eye worm) | hypothetical protein | 0.1604 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1366 | 0.1366 |
Onchocerca volvulus | 0.0271 | 0.1366 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1604 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1604 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1366 | 0.1366 |
Echinococcus multilocularis | acetylcholinesterase | 0.1604 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1604 | 1 | 1 |
Onchocerca volvulus | 0.0271 | 0.1366 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1366 | 0.1366 |
Echinococcus multilocularis | acetylcholinesterase | 0.1604 | 1 | 1 |
Onchocerca volvulus | 0.0271 | 0.1366 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1366 | 0.1366 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1604 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0271 | 0.1366 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1604 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1366 | 0.1366 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1366 | 0.1366 |
Brugia malayi | Carboxylesterase family protein | 0.0271 | 0.1366 | 0.1366 |
Brugia malayi | Carboxylesterase family protein | 0.0271 | 0.1366 | 0.1366 |
Brugia malayi | Carboxylesterase family protein | 0.1604 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0271 | 0.1366 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0271 | 0.1366 | 0.5 |
Brugia malayi | hypothetical protein | 0.0271 | 0.1366 | 0.1366 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0271 | 0.1366 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1604 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0271 | 0.1366 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0271 | 0.1366 | 0.1366 |
Brugia malayi | Carboxylesterase family protein | 0.0271 | 0.1366 | 0.1366 |
Onchocerca volvulus | 0.0271 | 0.1366 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1366 | 0.1366 |
Onchocerca volvulus | 0.0271 | 0.1366 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.1604 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0271 | 0.1366 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1604 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0271 | 0.1366 | 0.1366 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.