Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.0147 | 0.0538 |
Loa Loa (eye worm) | TAR-binding protein | 0.02 | 0.2592 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.02 | 0.2592 | 0.2586 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2592 | 1 |
Brugia malayi | TAR-binding protein | 0.02 | 0.2592 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2592 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0171 | 0.216 | 0.2153 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.1799 | 0.6932 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0008 | 0.0031 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0147 | 0.0173 |
Brugia malayi | RNA recognition motif domain containing protein | 0.02 | 0.2592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1099 | 0.4241 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.0147 | 0.0538 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0147 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0115 | 0.0442 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0115 | 0.0413 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0115 | 0.0413 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0115 | 0.0442 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.016 | 0.1988 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0115 | 0.0442 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0105 | 0.1156 | 0.3569 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.1489 | 0.5744 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.0147 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0115 | 0.0413 |
Echinococcus multilocularis | tumor protein p63 | 0.0691 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0147 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.216 | 0.8326 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.0147 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0147 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1988 | 0.7669 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0171 | 0.216 | 0.2153 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0115 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0115 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0008 | 0.0031 |
Onchocerca volvulus | 0.0036 | 0.0115 | 0.0978 | |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.016 | 0.1988 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 0.1982 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0147 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.3033 | 1 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0055 | 0.0405 | 0.1551 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0105 | 0.1156 | 0.1149 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.0147 | 0.0139 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.1799 | 0.6932 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0147 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0055 | 0.0405 | 0.1551 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.1489 | 0.5731 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.02 | 0.2592 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0147 | 1 |
Onchocerca volvulus | 0.0036 | 0.0115 | 0.0978 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0115 | 0.0107 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0105 | 0.1156 | 0.1149 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.0147 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0105 | 0.1156 | 0.5559 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.016 | 0.1988 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2592 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 0.1982 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0115 | 0.0413 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2592 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.02 | 0.2592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0115 | 0.0442 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2592 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0147 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0115 | 0.0413 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0171 | 0.216 | 0.8331 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0115 | 0.0442 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0147 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.1489 | 0.5744 |
Brugia malayi | RNA binding protein | 0.02 | 0.2592 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.0147 | 0.0567 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0101 | 0.1099 | 0.4223 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.0147 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0008 | 0.0031 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0147 | 1 |
Onchocerca volvulus | 0.0036 | 0.0115 | 0.0978 | |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.0147 | 0.0139 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.016 | 0.1988 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0147 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0405 | 0.1551 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0171 | 0.216 | 0.2153 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0115 | 0.0442 |
Onchocerca volvulus | 0.0101 | 0.1099 | 1 | |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1988 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.016 | 0.1988 | 0.7662 |
Echinococcus multilocularis | tar DNA binding protein | 0.02 | 0.2592 | 0.2586 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.016 | 0.1988 | 0.7662 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0115 | 0.0413 |
Onchocerca volvulus | 0.0099 | 0.1069 | 0.9723 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0115 | 0.0107 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0105 | 0.1156 | 0.3569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.