Detailed information for compound 1059076

Basic information

Technical information
  • TDR Targets ID: 1059076
  • Name: (2S)-2-[[4-(phenylmethyl)phenoxy]methyl]pyrro lidine
  • MW: 267.365 | Formula: C18H21NO
  • H donors: 1 H acceptors: 0 LogP: 3.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)Cc1ccc(cc1)OC[C@@H]1CCCN1
  • InChi: 1S/C18H21NO/c1-2-5-15(6-3-1)13-16-8-10-18(11-9-16)20-14-17-7-4-12-19-17/h1-3,5-6,8-11,17,19H,4,7,12-14H2/t17-/m0/s1
  • InChiKey: NXNMORHGFGYRDN-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[4-(benzyl)phenoxy]methyl]pyrrolidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens leukotriene A4 hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus granulosus leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus multilocularis leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma japonicum ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative Get druggable targets OG5_129538 All targets in OG5_129538
Loa Loa (eye worm) leukotriene A4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 leukotriene A4 hydrolase 611 aa 508 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable lipase LipE 0.0082 0.0818 1
Schistosoma mansoni smad 0.0016 0.0089 0.0241
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0948
Trypanosoma brucei quiescin sulfhydryl oxidase 0.0012 0.0038 0.0443
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0224
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0067 0.0794
Brugia malayi hypothetical protein 0.0009 0.0005 0.0008
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0067 0.0113
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0073 0.0718 0.8778
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0002 0.0006
Echinococcus granulosus smad 0.0016 0.0089 0.0241
Plasmodium vivax SET domain protein, putative 0.0031 0.025 0.3035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0965 0.0965
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0327 0.0891
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0067 0.0794
Entamoeba histolytica G protein alpha subunit, putative 0.0009 0.0005 0.0061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0199 0.2125 0.5791
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0067 0.0794
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0015 0.0075 0.0889
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0224 0.0684
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0009 0.0005 0.0008
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0009 0.0005 0.0008
Mycobacterium ulcerans beta-lactamase 0.0082 0.0818 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0075 0.0203
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0327 0.1001
Trichomonas vaginalis esterase, putative 0.0082 0.0818 0.3189
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0009 0.0005 0.0008
Toxoplasma gondii Erv1 / Alr family protein 0.0073 0.0718 0.8778
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0067 0.0113
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.219 0.6746
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0948
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0075 0.0075
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0008 0.0002 0.0006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.025 0.025
Onchocerca volvulus 0.0015 0.0075 0.0284
Loa Loa (eye worm) hypothetical protein 0.0048 0.0445 0.1366
Schistosoma mansoni atpase class VI type 11c 0.0008 0.0002 0.0006
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0002 0.0006
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0015 0.0075 0.0203
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0067 0.0794
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0521 0.5714 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0075 0.0889
Onchocerca volvulus 0.0014 0.0067 0.0253
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0067 0.0794
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0445 0.5428
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.0002 0.0006
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0015 0.0075 0.0075
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0067 0.0113
Loa Loa (eye worm) oxidoreductase 0.0014 0.0067 0.02
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0009 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0082 0.0818 0.2516
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0067 0.0794
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0067 0.0794
Schistosoma mansoni hypothetical protein 0.0095 0.0965 0.2631
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0818 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0948
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0075 0.0284
Onchocerca volvulus 0.0028 0.0224 0.0868
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0111
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0327 0.398
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0075 0.0284
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0067 0.0794
Echinococcus granulosus cation transporting atpase worm 0.0008 0.0002 0.0006
Brugia malayi MH1 domain containing protein 0.0016 0.0089 0.0267
Echinococcus multilocularis smad 0.0016 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0048 0.0445 0.1366
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0067 0.0113
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0067 0.0794
Brugia malayi G-protein alpha subunit 0.0009 0.0005 0.0008
Brugia malayi Pre-SET motif family protein 0.0209 0.224 0.6898
Onchocerca volvulus 0.0014 0.0067 0.0253
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0009 0.0005 0.0008
Schistosoma mansoni type V p-type atpase isoform 0.0008 0.0002 0.0006
Echinococcus multilocularis aminopeptidase N 0.0015 0.0075 0.0075
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0067 0.02
Echinococcus granulosus cation transporting ATPase 13A1 0.0008 0.0002 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0067 0.02
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0075 0.0075
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0075 0.0889
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0009 0.0005 0.0008
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0067 0.0794
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0818 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0279 0.3015 0.8218
Mycobacterium ulcerans hypothetical protein 0.0048 0.0445 0.5428
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0052
Mycobacterium ulcerans aminopeptidase N PepN 0.0015 0.0075 0.0889
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0445 1
Brugia malayi Erv1 / Alr family protein 0.0012 0.0038 0.0111
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0067 0.02
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0818 0.2516
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0067 0.0794
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0965 0.2631
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0948
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0818 0.3189
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0445 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Toxoplasma gondii Erv1 / Alr family protein 0.0012 0.0038 0.0443
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0009 0.0005 0.0013
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0067 0.0113
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0009 0.0005 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.025 0.0681
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0067 0.0794
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0009 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0224
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.025 0.3035
Brugia malayi MH2 domain containing protein 0.0236 0.2536 0.781
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0818 0.1429
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0008 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0445 0.1366
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.02
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0009 0.0005 0.0011
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0067 0.0794
Schistosoma mansoni cpg binding protein 0.0028 0.0224 0.0611
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0075 0.0224
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0818 0.1429
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0012 0.0038 0.0443
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0009 0.0005 0.0013
Echinococcus multilocularis cation transporting ATPase 13A3 0.0008 0.0002 0.0002
Onchocerca volvulus 0.0082 0.0818 0.3189
Echinococcus multilocularis sulfhydryl oxidase 1 0.0012 0.0038 0.0038
Brugia malayi hypothetical protein 0.0128 0.1338 0.4117
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0818 1
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0012 0.0038 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0818 1
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0965 0.2969
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0002 0.0006
Onchocerca volvulus 0.0082 0.0818 0.3189
Onchocerca volvulus 0.0014 0.0067 0.0253
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0015 0.0075 0.0889
Trypanosoma cruzi aminopeptidase, putative 0.0015 0.0075 0.0889
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0067 0.02
Entamoeba histolytica aminopeptidase, putative 0.0015 0.0075 0.1638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0288 0.05
Schistosoma mansoni GTP-binding protein alpha subunit 0.0009 0.0005 0.0013
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0067 0.0794
Onchocerca volvulus 0.0082 0.0818 0.3189
Trypanosoma brucei Aminopeptidase M1, putative 0.0015 0.0075 0.0889
Trypanosoma brucei aminopeptidase, putative 0.0015 0.0075 0.0889
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0067 0.02
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0818 0.3189
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.025 0.0681
Trypanosoma brucei Aminopeptidase M1, putative 0.0015 0.0075 0.0889
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0038 0.0504
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.2536 0.781
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0095 0.0965 0.2631
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0067 0.0794
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0199 0.2125 0.5791
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0009 0.0005 0.0013
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0089 0.0089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.03 0.3246 1
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0818 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0008
Loa Loa (eye worm) peptidase family M1 containing protein 0.0015 0.0075 0.0224
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0002 0.0002
Brugia malayi Augmenter of liver regeneration 0.0073 0.0718 0.2208
Mycobacterium ulcerans lipase LipD 0.0082 0.0818 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.03 0.3246 1
Toxoplasma gondii aminopeptidase N protein 0.0015 0.0075 0.0889
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0067 0.0182
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0327 0.398
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0075 0.0889
Schistosoma mansoni smad1 5 8 and 0.0016 0.0089 0.0241
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0067 0.0113
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0075 0.0224
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.002
Schistosoma mansoni aminopeptidase A (M01 family) 0.0015 0.0075 0.0203
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0015 0.0075 0.0203
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0067 0.0794
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0327 0.4534
Loa Loa (eye worm) hypothetical protein 0.0082 0.0818 0.2516
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0445 0.1366
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0067 0.0113
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0009 0.0005 0.0008
Schistosoma mansoni hypothetical protein 0.0095 0.0965 0.2631
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0067 0.0794
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0445 0.5428
Loa Loa (eye worm) hypothetical protein 0.0095 0.0965 0.2969
Brugia malayi MH1 domain containing protein 0.0016 0.0089 0.0267
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0012 0.0038 0.0443
Loa Loa (eye worm) TATA binding protein associated factor 0.0015 0.0075 0.0224
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0012 0.0038 0.0141
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0445 0.5428
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0818 0.223
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0067 0.0794
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0015 0.0075 0.0889
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0818 0.223
Brugia malayi beta-lactamase family protein 0.0082 0.0818 0.2516
Schistosoma mansoni ap endonuclease 0.0037 0.0327 0.0891
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0199 0.2125 0.5791
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0009 0.0005 0.0013
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0073 0.0718 0.8778
Toxoplasma gondii aminopeptidase N, putative 0.0015 0.0075 0.0889
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0075 0.0203
Loa Loa (eye worm) hypothetical protein 0.0031 0.025 0.0764
Loa Loa (eye worm) hypothetical protein 0.0082 0.0818 0.2516
Onchocerca volvulus 0.0031 0.025 0.0968
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0009 0.0005 0.0013
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0818 1
Brugia malayi hypothetical protein 0.0087 0.0873 0.2686
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0589 0.1605
Echinococcus granulosus cation transporting ATPase 13A3 0.0008 0.0002 0.0006
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0015 0.0075 0.0889
Onchocerca volvulus 0.0009 0.0005 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0327 0.398
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0224
Brugia malayi TATA binding protein associated factor 0.0015 0.0075 0.0224
Onchocerca volvulus 0.0238 0.2561 1
Echinococcus granulosus sulfhydryl oxidase 1 0.0012 0.0038 0.0104
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0008 0.0002 0.0006
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0002 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0818 0.1429
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0067 0.0794
Loa Loa (eye worm) hypothetical protein 0.03 0.3246 1
Trypanosoma cruzi pantothenate kinase subunit, putative 0.001 0.0016 0.0167
Schistosoma mansoni cpg binding protein 0.003 0.0242 0.066
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0327 0.398
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0008 0.0002 0.0006
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0067 0.0794
Schistosoma mansoni ATPase 0.0008 0.0002 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.025 0.0681
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0012 0.0038 0.0104
Mycobacterium tuberculosis Conserved protein 0.0082 0.0818 0.1429
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0199 0.2125 0.6544
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0288 0.05
Mycobacterium tuberculosis Conserved protein 0.0082 0.0818 0.1429
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.002
Schistosoma mansoni hypothetical protein 0.0205 0.219 0.597
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0067 0.0794
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0948
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0009 0.0005 0.0013
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0073 0.0718 0.1958
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0067 0.0794
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0818 0.2516
Loa Loa (eye worm) aminopeptidase N 0.0015 0.0075 0.0224
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0009 0.0005 0.0008
Echinococcus multilocularis cation transporting ATPase 13A1 0.0008 0.0002 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0018 0.0049
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0067 0.02
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0075 0.0075
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0075 0.0203
Echinococcus multilocularis GPCR, family 2 0.0095 0.0965 0.0965
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0009 0.0005 0.0013
Leishmania major pantothenate kinase subunit, putative 0.001 0.0016 0.0167
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0327 0.1001
Brugia malayi MH2 domain containing protein 0.0016 0.0089 0.0267
Brugia malayi Smad1 0.0016 0.0089 0.0267
Schistosoma mansoni smad1 5 8 and 0.0016 0.0089 0.0241
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0279 0.3015 0.8218
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0089 0.0241
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0045 0.0075
Loa Loa (eye worm) G protein alpha subunit 3 0.0009 0.0005 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0199 0.2125 0.2125
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0009 0.0005 0.0013
Brugia malayi quiescin Q6 0.0012 0.0038 0.0111
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0002 0.0002
Toxoplasma gondii ABC1 family protein 0.0082 0.0818 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0073 0.0718 0.0718
Echinococcus multilocularis cation transporting atpase worm 0.0008 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0338 0.3669 1
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.0002 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0288 0.05
Loa Loa (eye worm) hypothetical protein 0.0205 0.219 0.6746
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0015 0.0075 0.0889
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0008 0.0002 0.0002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0327 0.0327
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0075 0.0203
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0089 0.0267
Loa Loa (eye worm) Smad1 0.0016 0.0089 0.0267
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0445 0.5428
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0818 0.0818
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0818 0.3189
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0288 0.05
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0009 0.0005 0.0011
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.0002 0.0002
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0009 0.0005 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0445 0.5428
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0089 0.0241
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0818 0.223
Echinococcus granulosus geminin 0.0338 0.3669 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0445 0.1366
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.02
Brugia malayi hypothetical protein 0.0015 0.0075 0.0224
Loa Loa (eye worm) pigment dispersing factor receptor c 0.03 0.3246 1
Echinococcus multilocularis expressed protein 0.0009 0.0005 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0238 0.2561 1
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0009 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0082 0.0818 0.2516
Brugia malayi beta-lactamase 0.0082 0.0818 0.2516
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0067 0.0794
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0445 0.0776
Echinococcus multilocularis copper transporting ATPase 1 0.0008 0.0002 0.0002
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0009 0.0005 0.0013
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0067 0.0904
Brugia malayi beta-lactamase family protein 0.0082 0.0818 0.2516
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0067 0.0253
Leishmania major hypothetical protein, conserved 0.0073 0.0718 0.8778
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.025 0.0681
Echinococcus multilocularis geminin 0.0338 0.3669 0.3669
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.031 0.377
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0518 0.6317
Brugia malayi MH2 domain containing protein 0.0016 0.0089 0.0267
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0067 0.0794
Onchocerca volvulus 0.0014 0.0067 0.0253
Onchocerca volvulus 0.0015 0.0075 0.0284
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0818 0.1429
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0067 0.0794
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0075 0.0284
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0965 0.2969
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0008 0.0002 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0075 0.0203
Schistosoma mansoni cation-transporting ATPase 0.0008 0.0002 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0327 0.398
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0067 0.0113
Brugia malayi Pre-SET motif family protein 0.0031 0.025 0.0764
Brugia malayi hypothetical protein 0.0015 0.0075 0.0224
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0009 0.0005 0.0008
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0075 0.0203
Loa Loa (eye worm) quiescin Q6 0.0012 0.0038 0.0111
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0009 0.0005 0.0011
Leishmania major hypothetical protein, conserved 0.0082 0.0818 1
Loa Loa (eye worm) nuclear factor I 0.0009 0.0009 0.002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0327 0.398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0199 0.2125 0.6544
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0067 0.0794
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0009 0.0005 0.0011
Echinococcus multilocularis Smad4 0.0016 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0008
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0015 0.0075 0.0889
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0327 0.7332
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0818 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0327 0.5
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0067 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0067 0.0794
Echinococcus granulosus expressed protein 0.0009 0.0005 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0067 0.0794
Onchocerca volvulus 0.0009 0.0005 0.0011
Mycobacterium ulcerans aminopeptidase N PepN 0.0015 0.0075 0.0889
Onchocerca volvulus 0.0009 0.0005 0.0011
Schistosoma mansoni GTP-binding protein alpha subunit 0.0009 0.0005 0.0013
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0073 0.0718 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0009 0.0005 0.0013
Loa Loa (eye worm) Erv1/Alr family protein 0.0012 0.0038 0.0111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0445 0.0776
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0002 0.0002
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0073 0.0718 0.8778
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0327 0.1269
Schistosoma mansoni cpg binding protein 0.003 0.0242 0.066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0445 0.1366
Loa Loa (eye worm) histone methyltransferase 0.001 0.0019 0.0053
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0279 0.3015 0.3015
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0067 0.0113
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0009 0.0005 0.0008
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0009 0.0005 0.0008
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0075 0.0075
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0075 0.0889
Schistosoma mansoni smad1 5 8 and 0.0016 0.0089 0.0241
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0009 0.0005 0.0011
Echinococcus granulosus cpg binding protein 0.003 0.0242 0.066
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0089 0.0267
Mycobacterium tuberculosis Conserved protein 0.0082 0.0818 0.1429
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.2536 0.781
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0067 0.0253
Loa Loa (eye worm) hepatopoietin HPO2 0.0073 0.0718 0.2208
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.224 0.6898
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0445 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0818 0.3189
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0009 0.0005 0.0011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0231 0.0629
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0445 0.5428
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0327 0.1269
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0015 0.0075 0.0889
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0012 0.0038 0.0141
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.031 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0199 0.2125 0.5791
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0818 0.1429
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0445 0.5428
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.031 0.0539
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0445 0.5428
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0965 0.2631
Schistosoma mansoni eyes absent homolog 0.0087 0.0873 0.238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0199 0.2125 0.2125
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0075 0.0203
Trypanosoma cruzi aminopeptidase, putative 0.0015 0.0075 0.0889
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0067 0.0182
Onchocerca volvulus 0.0015 0.0075 0.0284
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0009 0.0005 0.0013
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0082 0.0818 0.2516
Schistosoma mansoni ATPase 0.0008 0.0002 0.0006
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0073 0.0718 0.8778
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0445 0.5428
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0073 0.0718 0.8778
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0009 0.0005 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0067 0.02
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0009 0.0005 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.025 0.025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0965 0.0965
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0075 0.0224
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.031 0.377
Loa Loa (eye worm) beta-lactamase 0.0082 0.0818 0.2516
Schistosoma mansoni Smad4 0.0016 0.0089 0.0241
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0089 0.0089
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0445 0.5428
Loa Loa (eye worm) hypothetical protein 0.0087 0.0873 0.2686
Schistosoma mansoni hypothetical protein 0.0095 0.0965 0.2631
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0818 0.1429
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0067 0.0794
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0008
Toxoplasma gondii Erv1 / Alr family protein 0.0073 0.0718 0.8778
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0445 0.5428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0199 0.2125 0.5791
Loa Loa (eye worm) hypothetical protein 0.0082 0.0818 0.2516
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0067 0.0113
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0009 0.0005 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0067 0.0794
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0015 0.0075 0.0889
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0008 0.0002 0.0002
Echinococcus granulosus Smad4 0.0016 0.0089 0.0241
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0327 0.0569
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0009 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0038 0.0443
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0009 0.0005 0.0008
Toxoplasma gondii aminopeptidase n, putative 0.0015 0.0075 0.0889
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0009 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0008
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0067 0.1462
Trypanosoma cruzi Aminopeptidase M1, putative 0.0015 0.0075 0.0889
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0015 0.0075 0.1013
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0009 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0338 0.3669 1
Toxoplasma gondii exonuclease III APE 0.0037 0.0327 0.398
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0818 0.1429
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.025 0.0681
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0327 1
Echinococcus granulosus aminopeptidase N 0.0015 0.0075 0.0203
Echinococcus multilocularis cpg binding protein 0.003 0.0242 0.0242
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0008 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0095 0.0965 0.2631
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0067 0.0794
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0009 0.0005 0.0005
Echinococcus granulosus copper transporting ATPase 1 0.0008 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.002
Schistosoma mansoni copper ABC transporter ATPase 0.0008 0.0002 0.0006
Onchocerca volvulus 0.0048 0.0445 0.1731
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0067 0.02
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0445 0.5428
Brugia malayi CXXC zinc finger family protein 0.0028 0.0224 0.0684
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0279 0.3015 0.9289
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0327 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0965 0.2969
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0009 0.0005 0.0013
Schistosoma mansoni ap endonuclease 0.0037 0.0327 0.0891
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0067 0.0794
Mycobacterium ulcerans hypothetical protein 0.0082 0.0818 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0111
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0067 0.0794
Loa Loa (eye worm) hypothetical protein 0.0087 0.0873 0.2686
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0009 0.0005 0.0005
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.031 0.4295
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0015 0.0075 0.1013
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0818 0.3189
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0089 0.0241

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 244 nM Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS ChEMBL. 19950900

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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