TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 696.999 | Formula: C42H68N2O6
H donors: 2 H acceptors: 4 LogP: 8.63 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: CC(=O)NCCCCCCNC(=O)[C@@]12CC[C@H]([C@@H]2[C@@H]2[C@](CC1)(C)[C@]1(C)CC[C@@H]3[C@]([C@H]1CC2)(C)CC[C@@H]([C@@]3(C)COC(=O)C)OC(=O)C)C(=C)C
InChi: 1S/C42H68N2O6/c1-27(2)31-16-21-42(37(48)44-25-13-11-10-12-24-43-28(3)45)23-22-40(8)32(36(31)42)14-15-34-38(6)19-18-35(50-30(5)47)39(7,26-49-29(4)46)33(38)17-20-41(34,40)9/h31-36H,1,10-26H2,2-9H3,(H,43,45)(H,44,48)/t31-,32+,33+,34+,35-,36+,38-,39-,40+,41+,42-/m0/s1
InChiKey: YYVTTWHVEWOBEK-PZFXBPFESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.0024	1
Brugia malayi	Muscleblind-like protein	0.0147	0.0259	0.0259
Brugia malayi	cathepsin L-like precursor	0.1389	0.3464	0.3464
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1539	0.3851	0.3851
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0085	0.0097	1
Onchocerca volvulus		0.1389	0.3464	0.6764
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0472	0.1098	0.2139
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.0215	0.0415
Giardia lamblia	Cathepsin B precursor	0.0472	0.1098	0.2427
Trypanosoma cruzi	cysteine protease, putative	0.1114	0.2755	0.1862
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0695	0.1672	0.3134
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Echinococcus granulosus	glycogen phosphorylase	0.013	0.0215	0.0215
Plasmodium vivax	vivapain-2	0.2031	0.5122	1
Brugia malayi	cathepsin L precursor	0.0472	0.1098	0.1098
Echinococcus granulosus	cathepsin L	0.1114	0.2755	0.2755
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0472	0.1098	0.1991
Loa Loa (eye worm)	hypothetical protein	0.1389	0.3464	0.3464
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Giardia lamblia	Encystation-specific protease	0.0557	0.1316	0.3027
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Brugia malayi	carbohydrate phosphorylase	0.013	0.0215	0.0215
Trichomonas vaginalis	chromobox protein, putative	0.008	0.0085	0.016
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0017	0.0017
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0185	0.0357	0.0357
Giardia lamblia	Cathepsin L-like protease	0.0472	0.1098	0.2427
Onchocerca volvulus		0.2031	0.5122	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0472	0.1098	0.1098
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.0215	0.0215
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2031	0.5122	1
Brugia malayi	Heterochromatin protein 1	0.008	0.0085	0.0085
Onchocerca volvulus		0.2031	0.5122	1
Trypanosoma cruzi	cysteine proteinase, putative	0.1114	0.2755	0.1862
Brugia malayi	follicle stimulating hormone receptor	0.0266	0.0564	0.0564
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1833	0.4611	0.3946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Leishmania major	cathepsin L-like protease	0.2475	0.6268	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0472	0.1098	0.2139
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0713	0.1719	0.3352
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0472	0.1098	0.1991
Brugia malayi	Papain family cysteine protease containing protein	0.2031	0.5122	0.5122
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1114	0.2755	0.5377
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Toxoplasma gondii	cathepsin CPL	0.2031	0.5122	1
Trichomonas vaginalis	conserved hypothetical protein	0.0472	0.1098	0.2139
Schistosoma mansoni	hypothetical protein	0.0184	0.0353	0.0353
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Trypanosoma cruzi	cysteine peptidase, putative	0.2475	0.6268	0.5808
Loa Loa (eye worm)	hypothetical protein	0.392	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0557	0.1316	0.3027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Echinococcus granulosus	cysteine protease	0.1114	0.2755	0.2755
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Brugia malayi	Cathepsin L-like precursor	0.0642	0.1536	0.1536
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0017	0.0017
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0642	0.1536	0.1536
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0472	0.1098	0.2106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0713	0.1719	0.3352
Schistosoma mansoni	chromobox protein	0.008	0.0085	0.0085
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Schistosoma mansoni	cathepsin F (C01 family)	0.2031	0.5122	0.5122
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0017	0.0017
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2031	0.5122	1
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0259	0.0259
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0056	0.0022	0.0022
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0017	0.0017
Giardia lamblia	Cathepsin B precursor	0.1539	0.3851	1
Trichomonas vaginalis	conserved hypothetical protein	0.0472	0.1098	0.2139
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.0215	0.0215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0557	0.1316	0.3027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0713	0.1719	0.1719
Echinococcus granulosus	cathepsin l1	0.2031	0.5122	0.5122
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Plasmodium vivax	serine-repeat antigen (SERA)	0.0472	0.1098	0.1991
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1389	0.3464	0.3464
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2031	0.5122	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0048	0.0003	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Giardia lamblia	Cathepsin B precursor	0.1539	0.3851	1
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.0215	1
Onchocerca volvulus	Cathepsin L homolog	0.2031	0.5122	1
Plasmodium falciparum	serine repeat antigen 4	0.0472	0.1098	0.1991
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0472	0.1098	0.1991
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Brugia malayi	Cathepsin L-like precursor	0.1389	0.3464	0.3464
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1114	0.2755	0.5377
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0472	0.1098	0.2139
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1536	0.1536
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Echinococcus multilocularis	muscleblind protein	0.0147	0.0259	0.0259
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0695	0.1672	0.3134
Schistosoma mansoni	glycogen phosphorylase	0.013	0.0215	0.0215
Onchocerca volvulus	Cathepsin L homolog	0.0472	0.1098	0.2143
Echinococcus multilocularis	cathepsin L	0.1114	0.2755	0.2755
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0085	0.0097	0.0097
Onchocerca volvulus	Cathepsin F homolog	0.2031	0.5122	1
Schistosoma mansoni	chromobox protein	0.008	0.0085	0.0085
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.392	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.392	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0472	0.1098	0.1991
Giardia lamblia	Cathepsin B precursor	0.0472	0.1098	0.2427
Plasmodium falciparum	serine repeat antigen 6	0.0472	0.1098	0.1991
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Plasmodium falciparum	serine repeat antigen 9	0.0472	0.1098	0.1991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Echinococcus multilocularis	cathepsin L cysteine protease	0.2031	0.5122	0.5122
Echinococcus granulosus	geminin	0.0184	0.0353	0.0353
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0185	0.0357	0.0357
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2031	0.5122	0.5122
Echinococcus granulosus	glycogen phosphorylase	0.013	0.0215	0.0215
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Toxoplasma gondii	cathepsin CPC2	0.0557	0.1316	0.2424
Echinococcus granulosus	cathepsin L cysteine protease	0.1114	0.2755	0.2755
Loa Loa (eye worm)	cathepsin B	0.1539	0.3851	0.3851
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1389	0.3464	0.6762
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0259	0.0259
Brugia malayi	cathepsin L-like cysteine proteinase	0.0472	0.1098	0.1098
Schistosoma mansoni	cathepsin C	0.0472	0.1098	0.1098
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0472	0.1098	0.1098
Brugia malayi	Papain family cysteine protease containing protein	0.1114	0.2755	0.2755
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0097	0.5
Plasmodium falciparum	serine repeat antigen 5	0.0472	0.1098	0.1991
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0472	0.1098	0.2139
Trichomonas vaginalis	chromobox protein, putative	0.008	0.0085	0.016
Echinococcus granulosus	peptidase Clp S14 family	0.0056	0.0022	0.0022
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Echinococcus multilocularis	muscleblind protein 1	0.0147	0.0259	0.0259
Trypanosoma cruzi	cruzipain precursor, putative	0.2475	0.6268	0.5808
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1536	0.1536
Plasmodium vivax	vivapain-3	0.1114	0.2755	0.529
Plasmodium vivax	serine-repeat antigen (SERA)	0.0472	0.1098	0.1991
Entamoeba histolytica	cysteine proteinase, putative	0.2031	0.5122	1
Schistosoma mansoni	cathepsin F (C01 family)	0.2031	0.5122	0.5122
Loa Loa (eye worm)	cysteine protease	0.2031	0.5122	0.5122
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Plasmodium falciparum	serine repeat antigen 3	0.0472	0.1098	0.1991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Echinococcus multilocularis	cathepsin b	0.392	1	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.0215	0.0375
Giardia lamblia	Hypothetical protein	0.0472	0.1098	0.2427
Trypanosoma cruzi	cysteine peptidase, putative	0.2475	0.6268	0.5808
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0097	0.0097
Echinococcus granulosus	cathepsin L	0.0472	0.1098	0.1098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Echinococcus granulosus	cathepsin b	0.392	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1389	0.3464	0.6762
Giardia lamblia	Cathepsin B precursor	0.0472	0.1098	0.2427
Giardia lamblia	Cysteine protease	0.0472	0.1098	0.2427
Schistosoma mansoni	cathepsin B (C01 family)	0.0472	0.1098	0.1098
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Entamoeba histolytica	cysteine proteinase 2	0.1114	0.2755	0.5357
Giardia lamblia	Cysteine protease	0.0472	0.1098	0.2427
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1539	0.3851	0.3093
Schistosoma mansoni	glycogen phosphorylase	0.013	0.0215	0.0215
Brugia malayi	cathepsin F-like cysteine proteinase	0.0642	0.1536	0.1536
Giardia lamblia	Cathepsin L-like protease	0.0472	0.1098	0.2427
Echinococcus multilocularis	chromobox protein 1	0.008	0.0085	0.0085
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0472	0.1098	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0642	0.1536	0.0492
Schistosoma mansoni	hypothetical protein	0.0286	0.0617	0.0617
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1114	0.2755	0.2755
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Echinococcus granulosus	cathepsin l1	0.1389	0.3464	0.3464
Toxoplasma gondii	cathepsin B	0.1539	0.3851	0.7471
Echinococcus multilocularis	cysteine protease	0.2031	0.5122	0.5122
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0713	0.1719	0.3352
Schistosoma mansoni	hypothetical protein	0.0184	0.0353	0.0353
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Giardia lamblia	Cathepsin B precursor	0.1539	0.3851	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0713	0.1719	0.1719
Loa Loa (eye worm)	hypothetical protein	0.1389	0.3464	0.3464
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Schistosoma mansoni	cathepsin s	0.0642	0.1536	0.1536
Trypanosoma cruzi	cysteine peptidase, putative	0.2475	0.6268	0.5808
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0695	0.1672	0.3134
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0472	0.1098	0.2139
Entamoeba histolytica	hypothetical protein	0.0472	0.1098	0.2106
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.0215	0.0215
Schistosoma mansoni	peptidase Clp (S14 family)	0.0085	0.0097	0.0097
Giardia lamblia	Cathepsin B precursor	0.0713	0.1719	0.4135
Echinococcus multilocularis	cathepsin b	0.392	1	1
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0695	0.1672	0.3134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0713	0.1719	0.3352
Loa Loa (eye worm)	hypothetical protein	0.2031	0.5122	0.5122
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0695	0.1672	0.3134
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0695	0.1672	0.4007
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1114	0.2755	0.2755
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0472	0.1098	0.2427
Plasmodium vivax	unspecified product	0.0642	0.1536	0.2863
Entamoeba histolytica	cysteine proteinase, putative	0.1114	0.2755	0.5357
Entamoeba histolytica	cysteine proteinase, putative	0.1389	0.3464	0.6749
Echinococcus multilocularis	chromobox protein 1	0.008	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Echinococcus multilocularis	geminin	0.0184	0.0353	0.0353
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Plasmodium falciparum	serine repeat antigen 8	0.0472	0.1098	0.1991
Onchocerca volvulus		0.2031	0.5122	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0472	0.1098	0.1991
Entamoeba histolytica	cysteine proteinase, putative	0.1114	0.2755	0.5357
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Echinococcus granulosus	chromobox protein 1	0.008	0.0085	0.0085
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0097	1
Leishmania major	cysteine peptidase A (CPA)	0.2031	0.5122	0.5258
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1539	0.3851	0.7517
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Plasmodium falciparum	serine repeat antigen 7	0.0472	0.1098	0.1991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2031	0.5122	1
Brugia malayi	Cathepsin L-like precursor	0.1389	0.3464	0.3464
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Entamoeba histolytica	cysteine proteinase 1, putative	0.1114	0.2755	0.5357
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Giardia lamblia	Cathepsin B precursor	0.0472	0.1098	0.2427
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.0215	0.0375
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2031	0.5122	0.5122
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1539	0.3851	0.312
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2031	0.5122	0.5122
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0557	0.1316	0.2424
Echinococcus multilocularis	cysteine protease	0.2031	0.5122	0.5122
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.392	1	1
Plasmodium falciparum	serine repeat antigen 1	0.0472	0.1098	0.1991
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1536	0.1536
Brugia malayi	Papain family cysteine protease containing protein	0.1114	0.2755	0.2755
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0642	0.1536	0.1536
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.0215	0.042
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.0215	0.0215
Leishmania major	cathepsin L-like protease	0.2475	0.6268	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1114	0.2755	0.2755
Onchocerca volvulus	Cathepsin L homolog	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.061	0.1454	0.2835
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1114	0.2755	0.529
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Brugia malayi	Papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0557	0.1316	0.2424
Schistosoma mansoni	cathepsin S (C01 family)	0.0472	0.1098	0.1098
Brugia malayi	Probable ClpP-like protease	0.0085	0.0097	0.0097
Echinococcus multilocularis	cathepsin L cysteine protease	0.2031	0.5122	0.5122
Trypanosoma cruzi	cysteine peptidase, putative	0.2031	0.5122	0.452
Entamoeba histolytica	cysteine proteinase, putative	0.1114	0.2755	0.5357
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Plasmodium falciparum	serine repeat antigen 2	0.0472	0.1098	0.1991
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0266	0.0564	0.0564
Loa Loa (eye worm)	fibroinase	0.2031	0.5122	0.5122
Giardia lamblia	Hypothetical protein	0.0472	0.1098	0.2427
Plasmodium vivax	vivapain-1	0.1114	0.2755	0.529
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0713	0.1719	0.1719
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.0215	0.0415
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Trypanosoma cruzi	cysteine proteinase, putative	0.1114	0.2755	0.1862
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0472	0.1098	0.1991
Onchocerca volvulus		0.2031	0.5122	1
Entamoeba histolytica	cysteine proteinase, putative	0.1114	0.2755	0.5357
Toxoplasma gondii	cathepsin CPC1	0.0695	0.1672	0.3134
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0472	0.1098	0.1098
Entamoeba histolytica	cysteine proteinase, putative	0.2031	0.5122	1
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.0215	0.0215
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0472	0.1098	0.1098
Schistosoma mansoni	cathepsin F (C01 family)	0.1389	0.3464	0.3464
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0097	0.5
Brugia malayi	fibroinase precursor	0.0472	0.1098	0.1098
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2031	0.5122	0.5122
Echinococcus granulosus	muscleblind protein	0.0147	0.0259	0.0259
Echinococcus multilocularis	cathepsin L	0.0472	0.1098	0.1098
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.392	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0472	0.1098	0.2106
Onchocerca volvulus		0.2031	0.5122	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2031	0.5122	0.5122
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.392	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0642	0.1536	0.0492
Brugia malayi	Papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1114	0.2755	0.1862
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0097	1
Giardia lamblia	Cysteine protease	0.0472	0.1098	0.2427
Onchocerca volvulus		0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Echinococcus granulosus	chromobox protein 1	0.008	0.0085	0.0085
Plasmodium vivax	unspecified product	0.0472	0.1098	0.1991
Loa Loa (eye worm)	hypothetical protein	0.1389	0.3464	0.3464
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0017	0.0017
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2031	0.5122	0.5122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0472	0.1098	0.1991
Loa Loa (eye worm)	MBCTL1	0.0054	0.0017	0.0017
Trypanosoma cruzi	cysteine peptidase, putative	0.1114	0.2755	0.1862
Loa Loa (eye worm)	heterochromatin protein 1	0.008	0.0085	0.0085
Onchocerca volvulus		0.2031	0.5122	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Brugia malayi	Papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Trypanosoma cruzi	major cysteine proteinase, putative	0.0916	0.2244	0.1288
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Loa Loa (eye worm)	ctsf protein	0.2031	0.5122	0.5122
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0695	0.1672	0.1672
Leishmania major	cathepsin L-like protease	0.2475	0.6268	1
Onchocerca volvulus		0.0472	0.1098	0.2143
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Plasmodium vivax	unspecified product	0.1114	0.2755	0.529
Giardia lamblia	Cysteine protease	0.0472	0.1098	0.2427
Entamoeba histolytica	cysteine protease, putative	0.2031	0.5122	1
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0085	0.0097	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Echinococcus granulosus	cathepsin b	0.392	1	1
Plasmodium vivax	vivapain-2	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0472	0.1098	0.2139

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 34.1 uM	Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins	ChEMBL.	19889536

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL566381

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1059300