Detailed information for compound 1059764

Basic information

Technical information
  • TDR Targets ID: 1059764
  • Name: 3-[(1-acetyl-5-bromo-2,3-dihydroindol-7-yl)su lfonyl]-1-[4-(2-chlorophenyl)piperazin-1-yl]p ropan-1-one
  • MW: 554.884 | Formula: C23H25BrClN3O4S
  • H donors: 0 H acceptors: 4 LogP: 2.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Brc1cc2CCN(c2c(c1)S(=O)(=O)CCC(=O)N1CCN(CC1)c1ccccc1Cl)C(=O)C
  • InChi: 1S/C23H25BrClN3O4S/c1-16(29)28-8-6-17-14-18(24)15-21(23(17)28)33(31,32)13-7-22(30)27-11-9-26(10-12-27)20-5-3-2-4-19(20)25/h2-5,14-15H,6-13H2,1H3
  • InChiKey: HGDSJUWZSQUTNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1-acetyl-5-bromo-indolin-7-yl)sulfonyl-1-[4-(2-chlorophenyl)piperazin-1-yl]propan-1-one
  • 3-[(1-acetyl-5-bromo-7-indolinyl)sulfonyl]-1-[4-(2-chlorophenyl)-1-piperazinyl]propan-1-one
  • 3-[(5-bromo-1-ethanoyl-2,3-dihydroindol-7-yl)sulfonyl]-1-[4-(2-chlorophenyl)piperazin-1-yl]propan-1-one
  • C137-0016
  • NCGC00104130-01
  • EU-0021869

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0936 0.0929
Trichomonas vaginalis dullard protein, putative 0.0026 0.0418 0.1569
Mycobacterium tuberculosis Probable ATP-dependent DNA helicase II UvrD2 0.0014 0.0126 0.0138
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0222 0.0219
Giardia lamblia DINP protein human, muc B family 0.0081 0.1767 1
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0072 0.028
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Echinococcus granulosus dnaJ subfamily C 6 0.0066 0.1396 0.1393
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.1767 0.2274
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0072 0.0069
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0206 0.4838 0.6244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0936 0.0929
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0418 0.1569
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.1222 0.5
Toxoplasma gondii exonuclease III APE 0.0059 0.1222 0.4067
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.2899 0.2893
Trichomonas vaginalis dullard protein, putative 0.0026 0.0418 0.1569
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0015 0.0138 0.0235
Loa Loa (eye worm) hypothetical protein 0.0316 0.754 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0936 0.1242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0098
Schistosoma mansoni blooms syndrome DNA helicase 0.0091 0.2023 0.2016
Brugia malayi CCR4 0.0012 0.0072 0.0095
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0973 0.1288
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0301 0.129
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.1767 0.2274
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.1222 0.4645
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0022 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0905 0.3432
Brugia malayi MH2 domain containing protein 0.001 0.0022 0.003
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0072 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0936 0.0929
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1463 0.188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2899 0.7204
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0411 0.1775
Schistosoma mansoni rab6-interacting 0.0021 0.0301 0.0293
Leishmania major DNA polymerase eta, putative 0.016 0.3718 0.4753
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0026 0.0418 0.2421
Echinococcus granulosus cathepsin L 0.0009 0.0008 0.0005
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0126 0.0518
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Onchocerca volvulus 0.0021 0.0301 0.0307
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0222 0.0219
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0356 0.0719
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0222 0.0944
Onchocerca volvulus 0.0018 0.0222 0.0202
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0222 0.0214
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0397 0.0389
Leishmania major DNA polymerase kappa, putative 0.0081 0.1767 0.221
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0654 0.0835
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.09 0.1153
Trypanosoma brucei unspecified product 0.0081 0.1767 0.2274
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0411 0.1775
Echinococcus multilocularis bloom syndrome protein 0.0115 0.262 0.2618
Brugia malayi MH2 domain containing protein 0.0144 0.3326 0.4411
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0026 0.0418 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Echinococcus granulosus dna polymerase kappa 0.0081 0.1767 0.1765
Schistosoma mansoni ap endonuclease 0.0059 0.1222 0.1214
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0953 0.1264
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0905 0.0902
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0222 0.0202
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0076 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0397 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0026 0.0418 0.0554
Schistosoma mansoni cript-related 0.0012 0.0072 0.0064
Trichomonas vaginalis DNA helicase recq, putative 0.0115 0.262 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0301 0.0395
Echinococcus multilocularis dna polymerase kappa 0.0081 0.1767 0.1765
Brugia malayi Cathepsin L-like precursor 0.0012 0.0076 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0222 0.0819
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.1222 0.2847
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0015 0.0138 0.0135
Echinococcus granulosus GPCR family 2 0.0049 0.0989 0.0987
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0206 0.4838 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.2899 0.7243
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0048 0.0953 0.095
Leishmania major mitochondrial DNA polymerase beta 0.0324 0.7743 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0101 0.2275 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0072 0.0082
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.1222 0.2946
Echinococcus granulosus synaptojanin 1 0.0012 0.0072 0.0069
Schistosoma mansoni DNA polymerase eta 0.016 0.3718 0.3713
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0206 0.4838 0.4836
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Schistosoma mansoni lipoxygenase 0.0088 0.1955 0.1948
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.1222 0.1569
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.1767 0.4345
Echinococcus granulosus cathepsin l1 0.0018 0.0222 0.0219
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.1145 0.147
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0324 0.7743 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0301 0.0298
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0076 0.0068
Schistosoma mansoni nocturnin 0.0012 0.0072 0.0064
Trypanosoma brucei unspecified product 0.0056 0.1151 0.1477
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0072 0.0069
Onchocerca volvulus 0.0018 0.0222 0.0202
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Brugia malayi hypothetical protein 0.0026 0.0411 0.0545
Schistosoma mansoni hypothetical protein 0.0049 0.0989 0.0982
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.1767 0.4265
Leishmania major hypothetical protein, conserved 0.0026 0.0411 0.0442
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0081 0.1767 0.1765
Trichomonas vaginalis DNA helicase recq1, putative 0.0115 0.262 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0905 0.2946
Brugia malayi cathepsin L-like precursor 0.0012 0.0076 0.0101
Loa Loa (eye worm) DnaJ domain-containing protein 0.0066 0.1396 0.1848
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0104 0.2348 0.8052
Toxoplasma gondii cathepsin CPL 0.0018 0.0222 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0222 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1463 0.188
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0072 0.0375
Toxoplasma gondii hypothetical protein 0.0052 0.1065 0.3514
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0072 0.0069
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.3602 0.3597
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0418 0.1569
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.09 0.1153
Plasmodium vivax vivapain-2 0.0018 0.0222 0.1265
Loa Loa (eye worm) hypothetical protein 0.016 0.3718 0.4929
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0026 0.0418 0.0415
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0072 0.0082
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0072 0.0069
Echinococcus multilocularis GPCR, family 2 0.0049 0.0989 0.0987
Onchocerca volvulus 0.0018 0.0222 0.0202
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0048 0.0953 0.4167
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.1463 0.188
Schistosoma mansoni hypothetical protein 0.0416 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0654 0.2474
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0063 0.006
Echinococcus multilocularis RUN 0.0021 0.0301 0.0298
Schistosoma mansoni transcription factor btf3 0.0036 0.0654 0.0647
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0023 0.0356 0.2052
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.0541
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0989 0.1312
Schistosoma mansoni blooms syndrome DNA helicase 0.0024 0.0378 0.037
Schistosoma mansoni cpg binding protein 0.0031 0.0539 0.0531
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0397 0.0503
Entamoeba histolytica recQ family helicase, putative 0.0062 0.1298 0.267
Entamoeba histolytica hypothetical protein 0.0036 0.0654 0.1338
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0301 0.1728
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0015 0.0138 0.017
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0072 0.028
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.3602 0.4777
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0081 0.1767 0.2341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0397 0.0503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0206 0.4838 0.6415
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Brugia malayi Bloom's syndrome protein homolog 0.0115 0.262 0.3475
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2899 0.7204
Brugia malayi MH1 domain containing protein 0.001 0.0022 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0416 1 1
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0012 0.0072 0.0082
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.1767 0.2344
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0936 0.0934
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Mycobacterium ulcerans hypothetical protein 0.0015 0.0138 0.0032
Mycobacterium leprae conserved hypothetical protein 0.0015 0.0138 0.5
Leishmania major DNA polymerase eta, putative 0.0104 0.2348 0.2967
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0397 0.0503
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0091
Leishmania major cathepsin L-like protease 0.0068 0.1463 0.1813
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.3975 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0953 0.3117
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0222 0.0219
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0654 0.2474
Onchocerca volvulus 0.0018 0.0222 0.0202
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0397 0.0503
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0063 0.006
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0072 0.0131
Brugia malayi MH2 domain containing protein 0.001 0.0022 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0222 0.0443
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0222 0.0219
Loa Loa (eye worm) hypothetical protein 0.0025 0.0397 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0126 0.045
Trichomonas vaginalis dullard protein, putative 0.0026 0.0418 0.1569
Brugia malayi Cytochrome P450 family protein 0.0049 0.0973 0.1291
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0953 0.1264
Onchocerca volvulus 0.0018 0.0222 0.0202
Loa Loa (eye worm) hypothetical protein 0.03 0.7151 0.9485
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0222 0.0819
Schistosoma mansoni hypothetical protein 0.0106 0.2391 0.2385
Echinococcus multilocularis Smad4 0.001 0.0022 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.1103 0.1415
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.2899 0.2893
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0126 0.0694
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0026 0.0418 0.0551
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0077 0.1678 0.5682
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0081 0.1767 0.4345
Leishmania major hypothetical protein, conserved 0.0026 0.0418 0.0451
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0015 0.0138 0.013
Echinococcus multilocularis smad 0.001 0.0022 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0936 0.0934
Leishmania major cathepsin L-like protease 0.0068 0.1463 0.1813
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0905 0.5296
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0076 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Schistosoma mansoni Smad4 0.001 0.0022 0.0014
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0026 0.0418 0.0415
Loa Loa (eye worm) Smad1 0.001 0.0022 0.0026
Schistosoma mansoni hypothetical protein 0.0026 0.041 0.0402
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0397 0.2299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.1767 0.6735
Schistosoma mansoni cpg binding protein 0.0029 0.0498 0.0491
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0222 0.0944
Onchocerca volvulus 0.0021 0.0301 0.0307
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0654 0.3818
Brugia malayi hypothetical protein 0.0017 0.0187 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0072 0.0064
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.2391 0.3172
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0654 0.0835
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.1222 0.6781
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.3549 0.4578
Entamoeba histolytica cysteine protease, putative 0.0018 0.0222 0.0443
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0022 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1151 0.1477
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0206 0.4838 0.6213
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1234 0.4111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0091
Giardia lamblia Sgs1 DNA helicase, putative 0.0048 0.0953 0.5197
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0206 0.4838 0.4836
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0206 0.4838 0.6244
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0072 0.0243
Leishmania major exosome subunit rrp6p homologue, putative 0.0015 0.0138 0.0086
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0072 0.028
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0654 0.0835
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0222 0.0291
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0072 0.0375
Echinococcus granulosus bloom syndrome protein 0.0115 0.262 0.2618
Schistosoma mansoni smad 0.001 0.0022 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0936 0.0934
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0072 0.0131
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.1222 0.162
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1463 0.188
Schistosoma mansoni DNA helicase recq1 0.0048 0.0953 0.0945
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0397 0.0503
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0072 0.0131
Trypanosoma cruzi DNA polymerase eta, putative 0.0104 0.2348 0.3025
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0301 0.0298
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0072 0.0069
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0397 0.1152
Loa Loa (eye worm) acetyltransferase 0.0155 0.3602 0.4775
Echinococcus multilocularis cysteine protease 0.0018 0.0222 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0072 0.0243
Leishmania major cathepsin L-like protease 0.0068 0.1463 0.1813
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0022 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Echinococcus granulosus RUN 0.0021 0.0301 0.0298
Entamoeba histolytica recQ family DNA helicase 0.0024 0.0378 0.0766
Schistosoma mansoni synaptojanin 0.0012 0.0072 0.0064
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0989 0.0987
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.3549 0.4533
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0811 0.1662
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.1222 0.1219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0222 0.0291
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0022 0.002
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0098
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0654 0.1338
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0222 0.0291
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.1222 0.1617
Schistosoma mansoni hypothetical protein 0.0049 0.0989 0.0982
Schistosoma mansoni loxhd1 0.0021 0.0301 0.0293
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0072 0.0069
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0012 0.0072 0.0082
Echinococcus granulosus cathepsin l1 0.0012 0.0076 0.0074
Echinococcus granulosus smad 0.001 0.0022 0.002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.2899 0.2897
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Mycobacterium ulcerans hypothetical protein 0.0171 0.3975 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Echinococcus multilocularis transcription factor Dp 1 0.0119 0.2708 0.2706
Brugia malayi hypothetical protein 0.0316 0.754 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0539 0.0537
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0072 0.0064
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0222 0.0202
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.2899 0.3685
Schistosoma mansoni hypothetical protein 0.0021 0.0301 0.0293
Echinococcus multilocularis cathepsin L 0.0009 0.0008 0.0005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.1222 0.5352
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0072 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0076 0.0261
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0418 0.1569
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0072 0.0243
Trypanosoma cruzi DNA polymerase eta, putative 0.016 0.3718 0.4796
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2899 0.7204
Trypanosoma brucei RNA editing exonuclease 2 0.0012 0.0072 0.0082
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0026 0.0418 0.041
Loa Loa (eye worm) cysteine protease 0.0018 0.0222 0.0291
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 0.7743 1
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0072 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0072 0.0243
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0301 0.0298
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0012 0.0072 0.0082
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0498 0.0657
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0015 0.0138 0.0168
Loa Loa (eye worm) fibroinase 0.0018 0.0222 0.0291
Trichomonas vaginalis DNA helicase recq, putative 0.0062 0.1298 0.4937
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0153 0.3549 0.4578
Schistosoma mansoni cpg binding protein 0.0031 0.0539 0.0531
Loa Loa (eye worm) hypothetical protein 0.0155 0.36 0.4772
Echinococcus granulosus CTD small phosphatase protein like 0.0026 0.0418 0.0415
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.1222 0.1499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0012 0.0072 0.0082
Trypanosoma brucei unspecified product 0.0056 0.1151 0.1477
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0072 0.0091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0989 0.0987
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0072 0.0243
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0062 0.1298 0.1667
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0026 0.0418 0.0848
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.1222 0.4645
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0301 0.0298
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0081 0.1767 0.1765
Schistosoma mansoni terminal deoxycytidyl transferase 0.0081 0.1767 0.1761
Trypanosoma brucei ribosomal RNA processing protein 6 0.0015 0.0138 0.0168
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0411 0.052
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0012 0.0072 0.0082
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0222 0.0219
Loa Loa (eye worm) hypothetical protein 0.0024 0.0378 0.0498
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0378 0.0478
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0048 0.0953 0.095
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.1317 0.1692
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0905 0.2946
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0222 0.0944
Loa Loa (eye worm) 3'-5' exonuclease 0.0015 0.0138 0.0179
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0811 0.3541
Echinococcus multilocularis dna polymerase eta 0.016 0.3718 0.3716
Loa Loa (eye worm) hypothetical protein 0.0048 0.0953 0.1261
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0072 0.0082
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Loa Loa (eye worm) ctsf protein 0.0018 0.0222 0.0291
Loa Loa (eye worm) hypothetical protein 0.0106 0.2391 0.3169
Loa Loa (eye worm) hypothetical protein 0.0049 0.0989 0.1309
Schistosoma mansoni hypothetical protein 0.0049 0.0989 0.0982
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0989 0.0987
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.1222 0.1569
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0026 0.0418 0.1225
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0022 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trypanosoma brucei DNA polymerase eta, putative 0.016 0.3718 0.4796
Giardia lamblia DNA damage repair protein 0.0025 0.0397 0.1921
Brugia malayi hypothetical protein 0.0021 0.0301 0.0399
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0654 0.2061
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.36 0.4774
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.36 0.4772
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0411 0.052
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0301 0.0298
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0072 0.0069
Loa Loa (eye worm) RecQ helicase 0.0115 0.262 0.3473
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0397 0.0503
Onchocerca volvulus 0.0012 0.0076 0.0006
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0026 0.0418 0.041
Leishmania major DNA damage repair protein, putative 0.0025 0.0397 0.0425
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1151 0.1477
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0098
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0397 0.0503
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0072 0.0064
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0989 0.0987
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0072 0.0082
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Brugia malayi CXXC zinc finger family protein 0.0029 0.0498 0.0661
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0022 0.002
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0206 0.4838 0.6416
Brugia malayi DnaJ domain containing protein 0.0066 0.1396 0.1851
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0012 0.0072 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Schistosoma mansoni synaptojanin 0.0012 0.0072 0.0064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0936 0.1238
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0026 0.0418 0.053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Echinococcus granulosus Smad4 0.001 0.0022 0.002
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0072 0.0243
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0072 0.0375
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0206 0.4838 0.6244
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0048 0.0953 0.1261
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0222 0.0214
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0072 0.0082
Onchocerca volvulus 0.0018 0.0222 0.0202
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0072 0.0243
Echinococcus granulosus transcription factor btf3 0.0036 0.0654 0.0652
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0397 0.0503
Schistosoma mansoni hypothetical protein 0.0012 0.0072 0.0064
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0048 0.0953 0.095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1303 0.1296
Schistosoma mansoni hypothetical protein 0.0049 0.0989 0.0982
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0022 0.002
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0222 0.0202
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.09 0.1153
Schistosoma mansoni lipoxygenase 0.0126 0.289 0.2884
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0008 0.0011
Onchocerca volvulus 0.0018 0.0222 0.0202
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0072 0.0069
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0301 0.0298
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.3602 0.36
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0072 0.0082
Leishmania major DNA polymerase kappa, putative 0.0025 0.0397 0.0425
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0081 0.1767 0.221
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0397 0.1717
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0014
Echinococcus multilocularis synaptojanin 1 0.0012 0.0072 0.0069
Brugia malayi Cathepsin L-like precursor 0.0012 0.0076 0.0101
Schistosoma mansoni hypothetical protein 0.0066 0.1396 0.1389
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0222 0.0219
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0206 0.4838 0.4833
Schistosoma mansoni rab6-interacting 0.0021 0.0301 0.0293
Schistosoma mansoni ap endonuclease 0.0059 0.1222 0.1214
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0418 0.1569
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0411 0.2377
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0936 0.0934
Plasmodium vivax vivapain-2 0.0018 0.0222 0.1265
Schistosoma mansoni polycystin 1-related 0.0021 0.0301 0.0293
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0072 0.0243
Echinococcus granulosus dna polymerase eta 0.016 0.3718 0.3716
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0654 0.285
Echinococcus multilocularis cysteine protease 0.0018 0.0222 0.0219
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0989 0.1309
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0397 0.1152
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0062 0.1298 0.1598
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0301 0.0395
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.1222 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.1222 0.2512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Onchocerca volvulus 0.0316 0.754 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0378 0.1084
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0072 0.0131
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0026 0.0418 0.2421
Loa Loa (eye worm) hypothetical protein 0.0026 0.041 0.054
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3326 0.4409
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0811 0.4359
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3326 0.4409
Entamoeba histolytica deoxycytidyl transferase, putative 0.0081 0.1767 0.3643
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.1767 0.2274
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0654 0.0864
Echinococcus granulosus cpg binding protein 0.0031 0.0539 0.0537
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0072 0.028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0091
Entamoeba histolytica exosome component 10, putative 0.0015 0.0138 0.0269
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.289 0.2888
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0138 0.0497
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0015 0.0138 0.0767
Onchocerca volvulus 0.0029 0.0498 0.0571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0081 0.1767 0.1761
Loa Loa (eye worm) hypothetical protein 0.0021 0.0301 0.0395
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0062 0.1298 0.1667
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0989 0.1312
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0048 0.0953 0.095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.36 0.4774
Brugia malayi Doublecortin family protein 0.0021 0.0301 0.0399
Echinococcus multilocularis 0.0026 0.0418 0.0415
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0012 0.0072 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1151 0.1477
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.1222 0.7169
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.2899 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.09 0.1153
Brugia malayi Smad1 0.001 0.0022 0.003
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0222 0.0196
Brugia malayi 3'-5' exonuclease family protein 0.0015 0.0138 0.0183
Brugia malayi ImpB/MucB/SamB family protein 0.016 0.3718 0.4931
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0953 0.3117
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0076 0.0101
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.1767 0.6735
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.289 0.2888
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0397 0.0503
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0411 0.052
Schistosoma mansoni hypothetical protein 0.0011 0.0063 0.0055
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0091
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0411 0.1199
Echinococcus granulosus cysteine protease 0.0009 0.0008 0.0005
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0026 0.0418 0.2042
Echinococcus granulosus transcription factor Dp 1 0.0119 0.2708 0.2706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0072 0.0243
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0072 0.0069
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.3495 0.3493
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.1222 0.1569
Schistosoma mansoni DNA helicase recq5 0.0048 0.0953 0.0945
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 0.7743 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0905 0.3432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Brugia malayi MH1 domain containing protein 0.001 0.0022 0.003
Mycobacterium ulcerans hypothetical protein 0.0025 0.0397 0.0706
Echinococcus multilocularis dnaJ subfamily C 6 0.0066 0.1396 0.1393
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0015 0.0138 0.0135
Trichomonas vaginalis protein kinase inhibitor, putative 0.0066 0.1396 0.5312
Brugia malayi beta-NAC-like protein 0.0036 0.0654 0.0868
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0222 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Treponema pallidum ATP-dependent DNA helicase 0.0024 0.0378 0.2666
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0008 0.0005
Brugia malayi hypothetical protein 0.0021 0.0301 0.0399
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0397 0.0503
Brugia malayi polk-prov protein 0.0025 0.0397 0.0527
Echinococcus multilocularis transcription factor btf3 0.0036 0.0654 0.0652
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.1767 0.4265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0654 0.2474
Leishmania major basic transcription factor 3a, putative 0.0036 0.0654 0.076
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.2899 0.2897
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0078 0.1701 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0222 0.0443
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0072 0.0375
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0418 0.053
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.1222 0.1219
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0378 0.0478

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4467 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.