Detailed information for compound 1059764

Basic information

Technical information
  • TDR Targets ID: 1059764
  • Name: 3-[(1-acetyl-5-bromo-2,3-dihydroindol-7-yl)su lfonyl]-1-[4-(2-chlorophenyl)piperazin-1-yl]p ropan-1-one
  • MW: 554.884 | Formula: C23H25BrClN3O4S
  • H donors: 0 H acceptors: 4 LogP: 2.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Brc1cc2CCN(c2c(c1)S(=O)(=O)CCC(=O)N1CCN(CC1)c1ccccc1Cl)C(=O)C
  • InChi: 1S/C23H25BrClN3O4S/c1-16(29)28-8-6-17-14-18(24)15-21(23(17)28)33(31,32)13-7-22(30)27-11-9-26(10-12-27)20-5-3-2-4-19(20)25/h2-5,14-15H,6-13H2,1H3
  • InChiKey: HGDSJUWZSQUTNP-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-(1-acetyl-5-bromo-indolin-7-yl)sulfonyl-1-[4-(2-chlorophenyl)piperazin-1-yl]propan-1-one
  • 3-[(1-acetyl-5-bromo-7-indolinyl)sulfonyl]-1-[4-(2-chlorophenyl)-1-piperazinyl]propan-1-one
  • 3-[(5-bromo-1-ethanoyl-2,3-dihydroindol-7-yl)sulfonyl]-1-[4-(2-chlorophenyl)piperazin-1-yl]propan-1-one
  • C137-0016
  • NCGC00104130-01
  • EU-0021869

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0072 0.0243
Loa Loa (eye worm) hypothetical protein 0.0106 0.2391 0.3169
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.1767 0.4345
Brugia malayi CCR4 0.0012 0.0072 0.0095
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Echinococcus granulosus dnaJ subfamily C 6 0.0066 0.1396 0.1393
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.2899 0.2893
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0062 0.1298 0.1667
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0014
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0072 0.0243
Brugia malayi Smad1 0.001 0.0022 0.003
Schistosoma mansoni hypothetical protein 0.0049 0.0989 0.0982
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0072 0.0082
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0654 0.285
Brugia malayi MH2 domain containing protein 0.001 0.0022 0.003
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0101 0.2275 1
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0026 0.0418 0.0415
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0222 0.0291
Brugia malayi DnaJ domain containing protein 0.0066 0.1396 0.1851
Echinococcus granulosus GPCR family 2 0.0049 0.0989 0.0987
Trypanosoma brucei unspecified product 0.0081 0.1767 0.2274
Onchocerca volvulus 0.0018 0.0222 0.0202
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.289 0.2888
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2899 0.7204
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0905 0.3432
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.1767 0.6735
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0411 0.1775
Brugia malayi MH1 domain containing protein 0.001 0.0022 0.003
Echinococcus granulosus transcription factor btf3 0.0036 0.0654 0.0652
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0654 0.0835
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0397 0.1152
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Echinococcus multilocularis dnaJ subfamily C 6 0.0066 0.1396 0.1393
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0222 0.0944
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0222 0.0219
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0012 0.0072 0.0082
Loa Loa (eye worm) 3'-5' exonuclease 0.0015 0.0138 0.0179
Brugia malayi beta-NAC-like protein 0.0036 0.0654 0.0868
Giardia lamblia Sgs1 DNA helicase, putative 0.0048 0.0953 0.5197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0411 0.052
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0126 0.0518
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0072 0.0243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.289 0.2888
Schistosoma mansoni rab6-interacting 0.0021 0.0301 0.0293
Mycobacterium leprae conserved hypothetical protein 0.0015 0.0138 0.5
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0015 0.0138 0.017
Echinococcus granulosus transcription factor Dp 1 0.0119 0.2708 0.2706
Onchocerca volvulus 0.0018 0.0222 0.0202
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0072 0.0091
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0026 0.0418 0.053
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0973 0.1288
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0418 0.1569
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1234 0.4111
Trichomonas vaginalis DNA helicase recq, putative 0.0062 0.1298 0.4937
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0072 0.0131
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2899 0.7204
Brugia malayi hypothetical protein 0.0021 0.0301 0.0399
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.1222 0.2847
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.2899 0.7243
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0026 0.0418 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Brugia malayi Cathepsin L-like precursor 0.0012 0.0076 0.0101
Leishmania major exosome subunit rrp6p homologue, putative 0.0015 0.0138 0.0086
Loa Loa (eye worm) hypothetical protein 0.016 0.3718 0.4929
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0378 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0222 0.0277
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.3549 0.4578
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.1222 0.7169
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0301 0.0298
Loa Loa (eye worm) hypothetical protein 0.03 0.7151 0.9485
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0062 0.1298 0.1598
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0076 0.0101
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0063 0.006
Leishmania major DNA polymerase kappa, putative 0.0081 0.1767 0.221
Echinococcus granulosus cathepsin l1 0.0018 0.0222 0.0219
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.1767 0.4265
Brugia malayi 3'-5' exonuclease family protein 0.0015 0.0138 0.0183
Plasmodium vivax vivapain-2 0.0018 0.0222 0.1265
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0222 0.0219
Brugia malayi MH2 domain containing protein 0.0144 0.3326 0.4411
Echinococcus multilocularis cysteine protease 0.0018 0.0222 0.0219
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Loa Loa (eye worm) Smad1 0.001 0.0022 0.0026
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0008 0.0011
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.1222 0.4645
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0222 0.0219
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0072 0.0069
Leishmania major DNA damage repair protein, putative 0.0025 0.0397 0.0425
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0026 0.0418 0.2042
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0222 0.0214
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0418 0.1569
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0072 0.0243
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0063 0.006
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0222 0.0944
Schistosoma mansoni terminal deoxycytidyl transferase 0.0081 0.1767 0.1761
Schistosoma mansoni hypothetical protein 0.0012 0.0072 0.0064
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Leishmania major DNA polymerase eta, putative 0.016 0.3718 0.4753
Onchocerca volvulus 0.0018 0.0222 0.0202
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0077 0.1678 0.5682
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0905 0.2946
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0397 0.0503
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Schistosoma mansoni lipoxygenase 0.0126 0.289 0.2884
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0062 0.1298 0.1667
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.09 0.1153
Loa Loa (eye worm) hypothetical protein 0.0048 0.0953 0.1261
Echinococcus multilocularis transcription factor Dp 1 0.0119 0.2708 0.2706
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.3602 0.36
Trichomonas vaginalis dullard protein, putative 0.0026 0.0418 0.1569
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.1222 0.1617
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.1222 0.162
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0153 0.3549 0.4578
Trichomonas vaginalis DNA helicase recq, putative 0.0115 0.262 1
Echinococcus multilocularis cathepsin L 0.0009 0.0008 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Loa Loa (eye worm) hypothetical protein 0.0018 0.0222 0.0291
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0397 0.0503
Mycobacterium tuberculosis Probable ATP-dependent DNA helicase II UvrD2 0.0014 0.0126 0.0138
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0654 0.0835
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0091
Brugia malayi MH1 domain containing protein 0.001 0.0022 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0022 0.0026
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.1222 0.4645
Brugia malayi Cathepsin L-like precursor 0.0012 0.0076 0.0101
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0301 0.129
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.36 0.4772
Schistosoma mansoni hypothetical protein 0.0011 0.0063 0.0055
Echinococcus multilocularis cysteine protease 0.0018 0.0222 0.0219
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.2899 0.2893
Giardia lamblia DINP protein human, muc B family 0.0081 0.1767 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0022 0.002
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0072 0.0375
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Schistosoma mansoni rab6-interacting 0.0021 0.0301 0.0293
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0072 0.0375
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0081 0.1767 0.1761
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0222 0.0196
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0411 0.1199
Leishmania major cathepsin L-like protease 0.0068 0.1463 0.1813
Schistosoma mansoni ap endonuclease 0.0059 0.1222 0.1214
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0072 0.0069
Brugia malayi hypothetical protein 0.0316 0.754 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Echinococcus multilocularis cpg binding protein 0.0031 0.0539 0.0537
Schistosoma mansoni hypothetical protein 0.0106 0.2391 0.2385
Entamoeba histolytica hypothetical protein 0.0036 0.0654 0.1338
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0411 0.052
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1463 0.188
Echinococcus granulosus cathepsin L 0.0009 0.0008 0.0005
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0048 0.0953 0.1261
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0072 0.0069
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0206 0.4838 0.6416
Trichomonas vaginalis dullard protein, putative 0.0026 0.0418 0.1569
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0397 0.0503
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0072 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0418 0.1569
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.36 0.4774
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Brugia malayi cathepsin L-like precursor 0.0012 0.0076 0.0101
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0076 0.0141
Echinococcus multilocularis RUN 0.0021 0.0301 0.0298
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.09 0.1153
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.3495 0.3493
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0012 0.0072 0.0082
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0072 0.028
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0654 0.1338
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0936 0.0929
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0012 0.0072 0.0082
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0397 0.0503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Loa Loa (eye worm) cysteine protease 0.0018 0.0222 0.0291
Echinococcus multilocularis dnaJ subfamily B 0.0416 1 1
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0072 0.0064
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0072 0.0069
Schistosoma mansoni hypothetical protein 0.0021 0.0301 0.0293
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0206 0.4838 0.6213
Trypanosoma cruzi DNA polymerase eta, putative 0.0104 0.2348 0.3025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0015 0.0138 0.013
Trichomonas vaginalis protein kinase inhibitor, putative 0.0066 0.1396 0.5312
Brugia malayi hypothetical protein 0.0017 0.0187 0.0249
Entamoeba histolytica cysteine protease, putative 0.0018 0.0222 0.0443
Onchocerca volvulus 0.0012 0.0076 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0378 0.0498
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0905 0.5296
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0104 0.2348 0.8052
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0072 0.0243
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0026 0.0418 0.1225
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Leishmania major DNA polymerase eta, putative 0.0104 0.2348 0.2967
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0222 0.0944
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0378 0.0478
Brugia malayi Bloom's syndrome protein homolog 0.0115 0.262 0.3475
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0301 0.0395
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0022 0.0014
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.2899 0.2897
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0126 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1151 0.1477
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0072 0.0082
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0397 0.0503
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0072 0.0069
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.1222 0.1219
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0072 0.0064
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0301 0.0298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Brugia malayi CXXC zinc finger family protein 0.0029 0.0498 0.0661
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.09 0.1153
Onchocerca volvulus 0.0021 0.0301 0.0307
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0014
Schistosoma mansoni blooms syndrome DNA helicase 0.0091 0.2023 0.2016
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0301 0.0298
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.1222 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.1767 0.4265
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Schistosoma mansoni lipoxygenase 0.0088 0.1955 0.1948
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0081 0.1767 0.2341
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0905 0.2946
Echinococcus granulosus dna polymerase kappa 0.0081 0.1767 0.1765
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0378 0.0478
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0397 0.0503
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0078 0.1701 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0072 0.028
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0098
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.1103 0.1415
Loa Loa (eye worm) hypothetical protein 0.0155 0.36 0.4772
Trichomonas vaginalis DNA helicase recq1, putative 0.0115 0.262 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0953 0.3117
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0953 0.3117
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.1222 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0222 0.0443
Echinococcus multilocularis dna polymerase eta 0.016 0.3718 0.3716
Brugia malayi MH2 domain containing protein 0.001 0.0022 0.003
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0026 0.0418 0.2421
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0081 0.1767 0.1765
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.2899 0.3685
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2899 0.7204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0936 0.0934
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.3602 0.3597
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0048 0.0953 0.095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.1222 0.5352
Schistosoma mansoni cpg binding protein 0.0031 0.0539 0.0531
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0206 0.4838 0.6244
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0418 0.1569
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0081 0.1767 0.1765
Onchocerca volvulus 0.0018 0.0222 0.0202
Trichomonas vaginalis dullard protein, putative 0.0026 0.0418 0.1569
Trypanosoma cruzi DNA polymerase eta, putative 0.016 0.3718 0.4796
Echinococcus granulosus synaptojanin 1 0.0012 0.0072 0.0069
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0072 0.0243
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0654 0.2061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0936 0.0934
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1463 0.188
Brugia malayi Cytochrome P450 family protein 0.0049 0.0973 0.1291
Mycobacterium ulcerans hypothetical protein 0.0171 0.3975 1
Echinococcus multilocularis GPCR, family 2 0.0049 0.0989 0.0987
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0072 0.0069
Leishmania major cathepsin L-like protease 0.0068 0.1463 0.1813
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3326 0.4409
Loa Loa (eye worm) hypothetical protein 0.0026 0.0418 0.0551
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0498 0.0657
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.1222 0.1499
Mycobacterium ulcerans hypothetical protein 0.0015 0.0138 0.0032
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0222 0.0214
Loa Loa (eye worm) acetyltransferase 0.0155 0.3602 0.4775
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0015 0.0138 0.0135
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.1145 0.147
Onchocerca volvulus 0.0029 0.0498 0.0571
Toxoplasma gondii exonuclease III APE 0.0059 0.1222 0.4067
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0411 0.052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0989 0.0987
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0012 0.0072 0.0082
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0324 0.7743 1
Trypanosoma brucei unspecified product 0.0056 0.1151 0.1477
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0072 0.0082
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0222 0.0291
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0222 0.0219
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.1767 0.2274
Echinococcus granulosus CTD small phosphatase protein like 0.0026 0.0418 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0072 0.0082
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0072 0.0069
Schistosoma mansoni cript-related 0.0012 0.0072 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Plasmodium vivax vivapain-2 0.0018 0.0222 0.1265
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0012 0.0072 0.0082
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0654 0.2474
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0072 0.0375
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Trypanosoma brucei DNA polymerase eta, putative 0.016 0.3718 0.4796
Onchocerca volvulus 0.0018 0.0222 0.0202
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0026 0.0418 0.041
Brugia malayi polk-prov protein 0.0025 0.0397 0.0527
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0072 0.028
Onchocerca volvulus 0.0021 0.0301 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1151 0.1477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Echinococcus multilocularis dna polymerase kappa 0.0081 0.1767 0.1765
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0015 0.0138 0.0135
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Schistosoma mansoni blooms syndrome DNA helicase 0.0024 0.0378 0.037
Schistosoma mansoni polycystin 1-related 0.0021 0.0301 0.0293
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0411 0.1775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0222 0.0443
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0072 0.0069
Loa Loa (eye worm) hypothetical protein 0.0316 0.754 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0654 0.2474
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0026 0.0418 0.041
Leishmania major hypothetical protein, conserved 0.0026 0.0418 0.0451
Schistosoma mansoni synaptojanin 0.0012 0.0072 0.0064
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0012 0.0072 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0418 0.053
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0222 0.0219
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0301 0.0298
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0091
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0953 0.1264
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.1222 0.2946
Leishmania major cathepsin L-like protease 0.0068 0.1463 0.1813
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0301 0.0298
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0098
Loa Loa (eye worm) RecQ helicase 0.0115 0.262 0.3473
Schistosoma mansoni hypothetical protein 0.0416 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0081 0.1767 0.221
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0397 0.0503
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0091
Schistosoma mansoni nocturnin 0.0012 0.0072 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.0541
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.3975 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0026 0.0418 0.2421
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0022 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0989 0.1312
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0356 0.0719
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.1463 0.188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0206 0.4838 0.6244
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.3602 0.4777
Trypanosoma brucei ribosomal RNA processing protein 6 0.0015 0.0138 0.0168
Schistosoma mansoni Smad4 0.001 0.0022 0.0014
Echinococcus multilocularis transcription factor btf3 0.0036 0.0654 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0138 0.0497
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Loa Loa (eye worm) fibroinase 0.0018 0.0222 0.0291
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0072 0.0082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.1222 0.1569
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0905 0.0902
Schistosoma mansoni cpg binding protein 0.0029 0.0498 0.0491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0023 0.0356 0.2052
Echinococcus granulosus RUN 0.0021 0.0301 0.0298
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0022 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.1222 0.1219
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.1767 0.6735
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0654 0.2474
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.2899 1
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0222 0.0202
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0072 0.0082
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0026 0.0418 0.0415
Schistosoma mansoni cpg binding protein 0.0031 0.0539 0.0531
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0206 0.4838 0.4836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.1222 0.1569
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0072 0.0131
Schistosoma mansoni hypothetical protein 0.0066 0.1396 0.1389
Entamoeba histolytica recQ family DNA helicase 0.0024 0.0378 0.0766
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0222 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Loa Loa (eye worm) hypothetical protein 0.0021 0.0301 0.0395
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.1222 0.1569
Echinococcus granulosus bloom syndrome protein 0.0115 0.262 0.2618
Echinococcus granulosus Smad4 0.001 0.0022 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.3549 0.4533
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0072 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Toxoplasma gondii cathepsin CPL 0.0018 0.0222 0.0533
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0048 0.0953 0.4167
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0048 0.0953 0.095
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0936 0.1242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Entamoeba histolytica exosome component 10, putative 0.0015 0.0138 0.0269
Schistosoma mansoni DNA polymerase eta 0.016 0.3718 0.3713
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0936 0.0929
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0397 0.2299
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.1767 0.2274
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0397 0.0503
Echinococcus granulosus cysteine protease 0.0009 0.0008 0.0005
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0811 0.3541
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.09 0.1153
Echinococcus granulosus smad 0.001 0.0022 0.002
Giardia lamblia DNA damage repair protein 0.0025 0.0397 0.1921
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0222 0.0219
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.2391 0.3172
Brugia malayi hypothetical protein 0.0026 0.0411 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1151 0.1477
Leishmania major mitochondrial DNA polymerase beta 0.0324 0.7743 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1303 0.1296
Onchocerca volvulus 0.0018 0.0222 0.0202
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0048 0.0953 0.095
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0072 0.0069
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0022 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0301 0.1728
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1463 0.188
Entamoeba histolytica recQ family helicase, putative 0.0062 0.1298 0.267
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0098
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0411 0.2377
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0397 0.1717
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0654 0.0864
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0989 0.1312
Echinococcus granulosus dna polymerase eta 0.016 0.3718 0.3716
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0072 0.0243
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Schistosoma mansoni smad 0.001 0.0022 0.0014
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Treponema pallidum ATP-dependent DNA helicase 0.0024 0.0378 0.2666
Toxoplasma gondii hypothetical protein 0.0052 0.1065 0.3514
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0072 0.0064
Onchocerca volvulus 0.0018 0.0222 0.0202
Echinococcus multilocularis synaptojanin 1 0.0012 0.0072 0.0069
Leishmania major cathepsin L-like protease 0.0018 0.0222 0.0196
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0206 0.4838 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Schistosoma mansoni DNA helicase recq1 0.0048 0.0953 0.0945
Leishmania major DNA polymerase kappa, putative 0.0025 0.0397 0.0425
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.1222 0.2512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0076 0.0261
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0397 0.1152
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.36 0.4774
Loa Loa (eye worm) hypothetical protein 0.0021 0.0301 0.0395
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0905 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0989 0.0987
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0048 0.0953 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0397 0.0503
Onchocerca volvulus 0.0316 0.754 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0936 0.0929
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0072 0.0375
Brugia malayi ImpB/MucB/SamB family protein 0.016 0.3718 0.4931
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0072 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1767 0.2274
Schistosoma mansoni synaptojanin 0.0012 0.0072 0.0064
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0989 0.0987
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0072 0.0131
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.1317 0.1692
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Mycobacterium ulcerans hypothetical protein 0.0025 0.0397 0.0706
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0015 0.0138 0.0168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0936 0.0934
Brugia malayi hypothetical protein 0.0021 0.0301 0.0399
Schistosoma mansoni loxhd1 0.0021 0.0301 0.0293
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 0.7743 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0301 0.0298
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0076 0.0068
Schistosoma mansoni transcription factor btf3 0.0036 0.0654 0.0647
Leishmania major hypothetical protein, conserved 0.0026 0.0411 0.0442
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.1767 0.2274
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0206 0.4838 0.4836
Echinococcus multilocularis Smad4 0.001 0.0022 0.002
Schistosoma mansoni ap endonuclease 0.0059 0.1222 0.1214
Echinococcus multilocularis 0.0026 0.0418 0.0415
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0026 0.0418 0.0848
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0989 0.0987
Leishmania major basic transcription factor 3a, putative 0.0036 0.0654 0.076
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.1767 0.2344
Echinococcus granulosus cathepsin l1 0.0012 0.0076 0.0074
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0072 0.028
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0072 0.0131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Loa Loa (eye worm) ctsf protein 0.0018 0.0222 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0222 0.0819
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0989 0.1309
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0222 0.0202
Brugia malayi Doublecortin family protein 0.0021 0.0301 0.0399
Loa Loa (eye worm) hypothetical protein 0.0026 0.041 0.054
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0072 0.0243
Schistosoma mansoni DNA helicase recq5 0.0048 0.0953 0.0945
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 0.7743 1
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0072 0.0243
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0397 0.0503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0222 0.0819
Loa Loa (eye worm) DnaJ domain-containing protein 0.0066 0.1396 0.1848
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0953 0.1264
Trypanosoma brucei RNA editing exonuclease 2 0.0012 0.0072 0.0082
Entamoeba histolytica deoxycytidyl transferase, putative 0.0081 0.1767 0.3643
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0811 0.4359
Schistosoma mansoni hypothetical protein 0.0049 0.0989 0.0982
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0222 0.0295
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0936 0.1238
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0072 0.028
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0397 0.0389
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0072 0.0082
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0072 0.0095
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.1222 0.6781
Schistosoma mansoni hypothetical protein 0.0049 0.0989 0.0982
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0026 0.0418 0.0554
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0206 0.4838 0.6244
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0081 0.1767 0.4345
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0206 0.4838 0.4833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0222 0.0819
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0012 0.0072 0.0082
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0015 0.0138 0.0235
Trypanosoma brucei unspecified product 0.0056 0.1151 0.1477
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0811 0.1662
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0397 0.0503
Loa Loa (eye worm) hypothetical protein 0.0049 0.0989 0.1309
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0397 0.0524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0936 0.0934
Brugia malayi Cathepsin L-like precursor 0.0018 0.0222 0.0295
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0126 0.0694
Schistosoma mansoni hypothetical protein 0.0049 0.0989 0.0982
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3326 0.4409
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0206 0.4838 0.6415
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.2899 0.2897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0076 0.0261
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0654 0.3818
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0072 0.0069
Echinococcus multilocularis smad 0.001 0.0022 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1463 0.188
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0072 0.0131
Echinococcus multilocularis bloom syndrome protein 0.0115 0.262 0.2618
Schistosoma mansoni hypothetical protein 0.0026 0.041 0.0402
Echinococcus granulosus cpg binding protein 0.0031 0.0539 0.0537
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0015 0.0138 0.0767
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0654 0.0835
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0008 0.0005

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4467 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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