TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 266.253 | Formula: C11H14N4O4
H donors: 6 H acceptors: 4 LogP: -2.54 Rotable bonds: 2
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@@]1(NC[C@@H]([C@@H]1O)O)c1c[nH]c2c1nc[nH]c2=O
InChi: 1S/C11H14N4O4/c16-3-11(9(18)6(17)2-15-11)5-1-12-8-7(5)13-4-14-10(8)19/h1,4,6,9,12,15-18H,2-3H2,(H,13,14,19)/t6-,9-,11+/m0/s1
InChiKey: AEUGGDFVABOKCJ-DQBIJJQNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	purine nucleoside phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	ko:K03783 purine-nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	Get druggable targets OG5_128114	All targets in OG5_128114
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	Purine nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium ulcerans	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	purine nucleoside phosphorylase	289 aa	255 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0154	0.5637	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0426	0.3579
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.1191	0.0409
Echinococcus multilocularis	uridine phosphorylase 1	0.0032	0.0816	0.1173
Leishmania major	nucleoside phosphorylase-like protein	0.0032	0.0816	0.509
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0154	0.5637	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1512	0.2447
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.1191	0.1468
Trypanosoma brucei	uridine phosphorylase	0.0032	0.0816	0.509
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0816	1
Echinococcus granulosus	uridine phosphorylase 1	0.0032	0.0816	0.1173
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.1191	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0675	0.1541
Brugia malayi	beta-lactamase family protein	0.0041	0.1191	0.186
Echinococcus multilocularis	lamin dm0	0.0061	0.1964	0.3276
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.1191	0.186
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5637	1
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	0.5637	1
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0032	0.0816	0.6847
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5637	1
Loa Loa (eye worm)	uridine phosphorylase	0.0032	0.0816	0.1863
Loa Loa (eye worm)	beta-lactamase	0.0041	0.1191	0.2721
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0032	0.0816	0.0747
Chlamydia trachomatis	AMP nucleosidase	0.0032	0.0816	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1512	0.3453
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0426	0.3579
Loa Loa (eye worm)	hypothetical protein	0.0122	0.4378	1
Echinococcus multilocularis	lamin	0.0061	0.1964	0.3276
Onchocerca volvulus		0.0061	0.1964	0.1739
Schistosoma mansoni	uridine phosphorylase	0.0032	0.0816	0.1447
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0175	0.04
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0033	0.0847	0.1934
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5637	1
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0816	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.1191	0.2113
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5637	1
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0426	0.0974
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.1191	0.186
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5637	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0033	0.0847	0.1229
Mycobacterium leprae	Probable lipase LipE	0.0041	0.1191	0.0779
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.1191	0.0409
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0426	0.046
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0675	0.1541
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	0.5637	1
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0816	0.0747
Entamoeba histolytica	hypothetical protein	0.0032	0.0816	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0893	0.1584
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.0032	0.0816	0.1863
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.0032	0.0816	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.1191	0.1468
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.1191	0.2721
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0029	0.0719	0.0995
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0154	0.5637	0.5249
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0426	0.0974
Brugia malayi	MTAP	0.0032	0.0816	0.1173
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1191	0.2721
Plasmodium falciparum	purine nucleoside phosphorylase	0.0032	0.0816	1
Mycobacterium ulcerans	beta-lactamase	0.0041	0.1191	0.0779
Brugia malayi	uridine phosphorylase family protein	0.0032	0.0816	0.1173
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0719	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1191	0.2721
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1564	0.2543
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.1191	0.186
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1191	0.2721
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0032	0.0816	0.6847
Echinococcus granulosus	intermediate filament protein	0.0061	0.1964	0.3276
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0154	0.5637	1
Mycobacterium ulcerans	lipase LipD	0.0041	0.1191	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0011	0.00000000035862	0.00000000081915
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0154	0.5637	1
Toxoplasma gondii	phosphorylase family protein	0.0032	0.0816	0.6847
Entamoeba histolytica	recQ family helicase, putative	0.0022	0.0426	0.5227
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5637	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0426	0.046
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0.0816	0.6847
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1564	0.2775
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.0032	0.0816	0.509
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5637	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.1191	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.1564	0.2543
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0816	0.0747
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0022	0.0426	0.046
Mycobacterium ulcerans	hypothetical protein	0.0041	0.1191	0.0779
Echinococcus granulosus	lamin	0.0061	0.1964	0.3276
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1191	0.2721
Schistosoma mansoni	hypothetical protein	0.0016	0.0175	0.0311
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0816	0.0747
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0022	0.0426	0.046
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0816	0.0747
Schistosoma mansoni	lamin	0.0061	0.1964	0.3485
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1191	0.0409
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0032	0.0816	0.0747
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5637	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.1191	0.2113
Echinococcus granulosus	methylthioadenosine phosphorylase	0.0032	0.0816	0.1173
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0032	0.0816	0.6847
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0816	0.0747
Treponema pallidum	pfs protein (pfs)	0.0032	0.0816	1
Echinococcus multilocularis	musashi	0.0061	0.1964	0.3276
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0816	1
Leishmania major	hypothetical protein, conserved	0.0041	0.1191	1
Toxoplasma gondii	ABC1 family protein	0.0041	0.1191	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1964	0.4487
Schistosoma mansoni	DNA helicase recq1	0.0022	0.0426	0.0756
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0032	0.0816	0.6847
Loa Loa (eye worm)	hypothetical protein	0.006	0.192	0.4387
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0175	0.04
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1512	0.3453
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0426	0.046
Trichomonas vaginalis	esterase, putative	0.0041	0.1191	0.1468
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.1191	1
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0816	0.0747
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0022	0.0426	0.0974
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.1191	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5637	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0022	0.0426	0.046
Echinococcus granulosus	lamin dm0	0.0061	0.1964	0.3276
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0816	1
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0154	0.5637	1
Leishmania major	methylthioadenosine phosphorylase, putative	0.0032	0.0816	0.509
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.1564	0.3572
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0816	0.0747
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5637	1
Loa Loa (eye worm)	intermediate filament protein	0.0061	0.1964	0.4487
Brugia malayi	beta-lactamase family protein	0.0041	0.1191	0.186
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0.0816	0.6847
Schistosoma mansoni	DNA helicase recq5	0.0022	0.0426	0.0756
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.1191	0.1468
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0122	0.4378	0.7695
Schistosoma mansoni	intermediate filament proteins	0.0061	0.1964	0.3485
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.1191	0.0409
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0893	0.1314
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.4378	0.7695
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0816	0.0747
Schistosoma mansoni	uridine phosphorylase	0.0032	0.0816	0.1447
Schistosoma mansoni	hypothetical protein	0.0016	0.0175	0.0311
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5637	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.1191	0.0779
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.1191	0.1468
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0029	0.0719	0.0995
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0154	0.5637	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5637	1
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0.0816	0.6847
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.1191	0.1468
Schistosoma mansoni	lamin	0.0061	0.1964	0.3485
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0426	0.046
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1191	0.2721
Schistosoma mansoni	hypothetical protein	0.0016	0.0175	0.0311
Onchocerca volvulus		0.0061	0.1964	0.1739
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1191	0.0409
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1512	0.2447
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0816	0.0747
Brugia malayi	Intermediate filament tail domain containing protein	0.0061	0.1964	0.3276
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0032	0.0816	0.1447
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5637	1
Treponema pallidum	purine nucleoside phosphorylase (deoD)	0.0032	0.0816	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.1191	0.0409
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0426	0.046
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1564	0.2775
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.1191	0.0779
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0022	0.0426	0.046
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1564	0.2543
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0061	0.1964	0.4487
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.0032	0.0816	0.1173
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0893	0.204
Brugia malayi	beta-lactamase	0.0041	0.1191	0.186
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0032	0.0816	0.1447
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.1191	0.0409
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.1191	0.0779
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0032	0.0816	0.1447
Brugia malayi	intermediate filament protein	0.0061	0.1964	0.3276
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.1191	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1564	0.2543
Treponema pallidum	uridine phosphorylase (udp)	0.0032	0.0816	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1191	0.2721
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0426	0.3579
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1564	0.2543
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.1191	0.0409
Schistosoma mansoni	hypothetical protein	0.0016	0.0175	0.0311
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.4378	0.7695
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1191	0.0409
Giardia lamblia	UPL-1	0.0032	0.0816	0.0747
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0816	1
Toxoplasma gondii	phosphorylase family protein	0.0032	0.0816	0.6847
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1564	0.2775
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5637	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 100 nM	Inhibition of human purine nucleoside phosphorylase	ChEMBL.	19386498

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL565199

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1060156