Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2616 | 0.2616 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.3374 | 0.3374 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.2616 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.9226 | 0.9226 |
Onchocerca volvulus | 0.0056 | 1 | 0.5 | |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.2616 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.4956 | 0.4956 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 1 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.3374 | 0.3374 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.4956 | 0.4956 |
Echinococcus multilocularis | lamin | 0.0056 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.9226 | 0.9226 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0056 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2355 | 0.2355 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.9739 | 0.9739 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2355 | 0.2355 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.4956 | 0.4956 |
Echinococcus granulosus | lamin | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0056 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.9226 | 0.9226 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.9226 | 0.9226 |
Onchocerca volvulus | 0.0056 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 38 % | Cytotoxicity against mouse J774 cells assessed as cell viability at 100 ug/mL after 24 hrs by MTT assay | ChEMBL. | 19403210 |
Activity (ADMET) | = 91 % | Cytotoxicity against mouse J774 cells assessed as cell viability at 10 ug/mL after 24 hrs by MTT assay | ChEMBL. | 19403210 |
Activity (ADMET) | = 100 % | Cytotoxicity against mouse J774 cells assessed as cell viability at 0.1 ug/mL after 24 hrs by MTT assay | ChEMBL. | 19403210 |
Activity (ADMET) | = 100 % | Cytotoxicity against mouse J774 cells assessed as cell viability at 1 ug/mL after 24 hrs by MTT assay | ChEMBL. | 19403210 |
IC50 (functional) | = 69.4 uM | Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake | ChEMBL. | 19403210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.