Detailed information for compound 1060260

Basic information

Technical information
  • TDR Targets ID: 1060260
  • Name: (E)-N-methyl-N-[(1-methylindol-2-yl)methyl]-3 -(4-oxo-1,2,3,5-tetrahydropyrido[5,6-b][1,4]d iazepin-8-yl)prop-2-enamide
  • MW: 389.45 | Formula: C22H23N5O2
  • H donors: 2 H acceptors: 3 LogP: 1.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCNc2c(N1)ncc(c2)/C=C/C(=O)N(Cc1cc2c(n1C)cccc2)C
  • InChi: 1S/C22H23N5O2/c1-26(14-17-12-16-5-3-4-6-19(16)27(17)2)21(29)8-7-15-11-18-22(24-13-15)25-20(28)9-10-23-18/h3-8,11-13,23H,9-10,14H2,1-2H3,(H,24,25,28)/b8-7+
  • InChiKey: XVCRSAAJAJMUPG-BQYQJAHWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-N-methyl-N-[(1-methyl-2-indolyl)methyl]-3-(4-oxo-1,2,3,5-tetrahydropyrido[5,6-b][1,4]diazepin-8-yl)prop-2-enamide
  • (E)-3-(4-keto-1,2,3,5-tetrahydropyrido[5,6-b][1,4]diazepin-8-yl)-N-methyl-N-[(1-methylindol-2-yl)methyl]acrylamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis heat shock protein, putative 0.0051 0.1202 0.4516
Toxoplasma gondii heat shock protein HSP90 0.0055 0.1304 0.2193
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0921 0.1591
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.1567 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0921 0.1591
Schistosoma mansoni hypothetical protein 0.0043 0.0946 0.1634
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0238 0.0546
Schistosoma mansoni hypothetical protein 0.0023 0.0335 0.0579
Trypanosoma brucei heat shock protein, putative 0.0055 0.1304 0.4937
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0213 0.0368
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0586 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0406 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1204 0.4524
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Schistosoma mansoni hypothetical protein 0.0023 0.0335 0.0579
Brugia malayi Bromodomain containing protein 0.0035 0.0699 0.1758
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.1113 0.1922
Trypanosoma brucei heat shock protein, putative 0.0055 0.1304 0.4937
Trypanosoma brucei heat shock protein, putative 0.0055 0.1304 0.4937
Brugia malayi Sema domain containing protein 0.0023 0.0335 0.0844
Plasmodium vivax heat shock protein 86, putative 0.0055 0.1304 0.1099
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.1567 0.2705
Trypanosoma brucei DNA polymerase eta, putative 0.0094 0.2492 0.9833
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.1304 0.4937
Loa Loa (eye worm) hypothetical protein 0.0023 0.0335 0.0833
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0341 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0609 0.1051
Schistosoma mansoni plexin 0.0055 0.1304 0.2251
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0555 0.0555
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0238 0.0401
Trypanosoma brucei unspecified product 0.0087 0.2293 0.9013
Mycobacterium ulcerans DNA polymerase IV 0.0095 0.2532 0.235
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0335 0.0833
Giardia lamblia DNA damage repair protein 0.002 0.0238 0.1319
Trypanosoma cruzi DNA polymerase kappa, putative 0.0095 0.2532 1
Entamoeba histolytica hypothetical protein 0.0043 0.0946 0.5972
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Brugia malayi ImpB/MucB/SamB family protein 0.0094 0.2492 0.6269
Loa Loa (eye worm) sema domain-containing protein 0.0023 0.0335 0.0833
Schistosoma mansoni hypothetical protein 0.0035 0.0699 0.1206
Echinococcus granulosus flap endonuclease 1 0.0031 0.0586 0.1011
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.1826 0.4533
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0047 0.1063 0.1836
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.1304 0.8292
Schistosoma mansoni flap endonuclease-1 0.0028 0.0495 0.0854
Schistosoma mansoni heat shock protein 0.0036 0.0745 0.1287
Echinococcus granulosus geminin 0.0203 0.5792 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.145 0.3601
Loa Loa (eye worm) plexin A 0.0065 0.1609 0.3994
Echinococcus granulosus peregrin 0.0035 0.0699 0.1206
Plasmodium falciparum heat shock protein 90, putative 0.0208 0.5945 0.5945
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Brugia malayi hypothetical protein 0.0023 0.0335 0.0844
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0071 0.1806 0.0688
Toxoplasma gondii ImpB/MucB/SamB family protein 0.005 0.1163 0.1956
Schistosoma mansoni jumonji domain containing protein 0.0091 0.2394 0.4134
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0238 0.0546
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0946 0.1634
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0699 0.1175
Plasmodium vivax endoplasmin, putative 0.0055 0.1304 0.1099
Loa Loa (eye worm) transcription factor SMAD2 0.0143 0.3974 0.9869
Trichomonas vaginalis heat shock protein, putative 0.004 0.0848 0.3057
Loa Loa (eye worm) hypothetical protein 0.0051 0.1204 0.2989
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.1202 0.4592
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0512 0.0884
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0238 0.0411
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Entamoeba histolytica hypothetical protein 0.0043 0.0946 0.5972
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0699 0.048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0213 0.0529
Trypanosoma brucei heat shock protein 84, putative 0.0036 0.0745 0.2636
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Loa Loa (eye worm) endoplasmin 0.0055 0.1304 0.3237
Brugia malayi heat shock protein 90 0.0055 0.1304 0.328
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Mycobacterium ulcerans DNA polymerase IV 0.0095 0.2532 0.235
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0238 0.0546
Schistosoma mansoni plexin 0.0032 0.0609 0.1051
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0555 0.1852
Echinococcus granulosus endoplasmin 0.0051 0.1202 0.2074
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.0478 0.0804
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0213 0.0368
Trypanosoma cruzi heat shock protein, putative 0.0036 0.0745 0.2636
Loa Loa (eye worm) heat shock protein 90 0.0055 0.1304 0.3237
Plasmodium falciparum heat shock protein 90 0.0055 0.1304 0.1304
Schistosoma mansoni hypothetical protein 0.0019 0.0213 0.0368
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0114 0.3107 0.5364
Echinococcus granulosus bloom syndrome protein 0.0029 0.0512 0.0884
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0341 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0335 0.0833
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0699 0.1206
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1304 0.4937
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0512 0.1673
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0877 0.2208
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Leishmania major heat shock protein, putative 0.0036 0.0745 0.268
Schistosoma mansoni semaphorin 5-related 0.0023 0.0335 0.0579
Brugia malayi hypothetical protein 0.0023 0.0335 0.0844
Plasmodium falciparum flap endonuclease 1 0.0031 0.0586 0.0586
Brugia malayi jmjC domain containing protein 0.0042 0.0921 0.2318
Trypanosoma brucei DNA polymerase IV, putative 0.0095 0.2532 1
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Schistosoma mansoni hypothetical protein 0.0019 0.0213 0.0368
Entamoeba histolytica hypothetical protein 0.0043 0.0946 0.5972
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1304 0.4937
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0328 0.0567
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.1567 0.3891
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0213 0.0529
Loa Loa (eye worm) hypothetical protein 0.006 0.1455 0.3613
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1208 0.4544
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.1304 0.2193
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0238 0.0546
Trypanosoma brucei DNA polymerase IV, putative 0.0095 0.2532 1
Trichomonas vaginalis heat shock protein, putative 0.0055 0.1304 0.4937
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0555 0.1379
Echinococcus multilocularis heat shock protein 0.0055 0.1304 0.2251
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0586 0.1977
Echinococcus multilocularis dna polymerase kappa 0.0095 0.2532 0.4372
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0213 0.0536
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.1304 0.4937
Brugia malayi Plexin repeat family protein 0.0055 0.1304 0.3281
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0238 0.0238
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.1567 0.2705
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0238 0.0546
Echinococcus granulosus heat shock protein 90 0.0055 0.1304 0.2251
Echinococcus multilocularis GPCR, family 2 0.0019 0.0213 0.0368
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0946 0.1634
Schistosoma mansoni hypothetical protein 0.0041 0.0877 0.1515
Loa Loa (eye worm) hypothetical protein 0.0041 0.0877 0.2179
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0036 0.0745 0.1287
Entamoeba histolytica hypothetical protein 0.0043 0.0946 0.5972
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0921 0.1591
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.1567 0.3943
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0341 1 1
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0921 0.2288
Trypanosoma brucei heat shock protein, putative 0.0055 0.1304 0.4937
Toxoplasma gondii heat shock protein 75, putative 0.0036 0.0745 0.1254
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.1304 0.7217
Trypanosoma brucei unspecified product 0.0044 0.0969 0.3557
Schistosoma mansoni hypothetical protein 0.0203 0.5792 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0095 0.2532 1
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0586 0.3631
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.1063 0.3946
Trypanosoma cruzi DNA polymerase kappa, putative 0.0095 0.2532 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1204 0.4524
Loa Loa (eye worm) heat shock protein 75 0.0036 0.0745 0.1851
Toxoplasma gondii Hsp90 domain-containing protein 0.0208 0.5945 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.145 0.3648
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0586 0.3242
Onchocerca volvulus Alhambra homolog 0.0035 0.0699 0.375
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.2293 0.9013
Loa Loa (eye worm) MH2 domain-containing protein 0.0143 0.3974 0.9869
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0036 0.0745 0.4233
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0238 0.0546
Trypanosoma brucei heat shock protein, putative 0.0055 0.1304 0.4937
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.1304 0.4937
Trypanosoma brucei heat shock protein, putative 0.0055 0.1304 0.4937
Echinococcus granulosus semaphorin 1A 0.0023 0.0335 0.0579
Leishmania major DNA polymerase eta, putative 0.005 0.1163 0.4431
Trypanosoma brucei unspecified product 0.0044 0.0969 0.3557
Mycobacterium ulcerans heat shock protein 90 0.0051 0.1202 0.0987
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0586 0.0985
Schistosoma mansoni heat shock protein 0.0055 0.1304 0.2251
Onchocerca volvulus 0.0055 0.1304 1
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0607 0.2066
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0238 0.0546
Schistosoma mansoni heat shock protein 0.0055 0.1304 0.2251
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Echinococcus multilocularis semaphorin 5B 0.0023 0.0335 0.0579
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Echinococcus granulosus heat shock protein 0.0055 0.1304 0.2251
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0213 0.0536
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.1806 0.7009
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0921 0.1591
Giardia lamblia DINP protein human, muc B family 0.0071 0.1806 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0512 0.1673
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0586 0.1977
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Trypanosoma brucei heat shock protein, putative 0.0055 0.1304 0.4937
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0586 0.1011
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.1567 0.2705
Loa Loa (eye worm) hypothetical protein 0.0094 0.2492 0.6187
Schistosoma mansoni DNA polymerase eta 0.0094 0.2492 0.4302
Echinococcus multilocularis geminin 0.0203 0.5792 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0335 0.0833
Leishmania major DNA polymerase kappa, putative 0.002 0.0238 0.0555
Loa Loa (eye worm) hypothetical protein 0.0035 0.0699 0.1735
Plasmodium vivax heat shock protein, putative 0.0208 0.5945 0.585
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.1304 0.4937
Echinococcus granulosus heat shock protein 90 0.0047 0.1063 0.1836
Echinococcus granulosus jumonji domain containing protein 0.0049 0.1113 0.1922
Plasmodium vivax heat shock protein 90, putative 0.0036 0.0745 0.0528
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0238 0.0546
Giardia lamblia Grp94/Hsp90 0.0051 0.1202 0.6651
Plasmodium falciparum endoplasmin, putative 0.004 0.0848 0.0848
Echinococcus granulosus GPCR family 2 0.0019 0.0213 0.0368
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0555 0.0934
Trypanosoma cruzi DNA polymerase kappa, putative 0.0095 0.2532 1
Plasmodium falciparum heat shock protein 90, putative 0.0032 0.0607 0.0607
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0051 0.0087
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0586 0.1977
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.1063 0.3946
Leishmania major DNA damage repair protein, putative 0.002 0.0238 0.0555
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0337 0.0952
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1208 0.4544
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0699 0.1735
Loa Loa (eye worm) hypothetical protein 0.0144 0.4027 1
Schistosoma mansoni hypothetical protein 0.0019 0.0213 0.0368
Loa Loa (eye worm) hypothetical protein 0.0055 0.1304 0.3238
Echinococcus granulosus dna polymerase kappa 0.0095 0.2532 0.4372
Brugia malayi Endoplasmin precursor 0.0055 0.1304 0.328
Brugia malayi hypothetical protein 0.0019 0.0231 0.0581
Schistosoma mansoni hypothetical protein 0.0019 0.0213 0.0368
Trichomonas vaginalis DNA polymerase eta, putative 0.0095 0.2532 1
Loa Loa (eye worm) hypothetical protein 0.006 0.145 0.3601
Brugia malayi PHD-finger family protein 0.0035 0.0699 0.1758
Schistosoma mansoni endoplasmin 0.0055 0.1304 0.2251
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0586 0.1454
Echinococcus granulosus plexin a4 0.0065 0.1609 0.2777
Treponema pallidum hypothetical protein 0.0341 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.1567 0.2705
Leishmania major DNA polymerase eta, putative 0.0094 0.2492 1
Trichomonas vaginalis heat shock protein, putative 0.0051 0.1202 0.4516
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0699 0.1206
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0036 0.0745 0.4667
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0087
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.1304 0.8292
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0555 0.0333
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0114 0.3107 0.5364
Brugia malayi Flap endonuclease-1 0.0031 0.0586 0.1474
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Trichomonas vaginalis endoplasmin, putative 0.004 0.0848 0.3057
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.1063 0.5887
Loa Loa (eye worm) hypothetical protein 0.0023 0.0335 0.0833
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0555 0.1852
Echinococcus granulosus dna polymerase eta 0.0094 0.2492 0.4302
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1304 0.4937
Brugia malayi hypothetical protein 0.003 0.0555 0.1397
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.1304 0.4937
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0555 0.1852
Trypanosoma brucei heat shock protein, putative 0.0055 0.1304 0.4937
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0223 0.0374
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.145 0.3648
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0213 0.0368
Echinococcus multilocularis peregrin 0.0035 0.0699 0.1206
Brugia malayi polk-prov protein 0.0051 0.1204 0.3028
Echinococcus multilocularis heat shock protein 90 0.0055 0.1304 0.2251
Leishmania major hypothetical protein, conserved 0.003 0.0555 0.1884
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0699 0.1175
Echinococcus multilocularis plexin a4 0.0065 0.1609 0.2777
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0512 0.1288
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1208 0.4544
Echinococcus multilocularis endoplasmin 0.0051 0.1202 0.2074
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0106 0.0517
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0586 0.2011
Plasmodium falciparum phd finger protein, putative 0.0035 0.0699 0.0699
Echinococcus multilocularis heat shock protein 90 0.0047 0.1063 0.1836
Schistosoma mansoni hypothetical protein 0.0203 0.5792 1
Echinococcus multilocularis dna polymerase eta 0.0094 0.2492 0.4302
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0341 1 1
Brugia malayi jmjC domain containing protein 0.0114 0.3107 0.7817
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0699 0.1206
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0051 0.1202 0.5
Brugia malayi plexin A 0.0065 0.1609 0.4047
Brugia malayi Sema domain containing protein 0.0023 0.0335 0.0844
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0238 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0238 0.0546
Brugia malayi hypothetical protein 0.0043 0.0946 0.2381
Brugia malayi MH2 domain containing protein 0.0143 0.3974 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0094 0.2492 0.9833
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0213 0.0368
Loa Loa (eye worm) RecQ helicase 0.0029 0.0512 0.1271
Trichomonas vaginalis heat shock protein, putative 0.0047 0.1063 0.3946
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.1567 0.0415
Leishmania major DNA polymerase kappa, putative 0.0071 0.1806 0.7128
Schistosoma mansoni endoplasmin 0.0055 0.1304 0.2251
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0555 0.0555
Trypanosoma cruzi DNA polymerase kappa, putative 0.0095 0.2532 1
Giardia lamblia PHD finger protein 15 0.0035 0.0699 0.3868
Loa Loa (eye worm) sema domain-containing protein 0.0023 0.0335 0.0833
Leishmania major heat shock protein 83-1 0.0055 0.1304 0.5021
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0071 0.1806 0.7128
Loa Loa (eye worm) hypothetical protein 0.0032 0.0609 0.1512
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.1163 0.4357
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0051 0.0087
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0946 0.1634
Loa Loa (eye worm) hypothetical protein 0.0023 0.0335 0.0833
Echinococcus granulosus semaphorin 5B 0.0023 0.0335 0.0579
Echinococcus multilocularis hypothetical protein 0.0023 0.0335 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.2532 1
Brugia malayi Hsp90 protein 0.0036 0.0745 0.1875
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0036 0.0745 0.1287

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 1 ug ml-1 Antibacterial activity against Escherichia coli efflux pump mutant by microdilution method ChEMBL. 19682900

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.